A device for radiation treatment of proliferative tissue surrounding a cavity in an animal body includes at least a first inflatable chamber having a wall for placement in the cavity, a supportive probe having an elongated body with a distal end connected with the first inflatable chamber and a proximal end remaining outside the cavity, a device for inflating and deflating the first chamber, and a radiation delivering device for placing at least one energy emitting source within the cavity for performing said radiation treatment. It is possible to temporarily position a solid energy emitting source in a reproducible manner at different locations within the inflated chamber, such that subsequent identical radiation treatment sessions can be performed, whereas the comfort of the patient is maxim and an out hospitalization treatment is possible.
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1. Device for radiation treatment of proliferative tissue surrounding a cavity in an animal body comprising:
at least a first inflatable chamber having a wall for placement in said cavity;
a supportive probe having an elongated body with a distal end connected with said at least first inflatable chamber and a proximal end remaining outside said cavity;
inflation means for inflating and deflating said at least first chamber;
radiation delivering means for placing at least one energy emitting source within said cavity for performing said radiation treatment, wherein
said radiation delivering means comprises at least one hollow, flexible tunnel channel having at least one fixation point to said wall of said first inflatable chamber and a proximal end remaining outside said cavity;
said at least one hollow, flexible tunnel channel serves to guide said at least one radiation emitting source inside said cavity, wherein a distal end of said at least one hollow, flexible tunnel channel is fixed to the inner side of said wall of said first inflatable chamber and when said chamber is deflated said at least one tunnel channel is accommodated in a corresponding longitudinal groove present in the circumferential surface of said elongated body of said supportive probe.
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This nonprovisional application claims priority under 35 U.S.C. § 119(a) on Patent Application No(s). 02079066.3 filed in European Patent Office on Sep. 27, 2002, which is(are) herein incorporated by reference.
The invention relates to a device for radiation treatment of proliferative tissue surrounding a cavity in an animal body comprising:
Such a device is for example known from the U.S. Pat. No. 5,492,582. In U.S. Pat. No. 5,492,582 a method and apparatus are described for treating tissue surrounding a surgically excised tumour with radioactive emissions to kill any cancer cells that may be present in the margins surrounding the excised tumour. Following surgical removal of a tumour, say in the brain or breast, a supportive probe having an inflatable chamber connected at a distal end thereof is introduced into the removal of a tumour. Subsequently the deflated chamber is inflated by suitable inflation means by injecting a fluid having radionuclide(s) therein within the distensible reservoir formed by the chamber, via a passageway in the supportive probe.
When it is considered that the absorbed dose rate at a point exterior to the radioactive source is inversely proportional to the square of the distance between the radiation source and the target point, tissue directly adjacent the wall of the inflated chamber may be exposed to an excessive amount of radiation, which “hot spots” may result in healthy tissue necrosis. In general, the amount of radiation desired by the physician is a certain minimum amount, that is delivered to a position 0-3 cms away from the wall of the excised tumour. It is desirable to keep the radiation in the space between that position and the wall of the inflated chamber as uniform as possible to prevent over-exposure to tissue at or near the reservoir wall. In treating other cancers, such as bladder cancer, where the neoplastic tissue is generally located on the bladder surface, deep penetration is unnecessary and to be avoided.
In U.S. Pat. No. 5,913,813 and U.S. Pat. No. 6,413,204 a suppportive probe is described also provided with an inflatable chamber connected to the distal end thereof. The inflatable chamber comprises an inner wall and an outer wall, resulting in—when inflated—a chamber with an inner spatial volume and an outer spatial volume surrounding the first spatial volume.
Similar to U.S. Pat. No. 5,429,582 the first spatial volume can be inflated using a liquid or solution containing radionuclide(s) by suitable inflation means via a suitable passageway present in the supportive probe. Hence the device according to U.S. Pat. No. 5,913,813 comprises two spherical chambers, one inside the other and appropriately spaced apart from each other.
However, the spacing between the inner and outer chambers needs to be held constant to avoid “hot spots” in the emitted radiation dose profile. This result can be achieved by careful placement of precision blown polymer parisons or by using compressible foams or mechanical spacers in the form of webs joining the inner wall to the outer wall, making the overall construction of U.S. Pat. No. 5,913,813 more complicated and costly.
