A servo controlled actuator for an automated liquid dispenser for dispensing reagents or diluting samples with reagent automatically in accord with a programmed local microprocessor or remote computer control. The dispenser has at least one reciprocable syringe, valving for it and a syringe actuator driven by a hybrid servo control. The actuator includes a bi-directional variable speed motor and an encoder developing a pulse train which in number is representative of the position of the syringe piston and in repetition rate is representative of piston velocity. A microprocessor controls the piston stroke from the pulse train by comparison to a memory-stored count and controls piston velocity in predetermined relation to the terminal end of piston travel.
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4. In an automated liquid dispenser having at least one metering syringe with a precision bored cylinder and a piston reciprocable within the cylinder, valve means for selectively connecting the syringe cylinder to one or more of a set of intake and delivery valve ports, improved servo controlled drive means for rotating the lead-screw and lead-screw nut relative to one another comprising
a motor rotating one or the other of the lead-screw and nut; an encoder developing from the motor rotation a train of pulses each representative of an increment of piston travel with their repetition rate representative of piston velocity; a driver for said motor; a position counter accumulating the pulses in said encoder pulse train; a microprocessor for polling the position counter and comparing its accumulated count to a predetermined memory-stored count representative of lengths of piston stroke, and for disabling the motor driver when the accumulated count in the position counter reaches the memory-stored count corresponding to a preselected stroke length; and a valve position encoder that supplies a position signal to the microprocessor representative of the position of the intake and delivery valve ports whereby the microprocessor in coordination with reciprocation of the syringe piston switches the valve position in a memory-stored sequence.
1. In an automated liquid dispenser having at least one metering syringe with a precision bored cylinder and a piston reciprocable within the cylinder, valve means for selectively connecting the syringe cylinder to one or more of a set of intake and delivery valve ports, a syringe actuator having a threaded lead-screw and a lead-screw nut for reciprocating the piston within the syringe cylinder, improved servo controlled drive means for rotating the lead-screw and lead-screw nut relative to one another comprising
a bi-directional variable speed motor rotating one or the other of the lead-screw and nut; an encoder developing from the motor rotation a train of pulses each representative of an increment of piston travel with their repetition rate representative of piston velocity; a driver for said motor; a position counter accumulating the pulses in said encoder pulse train; a microprocessor for polling the position counter and comparing its accumulated count to a predetermined memory-stored count representative of lengths of piston stroke, and for disabling the motor driver when the accumulated count in the position counter reaches the memory-stored count corresponding to a preselected stroke length; an error amplifier for supplying a variable velocity control signal to the driver for said motor; a tachometer converting the pulse train from the encoder to an analog voltage proporational to velocity of piston travel that is supplied to the error amplifier; a digital-to-analog converter also outputing an analog voltage to the error amplifier; and a microprocessor supplying a velocity command signal to the digital-to-analog converter in accord with memory-stored values relative to stroke end to cause an increase in converter output voltage during a preselected acceleration portion and a decrease in converter output voltage during a preselected deceleration portion of the piston stroke.
5. In an automated liquid dispenser having at least one metering syringe with a precision bored cylinder and a piston reciprocable within the cylinder, valve means for selectively connecting the syringe cylinder to one or more of a set of intake and delivery valve ports, a syringe actuator having a threaded lead-screw and a lead-screw nut for reciprocating the piston within the syringe cylinder, improved servo controlled drive means for rotating the lead-screw and lead-screw nut relative to one another having a velocity mode and a position mode comprising
a bi-directional variable speed motor rotating one or the other of the lead-screw and nut; an encoder developing from the motor rotation a train of pulses each representative of an increment of piston travel with their repetition rate representative of piston velocity; a driver for said motor; a position counter accumulating the pulses in said encoder pulse train; a microprocessor for polling the position counter and comparing its accumulated count to a predetermined memory-stored count representative of lengths of piston stroke, and for disabling the motor driver when the accumulated count in the position counter reaches the memory-stored count corresponding to a preselected stroke length; an error amplifier in a velocity mode for supplying a variable velocity control signal to the driver for said motor; a tachometer converter converting the pulse train from the encoder to an analog output proportional to velocity of piston travel that is supplied to the error amplifier; a digital-to-analog converter also supplying an analog output to the error amplifier; and a microprocessor supplying a velocity command signal to the digital-to-analog converter in accord with memory-stored values relative to stroke end to cause an increase in converter output during a preselected acceleration portion and a decrease in converter output during a preselected deceleration portion of the piston stroke, wherein the microprocessor at the terminal end of each piston displacement switches the error amplifier to position mode to supply a corrective countering output to the motor driver upon receipt of any signal from the tachometer converter.
2. The automated liquid dispenser of
3. The automated liquid dispenser of
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This invention relates generally to automated liquid dispensers and more particularly to electronic control for a bench-top laboratory instrument which employs one or more easily demountable precision metering syringes reciprocated in response to a programmed microprocessor or computer control for selectively dispensing reagent or diluting samples with reagent and other common normally manual laboratory procedures.
One object of the invention is to provide a precision laboratory instrument for automating many common normally manual liquid handling laboratory procedures with improved accuracy, precision, speed and reproducibility.
Another object of the invention is to provide a liquid dispensing apparatus capable of local microprocessor or remote computer control.
One other object is to provide precise servo control for each syringe which is responsive to its piston velocity, direction and position and compensates for mechanical backlash.
Still another object of the invention is a simple valve actuator and control for a plastic valve having planar seating faces which minimizes face wear.
Other objects and advantages of the invention will become apparent upon consideration of the following written description and the accompanying drawings wherein:
FIG. 1 is an overall perspective view of the liquid dispenser with dual syringes;
FIG. 2 is a partial perspective view illustrating a typical metering syringe and the actuator and valve means for it;
FIG. 2A is an elevational view of the position detector disc configuration shown in FIG. 2;
FIG. 3 is a vertical cross-sectional view of the instrument taken along line 3--3 of FIG. 1;
FIG. 4 is a plan view of one form of keyboard for the instrument taken along line 4--4 of FIG. 3.
