A computer controlled system for guiding the needle device, such as a biopsy needle, by reference to a single mode medical imaging system employing any one of computed tomography imaging (CTI) equipment, magnetic resonance imaging equipment (MRI), fluoroscopic imaging equipment, or 3d ultrasound system, or alternatively, by reference to a multi-modal imaging system, which includes any combination of the aforementioned systems. The 3d ultrasound system includes a combination of an ultrasound probe and both passive and active infrared tracking systems so that the combined system enables a real time image display of the entire region of interest without probe movement.
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20. A system for computer controlled guidance of a needle device comprising:
a needle device 3d image data set including 3d geometry of the needle device; an imaging system operable for imaging at least a part of the patient to provide a set of patient imaging data, the set of patient imaging data having a fixed frame of reference relative to the patient; a first processor configured for combining the needle device 3d image data set with the set of patient imaging data to provide a combined image data set; and a second processor configured for calculating a desired combined image data set corresponding to a desired position of the needle device relative to the patient and the fixed frame of reference wherein the desired combined image data set is available to cause relative movement between the patient and the needle device to move the needle device to the desired position.
1. A method for computer controlled guidance of a needle device configured to move in orthogonal coordinate directions relative to a fixed frame of reference in combination with a 3d imaging device, the method comprising the steps of:
imaging at least a portion of a patient with the imaging device to provide a set of patient imaging data, the set of patient imaging data having a fixed frame of reference relative to the patient; combining an image of the needle device with the set of patient imaging data to provide a combined image data set; calculating a desired combined image data set corresponding to a desired position of the needle device relative to the patient and the fixed frame of reference; and causing relative movement between the patient and the needle device, based on the desired combined image data set, to bring the needle device position data set into registry with the desired position of the needle device.
10. A method for computer controlled guidance of a needle device configured to move in orthogonal coordinate directions relative to a fixed frame of reference, the method comprising the steps of:
imaging at least a portion of a patient with a first imaging technique to provide a first set of imaging data, the first set of imaging data having a fixed frame of reference relative to the patient; imaging at least a part of the patient with a second imaging technique to provide a second set of imaging data, the part of the patient including at least some of the at least a portion of the patient, the second imaging technique being different than the first imaging technique, the second set of imaging data being data not necessarily being fixed relative to the fixed frame of reference; registering the second imaging data set with the first imaging data set to provide a first composite set of imaging data; providing an image data set of the needle device; combining the image data set of the needle device with the first composite set of image data to produce a second composite set of image data; and identifying in the second composite set of imaging data the position and orientation of the image of the needle device relative to the image of the at least a portion of the patient and determining therefrom a desired position and orientation of the needle device image corresponding to a desired actual position and orientation of the needle device relative to the patient.
21. A system for computer controlled guidance of a needle device carried by a needle device carrier configured for causing relative movement between a patient and the needle device comprising:
a plurality of patient position markers operable for fixing relative to the patient to define a fixed frame of reference; a needle device 3d image data set including 3d geometry of the needle device; an imaging system operable for imaging at least a part of the patient to provide a set of patient imaging data, the set of patient imaging data including positional data of the patient position markers representing a fixed frame of reference when the patient position markers are image-conspicuous, and combined with telemetry fiduciary data when telemetry readouts are arranged to correspond to successive positions of a patient to be scanned; a position determiner for identifying a current position description of the needle device carrier with respect to the fixed frame of reference; a first processor for calculating a needle position data set using the current position description; a second processor for calculating a composite data set by combining the patient image data set and the needle device 3d image data set, wherein the needle device 3d image data set is adjusted with respect to the patient image data set according to the needle position data set; and a third processor for calculating from the composite data set a selected set of co-ordinate locations defining a carrier guide path for movement of the needle device carrier with respect to the fixed frame of reference so that the needle device moves along a desired needle device guide path corresponding to the carrier guide path.
4. A method for computer controlled guidance of a needle device using a needle device 3d image data set including 3d geometry of a needle device, the needle device being configured to be carried by a needle device carrier, the needle device carrier being configured to move in orthogonal coordinate directions relative to a fixed frame of reference so that a current digital positional description of the needle device carrier with respect to the fixed frame of reference can be identified, the method comprising the steps of:
securing a plurality of patient position markers fixed relative to a patient, the patient position markers defining the fixed frame of reference relative to the patient; imaging at least a part of the patient using an imaging device to provide a set of patient imaging data, the set of patient imaging data being relative to the fixed frame of reference, the set of patient imaging data including positional data of the patient position markers when the patient position markers are image-conspicuous, and combined with telemetry fiduciary data when telemetry readouts are arranged to correspond to successive positions of a patient to be scanned; identifying the current position description of the needle device carrier with respect to the fixed frame of reference and calculating a needle position data set with respect to the fixed frame of reference; calculating a composite data set by combining the needle device 3d image data set and the patient image data set, wherein the needle device 3d image data set is adjusted with respect to the fixed frame of reference according to the needle position data set; and determining from the composite data set a selected set of co-ordinate locations defining a carrier guide path for movement of the needle device carrier with respect to the fixed frame of reference.
14. A method for computer controlled guidance of a needle device configured to move in orthogonal coordinate directions relative to a fixed frame of reference, the method comprising the steps of:
imaging at least a portion of a patient with a first imaging technique to provide a first set of imaging data, the first set of imaging data having a fixed frame of reference; imaging at least a part of the patient with a second imaging technique to provide a second set of imaging data, the part of the patient including at least some of the portion of the patient, the second imaging technique using an ultrasound device to provide a second set of imaging data, the second set of imaging data being 3d data relative to the ultrasound device and not being fixed relative to the fixed frame of reference, the ultrasound device being operable to provide the second set of imaging data without relative movement between the ultrasound device and the patient, wherein the first set of imaging data is obtained prior to acquisition of the second set of imaging data; determining position data for the ultrasound device; using the determined position data and the second set of imaging data to provide a converted set of imaging data corresponding to the second set of imaging data being referenced to the fixed frame of reference; combining the converted set of image data with at least some of the first set of imaging data to provide a first composite set of imaging data; providing an image data set of the needle device; combining the image data set of the needle device with the first composite set of image data to produce a second composite set of image data; and identifying in the second composite set of imaging data the position and orientation of the image of the needle device relative to the image of the at least a portion of the patient and determining therefrom a desired position and orientation of the needle device image corresponding to a desired actual position and orientation of the needle device relative to the patient. 24. A system for computer controlled guidance of a needle device carried by a needle device carrier configured for causing relative movement between a patient and the needle device comprising:
a plurality of patient position markers operable for fixing relative to a patient to define a fixed frame of reference; a needle device 3d image data set including 3d geometry of the needle device; a non-ultrasonic imaging subsystem operable for imaging at least a portion of the patient to provide a first patient imaging data set, the first patient imaging data set including positional data of the patient position markers representing a fixed frame of reference when the patient position markers are image-conspicuous, and combined with telemetry fiduciary data when telemetry readouts are arranged to correspond to successive positions of a patient to be scanned; an imaging subsystem operable for imaging at least a part of the patient to provide a second patient imaging data set, the part of the patient including at least some of the at least a portion of the patient, the imaging subsystem being configured to use an ultrasound device to provide a second patient imaging data set, the ultrasound device including an ultrasound probe that produces 3d imaging data without relative movement between the ultrasound probe and the patient, the second patient imaging data set being relative to the ultrasound device and not being fixed relative to the fixed frame of reference, the ultrasound device being operable to provide the second patient imaging data set without relative movement between the ultrasound device and the patient; a probe position determiner for determining position data for the ultrasound device; a second processor operable for using the determined position data and the second set of imaging data to calculate a converted set of imaging data corresponding to the second patient imaging data set being referenced to the fixed frame of reference; a third processor operable for combining the converted set of image data with at least some of the first patient imaging data set to provide a first composite imaging data set; a position determiner operable for determining a needle device actual position and orientation data set; and a fourth processor operable for applying the determined needle device actual position and orientation data set to the needle device 3d image data set and the first composite imaging data set to produce a second composite image data set, the second composite image data set being configured for identification of a position and orientation of the needle device image and determining therefrom a desired position and orientation of the needle device image corresponding to a desired actual position and orientation of the needle device relative to the patient.
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The present invention relates generally to interventional medicine, and particularly concerns properly locating, vectoring, and inserting a needle-like medical device toward and into a targeted patient anatomic feature while the patient is being imaged with single, or multi-modality medical imaging equipment such as computed tomography imaging (CTI) equipment, magnetic resonance imaging equipment (MRI), fluoroscopic imaging equipment, and 3D ultrasound equipment.
Among others, Frank J. Bova and William A. Friedman of the present inventors have pioneered the art of high precision planning and treatment of intracranial targets using radiation originating from medical linear accelerators. All of these previously developed planning and treatment systems have been based upon a rigid model consisting of the patient's skull, upper dentisia and intracranial anatomy. Exemplary of these systems and methods are those described in U.S. patent application Ser. No. 09/621,868, filed Jul. 21, 2000, and in the following U.S. Pat. Nos., all issued to the Bova and Friedman on the indicated dates, assigned to the assignee of the present application, the entire contents and disclosures of all of which are incorporated herein by reference:
| 5,954,647 | Marker system and related stereotactic | Sep. 21, 1999 |
| procedure | ||
| 5,588,430 | Repeat fixation for frameless stereotactic | Dec. 31, 1996 |
| procedure | ||
| 5,189,687 | Apparatus for stereotactic radiosurgery | Feb. 23, 1993 |
| 5,027,818 | Dosimetric technique for stereotactic | July 02, 1991 |
| radiosurgery | ||
Although this rigid model is valid for cranial targets, it is not practical for all anatomic regions. An example of a target that cannot be modeled with a rigid body modality is metastatic disease within the liver. In order to effect the application of high precision biopsy, radiation treatments or other medical procedures to such deformable anatomic regions, real time imaging of the target region must be incorporated into the treatment procedure.
Multiplanar x-rays and ultrasound are the best suited of all of the modalities available for such real time imaging. Multiplanar x-ray imaging, primarily orthogonal imaging, has been used to localize radiation targets for several decades. While this mode of target localization has several advantages, its primary disadvantages are the space and time it requires. The space required by the imaging chain, including x-ray source(s) and imaging electronics, is simply not available near or around a patient who is in position for real time treatment, especially if the treatment uses a medical linear accelerator. Depending on how fast an image of a given portion of the anatomy changes with time and the time required to complete a multiplanar x-ray process, the x-ray imaging may not be sufficiently fast to track changes and provide accurate real time data.