Therefore a need exists for a device, which may be used to deliver radiation from at least one energy emitting source to a target tissue within a cavity inside the animal body with a conformal radiation dose profile and of a desired intensity and at a predetermined distance from the radiation source without over-exposure of body tissue disposed between the radiation source and the target.
Furthermore the invention aims to provide a device according the above preamble, wherein it is possible to temporarily position a solid energy emitting source in a reproducible manner at different locations within the inflated chamber, such that subsequent identical radiation treatment sessions-can be performed, whereas that the comfort of the patient is maxim and an out hospitalization treatment is possible.
According to the invention said radiation delivering means comprises at least one hollow, flexible tunnel channel having at least one fixation point to said inner or outer wall of said first inflatable chamber and a proximal end remaining outside said cavity; and wherein said at least one hollow, flexible tunnel channel serves to guide said at least one radiation emitting source inside said cavity.
With the device according to the invention an exact positioning of one or more solid energy emitting sources within the cavity to be treated is obtained. Moreover-the positioning of the energy emitting sources can be reproduced allowing subsequent radiation treatment sessions. This allows the energy emitting source to be inserted in a reproducible manner into each tunnel channel during the subsequent radiation treatment sessions, which are therefore identical, resulting in a very precise overall radiation treatment.
More in particular said inflatable chamber is accommodated around said distal end of said supportive probe.
In a first embodiment a distal end of said at least one hollow, flexible tunnel channel is fixed to the inner side of said wall of said first inflatable chamber. In an advantageous embodiment said at least one tunnel channel is accommodated in a corresponding longitudinal groove present in the circumferential surface of said elongated body of said supportive probe, when said chamber is deflated.
In order to perform a spatial radiation treatment session exposing the tissue in the cavity with an accurate and precise radiation dose distribution the supportive probe according to the invention is provided with a plurality of longitudinal grooves present in said circumferential surface for accommodating a corresponding plurality of tunnel channels. This allows a proper storage and orientation of the tunnel channels during transport and insertion into a cavity without the risk of damage.
In order to obtain a precise radiation distribution the distal ends of said plurality of flexible tunnel channels are arranged in at least one perpendicular plan relative to the supportive probe. By using this approach, a conformal distribution is obtained.
In a second embodiment of the device according to the invention said at least one hollow, flexible tunnel channel is fixed to the outer side of said wall of said first inflatable chamber. More in particularly a plurality of said tunnel channels are fixed equidistant on the outer side of the wall of the first inflatable chamber. This also ensures a specific, well determined radiation dose distribution and avoids an over-exposure of healthy tissue to radiation.
To avoid hot spots at the contact surface with the tissue in a further embodiment said first inflatable chamber is surrounded by a second inflatable chamber, wherein said first and second inflatable chambers are separated by a third inflatable chamber system placed equidistant between said tunnel channels.
In a further embodiment said radiation delivering means comprises further at least one central catheter bore having a proximal remaining outside said cavity and distal end extending in longitudinal direction within said elongated body of said supportive probe.
Another advantageous embodiment of the device is characterized in that it further comprises protection means for covering said proximal end of said hollow tunnels, when the patient is not treated. As the inflated chamber inside a cavity, for example inside the head or a breast (of a woman) positions the tunnel channels in a fixed manner inside the cavity relative to the target tissue to be treated, this allows to place and inflate the chamber, the energy emitting source can be inserted in a reproducible manner through insertion catheters into each tunnel channel, during the subsequent radiation treatment sessions, which are therefore identical, resulting in a very precise overall radiation treatment.
After each individual radiation treatment session the energy emitting source are retracted from the insertion catheter present in each tunnel channel, which insertion catheters are subsequently retracted and the proximal ends of the tunnel channels are then covered and protected with the cap. The device according to the invention has a part placed outside the cavity with minimized dimensions increasing the patient's comfort. This part can be covered by a protection cap in between subsequent radiation treatment sessions and thus the patient is allowed to move freely with a minimum of discomfort, he/she may even leave the hospital with the inflated chamber stay fixed inside the cavity and the cap is removed when a next-treatment session has to performed.