FIG. 5 is vertical sectional view of the lead-screw drive for one syringe actuator taken along line 5--5 of FIG. 1;
FIG. 6 is a top view of the lead-screw nut and its clamping arrangement taken along line 6--6 of FIG. 5;
FIG. 7 is an exploded view of the internal lead-screw drive for each syringe actuator;
FIG. 8 is a vertical sectional view of the valve means for each syringe taken along line 8--8 of FIG. 1;
FIG. 9 is a plan view partly in section of the valve means and valve actuator taken along line 9--9 of FIG. 8;
FIG. 10 is a vertical, partially sectional view of the valve means taken along line 10--10 of FIG. 8;
FIG. 11 is an exploded view of the valve means and valve actuator for each metering syringe;
FIG. 12 illustrates the valving configuration for a dispenser with two syringes as shown in FIG. 1;
FIG. 13 illustrates the valving arrangement for a dispenser with three syringes for example;
FIG. 14 is a vertical sectional view of a small bore syringe used in the instrument;
FIG. 15 is a vertical sectional view of a large bore syringe used in the instrument; and
FIG. 16 is an exploded view of the metering syringe components;
FIG. 17 is an overall perspective view of the liquid dispenser with a single syringe;
FIG. 18 is an enlarged perspective view of the probe illustrated in FIGS. 1 and 17;
FIG. 19 is a cross-sectional view of the probe showing its internal construction;
FIG. 20 is a cross-sectional view of the probe taken along line 20--20 of FIG. 19; and
FIG. 21 is a schematic block diagram of the microprocessor control and other electronics for the illustrated dispenser.
The instrument illustrated in FIG. 1 is designed for actuation of two precision metering syringes. The invention also is useful in the form of a single syringe shown in FIG. 17 or more than two syringes with appropriate valving and actuator changes which will be apparent from a consideration of the following description.
The illustrated instrument includes one or more precision metering syringes 1 arranged for drawing sample by means of probe 2 from a test tube 3, for example, or for dispensing sample or reagent-diluted sample into test tube 3', shown in hidden lines in FIGS. 1 and 17. The instrument is capable of withdrawing reagent from a reservoir, such as from beaker 4, and then using it to dilute a sample or otherwise to be dispensed from the probe 2.
Each metering syringe 1 mounts upon a syringe actuator, referred to generally as 5, in FIG. 2 at its rod end and is in fluid-tight communication with valve means 6 in FIG. 2. The syringe actuator 5, valve means 6 and its valve actuator, referred to generally as 7, mount upon a rigid frame 8. A housing 9 of chemical resistent material encloses the working components of the instrument apart from the metering syringes which are open for observation and ease of removal and replacement. A keyboard 10 for local microprocessor control mounts on the housing 9 on the front of the instrument adjacent to the metering syringes.
Each metering syringe, as is more particularly shown in FIGS. 14-16, comprises a precision ground glass cylinder 15 and a piston 17 carried on a piston rod 16 reciprocable within the cylinder. A connecting flange and seat 18 seals upon the blind end of the cylinder. The seat fits within a recess in the valve means 6 that mounts upon the frame 8. The connecting flange 18 is clamped to the valve means 6 by clamp 22 and set-screw 23.
The end of the piston rod 16 remote from piston 17 carries a mounting flange 19 made from magnetic material. In the particular embodiment illustrated, the mounting flange 19 carries on its periphery an o-ring 20 with which to secure to the flange a centering sleeve 21. The centering sleeve, as is more particularly illustrated in FIG. 6, centers the mounting flange 19 upon the end of an externally threaded lead-screw nut 25 over which the sleeve fits. The nut 25 carries a permanent magnet 26 which holds the flange 19 of magnetic material firmly to the top of the lead-screw nut centered thereon by sleeve 21. The sleeve 21 sealed by o-ring 20 to mounting flange 19 also functions as an open reservoir to contain leaks or provide spill protection should a fragile glass syringe break, or fracture.
The external thread 27 on the lead-screw nut 25 threads upon corresponding threads 28 formed on the internal surface of lead-screw sleeve 29 which is rotably mounted in ball bearings 30 upon frame 8. The sleeve 29 is rotated by a toothed belt gear 31 and drive belt 32 by servo motor drive means 33 shown in FIG. 2.
The lead-screw nut 25 is restrained from rotation relative to this sleeve 29 by the pair of brackets 34 mounted at one end upon the frame 8 as shown in FIG. 7 and passing through slots 35 formed in the lead-screw nut 25. The brackets are secured at the bottom ends also to the frame 8 by means of a slotted plate 36 which fits over the free end of each bracket and is screwed to the frame as is illustrated in FIG. 5.
The valve means 6 mounted in fluid communication with the blind end of each metering syringe is more particularly shown in FIGS. 8-11. Each includes a valve body 40 having a generally planar valve seat 41 bored with four ports 42, 43, 44 and 45 as illustrated in FIG. 10. The illustrated ports are in diametrically opposed pairs and each is equidistant from the rotational axis of a mating rotor 46. The spring-loaded rotor 46 has a replaceable seating face 47 having a fluid communication groove 48 on its valving face which communicates pairs of the ports 42,44 or 43,45 with one another in a programmed selection sequence by valve actuator means 7. The valve actuator may be a gearhead motor or the illustrated drive motor 49 geared to a drive shaft 50 that is biased by spring 51, ball 52 and sleeve 53 against the rotor 46 to hold the rotor in fluid-tight seating relationship with the valve seat 41. The pin 54 carried on drive shaft 50 mates with a recess 55 in the sleeve 53 and pin 56 on the sleeve mates with recess 57 in rotor 46 to enable the actuator means 7 to rotate the groove 48 into selected communication among the valve port pairs 42,44 or 43,45.
The hand held probe 2 may carry electrical switches for actuating the delivery and aspiration cycles by energizing the valve actuator 7. The probe also may include indicating means showing the instantaneous status of the sequential mode of operation. The probe handle clamps to chemically inert tubing communicating it with the valve means 6 for one or several of the metering syringes. The tubing is bundled with electric conductors connecting the probe switches, microprocessor and valve actuating means.
