A lance is provided for puncturing skin and producing a sample of blood. The lance comprises a spring having a first end and a second end disposed between a needle and a base wherein the first end of spring is coupled to the base and the second end of the spring is coupled to the needle.

Patent
   6561989
Priority
Jul 10 2000
Filed
Jun 11 2001
Issued
May 13 2003
Expiry
Jun 11 2021
Assg.orig
Entity
Large
256
9
all paid
1. A test sensor for use in the determination of the concentration of a chemical in blood, the test sensor comprising:
a front and a rear panel;
a substantially flat test chamber disposed between the front and rear panels having an inlet, the test chamber being adapted to collect a sample of blood through the inlet; and
a substantially flat lance coupled to one of the front and rear panels, the lance being adapted to puncture skin.
7. A lance comprising:
a substantially flat base;
a substantially flat spring having a first end and a second end, the first end of the spring being attached to the base;
a substantially flat, generally U-shaped body having an interior edge and an exterior edge, the interior edge of the U-shaped body coupled to the second end of the spring, the generally U-shaped body having two sides for receiving an external force providing movement to the U-shaped member; and
a substantially flat needle attached to the exterior edge of the U-shaped body;
wherein, the base, the spring, the U-shaped body, and the needle are made out of a single piece of a material.
11. A blood glucose monitoring system comprising:
a substantially flat test sensor having an inlet for receiving a blood sample;
a substantially flat lance having a substantially flat base, a substantially flat spring, and a substantially flat, generally U-shaped body, the spring having first and second end, the first end being attached the base, the U-shaped body having an interior edge attached to the second end of the spring and an exterior edge, the lace having a substantially flat needle outwardly extending from the exterior edge of the U-shaped body for puncturing a user's skin; and
a forcing member providing movement to the needle of the lance in a first direction by contacting the U-shaped body, the spring retracting the flat lance in a second direction.
2. The test sensor of claim 1 wherein the lance includes:
a spring having a first end and a second end, the first end coupled to the test sensor; and
a needle coupled to the second end of the spring.
3. The test sensor of claim 1 wherein the lance includes:
a base;
a thin spring having a first end and a second end, the first end coupled to the base;
a thin, generally U-shaped body having an interior edge and an exterior edge, the second end of the thin spring coupled to the interior edge; and
a thin needle coupled to the exterior edge.
4. The test sensor of claim 1 wherein the test chamber includes a reagent, the reagent being adapted to produce an electrochemical reaction, the test sensor further comprising a pair of electrodes coupled to the test chamber.
5. The test sensor of claim 3 in combination with a sensor adapted to measure the concentration of a chemical in the blood.
6. The test sensor of claim 1 wherein the lance has a thickness of about 0.006 inch.
8. The lance of claim 7 wherein the single piece of material is a metal.
9. The lance of claim 7 wherein the base, the spring, the U-shaped body, and the needle are approximately 0.006 inch thick.
10. The lance of claim 7 further comprising a substantially flat test sensor for use in the determination of the concentration of a chemical in blood, the base of the lance being attached to the substantially flat test sensor such that an inlet of the test sensor is disposed proximate the substantially flat needle.
12. The system of claim 11 wherein the substantially flat, generally U-shaped body comprises two side portions for receiving a force from the force providing member.
13. The system of claim 11 wherein the substantially flat lance and the substantially flat test sensor are disposed in a disposable cap.
14. The system of claim 11 wherein the test sensor includes a reagent adapted to produce an electrochemical reaction indicative the concentration of glucose in the receive blood sample, the test sensor further comprising a pair of electrodes.
15. The system of claim 11 in combination with a device for measuring the concentration of the glucose in the blood.
16. The system of claim 11 wherein the substantially flat base, the substantially flat spring, the substantially flat, generally U-shaped body, and the a substantially flat needle are formed from a single piece of material.
17. The system of claim 16 wherein the material is metal.
18. The system of claim 11 wherein the substantially flat base, the substantially flat spring, the substantially flat, generally U-shaped body, and the a substantially flat needle are approximately 0.006 inch thick.

This application claims the benefit of Provisional application No. 60/216,972, filed Jul. 10, 2000.

The present invention relates generally to blood monitoring devices, and, more particularly, to a thin lance and a test sensor having the same for obtaining a sample of blood.

It is often necessary to quickly obtain a sample of blood and perform an analysis of the blood sample. One example of a need for painlessly obtaining a sample of blood is in connection with a blood glucose monitoring system where a user must frequently use the system to monitor the user's blood glucose level.

