A lens configured for implantation into an eye of a human can include an optic including transparent material. The optic can have an anterior surface and a posterior surface. Each of the anterior surface and the posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. The lens can also include at least one haptic disposed with respect to the optic to affix the optic in the eye when implanted therein. The anterior and posterior surfaces can include aspheric surfaces. The posterior surface can have an aspheric shape that comprises a biconic offset by perturbations comprising an aspheric higher order function of radial distance from the optical axis. The posterior surface can have an absolute value of ratio rx/ry between 0 and 100 and an absolute value of ratio kx/ky between 0 and 100.
|
1. A lens configured for implantation into an eye of a human, said lens comprising:
an optic comprising transparent material, said optic having an anterior surface and a posterior surface, each of said anterior surface and said posterior surface having a surface vertex, said optic having an optical axis through said surface vertices,
at least one haptic disposed with respect to the optic to affix the optic in the eye when implanted therein,
wherein said anterior and posterior surfaces comprise aspheric surfaces and said posterior surface has an aspheric shape that comprises a biconic offset by perturbations comprising an aspheric higher order function of radial distance from the optical axis,
wherein the posterior surface has a radius of curvature, ry a radius of curvature, rx, a conic constant, ky, and a conic constant, kx,
wherein the posterior surface has an absolute value of ratio rx/ry between 0 and 100 and an absolute value of ratio kx/ky between 0 and 100, and
wherein the anterior surface has a radius of curvature between 0 to 1 mm.
18. The lens of
wherein the anterior and posterior surfaces are shaped to provide a radial power profile characterized by Φ(r)=a+br2+cr4 +dr6 +er8 for wavefront at the exit pupil of the optic for an object vergence of 0 to 2.5 Diopter (D) where r is the radial distance from the optical axis and a, b, c, d, and e are coefficients.
19. The lens of
20. The lens of
21. The lens of
22. The lens of
24. The lens of
25. The lens of
26. The lens of
|
|||||||||||||||||||||||||||||||||
This application claims the benefit of priority of U.S. Provisional Application No. 62/306,003, filed on Mar. 9, 2016, and U.S. Provisional Application No. 62/306,034, filed on Mar. 9, 2016. The entire disclosures of each of the prior applications are hereby expressly incorporated by reference.
This disclosure relates to ophthalmic implants, for example, to ophthalmic implants with extended depth of field.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The lens can also include haptic portions disposed about the optic to affix the optic in the eye when implanted therein. The optic can include an anterior surface and a posterior surface. The anterior surface can be convex and the posterior surface can be concave such that the optic is meniscus shaped. Each of the convex anterior surface and the concave posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. In various embodiments, a thickness along the optical axis can be between about 100-700 micrometers (or any range formed by any of the values in this range). In addition, the anterior and posterior surfaces can comprise aspheric surfaces.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The lens can also include at least one haptic disposed with respect to the optic to affix the optic in the eye when implanted therein. The optic can have an anterior surface and a posterior surface. The anterior surface can be convex and the posterior surface can be concave such that the optic is meniscus shaped. Each of the convex anterior surface and the concave posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. In various embodiments, the anterior and posterior surfaces can comprise aspheric surfaces. The anterior surface can have an aspheric shape that comprises a conic or biconic offset by perturbations comprising an aspheric higher order function of radial distance from the optical axis.
In some such embodiments, the aspheric higher order function can include at least one even order term, a2nr2n, where n is an integer and a2n is a coefficient and r is the radial distance from the optical axis. For example, the aspheric higher order function can include a second order term, a2r2, where a2 is a coefficient and r is the radial distance from the optical axis. As another example, the aspheric higher order function can include a fourth order term, a4r4, where a4 is a coefficient and r is the radial distance from the optical axis. The aspheric higher order function also can include a sixth order term, a6r6 where a6 is a coefficient and r is the radial distance from the optical axis. Furthermore, the aspheric higher order function can include an eighth order term, a8r8 where a8 is a coefficient and r is the radial distance from the optical axis. In some embodiments of the lens, the optic can have a thickness along the optical axis that is between about 100-700 microns (or any range formed by any of the values in this range). In various embodiments, the anterior surface has an aspheric shape that comprises a biconic offset by the perturbations.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The lens can also include at least one haptic disposed with respect to the optic in the eye when implanted therein. The optic can have an anterior surface and a posterior surface. The anterior surface can be convex and the posterior surface can be concave such that the optic is meniscus shaped. Each of the convex anterior surface and the concave posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. In various embodiments, the anterior and posterior surfaces can comprise aspheric surfaces. The posterior surface can have an aspheric shape that comprises a conic or biconic offset by perturbations comprising an aspheric higher order function of radial distance from the optical axis. In various embodiments, the posterior surface has an aspheric shape that comprises a biconic offset by the perturbations.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The optic can have an anterior surface and a posterior surface. The anterior surface can comprise an aspheric surface. The anterior and posterior surfaces also can be shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 90% of the object vergences within the range of 0 to 2.5 Diopter (D) when the optic is inserted into the human eye having an aperture size of aperture size of 2 to 6 millimeters, 3 to 6 millimeters, or 4 to 6 millimeters (e.g., the aperture size can be 2 mm, 3 mm, 4 mm, 6 mm, any value within these ranges, or any range formed by such values). The average MTF values can comprise MTF values at 100 lines per millimeter integrated over the wavelengths between about 400 to 700 nm weighted by the photopic luminosity function for on axis objects.
In various embodiments, the human eye comprises a crystalline lens and the average modulation transfer function values are provided when the optic is inserted anterior of the crystalline lens. In various other embodiments, the human eye excludes a crystalline lens and the modulation transfer function values are provided when the optic is inserted in place of the crystalline lens. The lens further can comprise haptic portions. In addition, the optic can have an optical axis and a thickness through the optical axis that is between about 100-700 microns (or any range formed by any of the values in this range).
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The optic can have an anterior surface and a posterior surface. The anterior surface can comprise an aspheric surface. The anterior and posterior surfaces also can be shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 90% of the object vergences within the range of 0 to 2.5 Diopter (D) when the optic is inserted into a model eye having an aperture size of 2 to 6 millimeters, 3 to 6 millimeters, or 4 to 6 millimeters (e.g., the aperture size can be 2 mm, 3 mm, 4 mm, 6 mm, any value within these ranges, or any range formed by such values). The average MTF values can comprise MTF values at 100 lines per millimeter integrated over the wavelengths between about 400 to 700 nm weighted by the photopic luminosity function for on axis objects.
The model eye can comprise a Liou-Brennan model eye. Alternatively, the model eye can comprise a Badal model eye. Furthermore, the model eye can comprise an Arizona model eye or an Indiana model eye. Other standardized or equivalent model eyes can be used.
In some embodiments, the modulation transfer function values can be provided when the optic is inserted in the model eye in a phakic configuration. In some other embodiments, the modulation transfer function values can be provided when the optic is inserted in the model eye in an aphakic configuration. The lens can further comprise haptic portions. Furthermore, the optic can have an optical axis and a thickness through the optical axis that is between about 100-700 microns (or any range formed by any of the values in this range).
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The optic can have an anterior surface and a posterior surface and an exit pupil. The anterior surface can comprise an aspheric surface. The anterior and posterior surfaces can be shaped to provide a radial power profile characterized by Φ(r)=a+br2+cr4+dr6+er8 for wavefront at the exit pupil of the optic for an object vergence of 0 to 2.5 Diopter (D) where r is the radial distance from an optical axis extending through the surface vertices on the anterior and posterior surfaces and a, b, c, d, and e are coefficients.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The lens can also include at least one haptic disposed with respect to the optic to affix the optic in the eye when implanted therein. The optic can include an anterior surface and a posterior surface. Each of the anterior surface and the posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. The thickness along the optical axis can be between about 100-400 micrometers (or any range formed by any of the values in this range). In addition, at least one of the anterior and posterior surfaces can comprise aspheric surfaces. In some embodiments, the anterior surface can be convex. In addition, the posterior surface can be concave.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The lens can also include at least one haptic disposed with respect to the optic to affix the optic in the eye when implanted therein. The optic can include an anterior surface and a posterior surface. Each of the anterior surface and the posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. At least one of the anterior and posterior surfaces can comprise an aspheric surface including perturbations comprising an aspheric higher order function of radial distance from the optical axis and at least one of the surfaces can have an aspheric shape that comprises a biconic. In some embodiments, the anterior surface can be convex. In addition, the posterior surface can be concave.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The lens can also include haptic portions disposed about the optic to affix the optic in the eye when implanted therein. The optic can include an anterior surface and a posterior surface. Each of the anterior surface and the posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. The thickness along the optical axis can be between about 100-700 micrometers (or any range formed by any of the values in this range). In addition, the anterior and posterior surfaces can comprise aspheric surfaces.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The lens can also include at least one haptic disposed with respect to the optic to affix the optic in the eye when implanted therein. The optic can include an anterior surface and a posterior surface. Each of the anterior surface and the posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. At least one of the anterior and posterior surfaces can comprise an aspheric surface that comprises a conic or biconic offset by perturbations comprising an aspheric higher order function of radial distance from the optical axis.
In various embodiments of the lens described herein comprising a transparent material, the transparent material can comprise collamer. The transparent can comprise silicone, acrylics, or hydrogels. The transparent material can comprise hydrophobic or hydrophilic material.
In various embodiments of the lens described herein, the anterior surface can be rotationally symmetric. The anterior surface can have a shape that includes a conic or biconic term. The anterior surface can have a shape that includes a conic or biconic term and aspheric higher order perturbation terms. In some embodiments of the lens, the posterior surface can have a shape that includes a conic or biconic term. The conic or biconic term can have a conic constant having a magnitude greater than zero. For example, the conic or biconic term can have a conic constant having a magnitude of at least one. As another example, the conic or biconic term can have a conic constant having a magnitude of at least ten.
In various embodiments of the lens described herein, the posterior surface can be rotationally non-symmetric. The posterior surface can have different curvature along different directions through the optical axis of the optic. For example, the posterior surface can have different curvature along orthogonal directions through the optical axis of the optic. The shape of the posterior surface can include a biconic term. The biconic term can have a conic constant having a magnitude greater than zero. For example, the biconic term can have a conic constant having a magnitude of at least one. As another example, the conic or biconic term can have a conic constant having a magnitude of at least ten. In various embodiments of the lens described herein, the optic can have a thickness along the optical axis of between 100-400 micrometers. For example, the thickness along the optical axis can be between 100-300 micrometers, between 100-200 micrometers, between 200-300 micrometers, between 300-400 micrometers, or any range formed by any of the values in these ranges.
In various embodiments of the lens described herein, the anterior and posterior surfaces of the lens can be shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 90% of the object vergences within the range of 0 to 2.5 Diopter (D) when the optic is inserted into a model eye having an aperture size of 2 to 6 millimeters, 3 to 6 millimeters, or 4 to 6 millimeters (e.g., the aperture size can be 2 mm, 3 mm, 4 mm, 6 mm, any value within these ranges, or any range formed by such values). The average MTF values can comprise MTF values at 100 lines per millimeter integrated over the wavelengths between about 400 to 700 nm weighted by the photopic luminosity function for on axis objects. The model eye can comprise a Liou-Brennan model eye, a Badal model eye, an Arizona model eye, an Indiana model eye, or any standardized or equivalent model eye.
In some such embodiments, the anterior and posterior surfaces of the lens are shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 95% or 98% of the object vergences within the range of 0 to 2.5 Diopter (D).
In various embodiments of the lens described herein, the anterior and posterior surfaces can be shaped to provide modulation transfer functions (MTF) without phase reversal for at least 90% of the object vergences within the range of 0 to 2.5 Diopter (D) when the optic is inserted into the model eye. In some such embodiments, the anterior and posterior surfaces are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 95%, 98%, 99%, or 100% of the object vergences within the range of 0 to 2.5 Diopter (D) when said optic is inserted into the model eye.
In various embodiments of the lens described herein, the anterior surface can have a radius of curvature between 0 to 1 mm, between 1×10−6 to 1×10−3 mm, or between 5×10−6 to 5×10−4 mm. The anterior surface can have a conic constant between −1×106 to −100 or between −3×105 to −2×105. The posterior surface can have a radius of curvature, Ry, between 0 to 20 mm. The posterior surface can have a radius of curvature, Rx, between 0 to 20 mm. The posterior surface can have a conic constant, ky between −20 to 20. The posterior surface can have a conic constant, kx, between −25 to 0.
In some embodiments of the lens described herein, the lens can be configured to be disposed anterior to the natural lens of the eye. In some other embodiments of the lens, the lens can be configured to be disposed in the capsular bag.
Certain embodiments described herein include a method of implanting the lens of any of the embodiments of the lens. The method can include forming an opening in tissue of the eye and inserting the lens anterior of the natural lens of the eye. Certain embodiments described herein also include a method including forming an opening in tissue of the eye and inserting the lens in the capsular bag.
In various embodiments of the lens described herein, the optic can have a thickness along the optical axis that is between about 700 microns-4 millimeter. For example, the thickness along the optical axis can be between about 700 microns-3 millimeter, between about 700 microns-2 millimeter, between about 700 microns-1 millimeter, or any range formed by any of the values in these ranges.
Certain embodiments described herein include a lens pair configured for implantation into a pair of left and right eyes of a human. The lens pair includes a first lens. The first lens can include an optic comprising transparent material. The optic of the first lens can have an anterior surface and a posterior surface. The anterior surface can include an aspheric surface. The anterior and posterior surfaces of the first lens can be shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 90% of the object vergences within the range of 0 to 2.0 Diopter or 0 to 2.5 Diopter (D) when the optic of the first lens is inserted into a model eye having an aperture size of 2 to 6 millimeters, 3 to 6 millimeters, or 4 to 6 millimeters (e.g., the aperture size can be 2 mm, 3 mm, 4 mm, 6 mm, any value within these ranges, or any range formed by such values). The average MTF values of the first lens can comprise MTF values at 100 lines per millimeter integrated over the wavelengths between about 400 to 700 nm weighted by the photopic luminosity function for on axis objects.
The lens pair also includes a second lens. The second lens can include an optic comprising transparent material. The optic of the second lens can have an anterior surface and a posterior surface. The anterior surface can include an aspheric surface. The anterior and posterior surfaces of the second lens can be shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 90% of the object vergences within the range of −2.0 to 0 Diopter or −2.5 to 0 Diopter (D) when the optic of the second lens is inserted into a model eye having an aperture size of 2 to 6 millimeters, 3 to 6 millimeters, or 4 to 6 millimeters (e.g., the aperture size can be 2 mm, 3 mm, 4 mm, 6 mm, any value within these ranges, or any range formed by such values). The average MTF values of the second lens can comprise MTF values at 100 lines per millimeter integrated over the wavelengths between about 400 to 700 nm weighted by the photopic luminosity function for on axis objects.
The model eye can comprise a Liou-Brennan model eye. Alternatively, the model eye can comprise a Badal model eye. Furthermore, the model eye can comprise an Arizona model eye or an Indiana model eye. Other standardized or equivalent model eyes can be used.
In various embodiments of the lens pair, the modulation transfer function values of the first or second lens can be provided when the optic of the first or second lens is inserted in the model eye in a phakic configuration. In various other embodiments, the modulation transfer function values of the first or second lens can be provided when the optic of the first or second lens is inserted in the model eye in an aphakic configuration.