U.S. Pat. No. 5,893,832, issued to Song on Jun. 24, 1997, describes an ultrasound probe which provides a 3D image of an anatomic region without external probe movement. The probe effectively provides a 3D image of a selected anatomic region without the necessity for external probe movement. Ultrasound probes like those of the Song patent can provide real time imaging of a portion of the patient's anatomy, although the image data is with reference to the position of the ultrasound probe. As the ultrasound probe is moved, the point of reference changes.
U.S. patent application Ser. No. 09/621,868, filed Jul. 21, 2000 describes a system which enables image guidance during radiation therapy and surgery, by combining an ultrasound probe with both passive and active infrared tracking systems for production of a 3D image. The combined system enables a real time image display of the entire region of interest without probe movement. The system enables probe displacement during image acquisition so that all external displacements introduced by the probe can be accounted for at the time of placement of elements in support of a treatment protocol. This is accomplished by registration of a patient's real world anatomy with the patient's virtual world imaging study. The coordination of these two worlds allow for a clinician to perform a procedure in the virtual world and then, with the aid of computer guidance execute the procedure in the real world.
The first application of linking the real world with the virtual world was the establishment of stereotactic neurological procedures based upon rigid stereotactic frames. Frameless virtual guidance technology has also been established for several operative environments. Intracranial procedures, based upon CTI and or MRI scans have been available for several years. The same CTI or MRI based guidance have also been available for planning and guidance in spinal surgery. Recently, imaging support for the virtual environment has been extended to include virtual fluoroscopy. At the University of Florida the incorporation of both 2D and 3D ultrasound has now been made available for virtual procedures. This form of guidance is employed in many daily procedures including brain tumor biopsy, brain tumor resection, deep brain stimulation, pallidotomy for Parkinson's disease, lesioning procedures for pain, pedicle screw fixation, guidance for ENT surgical procedures, radiosurgery and stereotactic radiotherapy.
What is needed, is the extension of this technology to image guidance during biopsy. It is desirable to reapply the tools used to project a virtual surgical, or radiation, tool to a biopsy needle. More particularly, it is desirable to apply CTI, MRI, fluoroscopy and ultrasound procedures, either independently or in combination, i.e., multi modality imaging, to guidance and placement of a biopsy needle.
The present invention is described in terms of two embodiments, the first of which is a computer controlled system for guiding a needle device, such as a biopsy needle, by reference to a single mode medical imaging system employing any one of computed tomography imaging (CTI) equipment, magnetic resonance imaging equipment (MRI), fluoroscopic virtual imaging equipment, or 3D ultrasound equipment. The second embodiment is a computer controlled system for guiding the needle device by reference to a multi-modal system, which includes any combination of the above-listed systems.
In the first embodiment, the method of the present invention includes use of a needle device 3D image data set including 3D geometry of the needle device in conjunction with a data set obtained from a single image system, wherein the needle device is configured to be carried by a needle device carrier. The needle device carrier is configured to move in orthogonal coordinate directions relative to a fixed frame of reference so that a current digital positional description of the needle device carrier can be identified with respect to the fixed frame of reference, which is with reference to the real world patient's position.
A broad description of the first embodiment is directed to the steps of imaging at least a portion of a patient with an imaging device to provide a set of patient imaging data, the set of patient imaging data having a fixed frame of reference relative to the patient, combining an image of the needle device with the set of patient imaging data to provide a combined image data set, calculating a desired combined image data set corresponding to a desired position of the needle device relative to the patient and the fixed frame of reference and causing relative movement between the patient and the needle device, based on the desired combined image data set, to bring the needle device position data set into registry with the desired position of the needle device.
In a more detailed description of the first embodiment, the method includes the step of securing a plurality of patient position markers fixed relative to a patient, the patient position markers defining a fixed frame of reference. At least a part of the patient is imaged using an imaging device to provide a set of patient imaging data, the set of patient imaging data being relative to the fixed frame of reference. The set of patient imaging data includes positional data of the patient position markers when the patient position markers are image-conspicuous, and, alternatively, combined with telemetry fiduciary data when telemetry readouts are arranged to correspond to successive positions of a patient to be scanned. The set of patient imaging data is 3D data derived from 3D imaging systems, including virtual fluoroscopic and 3D ultrasound imaging systems, as well as CTI and MRI imaging systems, and any other 3D system to be developed.
The current position description of the needle device carrier is identified with respect to the fixed frame of reference and a needle position data set is calculated with respect to the fixed frame of reference. A composite data set is calculated by combining the needle device 3D image data set and the 3D patient image data set, wherein the needle device 3D image data set is adjusted with respect to the fixed frame of reference according to the needle position data set. The composite data set is determined from a selected set of co-ordinate locations defining a carrier guide path for movement of the needle device carrier with respect to the fixed frame of reference. The selected set of co-ordinate locations is applied to the needle device carrier so that the needle device moves along a desired needle device guide path corresponding to the carrier guide path.
As in the broad description of the first embodiment, the imaging device of the more detailed description is selected from a group of imaging devices including a computerized tomography imaging device, an magnetic resonance imaging device, a fluoroscopic imaging device, and a 3D ultrasound imaging device that produces 3D imaging data without relative movement between the ultrasound imaging device and the patient. Additionally, the needle device is selected from a group of needle devices including a biopsy needle, a needle configured for injection of toxin into diseased tissue, and an instrument configured for precision placement of a screw, such as a pedicle screw, and the needle device 3D image data set is selected from a group of 3D image data sets including a biopsy needle 3D image data set, an injection needle 3D image data set, and an instrument 3D image data set.
In one embodiment, the patient position markers are secured directly to the patient, and in a separate embodiment, the patent position markers are secured to the scanner table, which supports the patient. Alternatively, the patient position is determined by telemetry.
In the second embodiment of the present invention, there is provided a method and system for properly locating, vectoring, and inserting a needle device toward and into a targeted patient anatomic feature, including imaging at least a portion of a patient with a first imaging technique to provide a first set of imaging data, the first set of imaging data having a fixed frame of reference. In one form of the second embodiment, a second set of imaging data is obtained by a second imaging technique to provide a second set of imaging data, preferably after the first imaging technique is complete. The data sets obtained from the two techniques are then combined to provide a composite data set. Advantageously, if the second imaging technique is both operatively faster and more conducive to the patient treatment environment than the first technique, but is less discriminating than the first imaging technique in terms of image detail, the application of the second imaging data set, as obtained on a substantially real time basis, can be used to update, and effectively determine, a desired selected view obtained from a stored data set from the more detailed first imaging technique.
In a second form of the second embodiment of the present invention, after the above-described first set of imaging data has been obtained, at least a part of the patient is imaged with a second imaging technique which uses an ultrasound device to provide a second set of imaging data, the second set of imaging data being 3D data relative to the ultrasound device and not being fixed relative to the fixed frame of reference. The ultrasound device is operable to provide the 3D data without relative movement between the ultrasound device and the patient, as described in copending U.S. patent application Ser. No. 09/621,868. Position data is determined for the ultrasound device. Using the determined position data and the second set of imaging data, a converted set of imaging data corresponding to the second set of imaging data being referenced to the fixed frame of reference is provided. The converted set of image data is combined with at least some of the first set of imaging data to provide a first composite set of imaging data. An image of the needle device is provided. The image of the needle device is combined with the first composite set of image data to produce a second composite set of image data.
In the second composite set of imaging data the position and orientation of the image of the needle device is identified relative to the image of the at least a portion of the patient and a desired position and orientation of the needle device image corresponding to a desired actual position and orientation of the needle device relative to the patient is determined therefrom. The relative movement between the patient and the needle device is caused to bring the needle device position data set into registry with the desired position and orientation of the needle device.
The first imaging technique, as used to provide the first set of imaging data, is selected from the group consisting of computerized tomography imaging, magnetic resonance imaging, and fluoroscopic imaging. In one method of the invention, the first imaging technique is performed and completed prior to the imaging with the ultrasound device.
The step of imaging with the ultrasound device uses an ultrasound probe that produces 3D imaging data without relative movement between the ultrasonic probe and the patient. The step of determining position data for the ultrasound probe includes determining the position of a plurality of probe position markers on the ultrasound probe, the position of the probe position markers being determined by a technique not including the first and second imaging techniques. The position of the ultrasound probe is determined using infrared (IR) imaging
In the course of a medical procedure employing the present invention, as applied to a patient, an image of the needle device is used in combination with the converted set of imaging data to achieve positioning of the needle device relative to the patient. The needle device is selected from a group of needle devices including a biopsy needle, a needle configured for injection of toxin into diseased tissue, and an instrument configured for precision placement of a screw, and the needle device 3D image data set is selected from a group of 3D image data sets including a biopsy needle 3D image data set, an injection needle 3D image data set, and an instrument 3D image data set.
Relative movement is caused between the patient and the needle device to bring the second set of imaging data into registry with the first set of imaging data. Alternatively, the relative movement is accomplished by controlling the needle device with a robotic guidance apparatus.
The method further includes the step of, at least before completion of the first imaging technique, securing a plurality of patient position markers fixed relative to the patient. Alternatively, the patient position markers are secured to a scanner table for supporting the patient, or they are determined by telemetry or infrared (IR) imaging.
The system of the first embodiment of the present invention provides computer controlled guidance of a needle device including a plurality of patient position markers operable for defining a fixed frame of reference relative to a patient, a needle device, a needle device 3D image data set including 3D geometry of the needle device, and a needle device carrier configured for carrying the needle device for relative movement between the patient and the needle device.
The system also includes a 3D imaging system operable for imaging at least a part of the patient to provide a set of patient 3D imaging data, the set of patient 3D imaging data including positional data of the patient position markers representing a fixed frame of reference when the patient position markers are image-conspicuous, and combined with telemetry fiduciary data when telemetry readouts are arranged to correspond to successive positions of a patient to be scanned. A position determiner is provided for identifying a current position description of the needle device carrier with respect to the fixed frame of reference. A first processor is provided for calculating a needle position data set using the current position description, and a second processor is provided for calculating a composite data set by combining the patient 3D image data set and the needle device 3D image data set, wherein the needle device 3D image data set is adjusted with respect to the patient 3D image data set according to the needle position data set. A third processor is provided for calculating from the composite data set a selected set of co-ordinate locations defining a carrier guide path for movement of the needle device carrier with respect to the fixed frame of reference so that the needle device moves along a desired needle device guide path corresponding to the carrier guide path.
The needle device is selected from a group of needle devices including a biopsy needle, a needle configured for injection of toxin into diseased tissue, and an instrument configured for precision placement of a screw, and the needle device 3D image data set is selected from a group of 3D image data sets including a biopsy needle 3D image data set, an injection needle 3D image data set, and an instrument 3D image data set.