Those who have irregular blood glucose concentration levels are medically required to regularly self-monitor their blood glucose concentration level. An irregular blood glucose level can be brought on by a variety of reasons including illness such as diabetes. The purpose of monitoring the blood glucose concentration level is to determine the blood glucose concentration level and then to take corrective action, based upon whether the level is too high or too low, to bring the level back within a normal range. The failure to take corrective action can have serious implications. When blood glucose levels drop too low--a condition known as hypoglycemia--a person can become nervous, shaky, and confused. That person's judgment may become impaired and that person may eventually pass out. A person can also become very ill if their blood glucose level becomes too high--a condition known as hyperglycemia. Both conditions, hypoglycemia and hyperglycemia, are both potentially life-threatening emergencies.

One method of monitoring a person's blood glucose level is with a portable, hand-held blood glucose testing device. A prior art blood glucose testing device 100 is illustrated in FIG. 1. The portable nature of these devices 100 enables the users to conveniently test their blood glucose levels wherever the user may be. The glucose testing device contains a test sensor 102 to harvest the blood for analysis. The device 100 contains a switch 104 to activate the device 100 and a display 106 to display the blood glucose analysis results. In order to check the blood glucose level, a drop of blood is obtained from the fingertip using a lancing device. A prior art lancing device 120 is illustrated in FIG. 2. The lancing device 120 contains a needle lance 122 to puncture the skin. Some lancing devices implement a vacuum to facilitate the drawing of blood. Once the requisite amount of blood is produced on the fingertip, the blood is harvested using the test sensor 102. The test sensor 102, which is inserted into a testing unit 100, is brought into contact with the blood drop. The test sensor 102 draws the blood to the inside of the test unit 100 which then determines the concentration of glucose in the blood. Once the results of the test are displayed on the display 106 of the test unit 100, the test sensor 102 is discarded. Each new test requires a new test sensor 102.

One problem associated with some conventional lancing devices is that the user who regularly self-tests is required to carry at least two instruments--a lance and a test unit. This places a greater burden on the user to remember to carry as well as to maintain two separate devices. Further, a greater amount of space is occupied on the user's person. There can also be an increased expense associated with two separate units.

Another problem associated with some conventional blood glucose monitoring devices is that the user's blood physically contacts the elements within the testing unit. Cross-contamination can be a problem if the monitoring device is used by more than one user such as in a doctor's office or other clinical setting.

A lance is provided for puncturing skin and producing a sample of blood. The lance comprises a spring having a first end and a second end disposed between a needle and a base wherein the first end of integral spring is coupled to the base and the second end of the spring is coupled to the needle.

The above summary of the present invention is not intended to represent each embodiment, or every aspect, of the present invention. Additional features and benefits of the present invention will become apparent from the detailed description, figures, and claims set forth below.

Other objects and advantages of the invention will become apparent upon reading the following detailed description in conjunction with the drawings in which:

FIG. 1 is a top view of a prior art blood glucose testing device;

FIG. 2 is a perspective view of a prior art lance;

FIG. 3 is a perspective view of a test sensor having a thin lance according to one embodiment of the present invention;

FIG. 4 is front view of a thin lance according to one embodiment of the present invention;

FIG. 5 is a perspective view of test sensor according to one embodiment of the present invention;

FIG. 6 is a cross-sectional view of the test sensor illustrated in FIG. 5;

FIG. 7 is an embodiment of a blood glucose monitoring system for use in conjunction with a test sensor having a thin lance according to an alternative embodiment of the present invention;

FIG. 8 is a prospective view of an end cap and a blood glucose monitoring system for use in conjunction with a test sensor having a thin lance according to a second alternative embodiment of the present invention;

FIG. 9a is a cross-sectional view of the end cap illustrated in FIG. 8; and

FIG. 9b is a cross-sectional view of the end cap illustrated in FIG. 8 with the thin lance extended.

Referring now to FIG. 3, a test sensor having a thin sensor and lance ("sensor/lance" ) 200 according to one embodiment of the present invention is illustrated. The sensor/lance 200 includes a thin test sensor 202 and a thin lance 203. The thin lance 203 has a base 204 which is coupled to the test sensor 202. The remainder of the thin lance 203 is movable allowing a thin needle 206 to travel downward to puncture a user's skin in order to produce a drop of the user's blood. The test sensor 202 has an inlet 208 through which blood is moved by capillary action into the test sensor 202. The test sensor 202 and the lance 203 are generally thin and flat and each have a thickness of approximately 0.006 inch.