For guiding said at least one energy emitting source through said at least one tunnel channel until within said cavity at least one hollow insertion catheter with a proximal end and a distal end is introduced into said at least one tunnel channel.
More in particular said at least one hollow insertion catheter is connected with it's proximal end to an afterloader device, wherein said at least one energy emitting source is contained in said afterloader device and guided through said hollow insertion catheter toward said cavity using a source wire having a distal end connected to said energy emitting source.
This allows radiation treatment sessions to be performed with High Dose Rate (HDR) or Pulse Dose Rate (PDR) energy emitting sources, which require a special and safe handling prior to each treatment session. These HDR or PDR sources are for safety reasons stored in a radiation shielded compartment within the afterloader. After the hollow insertion catheters are inserted into each tunnel channel the medical personnel leaves the treatment room and the HDR or PDR energy emitting sources are moved from said shielded compartment through said insertion catheter towards the intended treatment position in the cavity using the source wires. After the radiation treatment session each energy emitting source is safely retracted from the cavity towards the shielded compartment for storing purposes using the source wire.
This is called “remote afterloading” as the energy emitting source is “loaded” or placed at the intended treatment site after the medical personnel has left the treatment room.
The device according to the invention is suitable for incorporating different energy emitting sources, for example a High Dose Rate Ir-192 source, a Pulse Dose Rate Ir-192 source, a miniature X-ray source or a radio-waves emitting source. However the invention is not limited to the use of one of the energy emitting sources listed above.
The invention will be now described with reference to the accompanying drawings, which drawings show:
The device according to the invention is used for treating tissue surrounding a surgically excised tumour with radiation emissions to kill cancel cells that may be present in the margin surrounding the excised tumour. For this purpose after insertion of the supportive probe 2 and the inflated chamber 3 surrounding the supportive probe the deflated chamber 3 is inflated using suitable inflation means (not shown) which are preferably connected with the proximal end 2b of the supportive probe 2 outside the cavity of the animal body.
This situation is shown in
As stated and explained above the invention claims to provide a device having a supportive probe and an inflatable chamber for insertion into a cavity in an animal body, wherein it is possible to temporarily position a solid energy emitting source in a reproducible manner at different locations within the inflated chamber. With this aim subsequent identical radiation treatment sessions can be performed, whereas the comfort of the patient is maxim and an out hospitalisation treatment is possible.
As shown in the lateral view of
Furthermore the elongated body 2 is provided with a central passageway 8 with a distal end 8a and a proximal end 8b, which fulfills the same function as the tunnel channels 5a-5d.
Whereas the distal ends 6a-6d of the hollow tunnel channels 5a-5d are fixed at the inner wall 4a of the inflated chamber 4, the proximal ends 6a′-6d′ of the hollow tunnel channels 5a-5d and the proximal end 8b of the central tunnel channel 8 are present at the proximal end 2b of the supportive probe 2 remaining outside the cavity 10 of the animal body.
For a proper storage of the hollow tunnel channels 5a-5d in the deflated states and to prevent damage to the hollow tunnel channels during insertion of the device 1 according to the invention in a cavity 10 inside an animal body, the elongated body of the supportive probe 2 is provided with longitudinal groves present 7a-7d in the circumferential service 3 of the elongated body 2, which grooves 7a-7d serve to accommodate and store each tunnel channel 5a-5d.
Although in the embodiments shown in the
The hollow tunnel channels 5a-5d-8 serve to guide a solid energy emitting source through the hollow tunnel channel 5a-5d-8 to a certain position within said tunnel channel and the inflatable chamber 4. More in particular, for applying a solid energy emitting source 11a-11e towards a position within the cavity 10 so-called hollow insertion catheters 9a-9e are inserted in each hollow tunnel channel 5a-5d-8. Subsequently, following the positioning of the insertion catheters 9a-9e in each hollow tunnel channel 5a-5d-8 solid energy emitting sources are inserted into each catheter 9a-9e and guided through the catheter 9a-9e (and thus through the hollow tunnel channel 5a-5d-8) towards a postion within the cavity 10.