The system of the second embodiment includes a plurality of patient position markers operable for fixing relative to a patient to define a fixed frame of reference, a needle device, a needle device 3D image data set including 3D geometry of the needle device, and a needle device carrier configured for carrying the needle device for relative movement between the patient and the needle device.
The system also includes a non-ultrasonic 3D imaging subsystem operable for imaging at least a portion of the patient to provide a first patient 3D imaging data set, the first patient 3D imaging data set including positional data of the patient position markers representing a fixed frame of reference when the patient position markers are image-conspicuous, and combined with telemetry fiduciary data when telemetry readouts are arranged to correspond to successive positions of a patient to be scanned.
A 3D imaging subsystem operable is provided for imaging at least a part of the patient to provide a second patient 3D imaging data set, the part of the patient including at least some of the at least a portion of the patient, the 3D imaging subsystem being configured to use an ultrasound device to provide a second patient 3D imaging data set, the second patient 3D imaging data set being 3D data relative to the ultrasound device and not being fixed relative to the fixed frame of reference, the ultrasound device being operable to provide the second patient 3D imaging data set without relative movement between the ultrasound device and the patient.
A determiner is provided for determining position data for the ultrasound device, and a second processor is provided for using the determined position data and the second set of imaging data to calculate a converted set of imaging data corresponding to the second patient 3D imaging data set being referenced to the fixed frame of reference. A third processor is provided, the processor being operable for combining the converted set of image data with at least some of the first patient 3D imaging data set to provide a first composite imaging data set.
Also included is a position determiner operable for determining a needle device actual position and orientation data set and a fourth processor is included, the processor being operable for applying the determined needle device actual position and orientation data set to the needle device 3D image data set to form a result and for combining the result with the first composite imaging data set to produce a second composite image data set. The second composite image data set is configured for identification of the position and orientation of the needle device image relative to the first patient 3D imaging data set and determining therefrom a desired position and orientation of the needle device image corresponding to a desired actual position and orientation of the needle device relative to the patient.
Relative movement can be caused between the patient and the needle device to bring the needle device position data set into registry with the desired position and orientation of the needle device, based on the determined desired position and orientation.
As in the first embodiment, the needle device for the second embodiment is selected from a group of needle devices including a biopsy needle, a needle configured for injection of toxin into diseased tissue, and an instrument configured for precision placement of a screw, and the needle device 3D image data set is selected from a group of 3D image data sets including a biopsy needle 3D image data set, an injection needle 3D image data set, and an instrument 3D image data set.
The non-ultrasonic 3D imaging subsystem is selected from the group consisting of a computerized tomography system, a magnetic resonance system, and a fluoroscopy system. The ultrasound device can be configured to include an ultrasound probe that produces 3D imaging data without relative movement between the ultrasound probe and the patient, and includes the ultrasound probe can include a plurality of probe position markers thereon.
Optionally, the position determiner includes a subsystem to determine the position of the probe position markers and the patient position markers. Further, the system optionally includes an infrared (IR) camera.
The above and other features of the present invention will be more readily understood when the following detailed description is considered in conjunction with the accompanying drawings wherein like characters represent like parts throughout the several views and in which:
Patient P is shown on a table 12 and a position reference device 14 with a plurality of patient position markers 16 thereon. The reference device 14 is preferably secured directly to a stable (such as skeletal) part of the patient. The markers 16 are preferably passive (reflecting devices) or active devices which can be sensed with an infrared (IR) camera (shown in
A needle device 18 attached to a needle device carrier 20 configured for carrying needle device 18 for relative movement between patient P and the needle device 18. A manipulator arm 22, which may be either a robotic arm controlled by known methods or an manually manipulated arm, is operatively attached to needle carrier 20.
A needle device 3D image data set 24 is stored in accordance with known data storage techniques and includes a digital depiction of the 3D geometry of the needle device 18.
A 3D imaging system 26, which is operable for imaging at least a part of patient P to provide a set of patient 3D imaging data 28. The set of patient 3D imaging data 28 includes positional data of the patient position markers 16 representing a fixed frame of reference when the patient position markers 16 are image-conspicuous, and can be combined with telemetry fiduciary data derived from a known telemetry system (not shown) when telemetry readouts are arranged to correspond to successive positions of a patient to be scanned.
A position determiner 30 is provided for identifying a current position description of the needle device carrier 20 with respect to the fixed frame of reference.
A first processor 32 is provided for calculating a needle position data set 34 using the current position description, and a second processor 36 is provided for calculating a composite data set by combining the patient 3D image data set 38 and the needle device 3D image data set 24, wherein the needle device 3D image data set 24 is adjusted with respect to the patient 3D image data set 28 according to the needle position data set 34. A third processor 40 is provided for calculating from the composite data set 38 a selected set of co-ordinate locations defining a carrier guide path for movement of the needle device carrier 20 with respect to the fixed frame of reference so that the needle device 18 moves along a desired needle device guide path corresponding to the carrier guide path.
System 10 further includes a fourth processor 42 configured for enabling a user to bring the needle device position data set 34 into registry with the desired position and orientation of the needle device 18, as represented relative to the patient 3D imaging data set 28, to produce a registry data set 44. An actuator 46 responsive to the registry data set 44 is attached to needle carrier 20 for relative movement between the patient P and the needle device 18. Alternatively, actuator 46 and manipulator arm 22 can be the same apparatus.
The needle device 18 is selected from a group of needle devices including a biopsy needle, a needle configured for injection of toxin into diseased tissue, and an instrument configured for precision placement of a screw, and the needle device 3D image data set is selected from a group of 3D image data sets including a biopsy needle 3D image data set 29, an injection needle 3D image data set 31, and an instrument 3D image data set 33.
First processor 32, second processor 36, third processor 40, and fourth processor 42 are computational units which can be software or hardware modules arranged separately or in any appropriate combination as part of a computer system 47. Needle device 3D image data set 24, patient 3D imaging data set 28, needle position data set 34, composite data set 38, and registry data set 44 are data sets 48 which reside on suitable data storage media and are configured for retrieval and update by computer system 47. Computer system 47 is operatively connected to 3D imaging system 64, position determiner 30, and manipulators 22 and 46, as appropriate and in accordance with known practices.
System 50 also includes first and second imaging subsystems, which can take the form of any combination of 3D imaging techniques. For illustrative purposes, the preferable combination of a 3D ultrasound imaging subsystem and any other 3D imaging subsystem will be described. In that arrangement, the first subsystem takes the form of a non-ultrasonic 3D imaging subsystem 64 operable for imaging at least a portion of patient P to provide a first patient 3D imaging data set 66. The first patient 3D imaging data set 66 includes positional data of patient position markers 56 representing a fixed frame of reference when the patient position markers 56 are image-conspicuous, and combined with telemetry fiduciary data when telemetry readouts are arranged to correspond to successive positions of a patient to be scanned. Non-ultrasonic 3D imaging subsystem 64 is generally similar to 3D imaging system 26 described in connection with system 10, including operative connections with a first computer system 67.
The second 3D imaging subsystem is subsystem 68, which is provided for imaging at least a part of patient P to provide a second patient 3D imaging data set 70 representing a part of patient P including at least some of the at least a portion of patient P. Although subsystem 68 can be any 3D imaging system, preferably, 3D imaging subsystem 68 is connected to a second computer system 76, including a second processor 77, and is configured to use a 3D ultrasound device 72 to provide the second patient 3D imaging data set 70, the second patient 3D imaging data set 70 being 3D data relative to ultrasound device 72 and not being fixed relative to the fixed frame of reference. The ultrasound device 72 is operable to provide the second patient 3D imaging data set 70 without relative movement between the ultrasound device 72 and patient P, as described in copending U.S. patent application Ser. No. 09/621,868, previously herein incorporated by reference.
The ultrasound imaging data obtained from the 3D ultrasound imaging subsystem 68 is converted to be relative to the fixed frame of reference and is then combined into the imaging data obtained from the non-ultrasonic 3D imaging subsystem 64. The result of the combined data sets are used for targeting needle device 58 to the proper part of patient P. By combining the ultrasound data with the imaging data of subsystem 64 one obtains the value of real time ultrasound data in combination with the higher resolution of the earlier obtained non-ultrasound imaging data set.
A probe position determiner 74 is provided for determining position data 100 for the ultrasound device 72, and second processor 77 is provided for using the determined position data 100 and the second set of imaging data 70 to calculate a converted set of imaging data 78 corresponding to the second patient 3D imaging data set 70 being referenced to the fixed frame of reference.
A third processor 80 is provided, processor 80 being operable for combining the converted set of image data 78 with at least some of the first patient 3D imaging data set 66 to provide a first composite imaging data set 82.
Also included is a needle position determiner 84 operable for determining, for the needle device 58, a needle device actual position and orientation data set 86.
A fourth processor 88 is operable for applying the determined needle device actual position and orientation data set 86 to needle device 3D image data set 62 to form a result and for combining the result with the first composite imaging data set 66 to produce a second composite image data set 90. The second composite image data set 90 is configured for identification of the position and orientation of needle device image 62 as shown in the overall second composite image data set 90 and determining therefrom a desired position and orientation of the needle device image 92 corresponding to a desired actual position and orientation of the needle device relative to patient P.
Relative movement is caused between patient P and needle device 58 to bring the needle device position data set 86 into registry with the desired position and orientation of the needle device 92, based on the determined desired position and orientation.
As in the first embodiment, needle device 58 for the second embodiment is selected from a group of needle devices including a biopsy needle, a needle configured for injection of toxin into diseased tissue, and an instrument configured for precision placement of a screw, and the needle device 3D image data set is selected from a group of 3D image data sets including a biopsy needle 3D image data set 94, an injection needle 3D image data set 95, and an instrument 3D image data set 96.
The non-ultrasonic 3D imaging subsystem 64 is selected from the group consisting of a computerized tomography system, a magnetic resonance system, and a fluoroscopy system. The ultrasound device 72 is configured to include an ultrasound probe 98 that produces 3D imaging data without relative movement between ultrasound probe 98 and patient P. Ultrasound probe 98 can include a plurality of probe position markers 102 thereon. Probe 102 provides 3D imaging data to processor 76. Reference device 54 is fixed to probe 102 and has probe position markers 56. Reference device 54 is similar in construction to device 14 of system 10 and has markers 56 similar to markers 16. Reference device 54 differs from device 14 in that device 54 may have fasteners (not shown) or otherwise be fixed to the probe 102.