The particular hand-held probe 2 illustrated in FIGS. 1 and 17 is shown in more detail in FIGS. 18-20. It comprises a handle 60 formed of an elongated bar of tubular or rectangular cross-section material, such as plastic, having a longitudinal circular bore 61 in the embodiment shown. A tube holder 62 fits within the bore preferrably in an interference fit. The tube holder is generally tubular in shape with internal bore 63 and at the one end has a goose-neck configuration with a pair of reverse curves 64, 65. The tube holder 62 ends beyond the goose-neck in a nose portion 66.
Ther tube holder 62 carries within it Teflon flexible pipette tubing 67 frequently used in pipetting which communicates with the valve means 6. The tubing 67 trains through the internal bore 63 of holder 62. The reverse curves at 64 and 65 provide interference or frictional engagement of the tubing 67 against the interior walls of the bore 63 and hold the tubing 67 firmly within tube holder 62 during normal operation. On the other hand, tubing 67 can easily be replaced by pulling it out of the tube holder and inserting another piece of Teflon pipette tubing. The tube holder may be secured within handle 60 by an annular groove 68 around its periphery and a set screw 69 as shown in FIG. 20. This arrangement permits the operator to twist the tube holder within handle 60 to provide any 360° orientation for the nose portion 66 as the operator sees fit. The interference fit holds the selected orientation.
In the probe 2 illustrated in FIGS. 18-20 a pair of pressure switches 71, 72 mount in handle 60 adjacent to a push button 73 pivoted at 74 by the pressure of the thumb 75 of the operator into contact with one or the other of pressure switches 71,72. Appropriate electrical conductors 76 connect the probe switches 71,72 to the microprocessor and electronic valve acuating means mounted on the dispenser frame. The probe 2 also may include indicating means such as light emitting diodes 77,78 to indicate the instantaneous state of the dispener's sequential mode of operation. For example, LED 77 may light to indicate that the probe is ready to dispense sample or reagent and/or LED 78 may light to indicate the probe is ready to draw in sample or reagent.
Operation of the illustrated dispenser is automated by a local microprocessor control using keyboard 10. The dispenser operation also can be controlled by a programmed remote computer or a local preprogrammed ROM cartridge for specific dedicated service. The computers control the stroke and speed and sense the instantaneous position of each piston 17 in the metering syringes so that those parameters can be varied upon a command inputed through the keyboard 10 or remote computer interface.
Various modes of operation may be selected and preprogrammed into the illustrated microprocessor including the basic liquid transfers of drawing fluid into each syringe from the reagent reservoir, dispensing fluid from the syringe into the reagent reservoir, drawing fluid into the syringe from the sample probe tubing or dispensing fluid from the syringe into the sample probe tubing. Various modes of operation are obtainable including a dispense mode wherein a measured volume of liquid is drawn into a syringe from the reagent reservoir and then dispensed. In a pipette/dilute mode a measured volume of liquid is drawn from the reagent reservoir and then one or more separate samples are aspirated into the sample probe tubing with air gaps separating one sample from another and from the reagent. Then the total content of the syringe may be dispensed back out through the sample probe tubing. Various wash, purge and other modes can also be programmed into the microprocessor.
The microprocessor and electronic control for the described dispenser is illustrated schematically in FIG. 21. It includes microprocessor 80 with power supply 81. A bi-directional system bus 82 interconnects the microprocessor 80 with a random access memory 83, a programmed memory 84, bit input-output circuitry 85 for the probe switches, valve actuator and syringe actuator and interconnects an internal timer 86. A hybrid servo control circuit 87 is provided for each syringe motor 33. Keyboard-display interface circuitry 88 connects the keyboard and display 10 to the microprocessor 80 and has audible alarm 89. The system bus 82 also may interconnect the microprocessor 80 with a universal synchronous/asynchronous receiver transmitter (USART) and interface circuit 90 for connection with other devices such as an external computer control of perhaps a local preprogrammed cartridge memory for dedicated service.
The foregoing components are generally available chips for various applications and in one embodiment of the system include:
______________________________________ |
microprocessor (80) |
Intel 8085 |
RAM (83), bit I/o (85) |
Intel 8156 |
and timer (86) |
ROM (84) Intel 2716 or 2732 |
keyboard/display (88) |
Intel 8279 |
USART (90) Intel 8251A with RS232C inter- |
face |
______________________________________ |
Each servo control circuit 87 is responsive to syringe piston velocity, direction and position and accurately positions, relative to one another, the lead-screw nut 25 and lead-screw sleeve 29 which drive each piston rod 16 as illustrated in FIG. 5. The hybrid servo system shown in FIG. 21 includes the bi-directional variable speed DC servo motor 33 shown in FIGS. 2, 3. A shaft encoder 91, which by reference to FIG. 2, includes slotted disc 92 on the motor shaft and a pair of optoelectric sensing means 93,94 arranged in phase quadrature that sense the presence of the one-hundred-fifty-five equally spaced slots 95 on disc 92. Each opto-electric sensing means can be a light coupled LED and a corresponding phototransistor, for example, to digitally encode syringe piston position, direction of movement and velocity as the rotating disc 92 interrupts the coupling. The encoder 91 supplies two trains of pulses in phase quadrature to tachometer converter 96 to control velocity and direction of motor rotation. The encoder 91 also supplies the pulses to position counter 97. It accumulates the pulse count the total of which is representative of the instantaneous piston location from a "home" position. The tachometer converter 96 and a velocity control DAC 99 each supply an analog output to error amplifier 98 which operates in velocity or position mode. Its output adjusts velocity and position by driving a pulse-width modulation motor driver 99a for the variable speed DC motor 33.
The microprocessor 80 controls the hybrid servo 87 with eight output lines and receives information from the servo with five input lines. Five of the microprocessor output lines at 100 comprise a five-bit velocity command to DAC 99 of the servo which converts this command to a command analog current. The other output line at 100 selects the sign of the velocity command to control polarity of the motor driver 99a and, thus, the direction of motor rotation. Another output line at 101 selects the velocity or position mode for servo operation. Another output line, not shown, acts as a chip enable for the servo motor driver 99a. Four of the input lines at 102 comprise a four-bit position word input to the microprocessor from the position counter 97. A fifth microprocessor input line 103 is the home position sensor input which indicates that the syringe piston 17 is at "zero" volume or its "home" position within cylinder 15.