In the drawings the hollow insertion catheters in the respective hollow tunnel channels 5a-5d-8 are depicted with the reference numerals 9a-9e, whereas the solid energy emitting sources within the hollow insertion catheters 9a-9e are depicted with the reference numerals 11a-11e. Furthermore the reference numerals, 11a-11a′-11a″ respectively (or 11d-11d′-11d″-11d′″) in
In the device according to the invention, by inserting a solid energy emitting source through the insertion catheters 9a-9e present in the tunnel channels 5a-5d-8 towards a certain, predetermined position within the cavity 10. Moreover the guidance of the solid energy emitting sources through a hollow insertion catheter 9a-9e within the hollow tunnel channels 5a-5d allows a temporarily insertion of the source in a reproducible manner at different locations.
The latter allows that subsequent identical radiation treatment sessions can be performed, significantly improving the quality of the radiation therapy treatment and the result achieved.
An example of a radiation treatment is now described in combination with
With the use of an afterloader device 12 it is possible to use the device according to the invention to perform radiation therapy treatment sessions with so called High Dose Rate (HDR) or Pulse Dose Rate (PDR) energy emitting sources, which require a special and safe handling prior to each treatment session. These HDR or PDR sources are characterized by a high radiation intensity profile and are thus for safety reasons stored in a radiation shielded compartment within the afterloader 12. Performing radiation therapy treatment sessions with such high intensity energy emitting sources requires specific proceedings concerning handling and storage of these sources.
For performing radiation therapy treatments with the device according to the invention using HDR or PDR sources (or other energy emitting sources having a high radiation intensity) hollow insertion catheters 9a-9d-9e are inserted into each hollow tunnel channel 5a-5d-8 with their respective distal ends. Said hollow insertion catheters 9a-9d-9e extend outside the proximal ends 6a′-6d′-8b of said hollow tunnel channels 5a-5d-8. More in particularly they are connected with their proximal ends 9a″-9e″ with suitable source openings 13a-13e present in the housing of the afterloader device 12.
Subsequently the energy emitting source can be redirected through an other insertion catheter (for example 9d) through the tunnel channel 5d towards a position within the inflated chamber (for example position 11d′).
Likewise a corresponding insertion catheter 9e can be used for inserting an energy emitting source 11e through the central bore 8.
When using an afterloader device subsequent radiation therapy treatments can be performed by using one energy emitting source or by inserting several emitting sources simultaneously at the same or a different location within, each hollow tunnel channel 5a-5d and 8 through the insertion catheters 9a-9e.
The use of an afterloader device 12 connected with several insertion catheters 9a-9e inserted in the several hollow tunnel channels 5a-5d-8 and the subsequent insertion of one or more solid energy emitting sources through said hollow insertion catheters 9a-9e using a source wire driven by suitable source driver means ensures the positioning of each energy emitting source in a fixed position within each tunnel channel 5a-5d and 8 or the guidance of each energy emitting source in a stepwise manner within each tunnel channel (insertion catheters) towards a plurality of positions within each insertion catheter (and tunnel channel).
This allows a number of different radiation therapy treatments sessions to be performed, depending on the individual case of the patient.
The use of an afterloader device 12 with the device according to the invention makes it possible to perform subsequent radiation treatments sessions during a longer period of times (days or weeks) as the device according to the invention allows a temporarily but accurate placement of the energy emitting source in a reproducible manner for subsequent identical radiation treatment sessions.
For that purpose the supportive probe 2 with the inflated chamber 4 remains within the cavity of the patient for that prolonged period of time allowing the patient to move freely, even outside the hospital and discomforts the patient to a minimum.
For each subsequent radiation treatment session the patient returns to the hospital where he/she is coupled to the afterloader device 12 for conducting a subsequent radiation treatment session. In between subsequent radiation treatment sessions a protection cap (not shown) can be placed over the proximal end 2b of the supportive probe 2 and the proximal ends 6a′-6d′ and 8b.
The inflating means for inflating and deflating the chamber 4 through a suitable passageway present within the supportive probe 2 and ending inside the chamber 4 (not shown) are provided with a valve or other suitable closure means.
In
In
Parts of the embodiment of
The embodiment of
A plurality of tunnel channels 5a-5g are fixed to the outer wall 4c of the inflatable chamber or balloon 4. The tunnel channels 5a-5g extend in longitudinal direction of the supportive probe 2 and are in a specific embodiment (shown in
Similar to the embodiment shown in
The plurality of hollow tunnel channels 5a-5g which are fixed to the outer wall 4c of the inflated chamber 4 serve to guide hollow insertion catheters 9a-9g, which are inserted from the proximal end of the supportive probe extending outside the cavity of the animal body towards the cavity 10 in which the inflated chamber 4 is positioned.