Optionally, position determiner 74 includes a subsystem to determine the position of the probe position markers 102 and the patient position markers 56. Further, the system a tracking system, such as, for example an infrared (IR) camera 104, which is connected to processor 76 and operatively tracks markers 56 and 102 according to techniques described in copending U.S. patent application Ser. No. 09/621,868, previously herein incorporated by reference. Other tracking systems are also suitable.
A module 105 is provided to bring the needle device position data set 86 into registry with the desired position and orientation 92 of the needle device 58 to produce a registry data set 106 and a mechanism 108 responsive to the registry data set 106 and attached to the needle carrier 60 for relative movement between patient P and needle device 58. Actuator 108 and manipulator 59 is the same automated device for actuating needle device carrier 60.
Second processor 77, third processor 80, and fourth processor 88 are computational units which are software or hardware modules arranged separately or in any appropriate combination as part of a computer system 76. Needle device 3D image data set 62, first patient 3D imaging data set 66, second patient 3D image data set 70, converted data set 78, needle position data set 86, first composite data set 82, second composite image data set 90, desired actual position and orientation of needle image data set 92, ultrasound determined position data set 100, and registry data set 106, together with biopsy needle image data set 94, injection needle image data set 95 and instrument 3D image data set 96, are stored in data storage system 110 and are configured for retrieval and update by computer systems 67 and 76. Computer system 67 is operatively connected to 3D imaging system 64, position determiner 84, and manipulators 59 and 108. Computer system 76 is operatively connected to second 3D imaging system 68, probe position determiner 74, probe 98, and infrared camera system 104, as appropriate and in accordance with known practices.
The operation of the method of the present invention will now be discussed in the context of each 3D imaging technology. For each 3D imaging procedure, the ability to register the imaging modality to the patient's real world position is an absolute requirement before a needle carrier path can be defined. The use of multi modality imaging, through the use of image registration technology, requires only one image data set derived from one image subsystem to be registered between the real and virtual worlds, while all other image data sets derived from other imaging subsystems are then registered to that data set. An example of this technique is the ability to plan a stereotactic biopsy based upon a stereotactic CTI scan and an MRI scan which is not stereotactically taken but registered anatomically to the CTI scan.
Each imaging modality has unique physical characteristics that require unique solutions in order to provide the real world to virtual world linkage. Any combination of these technologies can be co-registered, once their respective data sets are placed in the virtual world. For ease of description, the image acquisition, registration, and application to guidance of a needle device, such as a biopsy needle, will be separately discussed next in connection with each imaging technology.
Computer Tomography Imaging (CTI) Biopsy Subsystem:
The CTI based approach to locating, vectoring, and inserting a needle-like medical device toward, and into, a targeted patient anatomic feature requires that each individual CTI image, or CT slice, be registered to the patient. This in turn requires the definition of CTI room space and patient space and the ability to track one relative to the other. The definition of this space is through a stereotactic fiducial system incorporated into the scanner table, a reference attached to part of the patient's support-immobilization system, or, alternatively, it is through scanner telemetry readouts. In either situation, each pixel of CTI data is mapped into virtual space and becomes part of the patient's virtual image. When the patient is withdrawn from the scanner gantry, the telemetry system tracks the rigid body move, thereby keeping the patient's virtual data set registration to the patient. Simultaneously, the biopsy needle is introduced to the real world and is tracked in the virtual world through a six-degree of freedom tracking system. This tracking is accomplished through one of a variety of tracking technologies, such as, for example, optical tracking, as in the case of either active or passive infrared tracking systems, or magnetically tracking via an articulated arm system.
Prior to performance of the biopsy medical procedure, the biopsy needle is calibrated so that the needle geometry of the biopsy needle is known to the system and is accurately inserted into the virtual world model. Any movement of the biopsy needle in the real world is mirrored in the virtual world. This allows the clinician to plan a trajectory in the virtual world, in a manner similar to virtual surgical planning, and then guide the real world biopsy needle along this planned trajectory. To assist in the alignment of the biopsy several displays are provided to help align the needle in all size degrees of freedom. This alignment assistance is in the form of freehand guidance or is used to control a robotic guidance apparatus. In this later case the required needle movements are decoupled from the scanner room coordinate system and re-coupled to the robotic guidance coordinate system. This is similar to the decoupling that is provided in a radio camera system, wherein decoupling allows feedback to be aligned with the available linear accelerator table controls that rotate in room space, as the patient is setup.
To assist in the alignment and stabilization of the patient beginning with the scanning and continuing through the biopsy process it may be advantageous to provide a system that incorporates both a stereotactic fiducial system and an immobilization system. Several such systems are commercially available and in the development process the strengths and weaknesses of each should be considered.
Magnetic Resonance Imaging (MRI) Biopsy Subystem
According to the present invention, alternatively, an MRI biopsy system is made to function in a manner directly parallel to the above-described CTI system. Known software image registration techniques are used to combine the MRI and CTI image data sets to allow for both to be simultaneously available when planning in the virtual world.
Fluoroscopic Biopsy Subsystem:
A standalone fluoroscopic biopsy system configured to develop a virtual image is applied to locating, vectoring, and inserting a needle-like medical device toward, and into, a targeted patient anatomic feature resembles known systems used for virtual fluoroscopic navigation for spinal surgery. In the present invention, the x-ray source and the image intensifier are both fitted with fiducials that are tracked. A reference system is rigidly attached to the patient's anatomy, and in the application to spinal surgery, it usually is attached to a specific vertebra, creating a real world patient coordinate system. The geometry of all fluoroscopic views taken are known relative to the specific patient's reference coordinate system.
Once a set of fluoroscopic views that are sufficient for the clinician to appreciate when an acceptable alignment has been achieved, the fluoroscopic source is no longer used. A biopsy needle, with a known geometry and calibration, is introduced into the real world and mathematically inserted into the corresponding pre-recorded fluoroscopic views in the virtual world. While this system does not have the ability to present the clinician with a true 3D description of the patients anatomy, as would be provided if a CTI or MRI model, it does allow for a significant reduction in x-ray exposure to the patient and operating room personnel and also allows for multiple simultaneous virtual real time fluoroscopic view to be evaluated, eliminating the need to hold the needle's position while the fluoroscopic system is realigned.
As with the CT described above, the fluoroscopic system is made to function via a freehand guidance interface or through a robotic interface, with known coupling of a biopsy needle carrier attached to the biopsy needle with a robotic control system. This system can also be jointly coupled to a CTI biopsy needle guidance system. This is accomplished through a rigid relationship between the CTI room reference system and the fluoroscopic patient reference system. In the, combined system both the plane film fluoroscopic views as well as the true 3D anatomy are appreciated in the virtual world planning system.
Ultrasound Biopsy Subsystem:
An image from a 3D ultrasound system is obtained, transferred to a workstation, and then mapped into both room space and virtual room space. The room space is provided through any imaging source, such as a CTI or MRI imaging system. It is assumed that the patient and the room space form a rigid body system, i.e., the room reference system moves with the patient. With the image in virtual space, a biopsy probe, equipped with tracking, is introduced into room space and simultaneously displayed in virtual space. With the tracking of the probe the clinician is able to appreciate the orientation and trajectory of the biopsy probe in six degrees of freedom, relative to the anatomy that is being ultrasonically imaged. Although the assumption of a rigid body arrangement has been made, this assumption is modified if the interface between the ultrasound system and the workstation is sufficiently fast as to allow for the instantaneous update of the virtual image.
Although specific constructions have been presented, it is to be understood that these are for illustrative purposes only. Various modifications and adaptations will be apparent to those of skill in the art. Therefore, the scope of the present invention should be determined by reference to the claims.
Bova, Frank J., Friedman, William A.