The hybrid servo system can operate in two modes, i.e. a velocity mode or position mode. The servo starts out in velocity mode as the microprocessor outputs an increasingly larger five-bit velocity command word to the velocity digital-to-analog converter 99 along with a directional sign bit at 100. The time between successive velocity commands is variable to provide a variable acceleration characteristic in the converter output voltage. This parameter is keyed to various other system parameters such as currently programmed speed, current syringe size, probe tip size and fluid viscosity. The servo responds by accelerating syringe motor 33 to the commanded velocity and in the programmed direction.
While the motor 33 is in motion the position counter 97 accumulates counts and is periodically polled by the microprocessor 80. In this way the microprocessor keeps track of the instantaneous position of the piston 17, lead screw nut 25 and sleeve 29. As components approach their desired destination, the microprocessor causes the syringe motor 33 to decelerate by outputing successively smaller command words to DAC 99. The point at which each command outputs is determined by a variable lookup table in the software. Each entry in the table represents the number of position counts remaining in the current stroke and the position in the table represents the velocity DAC command appropriate for that number of counts to be sent to DAC 99. The microprocessor periodically compares the number of counts remaining with the table entry for the current velocity DAC command. If the table entry is less than the current number of counts remaining, the velocity DAC command is not changed. If the table entry is greater than or equal to the number of position counts remaining, the velocity DAC word is decremented by one and a comparison is made with the next table entry until one is found which is less than the number of counts. This process is then repeated until the piston terminal position is reached. This strategy controls piston velocity to optimize liquid delivery performance by minimizing undesirable effects such as liquid cavitation, frothing, splashing and denaturation.
When the piston and lead-screw elements reach their desired position the microprocessor outputs a zero velocity word and switches the servo to position mode. This stops the syringe motor and locks it in place with an electronic detenting action. Should the encoder 91 supply a pulse to tachometer converter 96 in this position mode, error amplifier 98 is directed to supply a countering output to hold the piston position.
Mechanical system backlash which can occur between the lead screw nut 25 and sleeve 29 or in the drive belt 32 or between syringe piston rod and Teflon syringe tip and thereby cause imprecision and inaccuracy, is taken out of the system by the microprocessor 80 which adds a small amount of piston travel to every downward displacement of the piston and returns up the same amount as the piston moves upward to the end of the piston motion or "home" position to which the piston is always returned. Thus, the servo control always approaches its final home destination moving in the "up" direction to subtract any backlash and thus prevent it from affecting system precision and accuracy.
The "soft home" detector 104 for the described dispenser includes another optically-coupled LED-phototransistor sensor 112 shown in FIGS. 6,7 which has its optical coupling interrupted by flag 113 mounted upon a flexure 114 secured to the frame 8 at the "soft home" position when abutment screw 115 on the lead-screw nut 25 moves the flag 113 upwardly to interrupt the optical coupling. The screw 115 permits adjustment of a precise "soft home" position short of the absolute or "hard" end of the piston stroke.
The valve motor 49 may be a permanent magnet synchronous motor drive in one direction with AC current from a secondary winding of the power transformer in power supply 81. It is controlled by the microprocessor 80 through opto-electric valve position encoder 105 and a triac. The valve position encoder 105 consists of a pair of sensors that are optically-coupled light emitting diodes and phototransistors 106 shown in FIGS. 2 and 3. They sense the presence of one of two differently positioned sets of slots 107, 108 on disc 109 that is attached to the drive saft 50 for valve rotor 46. One set of slots is on the disc periphery in one diametrically opposed pair, as at 107 shown in FIG. 2A, and represents the valve position with groove 48 communicating ports 43,45. The other set is cut inwardly from the disc edge in a diametrically opposed pair 108 to represent the port 42,44 position of the groove. The coupled light between the paired LED and phototransistor sensors 106 detects the valve position, with groove 48 communicating one or the other pairs of ports 43,45 or 42,44. The position information is fed to the valve controller 110 that interfaces with microprocessor 80. To switch the position of the valve groove 48, the microprocessor 80 turns on valve motor 49, which rotates the valve rotor 46 in one direction, and then polls the status of the valve position detector until the desired valve position is reached.
In reference to the keyboard 10 of FIG. 4 the operator initially presses the mode key and then may select one of the modes on the other keys by pressing for example, the dispense, pipette, transfer, etc. key to select the desired mode. If the dispense mode has been selected, the letters DP appear in the "mode" display and the current value for the amount of reagent to be dispensed appears in the "reagent" display. The operator may press the "enter" button to accept the displayed regent quantity or enter a new value in RAM 83 by depressing appropriate numeric keys and then entering its value which also appears on the "reagent" display. Upon entering the new value, the indicator LED 78 for intake on the probe 2 is energized and the displayed amount of reagent then can be drawn into the syringe by pressing the push button 73 on the probe to actuate switch 72.
The microprocessor then enables the syringe actuator motor 33 in the down stroke direction. Its speed is accelerated in accord with the program stored in ROM 84 relative to instantaneous stroke position accumulated in position counter 97. The measured volume of reagent is drawn into the syringe from the reagent vessel 4. The microprocessor decelerates and then stops the motor 33 at the selected stroke volume. The dispense LED 77 lights and depression of push button 73 to actuate switch 71 dispenses reagent to pipette tubing 67 at probe 2 with the piston 17 returning to the soft home position. The microprocessor disables the motor drive when that position is detected by the soft home detector 104.
Corresponding positioning of valve rotor 46 is accomplished by the microprocessor to switch the fluid communicating groove 48, for example, to the intake position shown for the right-hand syringe of FIG. 12 to connect the syringe port 43 with reagent intake port 45 to draw reagent into the syringe. At the bottom end of the stroke valve motor 49 switches the the groove 48 to communicate the syringe discharge port 42 to port 44 communicating with pipette tubing 67 as is shown in FIG. 13 for the righthand syringe.