In a similar manner like the embodiments described with reference to the
Likewise the supportive probe 2 can be provided with a central bore 8 through which a corresponding insertion catheter 9h can be placed for inserting an energy emitting source 11h within the inflated chamber 4.
As an additional protection of the tunnel channels 5a-5g placed on the outer side of the wall 4c of the inflated chamber 4 a second inflatable chamber 14 can be placed surrounding the first inflatable chamber 4 as well as the plurality of tunnel channels 5a-5g. This embodiment is disclosed in
In order to ensure a proper orientation of the tunnel channels 5a-5f and thus the energy emitting sources 11a-11f to be positioned within the insertion catheters 9a-9f placed within these tunnel channels 5a-5f said first and second inflatable chambers 4 and 14 are separated by a third inflatable chamber system 15 comprising of a plurality of inflatable chambers 15a-15f. These plurality of third inflatable chambers 15a-15f are placed equidistant between the flexible tunnel chambers 5a-5f, thus ensuring a fixed positioning within the cavity 10 at the time the first and second inflatable chambers 4 and 14 are placed inside a cavity and subsequently inflated by the inflation means. Likewise through the plurality of tunnel channels 5a-5f hollow insertion catheters 9a-9f are inserted for placing an energy emitting source 11a-11f using a source wire connected to an afterloader device.
Also with this embodiment disclosed in
Kindlein, Johann, Linares, Luis A.
Patent | Priority | Assignee | Title |
10004558, | Jan 12 2009 | Cilag GmbH International | Electrical ablation devices |
10022557, | Sep 30 2010 | Hologic, Inc. | Using a guided member to facilitate brachytherapy device swap |
10092291, | Jan 25 2011 | Ethicon Endo-Surgery, Inc | Surgical instrument with selectively rigidizable features |
10098527, | Feb 27 2013 | Cilag GmbH International | System for performing a minimally invasive surgical procedure |
10098691, | Dec 18 2009 | Cilag GmbH International | Surgical instrument comprising an electrode |
10105141, | Jul 14 2008 | Cilag GmbH International | Tissue apposition clip application methods |
10201688, | Mar 10 2011 | WESTERN NEW ENGLAND UNIVERSITY | Biopsy spacer device and method of operation |
10206709, | May 14 2012 | Cilag GmbH International | Apparatus for introducing an object into a patient |
10207126, | May 11 2009 | Hologic, Inc; Biolucent, LLC; Cytyc Corporation; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC ; Third Wave Technologies, INC; Gen-Probe Incorporated | Lumen visualization and identification system for multi-lumen balloon catheter |
10258406, | Feb 28 2011 | Cilag GmbH International | Electrical ablation devices and methods |
10278761, | Feb 28 2011 | Cilag GmbH International | Electrical ablation devices and methods |
10314603, | Nov 25 2008 | Cilag GmbH International | Rotational coupling device for surgical instrument with flexible actuators |
10314649, | Aug 02 2012 | Ethicon Endo-Surgery, Inc | Flexible expandable electrode and method of intraluminal delivery of pulsed power |
10342598, | Aug 15 2012 | Cilag GmbH International | Electrosurgical system for delivering a biphasic waveform |
10342992, | Jan 06 2011 | Hologic, Inc; Biolucent, LLC; Cytyc Corporation; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC ; Third Wave Technologies, INC; Gen-Probe Incorporated | Orienting a brachytherapy applicator |
10413750, | Nov 18 2005 | Hologic, Inc. | Brachytherapy device for facilitating asymmetrical irradiation of a body cavity |
10478248, | Feb 15 2007 | Cilag GmbH International | Electroporation ablation apparatus, system, and method |