In various embodiments of the lens pair, the first or second lens can further comprise haptic portions. The optic of the first or second lens can have an optical axis and a thickness through the optical axis that is between about 100-700 microns. In other embodiments, the optic of the first or second lens can have an optical axis and a thickness through the optical axis that is between about 700 microns-4 millimeter. In some such embodiments, the thickness along the optical axis can be between about 700 microns-3 millimeter, between about 700 microns-2 millimeter, between about 700 microns-1 millimeter, or any range formed by any of the values in these ranges.
In various embodiments of the lens pair, the anterior and posterior surfaces of the first lens can be shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 95% or 98% of the object vergences within the range of 0 to 2.5 Diopter (D).
In various embodiments of the lens pair, the anterior and posterior surfaces of the second lens can be shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 95% or 98% of the object vergences within the range of −2.5 to 0 Diopter (D).
In various embodiments of the lens pair, the anterior and posterior surfaces of the first lens can shaped to provide modulation transfer functions (MTF) without phase reversal for at least 90%, 95%, 98%, 99%, or 100% of the object vergences within the range of 0 to 2.5 Diopter (D) when said optic is inserted into the model eye.
In various embodiments of the lens pair, the anterior and posterior surfaces of the second lens can be shaped to provide modulation transfer functions (MTF) without phase reversal for at least 90%, 95%, 98%, 99%, or 100% of the object vergences within the range of −2.5 to 0 Diopter (D) when said optic is inserted into the model eye.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The optic can have an anterior surface and a posterior surface. Each of the anterior surface and the posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. At least one of the anterior and posterior surfaces can comprise a surface having a first portion and a second portion. The first portion can be disposed centrally about the optical axis. The second portion can surround the first portion and can have a different surface profile than the first portion. The first portion can be configured to provide an extended depth of field. The second portion can be configured to provide an enhanced vision quality metric at distance in comparison to the first portion.
In some such embodiments, distance can comprise objects between infinity to 2 meters or distance can comprises 0 D vergence. In various embodiments of the lens, the lens can further comprise a third portion surrounding the second portion. The third portion can have a different surface profile than the second portion. In some embodiments, the third portion can have a similar surface profile as the first portion. The second portion can be configured to provide an enhanced vision quality metric at distance in comparison to the third portion. For example, the enhanced vision quality metric can be a modulation transfer function, a contrast sensitivity, a derivation thereof, or a combination thereof. In some embodiments, the first portion can have a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations of the envelope comprising an aspheric higher order function of radial distance from the optical axis.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The optic can have an anterior surface and a posterior surface. Each of the anterior surface and the posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. At least one of the anterior and posterior surfaces can comprise a surface having a first portion and a second portion. The first portion can have a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations with respect to the envelope comprising an aspheric higher order function of radial distance from the optical axis. The second portion can have a shape that comprises a conic, biconic, or biaspheric envelope not offset by perturbations of the envelope comprising an aspheric higher order function of radial distance from the optical axis.
In various embodiments of the lens, the first portion can be disposed centrally about the optical axis. The second portion can surround said first portion. In some embodiments, the lens can include a third portion surrounding the second portion. The third portion can have a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations with respect to the envelope comprising an aspheric higher order function of radial distance from the optical axis. In some such embodiments, the third portion can have substantially the same conic, biconic, or biaspheric envelope offset by perturbations with respect to the envelope comprising an aspheric higher order function of radial distance from the optical axis as the first portion.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The optic can have an anterior surface and a posterior surface. Each of the anterior surface and the posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. At least one of the anterior and posterior surfaces can comprise a surface having a first portion and a second portion. The first portion can be disposed centrally about the optical axis. The second portion can surround the first portion. The first portion can have higher spherical aberration control that provides extended depth of field than the second portion.
In various embodiments, the lens can include a third portion surrounding the second portion. The third portion can have higher spherical aberration control that provides extended depth of field than the second portion. The third portion can have substantially the same spherical aberration control as the first portion. The first portion can have a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations from the envelope comprising an aspheric higher order function of radial distance from the optical axis.
In various embodiments of the lens having a third portion, the third portion can have a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations from the envelope comprising an aspheric higher order function of radial distance from the optical axis.
In various embodiments of the lens having a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations from the envelope comprising an aspheric higher order function of radial distance from the optical axis, the aspheric higher order function can include at least one even order term, a2nr2n, where n is an integer and a2n is a coefficient and r is the radial distance from the optical axis. For example, the aspheric higher order function can include a second order term, a2r2, where a2 is a coefficient and r is the radial distance from the optical axis. As another example, the aspheric higher order function can include a fourth order term, a4r4, where a4 is a coefficient and r is the radial distance from the optical axis. The aspheric higher order function can also include a sixth order term, a6r6 where a6 is a coefficient and r is the radial distance from the optical axis. Further, the aspheric higher order function can include an eighth order term, a8r8 where a8 is a coefficient and r is the radial distance from the optical axis.
In various embodiments of the lens having a first and second portion, the lens can further comprise a transition portion providing a smooth transition without discontinuity between the first and second portions. The transition portion can have a distance between inner and outer radii in the range of about 0.1-1 mm. The first portion can have a maximum cross-sectional diameter in the range of about 2.5-4.5 mm. For example, the first portion can have a maximum cross-sectional diameter of about 3.75 mm. The second portion can have a distance between inner and outer radii in the range of about 1-3.5 mm. In some embodiments, the second portion can have a distance between inner and outer radii in the range of about 0.25-1.5 mm.
In various embodiments of the lens, the optic can have a thickness along the optical axis that is in the range of about 100-700 microns (or any range formed by any of the values in this range). Alternatively, the optic can have a thickness along the optical axis that is in the range of about 700 microns to 4 millimeters (or any range formed by any of the values in this range). In various embodiments, the lens can also include at least one haptic disposed with respect to the optic to affix the optic in the eye when implanted therein. In some embodiments, the anterior surface can comprise the surface having the first and second portions. The posterior surface can comprise a shape having a biconic envelope.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The optic can have an anterior surface and a posterior surface. Each of the anterior surface and the posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. At least one of the anterior and posterior surfaces can comprise a surface having a first portion and a second portion. The first portion can be disposed centrally about the optical axis. The second portion can surround the first portion. The first portion can be configured to provide an extended depth of field. The second portion can be configured to provide a monofocal distance focusing.
In some such embodiments, the lens can further comprise a third portion surrounding the second portion. The third portion can be configured to provide an extended depth of field. The first portion can have a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations with respect to the envelope comprising an aspheric higher order function of radial distance from the optical axis. In addition, the third portion can have a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations with respect to the envelope comprising an aspheric higher order function of radial distance from the optical axis.
In various embodiments of the lens having first and second portions, each of the first and second portions can have a caustic. The second portion can have a conic constant such that the caustic of the second portion blends smoothly with the caustic of the first portion. In some examples, the caustic of the second portion blends more smoothly with the caustic of the first portion than if the second portion comprises a spherical surface. In various embodiments of the lens having a third portion, the second and third portions can have a caustic. The second portion can have a conic constant such that the caustic of the second portion blends smoothly with the caustic of the third portion. In some examples, the caustic of the second portion blends more smoothly with the caustic of the third portion than if the second portion comprises a spherical surface.
In certain embodiments of the lens having first and second portions, the anterior surface can be convex. The posterior surface can be concave. For example, the anterior surface can be convex and the posterior surface can be concave such that the optic is meniscus shaped. In various other embodiments, the posterior surface can be convex. In some embodiments, the anterior surface can be concave. In addition, in various embodiments of the lens having first and second portions, the second portion can have a shape that comprises a conic, biconic, or biaspheric envelope not offset by perturbations of the envelope comprising an aspheric higher order function of radial distance from the optical axis.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The optic can have an anterior surface and a posterior surface. Each of the anterior surface and the posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. The lens can include at least one haptic disposed with respect to the optic to affix the optic in the eye when implanted therein. The anterior and posterior surfaces can comprise aspheric surfaces and the posterior surface can have an aspheric shape that comprises a biconic offset by perturbations comprising an aspheric higher order function of radial distance from the optical axis. The posterior surface can have an absolute value of ratio Rx/Ry between 0, 0.1, 0.2, 0.25, or 0.5 and 100 and an absolute value of ratio kx/ky between 0, 0.1, 0.2, 0.25, or 0.5 and 100. In some embodiments, the absolute value of the ratio Rx/Ry is between 0, 0.1, 0.2, 0.25, or 0.5 and 75; 0, 0.1, 0.2, 0.25, or 0.5 and 50; 0, 0.1, 0.2, 0.25, or 0.5 and 25; or 0, 0.1, 0.2, 0.25, or 0.5 and 10. In addition, in some embodiments, the absolute value of the ratio kx/ky is between 0, 0.1, 0.2, 0.25, or 0.5 and 75; 0, 0.1, 0.2, 0.25, or 0.5 and 50; 0, 0.1, 0.2, 0.25, or 0.5 and 25; or 0, 0.1, 0.2, 0.25, or 0.5 and 10.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The optic can have an anterior surface and a posterior surface. The anterior surface or posterior surface can comprise an aspheric surface. The anterior and posterior surfaces can be shaped to provide a Salvador Image Quality (SIQ) metric that is at least 0.6, 0.7, 0.8, 0.9, or 1 for at least 90%, 95%, or 98% of the object vergences within the range of 0 to +1.5 D, 0 to +2.0 D, or 0 to +2.5 D when the optic is inserted into the human eye having an aperture size of 4 to 6 millimeters. For example, the aperture size can be 6 mm.
Certain embodiments described herein include a lens configured for implantation into an eye of a human. The lens can include an optic comprising transparent material. The optic can have an anterior surface and a posterior surface. The anterior surface or posterior surface can comprise an aspheric surface. The anterior and posterior surfaces can be shaped to provide an above average psychophysical grade for at least 90%, 95%, or 98% of the object vergences within the range of 0 to +1.5 D, 0 to +2.0 D, or 0 to +2.5 D when the optic is inserted into the human eye having an aperture size of 4 to 6 millimeters or into a model eye having an aperture size of 4 to 6 millimeters. In some such embodiment, each of the anterior surface and the posterior surface can have a surface vertex. The optic can have an optical axis through the surface vertices. The anterior or posterior surface can have an aspheric shape that comprises a biconic offset by perturbations comprising an aspheric higher order function of radial distance from the optical axis.
In various embodiments, the optic can comprise an exit pupil, and the anterior and posterior surfaces can be shaped to provide a radial power profile characterized by Φ(r)=a+br2+cr4+dr6+er8 for wavefront at the exit pupil of the optic for an object vergence of 0 to 2.5 D where r is the radial distance from the optical axis and a, b, c, d, and e are coefficients. In some embodiments, a thickness along the optical axis can be between about 100-700 micrometers. The anterior surface can be convex and the posterior surface can be concave such that the optic is meniscus shaped.
1. A lens configured for implantation into an eye of a human, said lens comprising:
2. The lens of Example 1, wherein said anterior surface is rotationally symmetric.
3. The lens of Example 1, wherein said anterior surface has a shape that includes a conic or biconic term.
4. The lens of Example 3, wherein said anterior surface has a shape that includes a conic or biconic term and aspheric higher order perturbation terms.
5. The lens of Example 2, wherein said posterior surface has a shape that includes a conic or biconic term.
6. The lens of Example 5, wherein said conic or biconic term has a conic constant having a magnitude greater than zero.
7. The lens of Example 6, wherein said conic or biconic term has a conic constant having a magnitude of at least one.
8. The lens of Example 7, wherein said conic or biconic term has a conic constant having a magnitude of at least ten.
9. The lens of any of Examples 2-4, wherein said posterior surface is rotationally non-symmetric and has different curvature along different directions through said optical axis of said optic.
10. The lens of Example 9, wherein said posterior surface has different curvature along orthogonal directions through said optical axis of said optic.
11. The lens of any of Examples 2-3, wherein said posterior surface is rotationally non-symmetric and has a shape that includes a biconic term.
12. The lens of Example 11, wherein said biconic term has a conic constant having a magnitude greater than zero.
13. The lens of Example 12, wherein said biconic term has a conic constant having a magnitude of at least one.
14. The lens of Example 13, wherein said biconic term has a conic constant having a magnitude of at least ten.
15. A lens configured for implantation into an eye of a human, said lens comprising:
16. The lens of Example 15, wherein said aspheric higher order function includes a second order term, a2r2, where a2 is a coefficient and r is the radial distance from the optical axis.
17. The lens of Example 15 or 16, wherein said aspheric higher order function includes a fourth order term, a4r4, where a4 is a coefficient and r is the radial distance from the optical axis.
18. The lens of any of Examples 15-17, wherein said aspheric higher order function includes a sixth order term, a6r6 where a6 is a coefficient and r is the radial distance from the optical axis.
19. The lens of any of Examples 15-18, wherein said aspheric higher order function includes an eighth order term, a8r8 where a8 is a coefficient and r is the radial distance from the optical axis.
20. The lens of Example 15, wherein said aspheric higher order function includes at least one even order term, a2nr2n, where n is an integer and a2n is a coefficient and r is the radial distance from the optical axis.
21. The lens of any of Examples 15-20, comprising a plurality of haptics.
22. The lens of any of Examples 15-21, wherein said optic has a thickness along said optical axis that is between about 100-700 microns.
23. The lens of any of Examples 15-22, wherein said anterior surface has an aspheric shape that comprises a biconic offset by said perturbations.
24. A lens configured for implantation into an eye of a human, said lens comprising:
25. The lens of Example 24, wherein said human eye comprises a crystalline lens and said average modulation transfer function values are provided when said optic is inserted anterior of said crystalline lens.
26. The lens of Example 24, wherein said human eye excludes a crystalline lens and said modulation transfer function values are provided when said optic is inserted in place of the crystalline lens.
27. The lens of any of Examples 24-26, further comprising haptic portions.
28. The lens of any of Examples 24-27, wherein said optic has an optical axis and a thickness through said optical axis that is between about 100-700 microns.
29. A lens configured for implantation into an eye of a human, said lens comprising:
30. The lens of Example 29, wherein said model eye comprises a Liou-Brennan model eye.
31. The lens of Example 29, wherein said model eye comprises a Badal model eye.
32. The lens of Example 29, wherein said model eye comprises an Arizona model eye or an Indiana model eye.
33. The lens of any of Examples 29-32, wherein said modulation transfer function values are provided when said optic is inserted in said model eye in a phakic configuration.
34. The lens of any of Examples 29-32, wherein said modulation transfer function values are provided when said optic is inserted in said model eye in an aphakic configuration.
35. The lens of any of Examples 29-34, further comprising haptic portions.
36. The lens of any of Examples 29-35, wherein said optic has an optical axis and a thickness through said optical axis that is between about 100-700 microns.
37. The lens of any of Examples 29-36, wherein said aperture size is 6 millimeters.
38. The lens of any of Examples 29-26, wherein said aperture size is 4 millimeters.
39. A lens configured for implantation into an eye of a human, said lens comprising:
40. A lens configured for implantation into an eye of a human, said lens comprising:
41. The lens of Example 40, wherein said aspheric higher order function includes a second order term, a2r2, where a2 is a coefficient and r is the radial distance from the optical axis.