The pipette and other modes can be similarly entered in the keyboard to draw in reagent as previously described. In pipette mode the operator selects a volume for each of the reagent and the desired number of samples by depressing the appropriate mode and digit keys and enters those values which appear in the reagent and sample displays along with a numeral to identify each particular sample. The microprocessor enables the motor drive 99a, the syringe draws in the entered amount of reagent and stops. The valve switches to dispense position and the piston moves down to draw an air gap into the end of tubing 67 from atmosphere to separate reagent from the first sample and the valve returns to intake position. The operator then places the probe in the sample reservoir, depresses the button 72,73 to draw sample into the probe. The operator repeats the sample take up for others that may be entered on the keyboard each time with an air gap between them. The operator then places the probe in position to dispense the entire contents of the pipette tubing and depresses the dispense button 71 to do so as described above.
Various modifications of the described dispenser microprocessor and control electronics will become apparent to those skilled in the art within the scope of the invention that is defined in the following claims.
Bilbrey, Robert A., Koball, Bruce R., Loram, John S. H.
Patent | Priority | Assignee | Title |
10022498, | Dec 16 2011 | ICU Medical, Inc | System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy |
10046112, | May 24 2013 | ICU Medical, Inc | Multi-sensor infusion system for detecting air or an occlusion in the infusion system |
10166328, | May 29 2013 | ICU Medical, Inc | Infusion system which utilizes one or more sensors and additional information to make an air determination regarding the infusion system |
10286152, | Sep 28 2012 | Bayer HealthCare LLC | Quick release plunger |
10342917, | Feb 28 2014 | ICU Medical, Inc | Infusion system and method which utilizes dual wavelength optical air-in-line detection |
10430761, | Aug 19 2011 | ICU Medical, Inc | Systems and methods for a graphical interface including a graphical representation of medical data |
10434249, | Nov 25 2003 | Bayer HealthCare LLC | Medical injector system |
10463788, | Jul 31 2012 | ICU Medical, Inc | Patient care system for critical medications |
10493194, | Oct 23 2012 | SPINESMITH PARTNERS, L P | Automated device for point-of-care cell processing |
10507319, | Jan 09 2015 | Bayer HealthCare LLC | Multiple fluid delivery system with multi-use disposable set and features thereof |
10512721, | Oct 28 2015 | Bayer HealthCare LLC | System and method for syringe plunger engagement with an injector |
10578474, | Mar 30 2012 | ICU Medical, Inc. | Air detection system and method for detecting air in a pump of an infusion system |
10596316, | May 29 2013 | ICU Medical, Inc. | Infusion system and method of use which prevents over-saturation of an analog-to-digital converter |
10635784, | Dec 18 2007 | ICU Medical, Inc | User interface improvements for medical devices |
10656894, | Dec 27 2017 | ICU Medical, Inc. | Synchronized display of screen content on networked devices |
10668221, | Mar 15 2006 | Bayer HealthCare LLC | Plunger covers and plungers for use in syringes |
10806852, | Mar 19 2014 | Bayer HealthCare LLC | System for syringe engagement to an injector |
10850024, | Mar 02 2015 | ICU Medical, Inc | Infusion system, device, and method having advanced infusion features |
10874793, | May 24 2013 | ICU Medical, Inc. | Multi-sensor infusion system for detecting air or an occlusion in the infusion system |
10894124, | Nov 25 2003 | Bayer HealthCare LLC | Medical injector system |
11004035, | Aug 19 2011 | ICU Medical, Inc. | Systems and methods for a graphical interface including a graphical representation of medical data |
11029911, | Dec 27 2017 | ICU Medical, Inc. | Synchronized display of screen content on networked devices |
11103637, | Mar 19 2014 | Bayer HealthCare LLC | System for syringe engagement to an injector |
11135360, | Dec 07 2020 | ICU Medical, Inc | Concurrent infusion with common line auto flush |
11246985, | May 13 2016 | ICU Medical, Inc. | Infusion pump system and method with common line auto flush |
11278671, | Dec 04 2019 | ICU Medical, Inc | Infusion pump with safety sequence keypad |
11324888, | Jun 10 2016 | ICU Medical, Inc. | Acoustic flow sensor for continuous medication flow measurements and feedback control of infusion |
11344668, | Dec 19 2014 | ICU Medical, Inc | Infusion system with concurrent TPN/insulin infusion |
11344673, | May 29 2014 | ICU Medical, Inc | Infusion system and pump with configurable closed loop delivery rate catch-up |
11376361, | Dec 16 2011 | ICU Medical, Inc. | System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy |
11383029, | Mar 19 2014 | Bayer HealthCare LLC | System for syringe engagement to an injector |
11433177, | May 29 2013 | ICU Medical, Inc. | Infusion system which utilizes one or more sensors and additional information to make an air determination regarding the infusion system |
11491318, | Jan 09 2015 | Bayer HealthCare LLC | Multiple fluid delivery system with multi-use disposable set and features thereof |
11547794, | Oct 28 2015 | Bayer HealthCare LLC | System and method for syringe plunger engagement with an injector |
11596735, | Nov 25 2003 | Bayer HealthCare LLC | Medical injector system |
11596737, | May 29 2013 | ICU Medical, Inc. | Infusion system and method of use which prevents over-saturation of an analog-to-digital converter |