Referring also to FIG. 4, the thin lance 203 of the sensor/lance 200 will be described in greater detail. The illustrated embodiment of the thin lance 203 is formed out of a single piece of metal. A thin spring 212 couples the base 204 to a U-shaped member 216. The spring 212 has a first end 218 and a second end 220, the first end 218 of which is coupled to the base 204 and the second end is coupled to an interior 222 of the U-shaped member 216. The thin needle 206 is formed on an exterior 224 of the U-shaped member. The two sides of the U-shaped member are force receiving members 232,234 for providing movement to the thin needle 206.

In operation, when a user is testing the glucose concentration of blood, the test sensor 202 remains stationary within a testing device while a force is imparted on to a top portion 236,238 of each force receiving member 232,234. The force receiving members 232,234 are driven downward thus forcing the needle 206 downward into the user's skin. Once the force is removed from the force receiving members 232,234, the spring 212 retracts the needle 206 from the user's skin.

Referring also to FIGS. 5 and 6, the thin test sensor 202 will be described in greater detail. The test sensor 202 comprises a test chamber having a test area 240 disposed between a front panel 242 and a rear panel 244. The test area 240 is designed to allow blood to move from the inlet 208 up the test area 240 via capillary action. An adhesive 246 is disposed on the front panel 242 to adhere the base 204 of the thin lance 203 to the front panel 240.

A reagent is incorporated into the test sensor 202. The reagent is designed to react with the glucose in the blood which moves up the test area 240. The reaction produces a detectable signal which is indicative of the glucose concentration in the sample of blood. That signal is then measured by a sensor which can measure the concentration of the glucose in the blood based on the signal. The specific reagent incorporated into the test sensor 202 is a function of the type of sensing employed to determine the concentration of glucose in the blood. In the illustrated embodiment of the test sensor 202, electrochemical sensing is employed. The test sensor 202 includes a pair of electrodes 250 (FIG. 6). It electrochemical analysis, the change in current across the electrodes 250 caused by the reaction of the glucose and the reagent is indicative of the concentration of the glucose in the blood. The reaction of the glucose and the reagent creates an oxidation current at the electrodes 250 which is directly proportional to the user's blood glucose concentration. This current can be measured by an appropriate sensor coupled to a pair of terminals 252 corresponding to the electrodes 250 implemented in a glucose monitoring device for use with the sensor/lance 200. The glucose monitoring device can then communicate to the user the blood glucose concentration. An example of an electrochemical testing system is described in detail by commonly-owned U.S. Pat. No. 5,723,284 entitled "Control Solution and Method for Testing the Performance of an Electrochemical Device for Determining the Concentration of an Analyte in Blood" which is incorporated herein by reference in its entirety.

Referring now to FIG. 7, an application of the sensor/lance 200 is in an integrated blood glucose monitoring system 300 which integrates the lancing, the blood harvesting, and a blood glucose analyzer into a single instrument. The integrated blood glucose monitoring system 300 contains a plurality of sensors/lances 200 for use in a plurality of blood glucose self-tests. In operation, a user would activate the system 300 with a switch 304. A new thin sensor/lance 200 is advanced to the test end 302 of the system 300. The user would then press the test end 302 of the system against the user's skin and depress a trigger 306 causing a spring loaded member (not shown) to apply a force to the force receiving members 232,234 of the thin lance 203. The needle 206 would then extend through an opening 308 in the test end 302 of the system 300 to puncture the user's skin. After the needle 206 is fully extended out of the opening 308, the spring 214 would withdraw the needle from the laceration created in the user's skin through the opening 308. Blood emerging from the laceration created in the user's skin is moved from the inlet 208 by capillary action into the test sensor 202. Once the requisite blood sample has been obtained and the requisite time has elapsed for the reaction in the test sensor 202 to take place, the blood glucose monitoring system 300 measurers the signal produced by the reaction and determines the blood glucose concentration of the blood sample. The results of the analysis are communicated to the user via a display 310. The sensor/lance 200 is then ejected from the system 300 and discarded.

Referring now to FIGS. 8, 9a, and 9b, another application of the sensor/lance 200 is in a disposable, protective end cap 350. In a clinical setting, such as a medical doctor's office where the user is a doctor, nurse, or technician seeing multiple patients, cross contamination is a serious concern. Obviously, components of medical devices which come into contact with one patient's blood can not come into contact with the user or another patient. The end cap 350 protects those who handle the end cap 350 from coming into contact with the needle 206 and any blood disposed thereon after the sensor/lance 200 within the end cap 350 have been used. Only when actuated (during testing), does the needle 206 extend beyond the area bounded by the end cap 350. Accordingly, a user (doctor, nurse, technician) is protected from being punctured with the needle 206 when connecting the end cap 350 to or removing the end cap 350 from the sensor/lance 200.