42. The lens of Example 40 or 41, wherein said aspheric higher order function includes a fourth order term, a4r4, where a4 is a coefficient and r is the radial distance from the optical axis.
43. The lens of any of Examples 40-42, wherein said aspheric higher order function includes a sixth order term, a6r6 where a6 is a coefficient and r is the radial distance from the optical axis.
44. The lens of any of Examples 40-43, wherein said aspheric higher order function includes an eighth order term, a8r8 where a8 is a coefficient and r is the radial distance from the optical axis.
45. The lens of Example 40, wherein said aspheric higher order function includes at least one even order term, a2nr2n, where n is an integer and a2n is a coefficient and r is the radial distance from the optical axis.
46. The lens of any of Examples 40-45, wherein said optic has a thickness along said optical axis that is between about 100-700 microns.
47. The lens of any of Examples 40-46, wherein said posterior surface has an aspheric shape that comprises a biconic offset by said perturbations.
48. A lens pair configured for implantation into a pair of left and right eyes of a human, comprising:
49. The lens pair of Example 48, wherein said model eye comprises a Liou-Brennan model eye.
50. The lens pair of Example 48, wherein said model eye comprises a Badal model eye.
51. The lens pair of Example 48, wherein said model eye comprises an Arizona model eye or an Indiana model eye.
52. A lens configured for implantation into an eye of a human, said lens comprising:
53. The lens of Example 52, wherein said anterior surface is convex.
54. The lens of Example 52 or 53, wherein said posterior surface is concave.
55. A lens configured for implantation into an eye of a human, said lens comprising:
56. The lens of Example 55, wherein said anterior surface is convex.
57. The lens of Example 55 or 56, wherein said posterior surface is concave.
58. A lens configured for implantation into an eye of a human, said lens comprising:
59. A lens configured for implantation into an eye of a human, said lens comprising:
60. The lens of any of Examples 1-47 or any of Examples 52-59, wherein said transparent material comprises collamer.
61. The lens of any of Examples 1-47 or any of Examples 52-59, wherein said transparent material comprises silicone, acrylic, or hydrogel.
62. The lens of any of Examples 1-47 or any of Examples 52-59, wherein said transparent material comprises hydrophobic or hydrophilic material.
63. The lens of any of Examples 1-23, 28, 36, any of Examples 39-47, or any of Examples 55-59, wherein said optic has a thickness along said optical axis of between 100-400 micrometers.
64. The lens of Example 63, wherein said optic has a thickness along said optical axis of between 100-300 micrometers.
65. The lens of Example 64, wherein said optic has a thickness along said optical axis of between 100-200 micrometers.
66. The lens of Example 64, wherein said optic has a thickness along said optical axis of between 200-300 micrometers.
67. The lens of Example 63, wherein said optic has a thickness along said optical axis of between 300-400 micrometers.
68. The lens of any of Examples 1-28, any of Examples 39-47, or any of Examples 52-59, wherein the anterior and posterior surfaces of said optic are shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 90% of the object vergences within the range of 0 to 2.5 Diopter (D) when said optic is inserted into a model eye having an aperture size of 4 to 6 millimeters, wherein said average MTF values comprise MTF values at 100 lines per millimeter integrated over the wavelengths between about 400 to 700 nm weighted by the photopic luminosity function for on axis objects.
69. The lens of Example 68, wherein said model eye comprises a Liou-Brennan model eye.
70. The lens of Example 68, wherein said model eye comprises a Badal model eye.
71. The lens of Example 68, wherein said model eye comprises an Arizona model eye or an Indiana model eye.
72. The lens of any of Examples 24-38 or any of Examples 68-71, wherein the anterior and posterior surfaces of said optic are shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 95% of the object vergences within the range of 0 to 2.5 Diopter (D).
73. The lens of Example 72, wherein the anterior and posterior surfaces of said optic are shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 98% of the object vergences within the range of 0 to 2.5 Diopter (D).
74. The lens of any of Examples 1-47 or any of Examples 52-73, wherein anterior and posterior surfaces are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 90% of the object vergences within the range of 0 to 2.5 Diopter (D) when said optic is inserted into a model eye having an aperture size of 4 to 6 millimeters.
75. The lens of Example 74, wherein anterior and posterior surfaces are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 95% of the object vergences within the range of 0 to 2.5 Diopter (D) when said optic is inserted into a model eye having an aperture size of 4 to 6 millimeters.
76. The lens of Example 75, wherein anterior and posterior surfaces are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 98% of the object vergences within the range of 0 to 2.5 Diopter (D) when said optic is inserted into a model eye having an aperture size of 4 to 6 millimeters.
77. The lens of Example 76, wherein anterior and posterior surfaces are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 99% of the object vergences within the range of 0 to 2.5 Diopter (D) when said optic is inserted into a model eye having an aperture size of 4 to 6 millimeters.
78. The lens of Example 77, wherein anterior and posterior surfaces are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 100% of the object vergences within the range of 0 to 2.5 Diopter (D) when said optic is inserted into a model eye having an aperture size of 4 to 6 millimeters.
79. The lens of any of Examples 1-47 or any of Examples 52-78, wherein the anterior surface has a radius of curvature between 0 to 1 mm.
80. The lens of any of Examples 1-47 or any of Examples 52-78, wherein the anterior surface has a radius of curvature between 1×10−6 to 1×10−3 mm.
81. The lens of any of Examples 1-47 or any of Examples 52-78, wherein the anterior surface has a radius of curvature between 5×10−6 to 5×10−4 mm.
82. The lens of any of Examples 1-47 or any of Examples 52-81, wherein the anterior surface has a conic constant between −1×106 to −100.
83. The lens of any of Examples 1-47 or any of Examples 52-81, wherein the anterior surface has a conic constant between −3×105 to −2×105.
84. The lens of any of Examples 1-47 or any of Examples 52-83, wherein the posterior surface has a radius of curvature, Ry, between 0 to 20 mm.
85. The lens of any of Examples 1-47 or any of Examples 52-84, wherein the posterior surface has a radius of curvature, Rx, between 0 to 20 mm.
86. The lens of any of Examples 1-47 or any of Examples 52-85, wherein the posterior surface has a conic constant, ky between −20 to 20.
87. The lens of any of Examples 1-47 or any of Examples 52-86, wherein the posterior surface has a conic constant, kx, between −25 to 0.
88. A method of implanting the lens of any of Examples 1-47 or any of Examples 52-87, comprising:
89. A method of implanting the lens of any of Examples 1-47 or any of Examples 52-87, comprising:
90. The lens of any of Examples 1-47 or any of Examples 52-87 configured to be disposed anterior of the natural lens of the eye.
91. The lens of any of Examples 1-47 or any of Examples 52-87 configured to be disposed in the capsular bag.
92. The lens of any of Examples 15-21, any of Examples 39-45, any of Examples 55-57, or Example 59, wherein said optic has a thickness along said optical axis that is between about 700 microns-4 millimeter.
93. The lens of Example 24 or any of Examples 29-32, wherein said optic has an optical axis and a thickness along said optical axis that is between about 700 microns-4 millimeter.
94. The lens of Example 92 or 93, wherein said optic has a thickness along said optical axis that is between about 700 microns-3 millimeter.
95. The lens of Example 94, wherein said optic has a thickness along said optical axis that is between about 700 microns-2 millimeter.
96. The lens of Example 95, wherein said optic has a thickness along said optical axis that is between about 700 microns-1 millimeter.
97. The lens pair of any of Examples 48-51, wherein said modulation transfer function values of said first or second lens are provided when said optic of said first or second lens is inserted in said model eye in a phakic configuration.
98. The lens pair any of Examples 48-51, wherein said modulation transfer function values of said first or second lens are provided when said optic of said first or second lens is inserted in said model eye in an aphakic configuration.
99. The lens pair of any of Examples 48-51 or any of Examples 97-98, wherein the first or second lens further comprises haptic portions.
100. The lens pair of any of Examples 48-51 or any of Examples 97-99, wherein said optic of said first or second lens has an optical axis and a thickness through said optical axis that is between about 100-700 microns.
101. The lens pair of any of Examples 48-51, wherein said optic of said first or second lens has an optical axis and a thickness through said optical axis that is between about 700 microns-4 millimeter.
102. The lens pair of Example 101, wherein said optic of said first or second lens has a thickness along said optical axis that is between about 700 microns-3 millimeter.
103. The lens pair of Example 102, wherein said optic of said first or second lens has a thickness along said optical axis that is between about 700 microns-2 millimeter.
104. The lens pair of Example 103, wherein said optic of said first or second lens has a thickness along said optical axis that is between about 700 microns-1 millimeter.
105. The lens pair of any of Examples 48-51 or any of Examples 97-104, wherein said aperture size is 6 millimeters.
106. The lens pair of any of Examples 48-51 or any of Examples 97-104, wherein said aperture size is 4 millimeters.
107. The lens pair of any of Examples 48-51 or any of Examples 97-106, wherein the anterior and posterior surfaces of said first lens are shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 95% of the object vergences within the range of 0 to 2.5 Diopter (D).
108. The lens pair of Example 107, wherein the anterior and posterior surfaces of said first lens are shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 98% of the object vergences within the range of 0 to 2.5 Diopter (D).
109. The lens pair of any of Examples 48-51 or any of Examples 97-108, wherein the anterior and posterior surfaces of said second lens are shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 95% of the object vergences within the range of −2.5 to 0 Diopter (D).
110. The lens pair of Example 109, wherein the anterior and posterior surfaces of said second lens are shaped to provide average modulation transfer function (MTF) values that are between 0.1 and 0.4 at 100 lines per millimeter for at least 98% of the object vergences within the range of −2.5 to 0 Diopter (D).
111. The lens pair of any of Examples 48-51 or any of Examples 97-110, wherein anterior and posterior surfaces of said first lens are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 90% of the object vergences within the range of 0 to 2.5 Diopter (D) when said optic is inserted into the model eye having an aperture size of 4 to 6 millimeters.
112. The lens pair of Example 111, wherein anterior and posterior surfaces of said first lens are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 95% of the object vergences within the range of 0 to 2.5 Diopter (D) when said optic is inserted into the model eye having an aperture size of 4 to 6 millimeters.
113. The lens pair of Example 112, wherein anterior and posterior surfaces of said first lens are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 98% of the object vergences within the range of 0 to 2.5 Diopter (D) when said optic is inserted into the model eye having an aperture size of 4 to 6 millimeters.
114. The lens pair of Example 113, wherein anterior and posterior surfaces of said first lens are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 99% of the object vergences within the range of 0 to 2.5 Diopter (D) when said optic is inserted into the model eye having an aperture size of 4 to 6 millimeters.
115. The lens pair of Example 114, wherein anterior and posterior surfaces of said first lens are shaped to provide modulation transfer functions (MTF) without phase reversal for 100% of the object vergences within the range of 0 to 2.5 Diopter (D) when said optic is inserted into the model eye having an aperture size of 4 to 6 millimeters.
116. The lens pair of any of Examples 48-51 or any of Examples 97-115, wherein anterior and posterior surfaces of said second lens are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 90% of the object vergences within the range of −2.5 to 0 Diopter (D) when said optic is inserted into the model eye having an aperture size of 4 to 6 millimeters.
117. The lens pair of Example 116, wherein anterior and posterior surfaces of said second lens are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 95% of the object vergences within the range of −2.5 to 0 Diopter (D) when said optic is inserted into the model eye having an aperture size of 4 to 6 millimeters.
118. The lens pair of Example 117, wherein anterior and posterior surfaces of said second lens are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 98% of the object vergences within the range of −2.5 to 0 Diopter (D) when said optic is inserted into the model eye having an aperture size of 4 to 6 millimeters.
119. The lens pair of Example 118, wherein anterior and posterior surfaces of said second lens are shaped to provide modulation transfer functions (MTF) without phase reversal for at least 99% of the object vergences within the range of −2.5 to 0 Diopter (D) when said optic is inserted into the model eye having an aperture size of 4 to 6 millimeters.
120. The lens pair of Example 119, wherein anterior and posterior surfaces of said second lens are shaped to provide modulation transfer functions (MTF) without phase reversal for 100% of the object vergences within the range of −2.5 to 0 Diopter (D) when said optic is inserted into the model eye having an aperture size of 4 to 6 millimeters.
121. A lens configured for implantation into an eye of a human, said lens comprising:
122. The lens of Example 121, further comprising a third portion surrounding said second portion, said third portion having a different surface profile than said second portion.
123. The lens of Example 122, wherein said third portion has a similar surface profile as said first portion.
124. The lens of any of Examples 121-123, wherein said second portion is configured to provide an enhanced vision quality metric at distance in comparison to said third portion.
125. The lens of any of Examples 121-124, wherein the enhanced vision quality metric is a modulation transfer function, a contrast sensitivity, a derivation thereof, or a combination thereof.
126. The lens of any of Examples 121-125, wherein said first portion has a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations of the envelope comprising an aspheric higher order function of radial distance from the optical axis.
127. A lens configured for implantation into an eye of a human, said lens comprising:
128. The lens of Example 127, wherein said first portion is disposed centrally about the optical axis, and said second portion surrounds said first portion.
129. The lens of Example 127 or 128, further comprising a third portion surrounding said second portion, said third portion having a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations with respect to the envelope comprising an aspheric higher order function of radial distance from the optical axis.
130. The lens of Example 129, wherein said third portion has substantially the same conic, biconic, or biaspheric envelope offset by perturbations with respect to the envelope comprising an aspheric higher order function of radial distance from the optical axis as said first portion.
131. A lens configured for implantation into an eye of a human, said lens comprising:
132. The lens of Example 131, further comprising a third portion surrounding said second portion, said third portion having higher spherical aberration control that provides extended depth of field than said second portion.
133. The lens of Example 132, wherein said third portion has substantially the same spherical aberration control as said first portion.
134. The lens of any of Examples 131-133, wherein said first portion has a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations from the envelope comprising an aspheric higher order function of radial distance from the optical axis.
135. The lens of any of Examples 122-126 or any of Examples 132-134, wherein said third portion has a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations from the envelope comprising an aspheric higher order function of radial distance from the optical axis.
136. The lens of any of Examples 126-130 or any of Examples 134-135, wherein said aspheric higher order function includes a second order term, a2r2, where a2 is a coefficient and r is the radial distance from the optical axis.
137. The lens of any of Examples 126-130 or any of Examples 134-136, wherein said aspheric higher order function includes a fourth order term, a4r4, where a4 is a coefficient and r is the radial distance from the optical axis.
138. The lens of any of Examples 126-130 or any of Examples 134-137, wherein said aspheric higher order function includes a sixth order term, a6r6 where a6 is a coefficient and r is the radial distance from the optical axis.
139. The lens of any of Examples 126-130 or any of Examples 134-138, wherein said aspheric higher order function includes an eighth order term, a8r8 where a8 is a coefficient and r is the radial distance from the optical axis.
140. The lens of any of Examples 126-130 or any of Examples 134-139, wherein said aspheric higher order function includes at least one even order term, a2nr2n, where n is an integer and a2n is a coefficient and r is the radial distance from the optical axis.
141. The lens of any of Examples 121-140, further comprising a transition portion providing a smooth transition without discontinuity between said first and second portions.
142. The lens of Example 141, wherein said transition portion has a distance between inner and outer radii in the range of about 0.1-1 mm.