| Patent | Priority | Assignee | Title |
| 10004875, | Aug 24 2005 | C. R. Bard, Inc. | Stylet apparatuses and methods of manufacture |
| 10010308, | Jul 21 2011 | The Research Foundation for The State University of New York | System and method for CT-guided needle biopsy |
| 10046139, | Aug 20 2010 | C. R. Bard, Inc. | Reconfirmation of ECG-assisted catheter tip placement |
| 10058681, | Sep 17 2002 | Medtronic, Inc. | Low profile instrument immobilizer |
| 10080617, | Jun 27 2011 | Board of Regents of the University of Nebraska | On-board tool tracking system and methods of computer assisted surgery |
| 10086193, | Feb 13 2004 | Medtronic, Inc. | Apparatus for securing a therapy delivery device within a burr hole and method for making same |
| 10105121, | Nov 26 2007 | C. R. Bard, Inc. | System for placement of a catheter including a signal-generating stylet |
| 10105149, | Mar 15 2013 | Board of Regents of the University of Nebraska | On-board tool tracking system and methods of computer assisted surgery |
| 10127629, | Aug 02 2006 | InnerOptic Technology, Inc. | System and method of providing real-time dynamic imagery of a medical procedure site using multiple modalities |
| 10136951, | Feb 17 2009 | InnerOptic Technology, Inc. | Systems, methods, apparatuses, and computer-readable media for image guided surgery |
| 10165962, | Nov 26 2007 | C. R. Bard, Inc. | Integrated systems for intravascular placement of a catheter |
| 10178979, | Mar 14 2013 | WEST VIRGINIA UNIVERSITY | Endorectal prostate probe composed of a combined mini gamma camera and ultrasound sensor |
| 10188467, | Dec 12 2014 | INNEROPTIC TECHNOLOGY, INC | Surgical guidance intersection display |
| 10201391, | Mar 20 2002 | P Tech, LLC | Methods of using a robotic spine system |
| 10219811, | Jun 27 2011 | Board of Regents of the University of Nebraska | On-board tool tracking system and methods of computer assisted surgery |
| 10231643, | Jun 12 2009 | Bard Access Systems, Inc. | Apparatus and method for catheter navigation and tip location |
| 10231753, | Nov 26 2007 | C. R. Bard, Inc. | Insertion guidance system for needles and medical components |
| 10238418, | Nov 26 2007 | C. R. Bard, Inc. | Apparatus for use with needle insertion guidance system |
| 10265128, | Mar 20 2002 | P Tech, LLC | Methods of using a robotic spine system |
| 10271762, | Jun 12 2009 | Bard Access Systems, Inc. | Apparatus and method for catheter navigation using endovascular energy mapping |
| 10278778, | Oct 27 2016 | INNEROPTIC TECHNOLOGY, INC | Medical device navigation using a virtual 3D space |
| 10279195, | Jul 18 2005 | Nucletron B.V. | Method for identifying the location of at least one treatment channel from a group of a plurality of treatment channels as well as a system for effecting radiation treatment on a pre-selected anatomical portion of an animal body |
| 10300268, | Apr 07 2000 | Medtronic, Inc.; Mayo Foundation for Medical Education and Research | Device for immobilizing a primary instrument and method therefor |
| 10314559, | Mar 14 2013 | INNEROPTIC TECHNOLOGY, INC | Medical device guidance |
| 10314564, | Oct 31 2014 | Covidien LP | Computed tomography enhanced fluoroscopic system, device, and method of utilizing the same |
| 10321898, | Oct 31 2014 | Covidien LP | Computed tomography enhanced fluoroscopic system, device, and method of utilizing the same |
| 10342575, | Nov 26 2007 | C. R. Bard, Inc. | Apparatus for use with needle insertion guidance system |
| 10349890, | Jun 26 2015 | C R BARD, INC | Connector interface for ECG-based catheter positioning system |
| 10368953, | Mar 20 2002 | P Tech, LLC | Robotic system for fastening layers of body tissue together and method thereof |
| 10376712, | Dec 01 2015 | University of Iowa Research Foundation | Real-time applicator position monitoring system |
| 10398513, | Feb 17 2009 | InnerOptic Technology, Inc. | Systems, methods, apparatuses, and computer-readable media for image management in image-guided medical procedures |
| 10433763, | Mar 15 2013 | SYNAPTIVE MEDICAL INC | Systems and methods for navigation and simulation of minimally invasive therapy |
| 10433814, | Feb 17 2016 | InnerOptic Technology, Inc. | Loupe display |
| 10434278, | Mar 05 2013 | eZono AG | System for image guided procedure |
| 10449330, | Nov 26 2007 | C R BARD, INC | Magnetic element-equipped needle assemblies |
| 10512475, | Aug 24 2011 | DEPUY SYNTHES PRODUCTS, INC | Cross pinning guide devices and methods |
| 10524691, | Nov 26 2007 | C R BARD, INC | Needle assembly including an aligned magnetic element |
| 10568560, | Mar 14 2013 | WEST VIRGINIA UNIVERSITY | Endorectal prostate probe with combined PET and US modalities |
| 10582972, | Apr 07 2011 | 3SHAPE A/S | 3D system and method for guiding objects |
| 10602958, | Nov 26 2007 | C. R. Bard, Inc. | Systems and methods for guiding a medical instrument |
| 10603512, | Aug 06 2010 | MIDCAP FUNDING IV TRUST, AS SUCCESSOR TO EXISTING ADMINISTRATIVE AGENT | Tracking during radiation treatment using ultrasound imaging |
| 10639008, | Oct 08 2009 | C R BARD, INC | Support and cover structures for an ultrasound probe head |
| 10674982, | Aug 06 2015 | Covidien LP | System and method for local three dimensional volume reconstruction using a standard fluoroscope |
| 10699448, | Jun 29 2017 | Covidien LP | System and method for identifying, marking and navigating to a target using real time two dimensional fluoroscopic data |
| 10702226, | Aug 06 2015 | Covidien LP | System and method for local three dimensional volume reconstruction using a standard fluoroscope |
| 10702712, | Aug 06 2010 | MIDCAP FUNDING IV TRUST, AS SUCCESSOR TO EXISTING ADMINISTRATIVE AGENT | Tumor tracking during radiation treatment using ultrasound imaging |
| 10716525, | Aug 06 2015 | Covidien LP | System and method for navigating to target and performing procedure on target utilizing fluoroscopic-based local three dimensional volume reconstruction |
| 10716634, | Apr 07 2011 | 3SHAPE A/S | 3D system and method for guiding objects |
| 10733700, | Aug 02 2006 | InnerOptic Technology, Inc. | System and method of providing real-time dynamic imagery of a medical procedure site using multiple modalities |
| 10751509, | Nov 26 2007 | C R BARD, INC | Iconic representations for guidance of an indwelling medical device |
| 10758155, | Sep 06 2011 | eZono AG | Imaging probe and method of obtaining position and/or orientation information |
| 10765343, | Sep 06 2011 | eZono AG | Imaging probe and method of obtaining position and/or orientation information |
| 10772686, | Oct 27 2016 | InnerOptic Technology, Inc. | Medical device navigation using a virtual 3D space |
| 10820885, | Jun 15 2012 | C R BARD, INC | Apparatus and methods for detection of a removable cap on an ultrasound probe |
| 10820944, | Oct 02 2014 | InnerOptic Technology, Inc. | Affected region display based on a variance parameter associated with a medical device |
| 10820946, | Dec 12 2014 | InnerOptic Technology, Inc. | Surgical guidance intersection display |
| 10846893, | Jun 29 2017 | Covidien LP | System and method for identifying, marking and navigating to a target using real time three dimensional fluoroscopic data |
| 10849695, | Nov 26 2007 | C. R. Bard, Inc. | Systems and methods for breaching a sterile field for intravascular placement of a catheter |
| 10863920, | Feb 06 2014 | C. R. Bard, Inc. | Systems and methods for guidance and placement of an intravascular device |
| 10869728, | Mar 20 2002 | P Tech, LLC | Robotic surgery |
| 10893843, | Oct 10 2017 | Covidien LP | System and method for identifying and marking a target in a fluoroscopic three-dimensional reconstruction |
| 10905498, | Feb 08 2018 | Covidien LP | System and method for catheter detection in fluoroscopic images and updating displayed position of catheter |
| 10912488, | Jun 12 2009 | Bard Access Systems, Inc. | Apparatus and method for catheter navigation and tip location |
| 10932869, | Mar 20 2002 | P Tech, LLC | Robotic surgery |
| 10959791, | Mar 20 2002 | P Tech, LLC | Robotic surgery |
| 10966630, | Nov 26 2007 | C. R. Bard, Inc. | Integrated system for intravascular placement of a catheter |
| 10973584, | Jan 19 2015 | BARD ACCESS SYSTEMS, INC ; ROMEDEX INTERNATIONAL SRL | Device and method for vascular access |
| 10974029, | Sep 17 2002 | Medtronic, Inc. | Low profile instrument immobilizer |
| 10992079, | Oct 16 2018 | BARD ACCESS SYSTEMS, INC | Safety-equipped connection systems and methods thereof for establishing electrical connections |
| 11000207, | Jan 29 2016 | C R BARD, INC | Multiple coil system for tracking a medical device |
| 11026630, | Jun 26 2015 | C. R. Bard, Inc. | Connector interface for ECG-based catheter positioning system |
| 11027101, | Aug 22 2008 | C. R. Bard, Inc. | Catheter assembly including ECG sensor and magnetic assemblies |
| 11051886, | Sep 27 2016 | Covidien LP | Systems and methods for performing a surgical navigation procedure |
| 11055648, | May 25 2006 | DePuy Synthes Products, Inc. | Method and system for managing inventories of orthopaedic implants |
| 11068822, | May 25 2006 | DePuy Synthes Products, Inc. | System and method for performing a computer assisted orthopaedic surgical procedure |
| 11103200, | Jul 22 2015 | InnerOptic Technology, Inc. | Medical device approaches |
| 11103213, | Oct 08 2009 | C. R. Bard, Inc. | Spacers for use with an ultrasound probe |
| 11116574, | Jun 16 2006 | Board of Regents of the University of Nebraska | Method and apparatus for computer aided surgery |
| 11123099, | Nov 26 2007 | C. R. Bard, Inc. | Apparatus for use with needle insertion guidance system |
| 11134915, | Nov 26 2007 | C. R. Bard, Inc. | System for placement of a catheter including a signal-generating stylet |
| 11135026, | May 11 2012 | Globus Medical, Inc | Robotic surgical system |
| 11147531, | Aug 12 2015 | SONETICS ULTRASOUND, INC | Method and system for measuring blood pressure using ultrasound by emitting push pulse to a blood vessel |
| 11172895, | Dec 07 2015 | Covidien LP | Visualization, navigation, and planning with electromagnetic navigation bronchoscopy and cone beam computed tomography integrated |
| 11173000, | Jan 12 2018 | Globus Medical, Inc | Robotic surgical control system |
| 11179136, | Feb 17 2016 | InnerOptic Technology, Inc. | Loupe display |
| 11207496, | Aug 24 2005 | C. R. Bard, Inc. | Stylet apparatuses and methods of manufacture |
| 11241296, | Nov 17 2005 | BREAST-MED, INC | Imaging fiducial markers and methods |