A blood glucose monitoring system 360 for use with the disposable end cap 350 having a sensor/lance 200 disposed therein is also illustrated in FIG. 8. The device 360 contains a switch 362 to activate the device 360. A trigger 364 is provided to fire a spring loaded plunger 366 to contact the force receiving members 232,234 which in turn provide movement to the needle 206. The when actuated, the spring loaded plunger 366 rapidly moves downward a predetermined distance to move the force receiving members 232,234 and in turn the needle 206 a predetermined distance causing the needle 206 to extend beyond a test end 352 of the end cap 350 a distance about equal to the needle 206 penetration depth. The distance that the needle 206 extends beyond the test end 352 of the end cap 350 is preferably a distance sufficient to draw a sample of blood for analysis. Once the plunger forces the needle downward, the spring loaded plunger 366 retracts a distance allowing the needle 206 to retract back within the bounds of the disposable end cap 350. Meanwhile, the sample of blood moves though the inlet 208 disposed adjacent to the test end 352 of the end cap 350) of the test sensor 202. Once the requisite blood sample has been obtained and the requisite time has elapsed for the reaction in the test sensor 202, the blood glucose monitoring system 360 measurers the signal produced by the reaction and determines the blood glucose concentration of the blood sample. The results of the analysis are communicated to the user via a display 368. The end cap 350 containing the used sensor/lance 200 is then removed from the system 300 and discarded. The end cap 350 and the blood glucose monitoring system 360 have suitable connectors 370, 372 for mating the end cap 350 with the blood glucose monitoring system 360.

Thus far, only electrochemical analysis to determine the glucose concentration of a blood sample has been discussed in conjunction with the present invention. However, the thin sensor/lance 203 of the present invention can be used with other types of blood glucose testing methods. For example, calorimetric testing may be implemented in the test sensor in conjunction with an alternative embodiment of the present invention. Colorimetric testing is described in commonly-owned U.S. Pat. No. 5,723,284 entitled "Control Solution and Method for Testing the Performance of an Electrochemical Device for Determining the Concentration of an Analyte in Blood," which was incorporated herein by reference above.

While the invention is susceptible to various modifications and alternative forms, specific embodiments thereof have been shown by way of example in the drawings and will be described in detail herein. It should be understood, however, that it is not intended to limit the invention to the particular forms disclosed, but, to the contrary, the intention is to cover all modifications, equivalents and alternatives falling within the spirit and scope of the invention as defined by the appended claims.

Whitson, Robert C.