143. The lens of any of Examples 121-142, wherein said first portion has a maximum cross-sectional diameter in the range of about 2.5-4.5 mm.
144. The lens of Example 143, wherein said first portion has a maximum cross-sectional diameter of about 3.75 mm.
145. The lens of any of Examples 121-144, wherein said second portion has a distance between inner and outer radii in the range of about 1-3.5 mm.
146. The lens of any of Examples 122-126, any of Examples 129-130, or any of Examples 132-133, wherein said second portion has a distance between inner and outer radii in the range of about 0.25-1.5 mm.
147. The lens of any of Examples 121-146, wherein said optic has a thickness along said optical axis that is in the range of about 100-700 microns.
148. The lens of any of Examples 121-147, further comprising at least one haptic disposed with respect to the optic to affix the optic in the eye when implanted therein.
149. The lens of any of Examples 121-148, wherein said anterior surface comprises said surface having said first and second portions.
150. The lens of any of Examples 121-149, wherein said posterior surface comprises a shape having a biconic envelope.
151. A lens configured for implantation into an eye of a human, said lens comprising:
152. The lens of Example 151, further comprising a third portion surrounding said second portion, said third portion configured to provide an extended depth of field.
153. The lens of Example 151 or 152, wherein said first portion has a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations with respect to the envelope comprising an aspheric higher order function of radial distance from the optical axis.
154. The lens of any of Examples 151-153, wherein said third portion has a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations with respect to the envelope comprising an aspheric higher order function of radial distance from the optical axis.
155. The lens of any of Examples 121-125, wherein distance comprise objects between infinity to 2 meters.
156. The lens of any of Examples 121-125, wherein distance comprises 0 D vergence.
157. The lens of any of Examples 121-156, wherein each of the first and second portions has a caustic, and wherein the second portion has a conic constant such that the caustic of the second portion blends smoothly with the caustic of the first portion.
158. The lens of any of Examples 122-123, any of Examples 129-130, any of Examples 132-133, or Example 152, wherein each of the second and third portions has a caustic, and wherein the second portion has a conic constant such that the caustic of the second portion blends smoothly with the caustic of the third portion.
159. The lens of any of Examples 121-156, wherein each of the first and second portions has a caustic, and wherein the second portion has a conic constant such that the caustic of the second portion blends more smoothly with the caustic of the first portion than if the second portion comprises a spherical surface.
160. The lens of any of Examples 122-123, any of Examples 129-130, any of Examples 132-133, or Example 152, wherein each of the second and third portions has a caustic, and wherein the second portion has a conic constant such that the caustic of the second portion blends more smoothly with the caustic of the third portion than if the second portion comprises a spherical surface.
161. The lens of any of Examples 121-146, wherein said optic has a thickness along said optical axis that is in the range of about 700 microns-4 millimeters.
162. The lens of any of Examples 121-161, wherein said anterior surface is convex.
163. The lens of any of Examples 121-161, wherein said posterior surface is concave.
164. The lens of any of Examples 121-163, wherein said anterior surface is convex and said posterior surface is concave such that said optic is meniscus shaped.
165. The lens of any of Examples 121-162, wherein said posterior surface is convex.
166. The lens of any of Examples 121-161 or Example 163, wherein said anterior surface is concave.
167. The lens of any of Examples 121-126, any of Examples 131-135, or any of Examples 151-156, wherein said second portion has a shape that comprises a conic, biconic, or biaspheric envelope not offset by perturbations of the envelope comprising an aspheric higher order function of radial distance from the optical axis.
168. The lens of Example 39, any of Examples 52-54, or Example 58, wherein said anterior surface is rotationally symmetric.
169. The lens of Example 39, any of Examples 52-54, or Example 58, wherein said anterior surface has a shape that includes a conic or biconic term.
170. The lens of Example 169, wherein said anterior surface has a shape that includes a conic or biconic term and aspheric higher order perturbation terms.
171. The lens of Example 168, wherein said posterior surface has a shape that includes a conic or biconic term.
172. The lens of Example 171, wherein said conic or biconic term has a conic constant having a magnitude greater than zero.
173. The lens of Example 172, wherein said conic or biconic term has a conic constant having a magnitude of at least one.
174. The lens of Example 173, wherein said conic or biconic term has a conic constant having a magnitude of at least ten.
175. The lens of any of Examples 168-170, wherein said posterior surface is rotationally non-symmetric and has different curvature along different directions through said optical axis of said optic.
176. The lens of Example 175, wherein said posterior surface has different curvature along orthogonal directions through said optical axis of said optic.
177. The lens of any of Examples 168-169, wherein said posterior surface is rotationally non-symmetric and has a shape that includes a biconic term.
178. The lens of Example 177, wherein said biconic term has a conic constant having a magnitude greater than zero.
179. The lens of Example 178, wherein said biconic term has a conic constant having a magnitude of at least one.
180. The lens of Example 179, wherein said biconic term has a conic constant having a magnitude of at least ten.
181. The lens of any of Examples 1-47 or any of Examples 52-96, wherein at least one of said anterior and posterior surfaces comprises a surface having a first portion and a second portion, said first portion disposed centrally about the optical axis, said second portion surrounding said first portion and having a different surface profile than said first portion, said first portion configured to provide an extended depth of field, and said second portion configured to provide an enhanced vision quality metric at distance in comparison to said first portion.
182. The lens of Example 181, further comprising a third portion surrounding said second portion, said third portion having a different surface profile than said second portion.
183. The lens of Example 182, wherein said third portion has a similar surface profile as said first portion.
184. The lens of any of Examples 181-183, wherein said second portion is configured to provide an enhanced vision quality metric at distance in comparison to said third portion.
185. The lens of any of Examples 181-184, wherein the enhanced vision quality metric is a modulation transfer function, a contrast sensitivity, a derivation thereof, or a combination thereof.
186. The lens of any of Examples 181-185, wherein said first portion has a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations of the envelope comprising an aspheric higher order function of radial distance from the optical axis.
187. The lens of any of Examples 181-186, wherein said second portion has a shape that comprises a conic, biconic, or biaspheric envelope not offset by perturbations of the envelope comprising an aspheric higher order function of radial distance from the optical axis.
188. The lens of any of Examples 182-183, wherein said third portion has a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations of the envelope comprising an aspheric higher order function of radial distance from the optical axis.
189. A method of manufacturing a lens configured for implantation into an eye of a human, the method comprising:
190. A method of manufacturing a lens pair configured for implantation into a pair of left and right eyes of a human, the method comprising:
191. A lens configured for implantation into an eye of a human, said lens comprising:
192. The lens of Example 191, wherein the absolute value of the ratio Rx/Ry is between 0 and 75.
193. The lens of Example 192, wherein the absolute value of the ratio Rx/Ry is between 0 and 50.
194. The lens of Example 193, wherein the absolute value of the ratio Rx/Ry is between 0 and 25.
195. The lens of Example 194, wherein the absolute value of the ratio Rx/Ry is between 0 and 10.
196. The lens of any of Examples 191-195, wherein the absolute value of the ratio kx/ky is between 0 and 75.
197. The lens of Example 196, wherein the absolute value of the ratio kx/ky is between 0 and 50.
198. The lens of Example 197, wherein the absolute value of the ratio kx/ky is between 0 and 25.
199. The lens of Example 198, wherein the absolute value of the ratio kx/ky is between 0 and 10.
200. A lens configured for implantation into an eye of a human, said lens comprising:
201. The lens of Example 200, wherein the anterior and posterior surfaces are shaped to provide the SIQ that is at least 0.6 for at least 95% of the object vergences within the range of 0 to +1.5 Diopter (D).
202. The lens of Example 201, wherein the anterior and posterior surfaces are shaped to provide the SIQ that is at least 0.6 for at least 98% of the object vergences within the range of 0 to +1.5 Diopter (D).
203. The lens of Example 202, wherein the anterior and posterior surfaces are shaped to provide the SIQ that is at least 0.6 for at least 98% of the object vergences within the range of 0 to +2.5 Diopter (D).
204. A lens configured for implantation into an eye of a human, said lens comprising:
205. The lens of Example 204, wherein the anterior and posterior surfaces are shaped to provide the above average psychophysical grade for at least 95% of the object vergences within the range of 0 to +1.5 Diopter (D).
206. The lens of Example 205, wherein the anterior and posterior surfaces are shaped to provide the above average psychophysical grade for at least 98% of the object vergences within the range of 0 to +1.5 Diopter (D).
207. The lens of Example 206, wherein the anterior and posterior surfaces are shaped to provide the above average psychophysical grade for at least 98% of the object vergences within the range of 0 to +2.5 Diopter (D).
208. The lens of any of Examples 200-207, wherein the aperture size is 6 millimeters.
209. The lens of any of Examples 200-208, wherein each of said anterior surface and said posterior surface has a surface vertex, said optic having an optical axis through said surface vertices, and
210. The lens of any of Examples 191-199 or Example 209, wherein said optic comprises an exit pupil, and
211. The lens of any of Examples 191-199 or any of Examples 209-210, wherein a thickness along said optical axis is between about 100-700 micrometers.
212. The lens of any of the preceding Examples, wherein said anterior surface is convex and said posterior surface is concave such that said optic is meniscus shaped.
213. The lens of Example 191, wherein the absolute value of the ratio Rx/Ry is between 0.1 and 10.
214. The lens of Example 213, wherein the absolute value of the ratio Rx/Ry is between 0.2 and 10.
215. The lens of Example 214, wherein the absolute value of the ratio Rx/Ry is between 0.25 and 10.
216. The lens of Example 215, wherein the absolute value of the ratio Rx/Ry is between 0.5 and 10.
217. The lens of any of Examples 191-195 or any of Examples 213-216, wherein the absolute value of the ratio kx/ky is between 0.1 and 10.
218. The lens of Example 217, wherein the absolute value of the ratio kx/ky is between 0.2 and 10.
219. The lens of Example 218, wherein the absolute value of the ratio kx/ky is between 0.25 and 10.
220. The lens of Example 219, wherein the absolute value of the ratio kx/ky is between 0.5 and 10.
Vision problems, such as myopia (nearsightedness), hyperopia (farsightedness), and astigmatism, have been corrected using eyeglasses and contact lenses. Surgical techniques, e.g., laser assisted in-situ keratomileusis (LASIK), have become more common to help address the inconvenience of eyeglasses and contact lenses. In LASIK, a laser is used to cut a flap in the cornea to access the underlying tissue, and to alter the shape of the cornea. In addition, an intraocular lens (IOL) has been used to help treat myopia and cataracts (clouding of the natural crystalline lens of the eye) by replacing the natural lens of with a pseudophakic lens configured to be secured within the capsular bag.
Another solution to treat imperfections in visual acuity is with phakic IOLs. Phakic IOLs are transparent lenses implanted within the eye without the removal of the natural crystalline lens. Accordingly, the phakic IOL together with the cornea and the crystalline lens provide optical power for imaging an object onto the retina. (In contrast, pseudophakic IOLs, which are lenses implanted within the eye to replace the natural lens, e.g., after removal of the cloudy natural lens to treat cataracts as described above.) Implantation of a phakic IOL can be employed to correct for myopia, hyperopia, as well as astigmatism, freeing a patient from the inconvenience of eyewear and contacts. Phakic IOL can also be removed, bringing the optics of the eye back toward a natural condition, or replaced to address changing vision correction or enhancement needs of the eye.
With age, people develop presbyopia (inability to focus on near objects), which has been addressed with reading glasses in order to provide the extra refractive power lost when accommodation for near objects is no longer attainable. Multifocal contact lenses and IOLs, which provide discrete foci for near and far vision, have also been used, but the losses in contrast sensitivity and the presence of coaxial ghost images in the patient's field of view have made the acceptance of such solutions limited.
Certain embodiments described herein can advantageously provide ophthalmic implants for vision correction of, including but not limited to, myopia, hyperopia, astigmatism, cataracts, and/or presbyopia with extended depth of field and enhanced visual acuity. In various embodiments, the ophthalmic implants include a lens configured for implantation into an eye of a patient, for example, a human being. Such lenses are particularly useful for treating presbyopia and onset of presbyopia in middle age populations.
Certain embodiments can include phakic lens implants, where the lens can be implanted in front of the natural crystalline lens 120, such as between the cornea 110 and the iris 115. Other embodiments are configured to be placed between the iris 115 and natural crystalline lens 120. Some example embodiments include lenses for treating myopia, hyperopia, astigmatism, and/or presbyopia.
Some other embodiments can include a pseudophakic lens implanted within the eye, for example, in the capsular bag, after removal of the crystalline lens 120. As discussed above, a pseudophakic lens can be used for treating cataracts as well as for providing refractive correction.
As shown in
In various implementations, for example, the lens is configured for implantation within the capsular bag after removal of the natural lens. Such pseudophakic lens may have haptics having a shape, size and/or number suitable for providing secure placement and orientation within the capsular bag after implantation.
The optic 201 can include a transparent material. For example, the transparent material can include a collagen copolymer material, a hydrogel, a silicone, and/or an acrylic. In some embodiments, the transparent material can include a hydrophobic material. In other embodiments, the transparent material can include a hydrophilic material. Other materials known or yet to be developed can be used for the optic 201.
Certain embodiments of the optic 201 can advantageously include a collagen copolymer material, e.g., similar to material used in Collamer® IOLs by STAAR® Surgical Company in Monrovia, Calif. An example collagen copolymer material is hydroxyethyl methacrylate (HEMA)/porcine-collagen based biocompatible polymer material. Since collagen copolymer materials can have characteristics similar to that of the human crystalline lens, certain embodiments of the lens described herein can perform optically similar to the natural lens. For example, in some embodiments, due to the anti-reflective properties and water content of about 40%, a lens 200 made with a collagen copolymer material can transmit light similar to the natural human crystalline lens. Less light can be reflected within the eye, leading to sharper, clearer vision, and fewer occurrences of glare, halos, or poor night vision compared with lenses made with other lens materials.
In some embodiments of the lens 200 made with a collagen copolymer material, the lens 200 can be flexible, allowing easy implantation within the eye. In addition, because collagen copolymer materials are made with collagen, various embodiments of the lens 200 are biocompatible with the eye. In some embodiments, the lens 200 can attract fibronectin, a substance found naturally in the eye. A layer of fibronectin can form around the lens 200, inhibiting white cell adhesion to the lens 200. The coating of fibronectin can help prevent the lens 200 from being identified as a foreign object. In addition, like the collagen it contains, various embodiments of the lens 200 can carry a slight negative charge. Since proteins in the eye also carry a negative charge, as these two negative forces meet along the border of the lens 200, the charge repulsion can help push away the proteins from the lens 200. As such, the lens 200 can naturally keep itself clean and clear.
Furthermore, in some embodiments, the lens 200 can include an ultraviolet (UV) blocker. Such a blocker can help prevent harmful UVA and UVB rays from entering the eye. Accordingly, certain embodiments can help prevent the development of UV related eye disorders.
In some embodiments, the haptic 205 (or one or more of the haptic portions 205a, 205b, 205c, and 205d) can also be made of the same material as the optic 201. For example, the haptic 205 can be made of a collagen copolymer, a hydrogel, a silicone, and/or an acrylic. In some embodiments, the haptic 205 can include a hydrophobic material. In other embodiments, the haptic 205 can include a hydrophilic material. Other materials known or yet to be developed can also be used for the haptic 205.