| 11253325, | Feb 08 2018 | Covidien LP | System and method for catheter detection in fluoroscopic images and updating displayed position of catheter |
| 11259879, | Aug 01 2017 | INNEROPTIC TECHNOLOGY, INC | Selective transparency to assist medical device navigation |
| 11341692, | Jun 29 2017 | Covidien LP | System and method for identifying, marking and navigating to a target using real time two dimensional fluoroscopic data |
| 11369439, | Oct 27 2016 | InnerOptic Technology, Inc. | Medical device navigation using a virtual 3D space |
| 11399734, | Mar 13 2013 | DePuy Synthes Products, Inc. | Methods, systems, and devices for guiding surgical instruments using radio frequency technology |
| 11419517, | Jun 12 2009 | Bard Access Systems, Inc. | Apparatus and method for catheter navigation using endovascular energy mapping |
| 11457831, | Jul 29 2016 | Micrima Limited | Medical imaging system and method |
| 11464575, | Feb 17 2009 | InnerOptic Technology, Inc. | Systems, methods, apparatuses, and computer-readable media for image guided surgery |
| 11464578, | Feb 17 2009 | INNEROPTIC TECHNOLOGY, INC | Systems, methods, apparatuses, and computer-readable media for image management in image-guided medical procedures |
| 11481868, | Aug 02 2006 | InnerOptic Technology, Inc. | System and method of providing real-time dynamic imagery of a medical procedure she using multiple modalities |
| 11484365, | Jan 23 2019 | INNEROPTIC TECHNOLOGY, INC | Medical image guidance |
| 11510728, | Aug 17 2017 | Micrima Limited | Medical imaging system and method |
| 11511132, | Aug 06 2010 | Accuray Incorporated | Tumor tracking during radiation treatment using ultrasound imaging |
| 11529070, | Nov 26 2007 | C. R. Bard, Inc. | System and methods for guiding a medical instrument |
| 11534245, | Dec 12 2014 | InnerOptic Technology, Inc. | Surgical guidance intersection display |
| 11547377, | Aug 06 2015 | Covidien LP | System and method for navigating to target and performing procedure on target utilizing fluoroscopic-based local three dimensional volume reconstruction |
| 11559266, | Aug 06 2015 | Covidien LP | System and method for local three dimensional volume reconstruction using a standard fluoroscope |
| 11564649, | Oct 10 2017 | Covidien LP | System and method for identifying and marking a target in a fluoroscopic three-dimensional reconstruction |
| 11621518, | Oct 16 2018 | Bard Access Systems, Inc. | Safety-equipped connection systems and methods thereof for establishing electrical connections |
| 11642182, | Sep 27 2016 | Brainlab AG | Efficient positioning of a mechatronic arm |
| 11684429, | Oct 02 2014 | InnerOptic Technology, Inc. | Affected region display associated with a medical device |
| 11701184, | Feb 08 2018 | Covidien LP | System and method for catheter detection in fluoroscopic images and updating displayed position of catheter |
| 11707205, | Nov 26 2007 | C. R. Bard, Inc. | Integrated system for intravascular placement of a catheter |
| 11707241, | Aug 06 2015 | Covidien LP | System and method for local three dimensional volume reconstruction using a standard fluoroscope |
| 11707329, | Aug 10 2018 | Covidien LP | Systems and methods for ablation visualization |
| 11779240, | Nov 26 2007 | C. R. Bard, Inc. | Systems and methods for breaching a sterile field for intravascular placement of a catheter |
| 11819300, | May 11 2012 | Globus Medical, Inc | Robotic surgical system and method |
| 11844543, | Oct 23 2017 | Globus Medical, Inc | Rotary oscillating/reciprocating surgical tool |
| 11857265, | Jun 16 2006 | of Nebraska | Method and apparatus for computer aided surgery |
| 11857351, | Nov 06 2018 | Globus Medical, Inc | Robotic surgical system and method |
| 11871913, | Oct 31 2014 | Covidien LP | Computed tomography enhanced fluoroscopic system, device, and method of utilizing the same |
| 11911117, | Jun 27 2011 | of Nebraska | On-board tool tracking system and methods of computer assisted surgery |
| 6907281, | Sep 07 2000 | STRYKER EUROPEAN HOLDINGS III, LLC | Fast mapping of volumetric density data onto a two-dimensional screen |
| 6990220, | Jun 14 2001 | IGO TECHNOLOGIES INC | Apparatuses and methods for surgical navigation |
| 7128711, | Mar 25 2002 | Insightec Ltd | Positioning systems and methods for guided ultrasound therapy systems |
| 7229401, | Nov 23 2001 | NUCLETRON OPERATIONS B V | Self controlled image guided device and method for inserting a needle in an animal body for effecting radiation therapy in said body |
| 7235084, | Apr 07 2000 | Image-Guided Neurologics, Inc.; Mayo Foundation for Medical Education and Research | Deep organ access device and method |
| 7237556, | Feb 11 2002 | Smith & Nephew, Inc | Image-guided fracture reduction |
| 7359746, | Sep 09 2002 | MAKO SURGICAL CORP | Image guided interventional method and apparatus |
| 7366561, | Apr 07 2000 | Medtronic, Inc | Robotic trajectory guide |
| 7477926, | Mar 31 2004 | Smith & Nephew, Inc | Methods and apparatuses for providing a reference array input device |
| 7485101, | Mar 22 2002 | Multiple shockwave focal treatment apparatus with targeting positioning and locating apparatus | |
| 7497863, | Dec 04 2004 | Medtronic, Inc | Instrument guiding stage apparatus and method for using same |
| 7525309, | Dec 30 2005 | DEPUY PRODUCTS, INC | Magnetic sensor array |
| 7547307, | Feb 11 2002 | Smith & Nephew, Inc | Computer assisted knee arthroplasty instrumentation, systems, and processes |
| 7559935, | Feb 20 2003 | IMAGE-GUIDED NEUROLOGICS, INC | Target depth locators for trajectory guide for introducing an instrument |
| 7594917, | Feb 11 2003 | DEPUY SYNTHES PRODUCTS, INC; DEPUY SYNTHES SALES, INC ; DEPUY SPINE, LLC; Depuy Synthes Products, LLC; DEPUY MITEK HOLDING CORPORATION; Synthes USA, LLC | Method and apparatus for fixing a graft in a bone tunnel |
| 7634304, | Aug 01 2000 | McGill University | Method and apparatus for lesion localization, definition and verification |
| 7636596, | Dec 20 2002 | Medtronic, Inc | Organ access device and method |
| 7637915, | Aug 17 2000 | Medtronic, Inc | Trajectory guide with instrument immobilizer |
| 7655011, | Mar 13 2001 | Ethicon, Inc. | Method and apparatus for fixing a graft in a bone tunnel |
| 7658879, | Feb 20 2003 | Medtronic, Inc. | Trajectory guide with angled or patterned guide lumens or height adjustment |
| 7660621, | Apr 07 2000 | Medtronic, Inc | Medical device introducer |
| 7674290, | Mar 13 2001 | Ethicon, Inc. | Method and apparatus for fixing a graft in a bone tunnel |
| 7676256, | Aug 14 2001 | ESAOTE S P A | Imaging apparatus |
| 7699783, | Apr 08 2004 | CVUS Clinical Trials, LLC | Method for imaging and treating a breast |
| 7699854, | Feb 20 2003 | University of South Florida | Trajectory guide with angled or patterned guide lumens or height adjustment |
| 7702378, | Nov 17 2005 | BREAST-MED, INC | Tissue marker for multimodality radiographic imaging |
| 7704260, | Sep 17 2002 | IMAGE-GUIDED NEUROLOGICS, INC | Low profile instrument immobilizer |
| 7728868, | Aug 02 2006 | INNEROPTIC TECHNOLOGY, INC | System and method of providing real-time dynamic imagery of a medical procedure site using multiple modalities |
| 7744606, | Dec 04 2004 | Medtronic, Inc | Multi-lumen instrument guide |
| 7756563, | May 23 2005 | SRONCUB, INC | Guidance method based on 3D-2D pose estimation and 3D-CT registration with application to live bronchoscopy |
| 7764985, | Oct 20 2003 | Smith & Nephew, Inc | Surgical navigation system component fault interfaces and related processes |
| 7771360, | Apr 09 2003 | CVUS Clinical Trials, LLC | Breast scanning system |
| 7794467, | Nov 14 2003 | Smith & Nephew, Inc. | Adjustable surgical cutting systems |
| 7803163, | Dec 04 2004 | Medtronic, Inc | Multiple instrument retaining assembly and methods therefor |
| 7815651, | Apr 07 2000 | Medtronic, Inc | Device for immobilizing a primary instrument and method therefor |
| 7828809, | Apr 07 2000 | Medtronic, Inc | Device for immobilizing a primary instrument and method therefor |
| 7833231, | Apr 07 2000 | Medtronic, Inc | Device for immobilizing a primary instrument and method therefor |
| 7857820, | Apr 07 2000 | Medtronic, Inc | Sheath assembly for an access device and method therefor |
| 7862570, | Oct 03 2003 | Smith & Nephew, Inc | Surgical positioners |
| 7867242, | Dec 04 2004 | Medtronic, Inc. | Instrument for guiding stage apparatus and method for using same |
| 7888709, | Dec 19 2006 | SONETICS ULTRASOUND, INC | Capacitive micromachined ultrasonic transducer and manufacturing method |
| 7889905, | May 23 2005 | SRONCUB, INC | Fast 3D-2D image registration method with application to continuously guided endoscopy |
| 7896889, | Feb 20 2003 | University of South Florida | Trajectory guide with angled or patterned lumens or height adjustment |
| 7912258, | Sep 27 2005 | Vanderbilt University | Method and apparatus for standardizing ultrasonography training using image to physical space registration of tomographic volumes from tracked ultrasound |
| 7981120, | Feb 20 2003 | University of South Florida | Trajectory guide with angled or patterned guide lumens or height adjustment |
| 8016835, | Aug 06 2004 | Depuy Synthes Products, LLC | Rigidly guided implant placement with control assist |
| 8046054, | Jan 23 2006 | Industry-University Cooperation Foundation, HANYANG UNIVERSITY, a university foundation of Seoul | Bi-planar fluoroscopy guided robot system for minimally invasive surgery and the control method thereof |
| 8064669, | May 23 2005 | SRONCUB, INC | Fast 3D-2D image registration system with application to continuously guided endoscopy |
| 8068648, | Dec 21 2006 | DEPUY PRODUCTS, INC | Method and system for registering a bone of a patient with a computer assisted orthopaedic surgery system |
| 8080013, | Mar 13 2001 | DePuy Mitek, Inc. | Method and apparatus for fixing a graft in a bone tunnel |
| 8081810, | Mar 22 2007 | Ethicon Endo-Surgery, Inc. | Recognizing a real world fiducial in image data of a patient |
| 8083753, | Apr 07 2000 | IMAGE-GUIDED NEUROLOGICS, INC | Robotic trajectory guide |
| 8109942, | Apr 21 2004 | Smith & Nephew, Inc. | Computer-aided methods, systems, and apparatuses for shoulder arthroplasty |
| 8116549, | Sep 27 2005 | Vanderbilt University | Method and apparatus for standardizing ultrasonography training using image to physical space registration of tomographic volumes from tracked ultrasound |
| 8116850, | Dec 20 2002 | Medtronic, Inc. | Organ access device and method |
| 8128634, | Mar 13 2001 | DePuy Mitek, Inc. | Method and apparatus for fixing a graft in a bone tunnel |