Patent Priority Assignee Title
10034628, Dec 12 2005 Sanofi-Aventis Deutschland GmbH Low pain penetrating member
10034629, Jan 06 2011 PEPEX BIOMEDICAL, INC Sensor module with enhanced capillary flow
10278632, Nov 14 2008 Pepex Biomedical, LLC. Electrochemical sensor module
11016052, Aug 30 2007 Pepex Biomedical Inc. Electrochemical sensor and method for manufacturing
11045124, Jun 04 2014 Pepex Biomedical, Inc.; PEPEX BIOMEDICAL, INC Electrochemical sensors and methods for making electrochemical sensors using advanced printing technology
11150212, Aug 30 2007 Pepex Biomedical, Inc. Electrochemical sensor and method for manufacturing
11224367, Dec 03 2012 PEPEX BIOMEDICAL, INC Sensor module and method of using a sensor module
6866675, Jan 22 2001 Roche Diabetes Care, Inc Lancet device having capillary action
7025774, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Tissue penetration device
7041068, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Sampling module device and method
7120483, Jan 13 2003 KONAMITE LIMITED Methods for analyte sensing and measurement
7179233, Oct 31 2003 Compact structure of a new biosensor monitor
7198606, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for a multi-use body fluid sampling device with analyte sensing
7214200, Dec 30 2002 Roche Diabetes Care, Inc Integrated analytical test element
7226461, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
7229458, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7232451, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7244264, Dec 03 2002 Roche Diabetes Care, Inc Dual blade lancing test strip
7244265, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7258693, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Device and method for variable speed lancet
7288073, Jul 20 2001 Roche Diabetes Care, Inc System for withdrawing small amounts of body fluid
7291117, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7297122, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7297151, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for body fluid sampling with improved sensing
7299081, Jun 15 2004 Abbott Diabetes Care Inc Analyte test device
7310543, Mar 26 2001 KUMETRIX, INC Silicon microprobe with integrated biosensor
7316700, Jun 12 2002 Sanofi-Aventis Deutschland GmbH Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
7322942, May 07 2004 Roche Diabetes Care, Inc Integrated disposable for automatic or manual blood dosing
7331931, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7344507, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for lancet actuation
7344894, Oct 16 2001 Sanofi-Aventis Deutschland GmbH Thermal regulation of fluidic samples within a diagnostic cartridge
7351212, Dec 30 2002 Roche Diabetes Care, Inc Blood acquisition suspension system
7371247, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7374544, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7374546, Jan 29 2003 Roche Diabetes Care, Inc Integrated lancing test strip
7396334, Aug 29 2001 Roche Diabetes Care, Inc Analytical device with lancet and test element
7410468, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7485128, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7488298, Oct 08 2004 Roche Diabetes Care, Inc Integrated lancing test strip with capillary transfer sheet
7491178, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7512432, Jul 27 2004 Abbott Diabetes Care Inc Sensor array
7524293, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7537571, Jun 12 2002 Sanofi-Aventis Deutschland GmbH Integrated blood sampling analysis system with multi-use sampling module
7547287, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7563232, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7604592, Jun 14 2004 Sanofi-Aventis Deutschland GmbH Method and apparatus for a point of care device
7608042, Sep 09 2004 INTELLECTUAL DISCOVERY CO , LTD Blood monitoring system
7625457, Dec 03 2002 Roche Diabetes Care, Inc Dual blade lancing test strip
7648468, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7666149, Dec 04 1997 Sanofi-Aventis Deutschland GmbH Cassette of lancet cartridges for sampling blood
7670301, May 07 2004 Roche Diabetes Care, Inc Integrated disposable for automatic or manual blood dosing
7674232, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7682318, Jun 12 2002 Sanofi-Aventis Deutschland GmbH Blood sampling apparatus and method
7691071, Jan 19 2001 PHC HOLDINGS CORPORATION Lancet-integrated sensor, measurer for lancet-integrated sensor, and cartridge
7695442, Apr 12 2005 Roche Diabetes Care, Inc Integrated lancing test strip with retractable lancet
7699791, Jun 12 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving success rate of blood yield from a fingerstick
7708701, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for a multi-use body fluid sampling device
7708703, Dec 30 2002 Roche Diabetes Care, Inc Integrated analytical test element
7713214, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
7717863, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7727166, Jul 26 2004 Nova Biomedical Corporation Lancet, lancet assembly and lancet-sensor combination
7727167, Jul 26 2004 Nova Biomedical Corporation Lancet sensor assembly and meter
7727467, Jun 20 2003 Roche Diabetes Care, Inc Reagent stripe for test strip
7731729, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7736322, Dec 27 2002 Roche Diabetes Care, Inc Precision depth control lancing tip
7749174, Jun 12 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
7749437, Jun 20 2003 Roche Diabetes Care, Inc Method and reagent for producing narrow, homogenous reagent stripes
7758517, Jan 19 2001 PHC HOLDINGS CORPORATION Lancet-integrated sensor, measuring device for lancet-integrated sensor, and cartridge