The lens 200 can be manufactured by diamond turning, molding, or other techniques known in the art or yet to be developed. In some embodiments of the lens 200 manufactured with a collagen copolymer material, the lens 200 can be machined in a dry state, followed by hydration to stabilize the lens 200. A similar approach can be employed for other material as well.
In some other embodiments for example, for pseudophakic lenses where the lens 201 replaces the natural crystalline lens, the thickness at the center Tc of the optic 201 can be thicker than those for phakic lenses, e.g., about 700 micrometers to about 4 mm, about 700 micrometers to about 3 mm, about 700 micrometers to about 2 mm, about 700 micrometers to about 1 mm, any value in between such ranges, or any ranges formed by any of the values in these ranges. For example, the thickness at the center Tc of the optic 201 can be about 700 micrometers, about 800 micrometers, about 900 micrometers, about 1 millimeter, about 1.5 millimeters, about 2 millimeters, about 2.5 millimeters, about 3 millimeters, about 3.5 millimeters, or about 4 millimeters or ranges therebetween. However, even for pseudophakic lenses the lens may employ smaller thicknesses, Tc, for example, thicknesses between about 300 micrometers to 700 micrometers, for example, 300 micrometers, 400 micrometers, 500 micrometers, 600 micrometers or 700 micrometers or any ranges therebetween such as 300 to 400 micrometer, 400 to 500 micrometers, 500 to 600 micrometers.
In accordance with certain embodiments described herein, the anterior surface 201a is convex and the posterior surface 201b is concave such that the optic 201 is meniscus shaped.
The meniscus shaped optic can be described as either positive or negative. As shown in
In various embodiments, the optic 201 is not meniscus shaped. For example, in some embodiments, the anterior surface 201a is substantially flat and the posterior surface 201b is concave such that the optic 201 is plano-concave. In other embodiments, both the anterior surface 201a and the posterior surface 201b are concave such that the optic 201 is biconcave. In further embodiments, the anterior surface 201a is convex and the posterior surface 201b is substantially flat such that the optic 201 is plano-convex. In yet further embodiments, both the anterior surface 201a and the posterior surface 201b are convex such that the optic 201 is biconvex.
In certain embodiments, the anterior surface 201a and/or the posterior surface 201b of the optic 201 can include aspheric surfaces. For example, the anterior surface 201a and/or the posterior surface 201b of the optic 201 can include a surface shape that is not a portion of a sphere. In various embodiments, the anterior surface 201a and/or the posterior surface 201b can be rotationally symmetric. For example, the surface profile or sag of the aspheric shape can include at least a conic term. The conic term can be described as:
where c is the curvature of the surface (or the inverse of the radius), k is the conic constant, and r is the radial distance from the surface vertex.
In some embodiments, the aspheric shape can include a conic offset by perturbations comprising, for example, a higher order function of radial distance from the surface vertex. Thus, the sag of the aspheric shape can include the conic term and a higher order function of radial distance from the surface vertex. The higher order function can describe the aspheric perturbations from the conic term. In some embodiments, the higher order function can include at least one even order term a2nr2n, where n is an integer, a2n is a coefficient, and r is the radial distance from the surface vertex. For example, the aspheric shape can be described using the conic term and the even-powered polynomial terms (e.g., describing an even asphere):
As can be seen in the example equation (2), the higher order function can include at least a second order term (a2r2), a fourth order term (a4r4), a sixth order term, (a6r6), and/or an eighth order term (a8r8). In some embodiments, the higher order function can include one or more odd order terms. For example, the higher order function can include only odd order terms or a combination of even and odd order terms.
As also shown in equation (2), the surface shape can depend on the conic constant k. If the conic constant k=0, then the surface is spherical. Thus, in some embodiments, k has a magnitude of at least zero, such that |k|≥0. In some embodiments, k has a magnitude greater than zero, such that |k|≥0. In various embodiments, k has a magnitude of at least one, such that |k|≥1. In some embodiments, |k|≥2, |k|≥3, |k|≥5, |k|≥7, or |k|≥10. For example, k≤−1, k≤−2, k≤−3, k≤−5, k≤−7, k≤−10. In various embodiments, therefore, the surface has a shape of a hyperbola. However, in certain embodiment, the magnitude of the conic constant may be less than one, e.g., 0≤|k|≤1.
In various embodiments, the anterior surface 201a and/or the posterior surface 201b can be rotationally non-symmetric and have different curvature along different directions through the center and/or optical axis of the optic 201. For example, the anterior surface 201a and/or the posterior surface 201b can have different curvature along orthogonal directions through the center of the optic 201. Certain such embodiments can be advantageous for treating astigmatism, where correction along different directions (meridians) can be desired.
In some embodiments, the sag of the rotationally non-symmetric surface can include at least a biconic term. A biconic surface can be similar to a toroidal surface with the conic constant k and radius different in the x and y directions. The biconic term can be described as:
where cx is the curvature of the surface in the x direction (or the inverse of the radius in the x direction), and cy is the curvature of the surface in the y direction (or the inverse of the radius in the y direction) while kx is the conic constant for the x direction, and ky is the conic constant for the y direction.
In some embodiments, the aspheric shape can include the biconic offset by perturbations comprising a higher order function of radial distance from the surface vertex. Thus, similar to equation (2), the sag of the aspheric shape can include the biconic term and a higher order function. The higher order function can include at least one even order term, e.g., at least a second order term (a2r2), a fourth order term (a4r4), a sixth order term, (a6r6), and/or an eighth order term (a8r8). For example, similar to equation (2), the higher order function can be a2r2+a4r4+a6r6+a8r8+ . . . .
In some embodiments, the higher order function can include one or more odd order terms. For example, the higher order function can include only odd order terms or a combination of even and odd order terms.
Accordingly, as described herein, the anterior surface 201a and/or the posterior surface 201b of the optic 201 can have a shape that includes a conic term (with or without a higher order function) or a biconic term (with or without a higher order function).
One example for vision correction for presbyopia and/or astigmatism includes an anterior surface 201a and a posterior surface 201b both having an aspheric surface. The aspheric surface of the anterior surface 201a has a shape that includes a conic term offset by perturbations comprising second, fourth, sixth, and eighth order terms; and the aspheric surface of the posterior surface 201b has a shape that includes a biconic term. The sag of the example aspheric anterior surface 201a can be given as:
Furthermore, the sag of the example posterior surface 201b, which can be biconic, can be given as:
which is similar to equation (3). Certain embodiments of such a lens may be, although is not limited to, a meniscus lens.
Other examples are possible. In certain embodiments, the particular shape (e.g., curvature of anterior surface, curvature of posterior surface, conic constants, coefficients of the higher order function, etc.) of the optic 201 can depend on the patient's prescription.
As some examples, for lenses having a nominal dioptric power between about −18 D to about 6 D sphere with 0 to about 2 D cylinder, with 0 to about 3 D cylinder, or with 0 to about 4 D cylinder, the following non-limiting example design parameters can be used in certain embodiments. The radius R of the anterior surface (e.g., the inverse of the curvature) can be between about −100 mm to about 100 mm, about −50 mm to about 50 mm, about −10 mm to about 10 mm, or about −5 mm to about 5 mm. In some examples, R of the anterior surface can be between about −1 mm to about 1 mm or 0 to about 1 mm. For example, the radius of the anterior surface can be between 0 to about 1×10−2 mm, between about 1×10−7 mm to about 5×10−3 mm, between about 1×10−6 mm to about 1×10−3 mm, or between about 5×10−6 mm to about 5×10−4 mm.
As described herein, in various embodiments, k of the anterior surface can have a magnitude greater than zero such that |k|>0. In some embodiments, k has a magnitude of at least one, such that |k|≥1. In some embodiments, |k|≥2, |k|≥3, |k|≥5, |k|≥7, or |k|≥10. For example, k≤−1, k≤−2, k≤−3, k≤−5, k≤−7, k≤−10. In some embodiments, k<<−10. For example, in some embodiments, k can be between about −1×106 to −100, between about −5×105 to about −5×104, or between about −3×105 to about −2×105.
Accordingly, in various embodiments the magnitude of the ratio of the conic constant of the anterior surface and the radius of curvature of the anterior surface may be between 104 and 1014, between 106 and 1012, between 108 and 1011, between 109 and 1011, between 108 and 1010, between 109 and 1010, in various embodiments.
The coefficient a2 for the second order term of the anterior surface in various embodiments can be between 0 to about 1. For example, a2 can be between 0 to about 0.5, between about 0.001 to about 0.3, or between about 0.005 to about 0.2.
The coefficient a4 for the fourth order term of the anterior surface in various embodiments can be between about −1 to 0. For example, a4 can be between about −0.1 to 0, between about −0.05 to about −1×10−4, or between about −0.01 to about −1×10−3.
The coefficient a6 for the sixth order term of the anterior surface in various embodiments can be between 0 to about 1. For example, a6 can be between 0 to about 0.1, between 0 to about 0.01, or between about 0.0001 to about 0.001.
In addition, the coefficient a8 for the eighth order term of the anterior surface in various embodiments can be between about −1 to 0. For example, a8 can be between about −0.001 to 0, between about −0.0005 to 0, or between about −0.0001 to 0.
Furthermore, for lenses having a nominal dioptric power between about −18 D to about 6 D sphere with 0 to about 2 D cylinder, with 0 to about 3 D cylinder, or with 0 to about 4 D cylinder, the following non-limiting example design parameters can be used in certain embodiments for the posterior surface. The radius Ry of the posterior surface in the y direction (e.g., the inverse of the curvature in the y direction) can be between 0 to about 20 mm. For example, the radius Ry of the posterior surface can be between 0 to about 15 mm, between about 2 mm to about 13 mm, or between about 3 mm to about 14 mm, or between about 4 mm to about 10 mm.
In various embodiments, ky of the posterior surface can be between about −20 to about 20, between about −18 to about 15, or between about −15 to about 5. In some such embodiments, ky of the posterior surface does not necessarily have a magnitude of at least one. For example, ky can be between about −1 to about 1. In various embodiments, |ky| is greater than zero.
The radius Rx of the posterior surface in the x direction (e.g., the inverse of the curvature in the x direction) can be between 0 to about 20 mm. For example, the radius of the posterior surface can be between 0 to about 15 mm, between 0 to about 12 mm, or between 0 to about 10 mm.
In various embodiments, kx of the posterior surface can be between about −25 to 0, between about −20 to 0, between about −18 to 0, between about −17.5 to 0, or between about −15.5 to 0. In various embodiments, |kx| is greater than zero.
In certain embodiments described herein, for lenses having a nominal dioptric power between about −18 D to about 6 D sphere with 0, 0.1, 0.2, 0.25, or 0.5 to about 10 D cylinder, or any ranges between any combination of these values (e.g., with 0.1 to about 2 D cylinder, with 0.5 to about 2 D cylinder, with 0.1 to about 3 D cylinder, with 0.5 to about 3 D cylinder, with 0.1 to about 4 D cylinder, with 0.5 to about 4 D cylinder, with 0.1 to about 5 D cylinder, with 0.5 to about 5 D cylinder, with 0.1 to about 6 D cylinder, with 0.5 to about 6 D cylinder, with 0.1 to about 7 D cylinder, with 0.5 to about 7 D cylinder, with 0.1 to about 8 D cylinder, with 0.5 to about 8 D cylinder, with 0.1 to about 9 D cylinder, with 0.5 to about 9 D cylinder, with 0.1 to about 10 D cylinder, with 0.5 to about 10 D cylinder, or any ranges between any combination of these values), the posterior surface can have a shape that includes a biconic term (with or without a higher order function). In some such embodiments, the posterior surface can have an absolute value of ratio Rx/Ry between 0, 0.1, 0.2, 0.25, or 0.5 and 100, or any ranges between any combination of these values (e.g., between 0 and 100, between 0.1 and 100, between 0.5 and 100, between 0 and 75, between 0.1 and 75, between 0.5 and 75, between 0 and 50, between 0.1 and 50, between 0.5 and 50, between 0 and 25, between 0.1 and 25, between 0.5 and 25, between 0 and 10, between 0.1 and 10, or between 0.5 and 10, or any ranges between any combination of these values). In various embodiments, the absolute value of ratio Rx/Ry is greater than zero. In addition, in some embodiments, the posterior surface can have an absolute value of ratio kx/ky between 0, 0.1, 0.2, 0.25, or 0.5 and 100, or any ranges between any combination of these values (e.g., between 0 and 100, between 0.1 and 100, between 0.5 and 100, between 0 and 75, between 0.1 and 75, between 0.5 and 75, between 0 and 50, between 0.1 and 50, between 0.5 and 50, between 0 and 25, between 0.1 and 25, between 0.5 and 25, between 0 and 10, between 0.1 and 10, or between 0.5 and 10, or any ranges between any combination of these values). In various embodiments, the absolute value of ratio kx/ky is greater than zero.
In some embodiments, the shape of the posterior surface can be related to the shape of the anterior surface. In some such embodiments, the posterior surface can have a shape that includes a biconic term (with or without a higher order function); and the anterior surface can have a shape that includes a conic term (with or without a higher order function). The relationship of the anterior and posterior surfaces can be non-linear. In various embodiments, a pattern can exist between Rx, Ry, kx, ky, of the posterior surface and the conic constant k of the anterior surface. For example, the absolute value of ratio Rx/Ry can be as described herein, the absolute value of kx/ky can be as described herein, and the conic constant k of the anterior surface can be less than −2×104, and in some cases <<−2×104. For example, the conic constant k of the anterior surface can be between −9×105 to −1×106, between −8×105 to −1×106, between −7×105 to −1×106, between −6×105 to −1×106, or between −5×105 to −1×106.
In various embodiments described herein, the lenses may be utilized in a relatively low-to-zero spherical power configuration, with the addition of relatively significant cylindrical correction, e.g., greater than or equal to +1.0 D cylinder to the spherical base, in order to provide a given patient with better retinal image quality in cases where age-induced aberrations of the eye or cataract surgery-induced astigmatism may be negatively impacting the quality of life of the patient. For example, the low-to-zero spherical power configuration can include between 0, 0.1, 0.2, 0.25, or 0.5 to 3 D sphere, 1 to 3 D sphere, 2 to 5 D sphere, or 3 to 6 D sphere, with the addition of +1.0 D to +10 D cylinder or any ranges between these values (e.g, +1.0 D cylinder to +2.0 D cylinder, +2.0 D cylinder to +3.0 D cylinder, +3.0 D cylinder to +4.0 D cylinder, +4.0 D cylinder to +5.0 D cylinder, +5.0 D cylinder to +6 D cylinder, +6.0 D cylinder to +7.0 D cylinder, +7.0 D cylinder to +8.0 D cylinder, +8.0 D cylinder to +9.0 D cylinder, or +9.0 D cylinder to +10.0 D cylinder, or any ranges between any combination of these values) to the spherical base. In some embodiments, the ratio sphere/cylinder can be between 0, 0.1, 0.2, 0.25, or 0.5 to 6, or any ranges between any combination of these values (e.g., between 0 to 1, between 0.25 to 1, between 0 to 2, between 0.25 to 2, between 0 to 3, between 0.25 to 3, between 0 to 4, between 0.25 to 4, between 0 to 5, between 0.25 to 5, between 0 to 6, between 0.25 to 6, between 1 to 6, or between 2 to 6, or any ranges between any combination of these values).