10492880, | Jul 30 2012 | Ethicon Endo-Surgery, Inc | Needle probe guide |
10779882, | Oct 28 2009 | Cilag GmbH International | Electrical ablation devices |
10835724, | Mar 10 2011 | WESTERN NEW ENGLAND UNIVERSITY | Biopsy spacer device and method of operation |
11033398, | Mar 15 2007 | Stryker European Operations Limited | Shoulder implant for simulating a bursa |
11284918, | May 14 2012 | Cilag GmbH International | Apparatus for introducing a steerable camera assembly into a patient |
11399834, | Jul 14 2008 | Cilag GmbH International | Tissue apposition clip application methods |
11484191, | Feb 27 2013 | Cilag GmbH International | System for performing a minimally invasive surgical procedure |
11759979, | Jun 23 2004 | Bioprotect Ltd. | Device system and method for tissue displacement or separation |
11826228, | Oct 18 2011 | Stryker European Operations Limited | Prosthetic devices |
7465268, | Nov 18 2005 | Hologic, Inc | Methods for asymmetrical irradiation of a body cavity |
8029504, | Feb 15 2007 | Cilag GmbH International | Electroporation ablation apparatus, system, and method |
8037591, | Feb 02 2009 | Ethicon Endo-Surgery, Inc | Surgical scissors |
8057379, | Nov 18 2005 | Hologic, Inc | Treatment of a body cavity |
8070759, | May 30 2008 | Cilag GmbH International | Surgical fastening device |
8075469, | Nov 18 2005 | Hologic, Inc | Methods for asymmetrical irradiation of a body cavity |
8075572, | Apr 26 2007 | Ethicon Endo-Surgery, Inc | Surgical suturing apparatus |
8079946, | Nov 18 2005 | Hologic, Inc | Asymmetrical irradiation of a body cavity |
8100922, | Apr 27 2007 | Ethicon Endo-Surgery, Inc | Curved needle suturing tool |
8114072, | May 30 2008 | Ethicon Endo-Surgery, Inc | Electrical ablation device |
8114119, | Sep 09 2008 | Ethicon Endo-Surgery, Inc | Surgical grasping device |
8157834, | Nov 25 2008 | Cilag GmbH International | Rotational coupling device for surgical instrument with flexible actuators |
8172772, | Dec 11 2008 | Ethicon Endo-Surgery, Inc | Specimen retrieval device |
8192344, | Nov 18 2005 | Hologic, Inc | Methods for asymmetrical irradiation of a body cavity |
8211125, | Aug 15 2008 | Ethicon Endo-Surgery, Inc | Sterile appliance delivery device for endoscopic procedures |
8221442, | Jun 23 2004 | BIOPROTECT LTD | Device system and method for tissue displacement or separation |
8241204, | Aug 29 2008 | Ethicon Endo-Surgery, Inc | Articulating end cap |
8251884, | Nov 18 2005 | Hologic, Inc | Methods for asymmetrical irradiation of a body cavity |
8252057, | Jan 30 2009 | Cilag GmbH International | Surgical access device |
8262563, | Jul 14 2008 | Ethicon Endo-Surgery, Inc | Endoscopic translumenal articulatable steerable overtube |
8262655, | Nov 21 2007 | Ethicon Endo-Surgery, Inc | Bipolar forceps |
8262680, | Mar 10 2008 | Ethicon Endo-Surgery, Inc | Anastomotic device |
8273006, | Nov 18 2005 | Hologic, Inc | Tissue irradiation |
8277370, | Mar 12 2007 | Hologic, Inc | Radiation catheter with multilayered balloon |
8287442, | Mar 12 2007 | Hologic, Inc | Radiation catheter with multilayered balloon |
8292794, | Nov 06 2002 | Hologic, Inc | Method for maintaining access to a biopsy site |
8317806, | May 30 2008 | Ethicon Endo-Surgery, Inc | Endoscopic suturing tension controlling and indication devices |
8328710, | Nov 06 2002 | Hologic, Inc | Temporary catheter for biopsy site tissue fixation |
8337394, | Oct 01 2008 | Ethicon Endo-Surgery, Inc | Overtube with expandable tip |
8353487, | Dec 17 2009 | Ethicon Endo-Surgery, Inc | User interface support devices for endoscopic surgical instruments |
8360950, | Jan 24 2008 | Hologic, Inc | Multilumen brachytherapy balloon catheter |