11599854, | Aug 19 2011 | ICU Medical, Inc. | Systems and methods for a graphical interface including a graphical representation of medical data |
11623042, | Jul 31 2012 | ICU Medical, Inc. | Patient care system for critical medications |
11868161, | Dec 27 2017 | ICU Medical, Inc. | Synchronized display of screen content on networked devices |
11883361, | Jul 21 2020 | ICU Medical, Inc. | Fluid transfer devices and methods of use |
11883636, | Feb 27 2018 | Bayer HealthCare LLC | Syringe plunger engagement mechanism |
11933650, | Mar 30 2012 | ICU Medical, Inc. | Air detection system and method for detecting air in a pump of an infusion system |
11969582, | Jan 06 2017 | Bayer HealthCare LLC | Syringe plunger with dynamic seal |
11972395, | Aug 19 2011 | ICU Medical, Inc. | Systems and methods for a graphical interface including a graphical representation of medical data |
11977091, | Jul 10 2020 | IDEXX Laboratories Inc. | Point-of-care medical diagnostic analyzer and devices, systems, and methods for medical diagnostic analysis of samples |
11998718, | Jun 18 2020 | Bayer HealthCare LLC | System and method for syringe plunger engagement with an injector |
12059551, | May 29 2013 | ICU Medical, Inc. | Infusion system and method of use which prevents over-saturation of an analog-to-digital converter |
12076531, | Jun 10 2016 | ICU Medical, Inc. | Acoustic flow sensor for continuous medication flow measurements and feedback control of infusion |
12083310, | Feb 28 2014 | ICU Medical, Inc. | Infusion system and method which utilizes dual wavelength optical air-in-line detection |
12102793, | Oct 28 2015 | Bayer HealthCare LLC | System and method for syringe plunger engagement with an injector |
12115337, | Mar 02 2015 | ICU Medical, Inc. | Infusion system, device, and method having advanced infusion features |
4586546, | Oct 23 1984 | CETUS CORPORATION, A CORP OF DELAWARE | Liquid handling device and method |
4598840, | Oct 11 1983 | BURG PAULETTE RENEE FORTY-ONE 41% PERCENT OF THE WHOLE INVENTION; BURG SHERI RENEE SIX 6% PERCENT OF THE WHOLE INVENTION; BURG DANIEL EARL SIX 6% PERCENT OF THE WHOLE INVENTION; BURG NICOLE RENEE SIX 6% PERCENT OF THE WHOLE INVENTION | Snap-in cartridge diluter |
4633413, | Jul 28 1983 | CAVRO SCIENTIFIC INSTRUMENTS, SUNNYVALE, CA , A CORP | Digital dilution apparatus and method |
4634431, | Nov 12 1976 | Syringe injector | |
4671123, | Feb 16 1984 | Rainin Instrument, LLC | Methods and apparatus for pipetting and/or titrating liquids using a hand held self-contained automated pipette |
4702393, | Feb 07 1985 | HYPERION, INC | Compensating diluter/dispenser |
4702674, | Oct 04 1985 | Dosapro Milton Roy | Method of accurately setting the flow rate of a variable-flow metering pump, and a metering pump employing the method |
4718576, | Dec 23 1985 | Oximetrix, Inc. | Fluid infusion pumping apparatus |
4760939, | May 04 1985 | Jencons (Scientific) Limited | Liquid dosing device with digital display |
4790823, | Feb 14 1986 | Societe Civile de Recherches Mesalyse | Apparatus for injecting or withdrawing substances |
4812724, | Nov 13 1984 | Liebel-Flarsheim Company | Injector control |
4815632, | May 04 1985 | Jencons (Scientific) Limited | Liquid dosing device with digital display |
4821586, | Feb 25 1988 | MLA SYSTEMS, INC | Programmable pipette |
4854324, | Jan 31 1984 | MTFP, INC | Processor-controlled angiographic injector device |
4869397, | Jun 24 1987 | TETRA PAK HOLDINGS S A A CORPORATION OF SWITZERLAND | Adjustable fill motor assembly |
4883199, | Jul 28 1987 | Graco Inc. | Fluid dispensing device |
4905526, | Feb 16 1984 | Rainin Instrument, LLC | Portable automated pipette for accurately pipetting and/or titrating liquids |
4921133, | Nov 06 1987 | GRACO, INC | Method and apparatus for precision pumping, ratioing and dispensing of work fluids |
4934564, | Mar 23 1989 | Eastman Kodak Company | Drop jet metering method and system |
4950134, | Dec 27 1988 | Entegris, Inc | Precision liquid dispenser |
4952205, | Apr 04 1987 | B. Braun Melsungen AG | Pressure infusion device |
4957226, | Jun 05 1987 | SHAWMUT CAPITAL CORPORATION | Automatic food dispensing method, apparatus and utensil |
4964533, | Mar 18 1985 | Isco, Inc. | Pumping system |
4967606, | Apr 29 1988 | WELLS, JOHN R | Method and apparatus for pipetting liquids |
4976161, | Apr 15 1988 | Przedsiebiorstwo Polonijno-Zagraniczne Plastomed | Fluid dispensing device |
4976696, | Aug 10 1987 | Fresenius AG | Syringe pump and the like for delivering medication |
5012845, | Aug 18 1988 | Varian, Inc | Fluid injector |
5027978, | Nov 06 1987 | GRACO, INC | Method and apparatus for precision pumping, ratioing, and dispensing of work fluid(s) |
5047012, | Feb 01 1989 | RICHARD WOLF, GMBH, A GERMAN CORP | Motorized syringe with multiple port manifold |
5076093, | Aug 19 1988 | Flow volume calibrator | |
5100699, | Nov 06 1987 | GRACO, INC | Method and apparatus for precision pumping, ratioing, and dispensing of work fluid(s) |
5228594, | Nov 30 1990 | Aeroquip Corporation | Metered liquid dispensing system |
5238654, | Jun 01 1992 | THERMO SEPARATION PRODUCTS INC | Syringe drive with lead screw mechanism |
5336467, | Nov 22 1989 | VetTest S.A. | Chemical analyzer |
5490765, | May 17 1993 | INTEGRATED DESIGNS L P | Dual stage pump system with pre-stressed diaphragms and reservoir |
5527161, | Feb 13 1992 | INTEGRATED DESIGNS L P | Filtering and dispensing system |
5558249, | May 05 1993 | E I DU PONT DE NEMOURS AND COMPANY | Precision liquid addition device |