Although the example design parameters of R, k, a2, a4, a6, and a8 for lenses having the above given nominal dioptric power were given for the anterior surface, and the example design parameters of Ry, ky, Rx, ky, ratio Rx/Ry, and ratio kx/ky were given for the posterior surface, the ranges of values for R, k, a2, a4, a6, and a8 can be used for the posterior surface, and the ranges of values for Ry, ky, Rx, and kx, ratio Rx/Ry, and ratio kx/ky can be used for the anterior surface. Additionally, although the anterior surface included the higher order aspheric perturbation terms (e.g., a2, a4, a6, and a8), the higher order aspheric perturbation terms (e.g., a2, a4, a6, and a8) can be used for the posterior surface instead of the anterior surface or for both the anterior and posterior surfaces. Any one or more of the values in these ranges can be used in any of these designs.
Furthermore, as described herein, the particular shape of various embodiments can be designed to increase the depth of field and to increase visual acuity. As shown in
In certain such embodiments, the image caustic can be sculpted for the vergence range of about 0 to about 2.5 Diopters or more although this range may be larger or smaller. As shown in
In certain embodiments, the surface shape of the anterior surface 201a and/or the surface shape of the posterior surface 201b can be determined such that the image caustic is sculpted around the hyperfocal plane of the eye. In some embodiments, the hyperfocal distance can be described as the focus distance which places the maximum allowable circle of confusion at infinity, or the focusing distance that produces the greatest depth of field. Accordingly, in certain embodiments, to increase the depth of field, the surface shape of the anterior surface 201a and/or the surface shape of the posterior surface 201b of the optic 200 can be such that the light rays are refocused to the hyperfocal distance.
In various embodiments, the surface shape of the anterior surface 201a and/or the surface shape of the posterior surface 201b of the optic 201 can be evaluated and designed using the defocus curves of the lens. A defocus curve can portray the response of a retinal image quality parameter, such as contrast, as a function of different vergences. An object at infinity has a vergence of 0 Diopter.
In certain embodiments, the surface shape of the anterior surface 201a and/or the surface shape of the posterior surface 201b of the optic 201 can be evaluated and/or designed using the Liou-Brennan model eye such as under Best Corrected Distance Visual Acuity (BCDVA) conditions.
Other models known in the art or yet to be developed can also be used. For example, the surface shape of the anterior surface 201a and/or the surface shape of the posterior surface 201b of the optic 201 can also be evaluated and/or designed using a Badal model eye, an Arizona model eye (University of Arizona model), an Indiana model eye (Indiana University model), an ISO model eye, or any standardized or equivalent model eye. In addition, the simulations can be performed using ray tracing and/or design software known in the art or yet to be developed. As one example software, Zemax design software by Zemax, LLC in Redmond, Wash. can be used for some embodiments. The physical limitations of the environment, for example, the placement of the IOL anterior to the natural lens are useful for performing simulations for a phakic lens design. Such simulations can simultaneously evaluate performance (e.g., RMS wavefront error across the complete pupil) for multiple vergences an include contributions from the different vergences in a merit function that is optimized. Multiple wavefronts are thus evaluated in unison to arrive at a balanced design that provides substantially similar sized circles of confusion through a range of locations along the optical axis. Varying pupil size for different vergences can also be employed.
In certain embodiments, the surface shape of the anterior surface 201a and/or the surface shape of the posterior surface 201b of the optic 201 can be advantageously evaluated and designed such that for the visible wavelengths, light from an on-axis object is focused substantially on-axis, with substantially similar magnitude, and substantially on the retina within the range of at least about 0 Diopter to about 2.5 Diopter. By controlling the different orders of spherical aberrations (e.g., which can be correlated with the higher order aspheric terms in equation (2)) to achieve a substantially similar size cross-sections of the caustic for different longitudinal positions along the optical axis near the retina, and including the toric balancing and correction (e.g., the biconic term in equation (3)) when necessary to treat patients with astigmatism, the radial power profile of the lens 200 can be described as:
Φ(r)=a+br2+cr4+dr6+er8, (6)
where a, b, c, d, and e are real numbers. Additionally, in various embodiments, the surface shape of the anterior surface 201a and/or the surface shape of the posterior surface 201b of the optic 201 can be evaluated and designed to account for the Stiles-Crawford effect. Furthermore, the surface shapes can also be designed to consider the pupil sizes varying with illumination and/or object vergence.
In certain embodiments described herein, the design parameters (e.g., Ry, ky, Rx, kx, ratio Rx/Ry, and ratio kx/ky for the posterior surface and/or R, k, a2, a4, a6, and a8 for the anterior surface) can be determined for the maximum aperture for the desired toric correction. For example, the toric correction with a relatively stable caustic for a maximum aperture of 4.0 mm may be different from the toric correction with a relatively stable caustic for a maximum aperture of 3.0 mm or 5.0 mm.
To describe the performance of the lens 200, the modulation transfer function (MTF) can be used in some embodiments. For example, the MTF can describe the ability of the lens 200 to transfer contrast at a particular resolution from the object to the image. In various embodiments of the lens 200, the anterior surface 201a and the posterior surface 201b can be shaped to provide MTF values for wavelengths between the range of about 400 nanometers to about 700 nanometers (weighted by photopic, scotopic and/or mesopic distributions) that are between about 0.1 and about 0.4 at spatial frequencies of about 100 line pairs per millimeter (e.g., 20/20 vision) for at least about 90%, at least about 95%, at least about 97%, at least about 98%, or at least about 99% of the object vergences within the range of at least about 0 Diopter to about 2.0, 2.1, 2.2, 2.3, 2.4 or 2.5 Diopter (or to about 2.6, 2.7, 2.8, 2.9, 3.0) when the optic 201 is inserted into an eye. For example, the eye could be a human eye having an aperture diameter of at least about 2 millimeters, at least about 3 millimeters, at least about 4 millimeters, for example, 2 to 6 millimeters, 3 to 6 millimeters, or 4 to 6 millimeters. The MTF values may thus be 0.1, 0.2, 0.3, or 0.4 or any range therebetween. Additionally, in various implementations, the anterior and posterior surfaces are shaped to provide modulation transfer functions without phase reversal for at least 90%, 95%, or 97%, up to 98%, 99%, or 100% of the object vergences within the range of 0 D to 2.5 D (or alternatively to 2.0, 2.1, 2.2, 2.3, 2.4, 2.6, 2.7, 2.8, 2.9, or 3.0 Diopter) when said optic is inserted into a model eye having an aperture size of 2 to 6 millimeters, 3 to 6 millimeters, or 4 to 6 millimeters. In some embodiments, when the human eye includes a crystalline lens, such MTF values can be provided when the optic 201 is inserted anterior of the crystalline lens. In other embodiments, when the human eye excludes a crystalline lens, such MTF values can be provided when the optic 201 is inserted in place of the crystalline lens. The MTF values may comprise average MTF values and may be calculated by integrating over the wavelength range which is weighted by any of the photopic, scotopic, mesopic distributions or combinations thereof.
As other examples, the eye could be a model eye (e.g., Liou-Brennan, Badal, Arizona, Indiana, ISO model eye, or any standardized or equivalent model eye) that models the human eye as opposed to a human eye itself. For example, the model eye in some embodiments can also include a Liou-Brennan model eye. In some embodiments, such MTF values can be provided when the optic 201 is inserted in the model eye in a phakic configuration. In other embodiments, such MTF values can be provided when the optic 201 is inserted in a pseudophakic configuration.
Other metrics to describe the performance of the lens 200 can also be used. For example, a normalized MTF metric, such as the Salvador Image Quality (SIQ) metric, can be used. The Salvador Image Quality metric can be described as:
The Area Under MTF Curve can be the positive area under a given MTF curve, from zero to a spatial frequency ζ of 100 cycles/mm or the cutoff frequency, whichever appears first in the given plot. The “standard eye” can include a model eye (e.g., the Liou-Brennan model eye with a dilated, 6.0 mm diameter pupil) for the normalization. The MTF for the eye of interest can be the measured MTF of a given patient's eye, at a given wavelength (e.g., with a 6.0 mm dilated pupil). It can be measured and compared at the same angular field as the reference baseline. In the case of non-rotationally symmetric ocular systems, the results for Saggital SIQ and Tangential SIQ can be averaged. The Saggital SIQ can be calculated from the MTF in the XZ plane, whereas the Tangential SIQ can be calculated from the MTF in the YZ plane.
In various embodiments
In certain embodiments described herein, the anterior and posterior surfaces can be shaped to provide a SIQ metric that is at least 0.6, 0.7, 0.8, 0.9, or 1 for at least 90%, 95%, or 97%, up to 98%, or 100% of the object vergences within the range of 0 to +1.5 D, 0 to +2.0 D, or 0 to +2.5 D when the optic is inserted into the human eye of the person whose correction is being provided having an aperture size of 4 to 6 millimeters (e.g., 4 mm, 5 mm, or 6 mm).
As another example, a psychophysical grade (e.g., standard psychophysical practices in imaging science) can be used to describe the performance of the lens. In certain embodiments described herein, the anterior and posterior surfaces can be shaped to provide an above average psychophysical grade (e.g., “good” or better) for at least 90%, 95%, or 97%, up to 98%, or 100% of the object vergences within the range of 0 to +1.5 D, 0 to +2.0 D, or 0 to +2.5 D when the optic is inserted into the human eye of the person whose correction is being provided having an aperture size of 4 to 6 millimeters (or into a model eye having an aperture size of 4 to 6 millimeters having vision similar to the person whose correction is being provided) Any grade lower than an above average psychophysical grade can determine the myopic edge for the performance of the lens. The myopic edge can be the limit of the near vision provided by the extended depth of field (e.g., +1.5 D, +2.0 D, or +2.5 D) of the lens.
Various implementations described herein comprise a single refractive lens that can be implanted in the eye, for example, posterior of the cornea. In certain implementations the refractive lens is configured to be implanted between the iris and the natural lens. In other implementations, the refractive lens is configured to be implanted in the capsular bag after removal of the natural lens. In various implementations, the refractive lens is not a diffractive lens and is devoid of a diffraction grating on the surfaces thereof. In various implementations, the refractive lens does not have discrete spaced apart foci. The anterior and posterior surfaces, for example, are shaped so as not to produce discrete foci where light is focused along the optical axis of the lens that are spaced apart from each other by regions where light is substantially less focused as provided in conventional multifocal lenses. Such multifocal design with discrete foci have multiple peaks of focused energy or of energy density at different locations on the optical axis.
Various implementations described herein can provide treatment for early onset and progression of presbyopia without need for laser surgery or reading glasses. Implementations may provide about 2.0D of near as well as intermediate viewing. Depth of field for range over 2 D for an aperture of 5.0 mm can be provided.
Various embodiments may be employed to provide modified monovision solutions. For example, a first lens may be provided that has an extended depth of focus for object vergences over 0 to 2.0 D or over 0 to 2.5 D and second lens may be provided that has an extended depth of focus for object vergences over −2.0 to 0 D or over −2.5 to 0 D. These respective lenses may be implanted in the patient's dominant and non-dominant respectively. A patient may then be provided with extended depth's of field that are different for each of the left and right eye. However the aggregate depth of field is larger than provided by one of the first or second lenses along. The design details of such lenses may otherwise be similar to those discussed above.
As described herein, various embodiments include a lens with extended depth of field. For example, with reference to lens 200 described herein (e.g., as shown in
As shown in
The second portion 702 can surround the first portion 701. The second portion 702 can extend from the first portion 701 to the end of the optic 700. Accordingly, in some examples, the width of the second portion 702 can be the distance between the outer periphery of the first portion 701 to the edge of the optic 700. For example, the second portion 702 can have a width (e.g., a distance between inner and outer radii) in the range of about 1.0-3.5 mm (e.g., 1.0 mm, 1.25 mm, 1.5 mm, 1.75 mm, 2.0 mm, 2.25 mm, 2.5 mm, 2.75 mm, 3.0 mm, 3.25 mm, 3.5 mm, or any ranges between any of these sizes). Sizes outside these ranges are also possible.
The second portion 702 can have a different surface profile than the first portion 701. The first portion 701 can have higher spherical aberration control that provides extended depth of field than the second portion 702. In some cases, the second portion 702 may have substantially no spherical aberration control or at least no aberration control that provides extended depth of focus. For example, the second portion 702 can have a shape that comprises a conic, biconic, or biaspheric envelope not offset by perturbations comprising an aspheric higher order function of radial distance from the optical axis. In some cases, the second portion can have a shape that is spherical.
The second portion 702 can allow greater control of the marginal rays of the system such that a higher percentage of the rays that propagate through this portion are focused on the retina potentially providing increased contrast or improved vision quality as measure by other metrics for objects at a distance such as at infinity in comparison to the first portion (e.g., for distance power or labeled power of about +6 to −18 D). This allows a more defined focus for distance (possibly a smaller spot at the distance plane for distance objects), yet still provides the extended depth of field provided by the first portion 701. Thus, the second portion 702 can increase the responsivity distance vision quality, creating an improvement in focusing objects at a distance. This improved distance vision can be perceived by a patient as an increase in brain-favored “positive” metrics, e.g., contrast sensitivity (CS).
In addition, as the first portion 701 is configured to provide an extended depth of field, it can supply near-equal visual acuity or vision, or at least more than the second portion 702, throughout a range of focus (or for a range of object distances). The spot size, wavefront of the lens, and quality (e.g., as measured by a figure of merit such as MTF or CS) at distance, intermediate, and near points are substantially similar. However, this attribute can create difficulties in evaluating the power of the lens using standard metrology. Post-operative clinical evaluation of a patient using classical Gaussian metrology methods can also be challenging. Any number of focal points could be labeled and found to be a valid base power (e.g., distance or label power). In certain embodiments, the second portion 702 directing a ring of marginal rays to a distance focus location can provide a repeatable measurement more closely corresponding to distance power. Likewise, the second portion 702 can provide a benefit in determination of the classical base power of the implanted or un-implanted lens, and can assist in the ability to accurately measure the power of the lens using industry standard metrology methods. Thus, certain embodiments described herein can allow for standardized measurement of a lens with extended depth of field, including, but not limited to, negative-powered, positive-powered, toric, or any combination therein.
In various embodiments described herein, the first portion 701 can allow for the usage of different orders of spherical aberration and of a conic, biconic, or biaspheric base curve in order to balance the entire wavefront at each of its points near the exit pupil of the implanted eye, and the second portion 702 can allow for enhanced distance vision and/or monofocal distance focusing and for use of standard metrology.
In various embodiments, the anterior surface and/or posterior surface of the optic 700 can include other portions. For example, the anterior surface and/or the posterior surface of the optic 700 can further include a transition portion (not shown) providing a smooth transition without discontinuity between the first portion 701 and the second portion 702. The transition portion can also allow for additional wavefront optimization. In some embodiments, the transition portion can have a width (e.g., distance between the inner radii and the outer radii) in the range of about 0 to 1 mm (e.g., 0 mm, 0.1 mm, 0.2 mm, 0.3 mm, 0.4 mm, 0.5 mm, 0.6 mm, 0.7 mm, 0.8 mm, 0.9 mm, 1.0 mm, or any ranges between any of these sizes). Values outside these ranges are also possible. In some instances, the transition between the curvatures of the first portion 701 and the second portion 702 can be smooth enough that no transition region is desired.