| 8131345, | Apr 11 2003 | Esaote S.p.A.; Medcom Gesellschaft fur Medizinische Bildverarbeitung mbH | Combining first and second image data of an object |
| 8137360, | Mar 13 2001 | DePuy Mitek, Inc. | Method and apparatus for fixing a graft in a bone tunnel |
| 8145290, | Jul 18 2005 | NUCLETRON OPERATIONS B V | Method for identifying the location of at least one treatment channel that is one of a plurality of treatment channels, as well as a system for effecting radiation treatment on a pre-selected anatomical portion of an animal body |
| 8148978, | Dec 30 2005 | DePuy Products, Inc. | Magnetic sensor array |
| 8155728, | Aug 22 2007 | Ethicon Endo-Surgery, Inc. | Medical system, method, and storage medium concerning a natural orifice transluminal medical procedure |
| 8177788, | Feb 22 2005 | Smith & Nephew, Inc | In-line milling system |
| 8182491, | Aug 06 2004 | Depuy Synthes Products, LLC | Rigidly guided implant placement |
| 8192445, | Aug 17 2000 | Medtronic, Inc. | Trajectory guide with instrument immobilizer |
| 8226716, | Mar 13 2001 | DePuy Mitek, Inc. | Method and apparatus for fixing a graft in a bone tunnel |
| 8231570, | Dec 11 2009 | Cilag GmbH International | Inverted conical expandable retractor |
| 8265949, | Sep 27 2007 | DePuy Products, Inc.; DEPUY PRODUCTS, INC | Customized patient surgical plan |
| 8282546, | Dec 11 2009 | Cilag GmbH International | Inverted conical expandable retractor with coil spring |
| 8308741, | Apr 28 2009 | GEARBOX, LLC | Systems and methods for automatically inserting a needle into a living subject |
| 8309428, | Sep 15 2004 | SONETICS ULTRASOUND, INC | Capacitive micromachined ultrasonic transducer |
| 8315125, | Mar 18 2009 | SONETICS ULTRASOUND, INC | System and method for biasing CMUT elements |
| 8340379, | Mar 07 2008 | INNEROPTIC TECHNOLOGY, INC | Systems and methods for displaying guidance data based on updated deformable imaging data |
| 8350902, | Aug 02 2006 | InnerOptic Technology, Inc. | System and method of providing real-time dynamic imagery of a medical procedure site using multiple modalities |
| 8353873, | Dec 11 2009 | Ethicon Endo-Surgery, Inc | Methods and devices for providing access through tissue to a surgical site |
| 8357088, | Dec 11 2009 | Cilag GmbH International | Methods and devices for providing access into a body cavity |
| 8366617, | May 15 2007 | CVUS Clinical Trials, LLC | Breast scanning system |
| 8369930, | Jun 16 2009 | CLEARPOINT NEURO, INC | MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time |
| 8376938, | Nov 20 2009 | Cilag GmbH International | Discrete flexion head for single port device |
| 8388541, | Nov 26 2007 | C R BARD, INC | Integrated system for intravascular placement of a catheter |
| 8388546, | Oct 23 2006 | BARD ACCESS SYSTEMS, INC | Method of locating the tip of a central venous catheter |
| 8396532, | Jun 16 2009 | CLEARPOINT NEURO, INC | MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time |
| 8399278, | Sep 15 2004 | SONETICS ULTRASOUND, INC | Capacitive micromachined ultrasonic transducer and manufacturing method |
| 8401620, | Oct 16 2006 | Perfint Healthcare Private Limited | Needle positioning apparatus and method |
| 8414483, | Dec 11 2009 | Cilag GmbH International | Methods and devices for providing access into a body cavity |
| 8435174, | Dec 11 2009 | Cilag GmbH International | Methods and devices for accessing a body cavity |
| 8437833, | Oct 07 2008 | BARD ACCESS SYSTEMS, INC | Percutaneous magnetic gastrostomy |
| 8444557, | Dec 11 2009 | Cilag GmbH International | Methods and devices for providing access through tissue to a surgical site |
| 8457718, | Mar 21 2007 | Ethicon Endo-Surgery, Inc. | Recognizing a real world fiducial in a patient image data |
| 8460186, | Dec 11 2009 | Cilag GmbH International | Methods and devices for providing access through tissue to a surgical site |
| 8478382, | Feb 11 2008 | C R BARD, INC | Systems and methods for positioning a catheter |
| 8482606, | Aug 02 2006 | InnerOptic Technology, Inc. | System and method of providing real-time dynamic imagery of a medical procedure site using multiple modalities |
| 8491597, | Oct 03 2003 | Smith & Nephew, Inc. (partial interest) | Surgical positioners |
| 8500633, | Dec 11 2009 | Ethicon Endo-Surgery, Inc | Methods and devices for providing surgical access through tissue to a surgical site |
| 8512256, | Oct 23 2006 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
| 8517932, | Dec 11 2009 | Ethicon Endo-Surgery, Inc | Methods and devices for providing access through tissue to a surgical site |
| 8544162, | Nov 17 2005 | BREAST-MED, INC | Tissue marker for multimodality radiographic imaging |
| 8554307, | Apr 12 2010 | INNEROPTIC TECHNOLOGY, INC | Image annotation in image-guided medical procedures |
| 8579787, | May 19 2008 | University of Maryland, College Park | Methods and systems for using therapeutic, diagnostic or prophylactic magnetic agents |
| 8585598, | Feb 17 2009 | InnerOptic Technology, Inc. | Systems, methods, apparatuses, and computer-readable media for image guided surgery |
| 8591580, | Mar 13 2001 | DePuy Mitek, LLC | Folded ligament graft |
| 8603078, | Oct 13 2010 | Ethicon Endo-Surgery, Inc | Methods and devices for guiding and supporting surgical instruments |
| 8611985, | Jan 29 2009 | IMACTIS | Method and device for navigation of a surgical tool |
| 8613748, | Nov 10 2010 | Perfint Healthcare Private Limited | Apparatus and method for stabilizing a needle |
| 8617176, | Aug 24 2011 | DEPUY SYNTHES SALES, INC ; DEPUY SYNTHES PRODUCTS, INC; DEPUY MITEK HOLDING CORPORATION; Depuy Synthes Products, LLC; DEPUY SPINE, LLC | Cross pinning guide devices and methods |
| 8641621, | Feb 17 2009 | INNEROPTIC TECHNOLOGY, INC | Systems, methods, apparatuses, and computer-readable media for image management in image-guided medical procedures |
| 8658453, | Sep 15 2004 | SONETICS ULTRASOUND, INC | Capacitive micromachined ultrasonic transducer |
| 8670816, | Jan 30 2012 | InnerOptic Technology, Inc.; INNEROPTIC TECHNOLOGY, INC | Multiple medical device guidance |
| 8672836, | Jan 31 2007 | SRONCUB, INC | Method and apparatus for continuous guidance of endoscopy |
| 8675935, | May 23 2005 | SRONCUB, INC | Fast 3D-2D image registration method with application to continuously guided endoscopy |
| 8690776, | Feb 17 2009 | INNEROPTIC TECHNOLOGY, INC | Systems, methods, apparatuses, and computer-readable media for image guided surgery |
| 8750568, | May 22 2012 | Covidien LP | System and method for conformal ablation planning |
| 8768433, | Jun 16 2009 | CLEARPOINT NEURO, INC | MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time |
| 8774901, | Oct 16 2006 | Perfint Healthcare Private Limited | Needle positioning apparatus and method |
| 8774907, | Oct 23 2006 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
| 8781555, | Nov 26 2007 | C R BARD, INC | System for placement of a catheter including a signal-generating stylet |
| 8784336, | Aug 24 2005 | C R BARD, INC | Stylet apparatuses and methods of manufacture |
| 8788019, | Feb 28 2005 | Robarts Research Institute | System and method for performing a biopsy of a target volume and a computing device for planning the same |
| 8801693, | Oct 29 2010 | C R BARD, INC | Bioimpedance-assisted placement of a medical device |
| 8825133, | Jun 16 2009 | CLEARPOINT NEURO, INC | MRI-guided catheters |
| 8831310, | Mar 07 2008 | InnerOptic Technology, Inc. | Systems and methods for displaying guidance data based on updated deformable imaging data |
| 8845656, | Apr 07 2000 | Medtronic, Inc.; Mayo Foundation for Medical Education and Research | Device for immobilizing a primary instrument and method therefor |
| 8849382, | Nov 26 2007 | C R BARD, INC | Apparatus and display methods relating to intravascular placement of a catheter |
| 8852210, | Aug 06 2004 | Depuy Synthes Products, LLC | Rigidly guided implant placement |
| 8858455, | Oct 23 2006 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
| 8862200, | Dec 30 2005 | Depuy Synthes Products, LLC | Method for determining a position of a magnetic source |
| 8886288, | Jun 16 2009 | CLEARPOINT NEURO, INC | MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time |
| 8888674, | Dec 11 2007 | University of Glasgow | Methods and systems for magnetic focusing of therapeutic, diagnostic or prophylactic agents to deep targets |
| 8911452, | Apr 07 2000 | Medtronic, Inc.; Mayo Foundation for Medical Education and Research | Device for immobilizing a primary instrument and method therefor |
| 8961536, | Apr 22 2010 | BLUE BELT TECHNOLOGIES, INC | Navigated freehand surgical tool and kit |
| 8966735, | Nov 17 2005 | Breast-Med, Inc. | Tissue marker for multimodality radiographic imaging |
| 8971994, | Feb 11 2008 | C. R. Bard, Inc. | Systems and methods for positioning a catheter |
| 9037215, | Jan 31 2007 | SRONCUB, INC | Methods and apparatus for 3D route planning through hollow organs |
| 9107698, | Apr 12 2010 | InnerOptic Technology, Inc. | Image annotation in image-guided medical procedures |
| 9108035, | May 19 2008 | University of Maryland, College Park; The United States of America as represented by the Secretary, Department of Health and Human Services, National Institutes of Health | Methods and systems for using therapeutic, diagnostic or prophylactic magnetic agents |
| 9108048, | Aug 06 2010 | MIDCAP FUNDING IV TRUST, AS SUCCESSOR TO EXISTING ADMINISTRATIVE AGENT | Systems and methods for real-time tumor tracking during radiation treatment using ultrasound imaging |
| 9125578, | Jun 12 2009 | Bard Access Systems, Inc. | Apparatus and method for catheter navigation and tip location |
| 9198688, | Apr 28 2009 | Koninklijke Philips Electronics N V | Biopsy guide with an ultrasound transducer and method of using same |
| 9211107, | Nov 07 2011 | C R BARD, INC | Ruggedized ultrasound hydrogel insert |
| 9226797, | Nov 04 2012 | MIBA MEDICAL INC | Computer aided implantation of body implants |
| 9237929, | Dec 22 2003 | Koninklijke Philips Electronics N V | System for guiding a medical instrument in a patient body |
| 9241773, | Nov 17 2005 | Breast-Med, Inc. | Imaging fiducial markers and methods |
| 9257220, | Mar 05 2013 | eZono AG | Magnetization device and method |
| 9259290, | Jun 08 2009 | CLEARPOINT NEURO, INC | MRI-guided surgical systems with proximity alerts |
| 9265443, | Oct 23 2006 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
| 9265572, | Jan 24 2008 | NORTH CAROLINA, UNIVERSITY OF, THE | Methods, systems, and computer readable media for image guided ablation |