5662612, | Nov 24 1993 | Liebel Flarsheim Company | Controlling plunger drives for fluid injections in animals |
5681286, | Nov 24 1993 | Liebel Flarsheim Company | Controlling plunger drives for fluid injections in animals |
5687779, | Sep 17 1992 | Tetra Laval Holdings & Finance S.A. | Packaging machine system for filling primary and secondary products into a container |
5695464, | Dec 29 1993 | Zambon Group SpA | Method of injection controlled by an infusion pump |
5755692, | Sep 28 1994 | Method and apparatus for administering a drug to a patient | |
5800397, | Apr 20 1995 | ACIST MEDICAL SYSTEMS, INC | Angiographic system with automatic high/low pressure switching |
5882343, | Apr 20 1995 | ACIST MEDICAL SYSTEMS, INC | Dual port syringe |
5896804, | Oct 29 1996 | Sysmex Corporation | Syringe pump |
5916197, | Feb 14 1997 | Bayer HealthCare LLC | Injection system, pump system for use therein and method of use of pumping system |
5921437, | Jun 23 1997 | Dispenser apparatus | |
5927349, | Dec 09 1996 | Baxter International Inc | Compounding assembly for nutritional fluids |
5928197, | Nov 24 1993 | Liebel-Flarsheim Company | Controlling plunger drives for fluid injections in animals |
5997502, | Aug 17 1992 | Medrad, Inc. | Front loading medical injector and syringe for use therewith |
6090064, | Aug 17 1992 | Medrad, Inc. | Front loading medical injector and syringe for use therewith |
6099502, | Apr 20 1995 | ACIST MEDICAL SYSTEMS, INC | Dual port syringe |
6197000, | Feb 14 1997 | Bayer HealthCare LLC | Injection system, pump system for use therein and method of use of pumping system |
6199603, | Aug 14 1998 | Baxter International Inc. | Compounding assembly for nutritional fluids |
6202711, | Dec 09 1996 | Baxter International Inc. | Compounding assembly for nutritional fluids |
6221045, | Oct 07 1997 | ACIST MEDICAL SYSTEMS, INC | Angiographic injector system with automatic high/low pressure switching |
6254832, | Mar 05 1999 | Rainin Instrument, LLC | Battery powered microprocessor controlled hand portable electronic pipette |
6285155, | Oct 29 1999 | ICU Medical, Inc | Pseudo half-step motor drive method and apparatus |
6344030, | Apr 20 1995 | ACIST Medical Systems, Inc. | Random speed change injector |
6370947, | Sep 08 1998 | TWITTER, INC | Substrate surface analysis |
6387077, | Oct 13 2000 | Mallinckrodt Inc. | Apparatus and method for providing a suspended agent |
6402717, | Aug 17 1992 | Medrad, Inc. | Front-loading medical injector and syringe for use therewith |
6402718, | Aug 17 1992 | Medrad, Inc. | Front-loading medical injector and syringe for use therewith |
6475192, | Aug 17 1992 | Medrad, Inc. | System and method for providing information from a syringe to an injector |
6499365, | Nov 02 1998 | Eppendorf AG | Electronic metering device |
6537244, | Jan 19 1999 | Assistive Technology Products, Inc. | Methods and apparatus for delivering fluids |
6562008, | Aug 17 1992 | Medrad, Inc. | Front loading medical injector and syringe for use therewith |
6626862, | Apr 04 2000 | ACIST Medical Systems, Inc. | Fluid management and component detection system |
6652489, | Feb 07 2000 | Bayer HealthCare LLC | Front-loading medical injector and syringes, syringe interfaces, syringe adapters and syringe plungers for use therewith |
6656157, | Apr 20 1995 | ACIST Medical Systems, Inc. | Infinitely refillable syringe |
6733478, | Aug 17 1992 | Medrad, Inc. | System and method for providing information from a syringe to an injector |
6752779, | Jan 19 1999 | Assistive Technology Products, Inc. | Methods and apparatus for delivering fluids |
6789467, | Nov 16 2001 | MERIAL, INC | Automatic poultry injection delivery apparatus |
6808513, | Aug 17 1992 | Medrad, Inc. | Front loading medical injector and syringe for use therewith |
6958053, | Nov 24 1999 | Bayer HealthCare LLC | Injector providing drive member advancement and engagement with syringe plunger, and method of connecting a syringe to an injector |
6966895, | Aug 16 2000 | Smiths Group PLC | Syringe pumps |
6978911, | Dec 19 2001 | Illinois Tool Works Inc | Apparatus and methods for producing and dispensing automobile appearance care products charged to a customer on a selected bases |
6988637, | Dec 19 2001 | Illinois Tool Works Inc | Apparatus and methods for a customer to produce and dispense automobile appearance care products |
6997068, | Jul 31 2002 | Drummond Scientific Company | Foot-operated pipette dispenser |
7008535, | Aug 04 2000 | NEXTEC ENVIRONMENTAL INC | Apparatus for oxygenating wastewater |
7029459, | Nov 24 1999 | Bayer HealthCare LLC | Injector system including a powered loading device for connecting a syringe to an injector |
7081105, | Aug 17 1992 | MEDRAD, INC | Injector system having a front loading pressure jacket assembly |
7273591, | Aug 12 2003 | IDEXX LABORATORIES, INC ; ECLIPSE PRODUCT DEVELOPMENT CORP | Slide cartridge and reagent test slides for use with a chemical analyzer, and chemical analyzer for same |
7284454, | May 27 2004 | Matrix Technologies Corporation | Hand held pipette |
7294278, | Aug 04 2000 | NEXTEC ENVIRONMENTAL INC | Method for oxygenating wastewater |
7350423, | Jan 14 2004 | GOOGLE LLC | Real time usage monitor and method for detecting entrapped air |
7416704, | Jun 26 2000 | VISTABLAB TECHNOLOGIES, LLC; VISTALAB TECHNOLOGIES, LLC | Handheld pipette |
7419478, | Jun 25 2003 | Bayer HealthCare LLC | Front-loading syringe for medical injector having a flexible syringe retaining ring |