The third portion 703 can have a different surface profile than the second profile 702. For example, the third portion 703 can have higher spherical aberration control that provides extended depth of field than the second portion 702. In some examples, the third portion 703 can have a shape that comprises a conic, biconic, or biaspheric envelope offset by perturbations comprising an aspheric higher order function of radial distance from the optical axis.
In some embodiments, the third portion 703 can have a similar surface profile and/or substantially the same spherical aberration control as the first portion 701. For example, the third portion 703 can have substantially the same conic, biconic, or biaspheric envelope offset by perturbations with respect to the envelope comprising an aspheric higher order function of radial distance from the optical axis as the first portion.
As described herein, the first portion 701 and/or the third portion 703 can have a shape that comprises a conic, biconic, biaspheric envelope offset by perturbations comprising an aspheric higher order function of radial distance from the optical axis. In various embodiments, the aspheric higher order function can include at least one even order term, a2nr2n, where n is an integer and a2n is a coefficient and r is the radial distance from the optical axis. For example, the aspheric higher order function can include a second order term, a2r2, where a2 is a coefficient and r is the radial distance from the optical axis. The aspheric higher order function can include a fourth order term, a4r4, where a4 is a coefficient and r is the radial distance from the optical axis. The aspheric higher order function can also include a sixth order term, a6r6 where a6 is a coefficient and r is the radial distance from the optical axis. The aspheric higher order function can further include an eighth order term, a8r8 where a8 is a coefficient and r is the radial distance from the optical axis. The aspheric higher order function can include any combination of these higher order terms and possibly more terms.
In various embodiments, the anterior surface and/or the posterior surface of the optic 700 can further include a transition portion (not shown) providing a smooth transition without discontinuity between the second portion 702 and the third portion 703. The transition portion can also allow for additional wavefront optimization. In some embodiments, the transition portion can have a width (e.g., distance between the inner radii and the outer radii) in the range of about 0 to 1 mm (e.g., 0 mm, 0.1 mm, 0.2 mm, 0.3 mm, 0.4 mm, 0.5 mm, 0.6 mm, 0.7 mm, 0.8 mm, 0.9 mm, 1.0 mm, or any ranges between any of these sizes). Dimensions outside these ranges are also possible. In some instances, the transition between the curvatures of the second portion 702 and the third portion 703 can be smooth enough that no transition region is desired.
In some embodiments, the caustic of the second portion 702 can be sculpted to blend smoothly (or to provide a smoother transition) with the caustic of the first portion 701 and/or the caustic of the third portion 703. For example, as shown in
The various disclosures with respect to the optic 201 described herein can also apply to the various embodiments of
The terms “about” and “substantially” as used herein represent an amount equal to or close to the stated amount (e.g., an amount that still performs a desired function or achieves a desired result). For example, unless otherwise stated, the terms “about” and “substantially” may refer to an amount that is within (e.g., above or below) 10% of, within (e.g., above or below) 5% of, within (e.g., above or below) 1% of, within (e.g., above or below) 0.1% of, or within (e.g., above or below) 0.01% of the stated amount.
Various embodiments of the present invention have been described herein. Although this invention has been described with reference to these specific embodiments, the descriptions are intended to be illustrative of the invention and are not intended to be limiting. Various modifications and applications may occur to those skilled in the art without departing from the true spirit and scope of the invention.
Pinto, Candido Dionisio, Fay, Constance Elizabeth
| Patent | Priority | Assignee | Title |
| 11982881, | May 09 2018 | Johnson & Johnson Vision Care, Inc. | Electronic ophthalmic lens for measuring distance using ultrasound time-of-flight |
| Patent | Priority | Assignee | Title |
| 10117775, | Apr 20 2012 | STAAR Surgical Company | Pre-loaded injector for use with intraocular lens |
| 4199231, | Aug 21 1978 | UNILENS OPTICAL CORP , 1250 - 400 BURRARD STREET, VANCOUVER, BRITISH COLUMBIA, V6C 3A6 | Hydrogel contact lens |
| 4373225, | Jul 06 1979 | Friedrich Wilh. Schwing, GmbH | Piping valve with a housing for the transfer of a wiper insertable in conduits that supply pressurized viscous material, preferably concrete |
| 4504982, | Aug 05 1982 | CIBA Vision AG | Aspheric intraocular lens |
| 4525043, | Nov 11 1977 | MENICON CO , LTD | Contact lens |
| 4529657, | May 30 1978 | PPG Industries, Inc. | Method for lowering the surface energy of glass |
| 4640595, | May 02 1984 | BAND, JORDAN C CO-TRUSTEE UNDER THE WILL OF DAVID VOLK; VOLK, MYRON CO-TRUSTEE UNDER THE WILL OF DAVID VOLK | Aspheric contact lens |
| 4642112, | Apr 29 1981 | Novartis AG | Artificial eye lenses |
| 4681102, | Sep 11 1985 | MASTELLONE, CHARLES; BARTELL, MICHAEL | Apparatus and method for insertion of an intra-ocular lens |
| 4710193, | Aug 18 1986 | VOLK OPTICAL, INC ; TRUST UNDER THE WILL OF DAVID VOLK | Accommodating intraocular lens and lens series and method of lens selection |
| 4731079, | Nov 26 1986 | CIBA Vision AG | Intraocular lenses |
| 4752123, | Nov 19 1985 | University Optical Products Co. | Concentric bifocal contact lens with two distance power regions |
| 4769033, | Jul 02 1987 | Abbott Medical Optics Inc | Intraocular multifocal lens |
| 4769035, | Jun 02 1987 | Artificial lens and the method for implanting such lens | |
| 4787904, | Jul 06 1984 | Hydrophillic intraocular lens | |
| 4834750, | Sep 17 1987 | AMO PUERTO RICO, INC | Deformable-elastic intraocular lens |
| 4981342, | Sep 24 1987 | FIALA, WERNER J | Multifocal birefringent lens system |
| 4990582, | Jul 18 1986 | OPTIMERS, INC | Fluorine containing soft contact lens hydrogels |
| 5000676, | Nov 21 1985 | Braun Aktiengesellschaft | Method and apparatus for increasing the temperature of catalysts |
| 5019098, | May 19 1989 | Essilor International Cie Generale d'Optique | Sight-correcting optical component such as an intra-ocular implant or contact lens |
| 5044742, | Mar 24 1988 | Contact lens | |
| 5073021, | Mar 17 1989 | ERIM INTERNATIONAL, INC ; Environmental Research Institute of Michigan | Bifocal ophthalmic lens constructed from birefringent material |
| 5142411, | Sep 24 1987 | FIALA, WERNER J | Multifocal birefringent lens system |
| 5161964, | Jul 10 1990 | (Societe Anonyme) Cricket | Catalytic burner |
| 5198844, | Jul 10 1991 | JOHNSON & JOHNSON VISION PRODUCTS, INC A CORPORATION OF FL | Segmented multifocal contact lens |
| 5217491, | Dec 27 1990 | American Cyanamid Company | Composite intraocular lens |
| 5245366, | Oct 31 1991 | Bifocal contact lens and method of making same | |
| 5260727, | Oct 22 1990 | Wide depth of focus intraocular and contact lenses | |
| 5286829, | Oct 13 1989 | Staar Surgical AG | Biocompatible polymer material and a process for producing same |
| 5290892, | Nov 07 1990 | Nestle S.A. | Flexible intraocular lenses made from high refractive index polymers |
| 5329363, | Jun 15 1993 | 3M Innovative Properties Company | Projection lens systems having reduced spherochromatism |
| 5331027, | Sep 02 1987 | ANGIOTECH BIOCOATINGS CORP | Lubricious hydrophilic coating, resistant to wet abrasion |
| 5349396, | Jul 10 1991 | Johnson & Johnson Vision Products, Inc. | Clear axis, segmented multifocal ophthalmic lens |
| 5359021, | Nov 09 1992 | Abbott Medical Optics Inc | Polymeric compositions and intraocular lenses made from same |
| 5410375, | Mar 15 1990 | Multifocal birefrigent lens with adjusted birefringence | |
| 5436678, | Sep 30 1993 | WILMINGTON PARTNERS L P | Aspheric multifocal contact lens |
| 5437647, | May 09 1990 | SAFETY SYRINGES, INC DELAWARE CORPORATION | Disposable self-shielding aspirating syringe |
| 5480428, | Apr 22 1993 | Staar Surgical AG | Corrective intraocular lens |
| 5485228, | Jul 10 1991 | Johnson & Johnson Vision Products, Inc. | Multifocal ophthalmic lens pair |
| 5494484, | Sep 30 1992 | STAAR Surgical Company | Deformable intraocular lens injecting device |
| 5499987, | Sep 30 1992 | STAAR Surgical Company | Deformable intraocular lens cartridge |
| 5517260, | Mar 28 1994 | Vari-Site, Inc. | Ophthalmic lens having a progressive multifocal zone and method of manufacturing same |
| 5523316, | Jun 23 1994 | ALCON MANUFACTURING, LTD | Intraocular irrigating solution containing agent for controlling IOP |
| 5574518, | Jan 10 1995 | COOPERVISION INTERNATIONAL LIMITED | System incorporation two different sphero-non-spherical contact lenses for correcting presbytia |
| 5603774, | Sep 27 1993 | Alcon Research, Ltd | Method for reducing tackiness of soft acrylic polymers |
| 5616148, | Feb 15 1994 | STAAR SURGICAL COMPANY, INC | Transverse hinged deformable intraocular lens injecting apparatus |
| 5620450, | Feb 15 1994 | STAAR SURGICAL COMPANY, INC | Transverse hinged deformable intraocular lens injecting apparatus |
| 5654349, | Jul 22 1994 | STAAR SURGICAL COMPANY, INC | Biocompatible optically transparent polymeric material based upon collagen and method of making |
| 5654363, | Jul 22 1994 | STAAR SURGICAL COMPANY, INC | Biocompatible optically transparent polymeric material based upon collagen and method of making |
| 5654388, | Jul 22 1994 | STAAR SURGICAL COMPANY, INC | Biocompatible optically transparent polymeric material based upon collagen and method of making |
| 5661218, | Jul 22 1994 | NEC Electronics Corporation | Biocompatible optically transparent polymeric material based upon collagen and method of making |
| 5674282, | Apr 27 1990 | The Nice Trust, A Trust Of The Isle of Man | Accommodating intraocular lens |
| 5684560, | May 04 1995 | Johnson & Johnson Vision Products, Inc. | Concentric ring single vision lens designs |
| 5693095, | Jun 07 1995 | Alcon Research, Ltd | High refractive index ophthalmic lens materials |
| 5715031, | May 04 1995 | Johnson & Johnson Vision Products, Inc. | Concentric aspheric multifocal lens designs |
| 5716364, | Jul 10 1996 | Abbott Medical Optics Inc | IOL insertion apparatus and method for making and using same |
| 5766245, | Dec 30 1996 | Staar Surgical AG; EYE MICROSURGERY INTERSECTORAL RESEARCH AND TECHNOLOGY COMPLEX | Intraocular lens for correcting moderate to severe hypermetropia |
| 5771088, | Mar 27 1993 | Novartis AG | Contact lens designed to accommodate and correct for the effects of presbyopia |
| 5796462, | May 04 1995 | Johnson & Johnson Vision Products, Inc. | Aspheric toric lens designs |
| 5800532, | Jun 06 1995 | Scientific Optics, Inc. | Asymmetric intraocular lens |
| 5814680, | Feb 23 1995 | Hoya Corporation | Soft intraocular lens |
| 5822091, | Feb 22 1993 | Extreme depth-of-field optical lens and holographic projector system for its production | |
| 5843186, | Dec 20 1996 | BRIDGE BLOOD TECHNOLOGIES LLC, NEW YORK LIMITED LIABILITY COMPANY | Intraocular lens with antimicrobial activity |
| 5843188, | Oct 20 1997 | Surgical Concepts, Inc | Accommodative lens implantation |
| 5847802, | May 04 1995 | Johnson & Johnson Vision Products, Inc. | Concentric annular ring lens designs for astigmatic presbyopes |
| 5856120, | Jan 29 1997 | Staar Surgical AG; EYE MICROSURGERY INTERSECTORAL RESEARCH AND TECHNOLOGY COMPLEX | Method of preparing a biological material for use in ophthalmology |
| 5864378, | May 21 1996 | Abbott Medical Optics Inc | Enhanced monofocal IOL or contact lens |
| 5882421, | Sep 27 1993 | Alcon Research, Ltd | Method for reducing taciness of soft acrylic polymers |
| 5910537, | Jul 22 1994 | STAAR SURGICAL COMPANY, INC | Biocompatible, optically transparent, ultraviolet light absorbing, polymeric material based upon collagen and method of making |
| 5913989, | Jul 08 1996 | Alcan International Limited | Process for producing aluminum alloy can body stock |
| 5922821, | |||
| 5929969, | May 04 1995 | JOHNSON & JOHNSON VISION PRODUCTS, INC | Multifocal ophthalmic lens |
| 5947975, | Mar 07 1997 | STAAR JAPAN INC | Inserting device for deformable intraocular lens |
| 5982543, | Mar 17 1994 | Bifocon Optics Forschungs-Und Entwicklungsgmbh | Zoned lens |
| 6024447, | May 21 1996 | Abbott Medical Optics Inc | Enhanced monofocal ophthalmic lens |
| 6036891, | May 11 1998 | AMO UPPSALA AB | Polymerizable hydrophilic ultraviolet light absorbing monomers |
| 6045578, | Nov 28 1995 | Queensland University of Technology | Optical treatment method |
| 6106553, | Oct 06 1994 | STAAR SURGICAL COMPANY, INC | Intraocular refractive correction lens |
| 6110202, | Feb 20 1996 | Corneal Laboratoires | Intraocular implant for correcting short-sightedness |
| 6120148, | Oct 05 1998 | Bifocon Optics GmbH | Diffractive lens |
| 6126286, | May 21 1996 | Abbott Medical Optics Inc | Enhanced monofocal ophthalmic lens |
| 6148862, | Mar 27 1998 | Applied Power Inc. | Solenoid valve coil pack |
| 6150472, | Dec 22 1995 | HOLLAND BIOMATERIALS GROUP B V | Multi-functional site containing polymers, and applications thereof |