7766845, Jun 21 2004 Roche Diabetes Care, Inc Disposable lancet and lancing cap combination for increased hygiene
7780631, Mar 30 1998 Sanofi-Aventis Deutschland GmbH Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
7803123, Jan 22 2001 Roche Diabetes Care, Inc Lancet device having capillary action
7815579, Mar 02 2005 Roche Diabetes Care, Inc Dynamic integrated lancing test strip with sterility cover
7822454, Jan 03 2005 AUTO INJECTION TECHNOLOGIES LLC Fluid sampling device with improved analyte detecting member configuration
7829023, Jun 20 2003 Roche Diabetes Care, Inc Test strip with vent opening
7833171, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7841993, Jan 19 2001 PHC HOLDINGS CORPORATION Lancet-integrated sensor, measuring device for lancet-integrated sensor, and cartridge
7850621, Jun 07 2004 AUTO INJECTION TECHNOLOGIES LLC Method and apparatus for body fluid sampling and analyte sensing
7850622, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
7862520, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Body fluid sampling module with a continuous compression tissue interface surface
7874994, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7875047, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
7879618, Jun 20 2003 Roche Diabetes Care, Inc Method and reagent for producing narrow, homogenous reagent strips
7892183, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for body fluid sampling and analyte sensing
7892185, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for body fluid sampling and analyte sensing
7892849, Jun 20 2003 Roche Diabetes Care, Inc Reagent stripe for test strip
7901362, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7901365, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7905843, Jan 19 2001 PHC HOLDINGS CORPORATION Lancet-integrated sensor and measuring device for lancet-integrated sensor
7909775, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
7909777, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7909778, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7914465, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7922971, Nov 30 2005 Abbott Diabetes Care Inc Integrated meter for analyzing biological samples
7927291, Dec 30 2002 Roche Diabetes Care, Inc Blood acquisition suspension system
7935063, Mar 02 2005 Roche Diabetes Care, Inc System and method for breaking a sterility seal to engage a lancet
7938787, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
7972281, Jul 26 2004 Nova Biomedical Corporation Lancet sensor assembly and meter
7976476, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Device and method for variable speed lancet
7976477, Dec 27 2002 Roche Diabetes Care, Inc Precision depth control lancing tip
7981055, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
7981056, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Methods and apparatus for lancet actuation
7988644, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
7988645, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
7993284, Jul 20 2001 Roche Diabetes Care, Inc System for withdrawing small amounts of body fluid
8007446, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8016774, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
8016775, Dec 03 2002 Roche Diabetes Care, Inc Dual blade lancing test strip
8025628, Apr 12 2005 Roche Diabetes Care, Inc Integrated lancing test strip with retractable lancet
8048098, Jul 14 2005 Ascensia Diabetes Care Holdings AG Lancing device for one skin puncture
8052926, Dec 27 2002 Roche Diabetes Care, Inc Method for manufacturing a sterilized lancet integrated biosensor
8061004, Aug 20 2009 Roche Diabetes Care, Inc Method of manufacturing a test strip
8062231, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8062232, Feb 09 2006 Roche Diabetes Care, Inc Test element with elastically mounted lancet
8066649, Nov 30 2005 Abbott Diabetes Care Inc. Integrated sensor for analyzing biological samples
8070692, Nov 30 2005 Abbott Diabetes Care Inc. Integrated sensor for analyzing biological samples
8071030, Jun 20 2003 Roche Diabetes Care, Inc Test strip with flared sample receiving chamber
8079960, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Methods and apparatus for lancet actuation
8092385, May 23 2006 INTELLECTUAL DISCOVERY CO , LTD Fluid access interface
8105244, Nov 30 2005 ABBOTT DIABETES CARE, INC Integrated sensor for analyzing biological samples
8105245, Nov 30 2005 Abbott Diabetes Care Inc. Integrated sensor for analyzing biological samples
8118756, Jan 19 2001 PHC HOLDINGS CORPORATION Lancet-integrated sensor
8123700, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
8142721, Jun 20 2003 Roche Diabetes Care, Inc Test strip with slot vent opening
8148164, Jun 20 2003 Roche Diabetes Care, Inc System and method for determining the concentration of an analyte in a sample fluid
8157748, Apr 16 2002 Sanofi-Aventis Deutschland GmbH Methods and apparatus for lancet actuation
8157750, Dec 30 2002 Roche Diabetes Care, Inc Integrated analytical test element
8197421, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8197423, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8202231, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8206317, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
8206319, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
8211037, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
8216154, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
8221334, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8222044, Jun 20 2003 Roche Diabetes Care, Inc Test strip with flared sample receiving chamber
8235914, Jan 19 2001 PHC HOLDINGS CORPORATION Measuring device for a lancet-integrated sensor