7465290, | Nov 24 1999 | Bayer HealthCare LLC | Injector system including an injector drive member that automatically advances and engages a syringe plunger |
7540856, | Feb 07 2000 | Bayer HealthCare LLC | Front-loading medical injector adapted to releasably engage a syringe regardless of the orientation of the syringe with respect to the injector |
7553294, | May 30 2002 | Bayer HealthCare LLC | Syringe plunger sensing mechanism for a medical injector |
7594801, | Dec 27 2001 | Koganei Corporation | Chemical liquid apparatus and deaerating method |
7708880, | Dec 28 2001 | Koganei Corporation | Chemical liquid supply apparatus and a chemical liquid supply method |
7726516, | Jan 15 2002 | Pump | |
7748281, | Jun 09 2005 | Beckman Coulter, Inc | Dispensing apparatus, dispensing method, and analyzer |
7794429, | Nov 24 1993 | Liebel-Flarsheim Co. | Controlling plunger drives for fluid injections in animals |
7824374, | Nov 24 1993 | Liebel-Flarsheim Co. | Controlling plunger drives for fluid injections in animals |
8114362, | Jun 26 2000 | VISTABLAB TECHNOLOGIES, LLC; VISTALAB TECHNOLOGIES, LLC | Automatic pipette identification |
8133203, | May 30 2002 | Bayer HealthCare LLC | Method of injecting fluids from a dual syringe injector system |
8287823, | Aug 12 2003 | Idexx Laboratories, Inc. | Slide cartridge and reagent test slides for use with a chemical analyzer, and chemical analyzer for same |
8574200, | May 30 2002 | Bayer HealthCare LLC | Dual syringe injector system |
8580198, | May 07 1999 | Toshiba Medical Systems Corporation | Automatic analyzer |
8585989, | Dec 04 2003 | Idexx Laboratories, Inc. | Retaining clip for reagent test slides |
8721596, | Feb 07 2000 | Bayer HealthCare LLC | Front-loading syringe adapted to releasably engage a medical injector regardless of the orientation of the syringe with respect to the injector |
8912008, | May 07 1999 | Toshiba Medical Systems Corporation | Automatic analyzer |
8944780, | Mar 25 2011 | Bayer HealthCare LLC | Pumping devices, systems including multiple pistons and methods for use with medical fluids |
9108047, | Jun 04 2010 | Bayer HealthCare LLC | System and method for planning and monitoring multi-dose radiopharmaceutical usage on radiopharmaceutical injectors |
9116129, | May 08 2007 | IDEXX LABORATORIES, INC | Chemical analyzer |
9463335, | Jun 04 2010 | Bayer HealthCare LLC | System and method for planning and monitoring multi-dose radiopharmaceutical usage on radiopharmaceutical injectors |
9480791, | Dec 21 2009 | Bayer HealthCare LLC | Pumping devices, systems and methods for use with medical fluids including compensation for variations in pressure or flow rate |
9480797, | Oct 28 2015 | Bayer HealthCare LLC | System and method for syringe plunger engagement with an injector |
9522261, | Jan 22 2010 | MONTGOMERY, HUGH E; MYTHEN, MICHAEL | Method and apparatus for providing hydration fluid |
9636452, | Sep 05 2000 | Bayer HealthCare LLC | Front-loading medical injector adapted to releasably engage a syringe regardless of the orientation of the syringe with respect to the injector |
9649436, | Sep 21 2011 | Bayer HealthCare LLC | Assembly method for a fluid pump device for a continuous multi-fluid delivery system |
9694131, | Nov 25 2003 | Bayer HealthCare LLC | Medical injector system |
9744305, | Sep 28 2012 | Bayer HealthCare LLC | Quick release plunger |
9797916, | Jan 10 2014 | IDEXX LABORATORIES, INC | Chemical analyzer |
9823109, | May 08 2007 | Idexx Laboratories, Inc. | Chemical analyzer |
9844622, | Jul 10 2000 | Bayer HealthCare LLC | Syringes for medical injector systems |
9855390, | Mar 15 2006 | Bayer HealthCare LLC | Plunger covers and plungers for use in syringes |
9880525, | Nov 30 2010 | LSIS CO , LTD | Positioning apparatus and PLC system using same |
9995611, | Mar 30 2012 | ICU Medical, Inc | Air detection system and method for detecting air in a pump of an infusion system |
D412205, | Jul 29 1997 | ACIST MEDICAL SYSTEMS, INC | Dual port syringe |
D620602, | Jan 03 2008 | VISTABLAB TECHNOLOGIES, LLC; VISTALAB TECHNOLOGIES, LLC | Pipette |
D847985, | Mar 14 2007 | Bayer HealthCare LLC | Syringe plunger cover |
D942005, | Mar 14 2007 | Bayer HealthCare LLC | Orange syringe plunger cover |
ER1458, | |||
ER5304, | |||
ER5521, | |||
ER5666, | |||
ER6735, | |||
ER7577, |
Patent | Priority | Assignee | Title |
3173575, | |||
3701345, | |||
3751642, | |||
3756456, | |||
4346742, | Jun 02 1980 | P M AMERICA, INC , A CORP OF DE | Method for diluting a liquid test sample and computer controlld diluting apparatus |
4387374, | Mar 30 1977 | Raytheon Company | Range mark position control employing optical encoding |
Executed on | Assignor | Assignee | Conveyance | Frame | Reel | Doc |
Aug 27 1981 | BILBREY, ROBERT A | SCIENTIFIC MANUFACTURING INDUSTRIES, INC , A CORP OF CA | ASSIGNMENT OF ASSIGNORS INTEREST | 003924 | /0717 | |
Aug 27 1981 | KOBALL, BRUCE R | SCIENTIFIC MANUFACTURING INDUSTRIES, INC , A CORP OF CA | ASSIGNMENT OF ASSIGNORS INTEREST | 003924 | /0717 | |
Aug 27 1981 | LORAM, JOHN S H | SCIENTIFIC MANUFACTURING INDUSTRIES, INC , A CORP OF CA | ASSIGNMENT OF ASSIGNORS INTEREST | 003924 | /0717 | |
Aug 31 1981 | American Hospital Supply Corporation | (assignment on the face of the patent) | / | |||
Jul 01 1983 | SCIENTIFIC MANUFACTURING INDUSTRIES, | SMI ACQUISITION CORPORATION, A DE CORP | ASSIGNMENT OF ASSIGNORS INTEREST | 004149 | /0597 | |
Jun 22 1984 | SMI ACQISITION CORPORATION | AMERICAN HOSPITAL SUPPLY CORPORATION, | ASSIGNMENT OF ASSIGNORS INTEREST EFFECTIVE DATE JULY 3,1983 | 004277 | /0228 | |
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