| 9271686, | Mar 14 2013 | WEST VIRGINIA UNIVERSITY | Endorectal prostate probe composed of a combined mini gamma camera and ultrasound sensor |
| 9271745, | Aug 24 2011 | DePuy Mitek, LLC | Cross pinning guide devices and methods |
| 9282947, | Dec 01 2009 | INNEROPTIC TECHNOLOGY, INC | Imager focusing based on intraoperative data |
| 9314332, | Mar 13 2001 | DePuy Mitek, LLC | Method and apparatus for fixing a graft in a bone tunnel |
| 9326825, | Jun 17 2013 | CHILDREN S NATIONAL MEDICAL CENTER | Patient mounted MRI and CT compatible robot for needle guidance in interventional procedures |
| 9339206, | Jun 12 2009 | BARD ACCESS SYSTEMS, INC | Adaptor for endovascular electrocardiography |
| 9345422, | Oct 23 2006 | Bard Acess Systems, Inc. | Method of locating the tip of a central venous catheter |
| 9364294, | Feb 17 2009 | InnerOptic Technology, Inc. | Systems, methods, apparatuses, and computer-readable media for image management in image-guided medical procedures |
| 9364685, | Jul 18 2005 | NUCLETRON OPERATIONS B.V. | Method for identifying the location at least one treatment channel from a group of a plurality of treatment channels as well as a system for effecting radiation treatment on a pre-selected anatomical portion of an animal body |
| 9398936, | Feb 17 2009 | InnerOptic Technology, Inc. | Systems, methods, apparatuses, and computer-readable media for image guided surgery |
| 9406134, | Mar 22 2007 | SIEMENS HEALTHINEERS AG | Image system for supporting the navigation of interventional tools |
| 9415188, | Oct 29 2010 | C R BARD, INC | Bioimpedance-assisted placement of a medical device |
| 9439622, | May 22 2012 | Covidien LP | Surgical navigation system |
| 9439623, | May 22 2012 | Covidien LP | Surgical planning system and navigation system |
| 9439627, | May 22 2012 | Covidien LP | Planning system and navigation system for an ablation procedure |
| 9439735, | Jun 08 2009 | CLEARPOINT NEURO, INC | MRI-guided interventional systems that can track and generate dynamic visualizations of flexible intrabody devices in near real time |
| 9445734, | Jun 12 2009 | BARD ACCESS SYSTEMS, INC | Devices and methods for endovascular electrography |
| 9456766, | Nov 26 2007 | C R BARD, INC | Apparatus for use with needle insertion guidance system |
| 9459087, | Mar 05 2013 | eZono AG | Magnetic position detection system |
| 9468413, | Sep 05 2008 | General Electric Company | Method and apparatus for catheter guidance using a combination of ultrasound and X-ray imaging |
| 9492097, | Nov 26 2007 | C R BARD, INC | Needle length determination and calibration for insertion guidance system |
| 9498182, | May 22 2012 | Covidien LP | Systems and methods for planning and navigation |
| 9498231, | Jun 27 2011 | Board of Regents of the University of Nebraska | On-board tool tracking system and methods of computer assisted surgery |
| 9521961, | Nov 26 2007 | C R BARD, INC | Systems and methods for guiding a medical instrument |
| 9526440, | Nov 26 2007 | C.R. Bard, Inc. | System for placement of a catheter including a signal-generating stylet |
| 9532724, | Jun 12 2009 | Bard Access Systems, Inc. | Apparatus and method for catheter navigation using endovascular energy mapping |
| 9549685, | Nov 26 2007 | C. R. Bard, Inc. | Apparatus and display methods relating to intravascular placement of a catheter |
| 9554716, | Nov 26 2007 | C R BARD, INC | Insertion guidance system for needles and medical components |
| 9561095, | Oct 12 2015 | Body augmentation device | |
| 9597008, | Sep 06 2011 | eZono AG | Imaging probe and method of obtaining position and/or orientation information |
| 9636031, | Nov 26 2007 | C.R. Bard, Inc. | Stylets for use with apparatus for intravascular placement of a catheter |
| 9649048, | Nov 26 2007 | C R BARD, INC | Systems and methods for breaching a sterile field for intravascular placement of a catheter |
| 9659345, | Aug 02 2006 | InnerOptic Technology, Inc. | System and method of providing real-time dynamic imagery of a medical procedure site using multiple modalities |
| 9668768, | Mar 15 2013 | SYNAPTIVE MEDICAL INC | Intelligent positioning system and methods therefore |
| 9675272, | Mar 13 2013 | DEPUY SYNTHES PRODUCTS, INC | Methods, systems, and devices for guiding surgical instruments using radio frequency technology |
| 9675319, | Feb 17 2016 | InnerOptic Technology, Inc. | Loupe display |
| 9675420, | Jan 31 2007 | The Penn State Research Foundation | Methods and apparatus for 3D route planning through hollow organs |
| 9681823, | Nov 26 2007 | C. R. Bard, Inc. | Integrated system for intravascular placement of a catheter |
| 9795319, | Jan 29 2009 | IMACTIS | Method and device for navigation of a surgical tool |
| 9795455, | Aug 22 2014 | BREAST-MED, INC | Tissue marker for multimodality radiographic imaging |
| 9814442, | Jan 17 2011 | Koninklijke Philips Electronics N V | System and method for needle deployment detection in image-guided biopsy |
| 9833169, | Oct 23 2006 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
| 9839372, | Feb 06 2014 | C R BARD, INC | Systems and methods for guidance and placement of an intravascular device |
| 9861450, | Nov 17 2005 | Breast-Med, Inc. | Imaging fiducial markers and methods |
| 9901406, | Oct 02 2014 | INNEROPTIC TECHNOLOGY, INC | Affected region display associated with a medical device |
| 9901713, | Sep 17 2002 | Medtronic, Inc. | Low profile instrument immobilizer |
| 9901714, | Aug 22 2008 | C R BARD, INC | Catheter assembly including ECG sensor and magnetic assemblies |
| 9907513, | Oct 07 2008 | Bard Access Systems, Inc. | Percutaneous magnetic gastrostomy |
| 9949700, | Jul 22 2015 | InnerOptic Technology, Inc. | Medical device approaches |
| 9974525, | Oct 31 2014 | Covidien LP | Computed tomography enhanced fluoroscopic system, device, and method of utilizing the same |
| 9986983, | Oct 31 2014 | Covidien LP | Computed tomography enhanced fluoroscopic system, device, and method of utilizing the same |
| 9999371, | Nov 26 2007 | C. R. Bard, Inc. | Integrated system for intravascular placement of a catheter |
| D699359, | Aug 09 2011 | C R BARD, INC | Ultrasound probe head |
| D724745, | Aug 09 2011 | C R BARD, INC | Cap for an ultrasound probe |
| D754357, | Aug 09 2011 | C. R. Bard, Inc. | Ultrasound probe head |
| Patent | Priority | Assignee | Title |
| 4350159, | Feb 29 1980 | Frame for stereotactic surgery | |
| 4455609, | Sep 17 1980 | Nippon Electric Co., Ltd. | Apparatus for realtime fast reconstruction and display of dose distribution |
| 4750487, | Nov 24 1986 | Stereotactic frame | |
| 4869247, | Mar 11 1988 | UNIVERSITY OF VIRGINIA ALUMNI, THE | Video tumor fighting system |
| 5027818, | Dec 03 1987 | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED A NOT FOR PROFIT CORP OF FLORIDA | Dosimetric technique for stereotactic radiosurgery same |
| 5095501, | Dec 06 1989 | Kabushiki Kaisha Toshiba | X-ray image-pickup apparatus |
| 5125888, | Jan 10 1990 | University of Washington | Magnetic stereotactic system for treatment delivery |
| 5163076, | Oct 31 1990 | Kabushiki Kaisha Toshiba | X-ray image display apparatus |
| 5189687, | Dec 02 1988 | University of Florida Research Foundation, Incorporated | Apparatus for stereotactic radiosurgery |
| 5313844, | Jun 10 1992 | Haldex Hydraulics Corporation | Flow transducer |
| 5314432, | Aug 05 1993 | Lumbar spinal disc trocar placement device | |
| 5339812, | Mar 28 1990 | Medical Instrumentation and Diagnostic Corporation; Tyrone L., Hardy | Three-dimensional computer graphics simulation and computerized numerical optimization for dose delivery and treatment planning |
| 5368049, | May 15 1991 | C. R. Bard, Inc. | Superelastic formable guidewire with malleable cladding |
| 5526822, | Mar 24 1994 | DEVICOR MEDICAL PRODUCTS, INC | Method and apparatus for automated biopsy and collection of soft tissue |
| 5531227, | Jan 28 1994 | SCHNEIDER MEDICAL TECHNOLOGIES, INC | Imaging device and method |
| 5588430, | Feb 14 1995 | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC | Repeat fixation for frameless stereotactic procedure |
| 5772594, | Oct 16 1996 | SOFAMOR DANEK HOLDINGS, INC | Fluoroscopic image guided orthopaedic surgery system with intraoperative registration |
| 5799055, | May 15 1996 | Northwestern University | Apparatus and method for planning a stereotactic surgical procedure using coordinated fluoroscopy |
| 5891034, | Oct 19 1990 | ST LOUIS UNIVERSITY | System for indicating the position of a surgical probe within a head on an image of the head |
| 5893832, | Jun 25 1996 | Medison Co., Ltd. | Transducer element alignment structure in two-dimensional transducer array for forming ultra-sonic three-dimensional images |
| 5916163, | Mar 07 1997 | EP Technologies, Inc. | Graphical user interface for use with multiple electrode catheters |
| 5954647, | Feb 14 1995 | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC | Marker system and related stereotactic procedure |
| 6050724, | Jan 31 1997 | U. S. Philips Corporation | Method of and device for position detection in X-ray imaging |
| 6076008, | Apr 26 1993 | St. Louis University | System for indicating the position of a surgical probe within a head on an image of the head |
| 6129668, | May 08 1997 | BARD ACCESS SYSTEMS, INC | System and method to determine the location and orientation of an indwelling medical device |
| 6159221, | Nov 25 1998 | The Ohio State University; OHIO STATE UNIVERSITY, THE | Stereotactic apparatus and methods |
| 6236875, | Oct 07 1994 | SURGICAL NAVIGATION TECHNOLOGIES, INC ; ST LOUIS UNIVERSITY | Surgical navigation systems including reference and localization frames |
| 6246898, | Mar 28 1995 | Sonometrics Corporation | Method for carrying out a medical procedure using a three-dimensional tracking and imaging system |
| 6263230, | May 08 1997 | BARD ACCESS SYSTEMS, INC | System and method to determine the location and orientation of an indwelling medical device |
| 6314310, | Mar 31 1997 | Biosense, Inc. | X-ray guided surgical location system with extended mapping volume |
| 6347240, | Oct 19 1990 | ST LOUIS UNIVERSITY | System and method for use in displaying images of a body part |
| 6390982, | Jul 23 1999 | FLORIDA RESEARCH FOUNDATION, INC , UNIVERSITY OF | Ultrasonic guidance of target structures for medical procedures |
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| Dec 19 2001 | BOVA, FRANK J | FLORIDA, UNIVERSITY OF | ASSIGNMENT OF ASSIGNORS INTEREST SEE DOCUMENT FOR DETAILS | 012488 | /0069 | |
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