8235915, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8251921, Jun 06 2003 Sanofi-Aventis Deutschland GmbH Method and apparatus for body fluid sampling and analyte sensing
8257258, Jul 27 2004 Abbott Diabetes Care Inc Integrated lancet and blood glucose meter system
8257276, Jan 22 2001 Roche Diabetes Care, Inc Lancet device having capillary action
8262614, Jun 01 2004 AUTO INJECTION TECHNOLOGIES LLC Method and apparatus for fluid injection
8267870, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for body fluid sampling with hybrid actuation
8282576, Sep 29 2004 Sanofi-Aventis Deutschland GmbH Method and apparatus for an improved sample capture device
8282577, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
8287703, Oct 04 1999 Roche Diabetes Care, Inc Biosensor and method of making
8296918, Dec 31 2003 AUTO INJECTION TECHNOLOGIES LLC Method of manufacturing a fluid sampling device with improved analyte detecting member configuration
8298828, Jun 20 2003 Roche Diabetes Care, Inc System and method for determining the concentration of an analyte in a sample fluid
8303615, Mar 12 2007 Ascensia Diabetes Care Holdings AG Lancet-eject mechanism
8328737, Apr 12 2005 Roche Diabetes Care, Inc Integrated lancing test strip with retractable lancet
8333782, Jul 14 2005 Bayer HealthCare LLC Lancing device for one skin puncture
8337421, Oct 04 2005 Sanofi-Aventis Deutschland GmbH Tissue penetration device
8360991, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
8360992, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8366637, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8372016, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for body fluid sampling and analyte sensing
8382682, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8382683, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
8388551, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for multi-use body fluid sampling device with sterility barrier release
8388552, Jul 20 2001 Roche Diabetes Care, Inc System for withdrawing small amounts of body fluid
8403864, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8414503, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Methods and apparatus for lancet actuation
8430828, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
8435190, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8435447, Nov 30 2005 Abbott Diabetes Care Inc. Integrated meter for analyzing biological samples
8439872, Mar 30 1998 Sanofi-Aventis Deutschland GmbH Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
8491500, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Methods and apparatus for lancet actuation
8496601, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Methods and apparatus for lancet actuation
8506740, Nov 14 2008 Pepex Biomedical, LLC Manufacturing electrochemical sensor module
8509870, Jun 15 2004 Abbott Diabetes Care Inc Analyte test device
8523784, Aug 29 2001 Roche Diabetes Care, Inc Analytical device with lancet and test element
8551017, Jan 19 2001 PHC HOLDINGS CORPORATION Lancet-integrated sensor, measuring device for lancet-integrated sensor, and cartridge
8551308, Oct 04 1999 Roche Diabetes Care, Inc Biosensor and method of making
8556829, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8562545, Oct 04 2005 Sanofi-Aventis Deutschland GmbH Tissue penetration device
8574895, Dec 30 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus using optical techniques to measure analyte levels
8579831, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8586373, Jun 20 2003 Roche Diabetes Care, Inc System and method for determining the concentration of an analyte in a sample fluid
8617195, Aug 04 2005 Ascensia Diabetes Care Holdings AG Lancing device
8622930, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
8636672, Feb 28 2007 TRIVIDIA HEALTH, INC Test strip with integrated lancet
8636673, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Tissue penetration device
8636674, May 07 2004 Roche Diabetes Care, Inc Integrated disposable for automatic or manual blood dosing
8641643, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Sampling module device and method
8641644, Nov 21 2000 Sanofi-Aventis Deutschland GmbH Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
8652068, Nov 30 2005 Abbott Diabetes Care Inc. Integrated sensor for analyzing biological samples
8652831, Dec 30 2004 Sanofi-Aventis Deutschland GmbH Method and apparatus for analyte measurement test time
8668656, Dec 31 2003 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
8679033, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
8679853, Jul 03 2007 Roche Diabetes Care, Inc Biosensor with laser-sealed capillary space and method of making
8684951, Dec 30 2002 Roche Diabetes Care, Inc Blood acquisition suspension system
8690796, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8702624, Sep 29 2006 AUTO INJECTION TECHNOLOGIES LLC Analyte measurement device with a single shot actuator
8702932, Aug 30 2007 Pepex Biomedical, LLC Electrochemical sensor and method for manufacturing
8721671, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Electric lancet actuator
8753290, Mar 27 2009 INTELLECTUAL DISCOVERY CO , LTD Fluid transfer system and method
8758267, Mar 17 2009 Nova Biomedical Corporation Modified lancet carrier for single-use lancet sensor assembly
8784335, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Body fluid sampling device with a capacitive sensor
8784444, Mar 04 2005 Ascensia Diabetes Care Holdings AG Lancet release mechanism
8808201, Apr 19 2002 SANOFI S A ; Sanofi-Aventis Deutschland GmbH Methods and apparatus for penetrating tissue
8815175, Nov 30 2005 Abbott Diabetes Care Inc Integrated meter for analyzing biological samples
8821413, Jul 20 2001 Roche Diabetes Care, Inc System for withdrawing small amounts of body fluid