| 6165490, | Apr 05 1996 | Staar Surgical AG | Biological material, method of preparing such materials, uses thereof and products made therefrom |
| 6179420, | Apr 21 1999 | JOHNSON & JOHNSON VISION PRODUCTS | Multifocal ophthalmic lenses |
| 6203973, | Mar 25 1999 | Eastman Kodak Company | Polymer latexes with core-shell morphology |
| 6238975, | Nov 25 1998 | MONTEREY RESEARCH, LLC | Method for improving electrostatic discharge (ESD) robustness |
| 6241766, | Oct 29 1998 | JOHNSON & JOHNSON SURGICAL VISION, INC | Intraocular lenses made from polymeric compositions |
| 6244709, | Mar 12 1999 | Bausch & Lomb Incorporated | Multifocal lens article |
| 6245106, | Apr 05 1999 | JOHNSON & JOHNSON SURGICAL VISION, INC | Intraocular lenses made from polymeric compositions and monomers useful in said compositions |
| 6271281, | Aug 26 1999 | Medennium, Inc. | Homopolymers containing stable elasticity inducing crosslinkers and ocular implants made therefrom |
| 6386357, | Jul 12 1999 | Hoya Healthcare Corporation | Soft intraocular lens-folding device and storage case |
| 6398809, | Apr 12 2000 | Bausch & Lomb Incorporated | Intraocular lens |
| 6457826, | Aug 06 1998 | Multifocal aspheric lens | |
| 6488708, | Apr 09 1999 | Open chamber, elliptical, accommodative intraocular lens system | |
| 6500181, | Oct 17 2000 | AAREN SCIENTIFIC, INC | Instrument for folding and inserting anterior chamber intraocular lenses |
| 6506212, | Jul 07 2000 | IMPLANTABLE VISION | Anatomically compatible posterior chamber phakic refractive lenses |
| 6520638, | Aug 14 2001 | JOHNSON & JOHNSON VISION PRODUCTS, INC | Methods for designing multifocal ophthalmic lenses |
| 6533416, | Jul 20 2001 | COOPERVISION INTERNATIONAL LIMITED | Contact or intraocular lens and method for its preparation |
| 6536899, | Jul 14 1999 | ACRI TEC GMBH; *ACRI TEC GMBH | Multifocal lens exhibiting diffractive and refractive powers |
| 6537317, | May 03 2000 | JOHNSON & JOHNSON SURGICAL VISION, INC | Binocular lens systems |
| 6547822, | May 03 2000 | JOHNSON & JOHNSON SURGICAL VISION, INC | Opthalmic lens systems |
| 6557998, | Feb 04 1999 | Abbott Medical Optics Inc | Multifocal ophthalmic lens with reduced halo size |
| 6576011, | Jan 26 1996 | Abbott Medical Optics Inc | Multifocal ophthalmic lens |
| 6576012, | Mar 28 2001 | JOHNSON & JOHNSON SURGICAL VISION, INC | Binocular lens systems |
| 6609793, | May 23 2000 | AMO GRONINGEN B V | Methods of obtaining ophthalmic lenses providing the eye with reduced aberrations |
| 6709103, | Oct 31 2002 | Johnson & Johnson Vision Care, Inc | Methods for designing multifocal ophthalmic lenses |
| 6737448, | Jun 03 2002 | STAAR Surgical Company | High refractive index, optically clear and soft hydrophobic acrylamide copolymers |
| 6790232, | Apr 30 1999 | JOHNSON & JOHNSON SURGICAL VISION, INC | Multifocal phakic intraocular lens |
| 6802606, | Feb 04 2003 | Johnson & Johnson Vision Care, Inc. | Multifocal contact lens pairs |
| 6824563, | Mar 28 2001 | JOHNSON & JOHNSON SURGICAL VISION, INC | Binocular lens systems |
| 6899425, | Oct 28 2003 | Johnson & Johnson Vision Care, Inc. | Multifocal ophthalmic lenses |
| 6923539, | May 12 2003 | Alcon Inc | Aspheric lenses |
| 6957891, | Sep 29 2000 | Ophthalmic lens with surface structures | |
| 7036931, | Jan 29 2003 | Alcon Inc | Ophthalmic lenses |
| 7057816, | Feb 29 1996 | 3M Innovative Properties Company | Optical film with co-continuous phases |
| 7061693, | Aug 16 2004 | Brien Holden Vision Institute | Optical method and system for extended depth of focus |
| 7073906, | May 12 2005 | VISION ADVANCEMENT LLC | Aspherical diffractive ophthalmic lens |
| 7118214, | Oct 19 2001 | Bausch & Lomb Incorporated | Presbyopic vision improvement |
| 7157538, | Aug 13 2004 | Alcon Inc | Covalently-bound, hydrophilic coating compositions for surgical implants |
| 7178918, | Sep 08 2000 | VISIONEERING TECHNOLOGIES, INC | Ophthalmic lenses with induced aperture and redundant power regions |
| 7261412, | Jun 30 2005 | AMO Manufacturing USA, LLC | Presbyopia correction through negative high-order spherical aberration |
| 7543937, | Nov 29 2002 | AMO GRONINGEN B.V. | Multifocal ophthalmic lens |
| 7789910, | Nov 30 2007 | University of Rochester | Optical material and method for modifying the refractive index |
| 7828431, | Nov 10 2000 | COOPERVISION INTERNATIONAL LIMITED | Junctionless ophthalmic lenses and methods for making same |
| 7871162, | Apr 24 2008 | AMO GRONINGEN B V | Diffractive multifocal lens having radially varying light distribution |
| 7918886, | May 25 2006 | VOT FUNDING LLC, A DELAWARE LIMITED LIABILITY COMPANY VOT ; VISIONCARE, INC | Double insertion intraocular implant |
| 7997727, | Jan 12 2006 | Brien Holden Vision Institute | Method and apparatus for controlling peripheral image position for reducing progression of myopia |
| 8066767, | Jun 06 2003 | Carl Zeiss Meditec AG | Intraocular lens |
| 8231219, | Apr 24 2008 | AMO GRONINGEN B V | Diffractive lens exhibiting enhanced optical performance |
| 8425597, | Apr 30 1999 | Abbott Medical Optics Inc. | Accommodating intraocular lenses |
| 8485662, | Feb 15 2005 | Queensland University of Technology | Control of myopia using contact lenses |
| 8486055, | Jun 26 2007 | University of Rochester | Method for modifying the refractive index of ocular tissues |
| 8562675, | Jul 15 2008 | Novartis AG | Extended depth of focus (EDOF) lens to increase pseudo-accommodation by utilizing pupil dynamics |
| 8580228, | Dec 27 2006 | Chevron Corporation | Treatment of cold start engine exhaust |
| 8617147, | Jun 26 2007 | University of Rochester | Method for modifying the refractive index of ocular tissues |
| 8740978, | Aug 27 2007 | AMO Regional Holdings | Intraocular lens having extended depth of focus |
| 8747466, | Aug 27 2007 | AMO GRONINGEN B V | Intraocular lens having extended depth of focus |
| 8862447, | Apr 30 2010 | AMO GRONINGEN B V | Apparatus, system and method for predictive modeling to design, evaluate and optimize ophthalmic lenses |
| 8894204, | Dec 17 2010 | JOHNSON & JOHNSON SURGICAL VISION, INC | Ophthalmic lens, systems and methods having at least one rotationally asymmetric diffractive structure |
| 8911086, | Dec 06 2002 | AMO Manufacturing USA, LLC | Compound modulation transfer function for laser surgery and other optical applications |
| 8974526, | Aug 27 2007 | AMO GRONINGEN B V | Multizonal lens with extended depth of focus |
| 9060847, | May 19 2008 | University of Rochester | Optical hydrogel material with photosensitizer and method for modifying the refractive index |
| 9101466, | Dec 18 2008 | Alcon Inc | Intraocular lens with extended depth of focus |
| 9144491, | Jun 02 2011 | University of Rochester | Method for modifying the refractive index of an optical material |
| 9195074, | Apr 05 2012 | Brien Holden Vision Institute | Lenses, devices and methods for ocular refractive error |
| 9201250, | Oct 17 2012 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
| 9216080, | Aug 27 2007 | AMO GRONINGEN B V | Toric lens with decreased sensitivity to cylinder power and rotation and method of using the same |
| 9220591, | Dec 21 2012 | JOHNSON & JOHNSON SURGICAL VISION, INC | Accommodating intraocular lens providing progressive power change |
| 9301833, | Apr 20 2012 | STAAR Surgical Company | Pre-loaded injector for use with intraocular lens |
| 9329408, | Jun 03 2009 | SEED CO , LTD | Wettable hydrogel contact lens and method for producing same |
| 9454018, | Feb 15 2008 | AMO GRONINGEN B.V. | System, ophthalmic lens, and method for extending depth of focus |
| 9535263, | Apr 05 2012 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
| 9541773, | Oct 17 2012 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
| 9545340, | Jun 26 2007 | ROCHESTER, UNIVERSITY OF | Multi-photon absorption for femtosecond micromachining and refractive index modification of tissues |
| 9557579, | Aug 22 2007 | Alcon Inc | Presbyopic treatment system |
| 9636216, | Apr 19 2013 | STAAR Surgical Company | Injector cartridge with improved lubricity |
| 9690882, | Sep 29 2011 | Carl Zeiss AG | Lens having an extended range of focus and method of making the same |
| 9717628, | Dec 04 2012 | AMO GRONINGEN B V | Lenses, systems and methods for providing binocular customized treatments to correct presbyopia |
| 9823493, | Aug 30 2012 | Johnson & Johnson Vision Care, Inc. | Compliant dynamic translation zones for contact lenses |
| 20010044657, | |||
| 20020120330, | |||
| 20030014107, | |||
| 20030063254, | |||
| 20030081171, | |||
| 20030097177, | |||
| 20030103187, | |||
| 20030187505, | |||
| 20040087963, | |||
| 20050027354, | |||
| 20050125000, | |||
| 20050147735, | |||
| 20050259222, | |||
| 20060089712, | |||
| 20060095127, | |||
| 20060098162, | |||
| 20060098163, | |||
| 20060116763, | |||
| 20060167545, | |||
| 20060176572, | |||
| 20060187413, | |||
| 20060200167, | |||
| 20060244904, | |||
| 20060244906, | |||
| 20070000801, | |||
| 20070002274, | |||
| 20070168028, | |||
| 20070258143, | |||
| 20080013043, | |||
| 20080086208, | |||
| 20080114373, | |||
| 20080225409, | |||
| 20090059163, | |||
| 20090112313, | |||
| 20090157179, | |||
| 20090210054, | |||
| 20090279048, | |||
| 20100057202, | |||
| 20100079723, | |||
| 20100087921, | |||
| 20100100177, | |||
| 20100125279, | |||
| 20100131059, | |||
| 20100161051, | |||
| 20100188636, | |||
| 20110046634, | |||
| 20110218623, | |||
| 20110313519, | |||
| 20110313525, | |||
| 20120071888, | |||
| 20120136438, | |||
| 20130090730, | |||
| 20130226294, | |||
| 20130278888, | |||
| 20140022508, | |||
| 20140104563, | |||
| 20140135919, | |||
| 20140135921, | |||
| 20140155999, | |||
| 20140200588, | |||
| 20150182329, | |||
| 20150366656, | |||
| 20160067035, | |||
| 20160116764, | |||
| 20160193037, | |||
| 20160193040, | |||
| 20160198942, | |||
| 20160302916, | |||
| 20160320633, | |||
| 20160324629, | |||
| 20160346076, | |||
| 20170007396, | |||
| 20170102556, | |||
| 20170196682, | |||
| 20170245983, | |||
| 20170245987, | |||
| 20170276963, | |||
| 20170290657, | |||
| 20170319332, | |||
| 20170325937, | |||
| 20170326002, | |||
| 20200085567, | |||
| AU2015323668, | |||
| BE1016898, | |||
| CN101039635, | |||
| CN101073519, | |||
| CN101199437, | |||
| CN101252895, | |||
| CN101437468, | |||
| CN101490600, | |||
| CN101796451, | |||
| CN102106764, | |||
| CN1575146, | |||
| CN1671336, | |||
| CN1835719, | |||
| CN1845712, | |||
| CN202086618, | |||
| EP470811, | |||
| EP503111, | |||
| EP742466, | |||
| EP1402852, | |||
| EP1424049, | |||
| EP1862148, | |||
| EP1958593, | |||
| EP485197, | |||
| FR2745711, | |||
| JP2001235712, | |||
| JP2005002377, | |||
| JP2005062965, | |||
| JP2005523981, | |||
| JP2006522674, | |||
| JP2007536047, | |||
| JP2009525835, | |||
| JP2009528855, | |||
| JP2012517029, | |||
| JP63310820, | |||
| JP64002644, | |||
| JP7184989, | |||
| KR101030689, | |||
| KR101248488, | |||
| RE45969, | Jul 15 2008 | Alcon Inc | Extended depth of focus (EDOF) lens to increase pseudo-accommodation by utilizing pupil dynamics |
| WO1071392, | |||
| WO110354, | |||
| WO189424, | |||
| WO2051338, | |||
| WO3101355, | |||
| WO4095187, | |||
| WO5046527, | |||
| WO5099630, | |||
| WO6014624, | |||
| WO6018834, | |||
| WO6056847, | |||
| WO6100086, | |||
| WO6108005, | |||
| WO7137100, | |||
| WO8065573, | |||
| WO8077006, | |||
| WO8080464, | |||
| WO9130610, | |||
| WO10100523, | |||
| WO11135685, | |||
| WO11153158, | |||
| WO12083143, | |||
| WO13028992, | |||
| WO16025315, | |||
| WO16040331, | |||
| WO16145068, | |||
| WO16167906, | |||
| WO17149401, | |||
| WO17156077, | |||
| WO2009029481, | |||
| WO2010135685, | |||
| WO2012015300, | |||
| WO2013159045, | |||
| WO2016040331, | |||
| WO94025510, | |||
| WO9407436, | |||
| WO9413225, | |||
| WO96040303, | |||
| WO9726843, | |||
| WO9735896, | |||
| WO9803894, | |||
| WO9957720, |
| Executed on | Assignor | Assignee | Conveyance | Frame | Reel | Doc |
| Mar 08 2017 | STAAR Surgical Company | (assignment on the face of the patent) | / | |||
| Apr 02 2018 | PINTO, CANDIDO DIONISIO | STAAR Surgical Company | ASSIGNMENT OF ASSIGNORS INTEREST SEE DOCUMENT FOR DETAILS | 045437 | /0397 | |
| Apr 02 2018 | FAY, CONSTANCE ELIZABETH | STAAR Surgical Company | ASSIGNMENT OF ASSIGNORS INTEREST SEE DOCUMENT FOR DETAILS | 045437 | /0397 |
| Date | Maintenance Fee Events |
| Sep 04 2018 | BIG: Entity status set to Undiscounted (note the period is included in the code). |
| Sep 04 2018 | SMAL: Entity status set to Small. |
| Dec 03 2020 | BIG: Entity status set to Undiscounted (note the period is included in the code). |
| Jun 07 2021 | M1559: Payment of Maintenance Fee under 1.28(c). |
| Jun 07 2021 | R1559: Refund - Payment of Maintenance Fee under 1.28(c). |
| Jul 22 2021 | PTGR: Petition Related to Maintenance Fees Granted. |
| Jun 19 2024 | M1551: Payment of Maintenance Fee, 4th Year, Large Entity. |
| Date | Maintenance Schedule |
| Jan 05 2024 | 4 years fee payment window open |
| Jul 05 2024 | 6 months grace period start (w surcharge) |
| Jan 05 2025 | patent expiry (for year 4) |
| Jan 05 2027 | 2 years to revive unintentionally abandoned end. (for year 4) |
| Jan 05 2028 | 8 years fee payment window open |
| Jul 05 2028 | 6 months grace period start (w surcharge) |
| Jan 05 2029 | patent expiry (for year 8) |
| Jan 05 2031 | 2 years to revive unintentionally abandoned end. (for year 8) |
| Jan 05 2032 | 12 years fee payment window open |
| Jul 05 2032 | 6 months grace period start (w surcharge) |
| Jan 05 2033 | patent expiry (for year 12) |
| Jan 05 2035 | 2 years to revive unintentionally abandoned end. (for year 12) |