8828203, May 20 2005 SANOFI S A Printable hydrogels for biosensors
8845549, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method for penetrating tissue
8845550, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
8864783, Aug 04 2005 Ascensia Diabetes Care Holdings AG Lancing device
8905945, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
8945910, Sep 29 2003 Sanofi-Aventis Deutschland GmbH Method and apparatus for an improved sample capture device
8951377, Nov 14 2008 Pepex Biomedical, Inc. Manufacturing electrochemical sensor module
8956308, Sep 29 2008 Ascensia Diabetes Care Holdings AG Integrated-testing system
8965476, Apr 16 2010 Pelikan Technologies, Inc Tissue penetration device
8971980, Jun 15 2004 Abbott Diabetes Care Inc Analyte test device
9034250, Mar 02 2005 Roche Diabetes Care, Inc Dynamic integrated lancing test strip with sterility cover
9034639, Dec 30 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus using optical techniques to measure analyte levels
9044178, Aug 30 2007 Pepex Biomedical, LLC Electrochemical sensor and method for manufacturing
9055898, Mar 04 2005 Ascensia Diabetes Care Holdings AG Lancet release mechanism
9072842, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
9089294, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Analyte measurement device with a single shot actuator
9089678, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
9101302, May 03 2004 Abbott Diabetes Care Inc Analyte test device
9144401, Dec 12 2005 Sanofi-Aventis Deutschland GmbH Low pain penetrating member
9186104, Apr 30 2007 Roche Diabetes Care, Inc Instruments and system for producing a sample of a body fluid and for analysis thereof
9186468, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
9215993, Aug 29 2001 Roche Diabetes Care, Inc Analytical device with lancet and test element
9226699, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Body fluid sampling module with a continuous compression tissue interface surface
9248267, Oct 04 2005 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
9261476, May 20 2004 Sanofi SA Printable hydrogel for biosensors
9314194, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Tissue penetration device
9339612, Oct 04 2005 Sanofi-Aventis Deutschland GmbH Tissue penetration device
9351680, Oct 14 2003 AUTO INJECTION TECHNOLOGIES LLC Method and apparatus for a variable user interface
9375169, Jan 30 2009 Sanofi-Aventis Deutschland GmbH Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
9375175, Aug 04 2005 Ascensia Diabetes Care Holdings AG Lancing device
9386944, Apr 11 2008 Sanofi-Aventis Deutschland GmbH Method and apparatus for analyte detecting device
9427532, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
9445755, Nov 14 2008 Pepex Biomedical, LLC Electrochemical sensor module
9445756, Mar 02 2005 Roche Diabetes Care, Inc Dynamic integrated lancing test strip with sterility cover
9459228, Aug 30 2007 Pepex Biomedical, Inc. Electrochemical sensor and method for manufacturing
9475044, Aug 20 2009 Roche Diabetes Care, Inc Test strip with a shaped tip for skin straightening
9498160, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method for penetrating tissue
9504162, May 20 2011 PEPEX BIOMEDICAL, INC Manufacturing electrochemical sensor modules
9554741, Dec 27 2002 Roche Diabetes Care, Inc Precision depth control lancing tip
9560993, Nov 21 2001 Sanofi-Aventis Deutschland GmbH Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
9561000, Dec 31 2003 Sanofi-Aventis Deutschland GmbH Method and apparatus for improving fluidic flow and sample capture
9622688, Mar 04 2005 Ascensia Diabetes Care Holdings AG Lancet-release mechanism
9694144, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Sampling module device and method
9724021, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
9746440, Aug 30 2007 Pepex Biomedical, LLC Electrochemical sensor and method for manufacturing
9775553, Jun 03 2004 Sanofi-Aventis Deutschland GmbH Method and apparatus for a fluid sampling device
9795334, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
9795747, Jun 02 2010 Pelikan Technologies, Inc Methods and apparatus for lancet actuation
9802007, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Methods and apparatus for lancet actuation
9820684, Jun 03 2004 Sanofi-Aventis Deutschland GmbH Method and apparatus for a fluid sampling device
9839386, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Body fluid sampling device with capacitive sensor
9877677, Sep 29 2008 Ascensia Diabetes Care Holdings AG Integrated-testing system
9907502, Apr 19 2002 Sanofi-Aventis Deutschland GmbH Method and apparatus for penetrating tissue
9937298, Jun 12 2001 Sanofi-Aventis Deutschland GmbH Tissue penetration device
RE43187, Jan 13 2003 KONAMITE LIMITED Methods for analyte sensing and measurement
Patent Priority Assignee Title
4627445, Apr 08 1985 KUDD, ARTHUR R ; DAYTON, JUDSON M Glucose medical monitoring system
4787398, Apr 08 1985 KUDD, ARTHUR R ; DAYTON, JUDSON M Glucose medical monitoring system
4869249, May 01 1987 Owen Mumford Limited Blood sampling devices
5971941, Dec 04 1997 Sanofi-Aventis Deutschland GmbH Integrated system and method for sampling blood and analysis
6056701, May 16 1997 Roche Diabetes Care, Inc Body fluid sampling device and methods of use
6071294, Dec 04 1997 Sanofi-Aventis Deutschland GmbH Lancet cartridge for sampling blood
6159424, Jun 19 1997 WSOU Investments, LLC Apparatus for taking samples
20010056284,
20020103499,
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Jan 04 2016Bayer HealthCare LLCAscensia Diabetes Care Holdings AGASSIGNMENT OF ASSIGNORS INTEREST SEE DOCUMENT FOR DETAILS 0378800604 pdf
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