8361112, | Jun 27 2008 | Ethicon Endo-Surgery, Inc | Surgical suture arrangement |
8398534, | Nov 05 2004 | Theragenics Corporation | Expandable brachytherapy device |
8398535, | Nov 06 2002 | Hologic, Inc | Catheter assembly for delivering a radiation source into a body cavity |
8403926, | Jun 05 2008 | Ethicon Endo-Surgery, Inc | Manually articulating devices |
8409200, | Sep 03 2008 | Ethicon Endo-Surgery, Inc | Surgical grasping device |
8425505, | Feb 15 2007 | Cilag GmbH International | Electroporation ablation apparatus, system, and method |
8449538, | Feb 15 2007 | Cilag GmbH International | Electroporation ablation apparatus, system, and method |
8480647, | May 14 2007 | BIOPROTECT LTD | Delivery device for delivering bioactive agents to internal tissue in a body |
8480657, | Oct 31 2007 | Ethicon Endo-Surgery, Inc | Detachable distal overtube section and methods for forming a sealable opening in the wall of an organ |
8480689, | Sep 02 2008 | Ethicon Endo-Surgery, Inc | Suturing device |
8496574, | Dec 17 2009 | KARL STORZ ENDOVISION, INC | Selectively positionable camera for surgical guide tube assembly |
8506564, | Dec 18 2009 | Ethicon Endo-Surgery, Inc | Surgical instrument comprising an electrode |
8517906, | Nov 06 2002 | Hologic, Inc | Brachytherapy device |
8529563, | Aug 25 2008 | Ethicon Endo-Surgery, Inc | Electrical ablation devices |
8562504, | Nov 05 2004 | Theragenics Corporation | Expandable brachytherapy device |
8568284, | Nov 05 2004 | Theragenics Corporation | Expandable brachytherapy device |
8568410, | Aug 31 2007 | Ethicon Endo-Surgery, Inc | Electrical ablation surgical instruments |
8579897, | Nov 21 2007 | Ethicon Endo-Surgery, Inc | Bipolar forceps |
8608652, | Nov 05 2009 | Ethicon Endo-Surgery, Inc | Vaginal entry surgical devices, kit, system, and method |
8636637, | Nov 18 2005 | Hologic, Inc | Methods for asymmetrical irradiation of a body cavity |
8652150, | May 30 2008 | Ethicon Endo-Surgery, Inc | Multifunction surgical device |
8679003, | May 30 2008 | Ethicon Endo-Surgery, Inc | Surgical device and endoscope including same |
8690746, | Nov 05 2004 | Theragenics Corporation | Expandable brachytherapy device |
8740763, | Jan 24 2008 | Hologic, Inc | Multilumen brachytherapy balloon catheter |
8753390, | Mar 15 2007 | Stryker European Operations Limited | Methods for implanting a prosthesis in a human shoulder |
8758214, | Mar 12 2007 | Hologic, Inc | Radiation catheter with multilayered balloon |
8771260, | May 30 2008 | Ethicon Endo-Surgery, Inc | Actuating and articulating surgical device |
8828031, | Jan 12 2009 | Ethicon Endo-Surgery, Inc | Apparatus for forming an anastomosis |
8888792, | Jul 14 2008 | Cilag GmbH International | Tissue apposition clip application devices and methods |
8894713, | Aug 04 2010 | Stryker European Operations Limited | Shoulder implant |
8906035, | Jun 04 2008 | Ethicon Endo-Surgery, Inc | Endoscopic drop off bag |
8932251, | Mar 10 2011 | WESTERN NEW ENGLAND UNIVERSITY | Biopsy spacer device and method of operation |
8939897, | Oct 31 2007 | Ethicon Endo-Surgery, Inc. | Methods for closing a gastrotomy |
8986199, | Feb 17 2012 | Ethicon Endo-Surgery, Inc | Apparatus and methods for cleaning the lens of an endoscope |
9005198, | Jan 29 2010 | Ethicon Endo-Surgery, Inc | Surgical instrument comprising an electrode |
9011431, | Jan 12 2009 | Cilag GmbH International | Electrical ablation devices |
9028483, | Dec 18 2009 | Cilag GmbH International | Surgical instrument comprising an electrode |
9049987, | Mar 17 2011 | Cilag GmbH International | Hand held surgical device for manipulating an internal magnet assembly within a patient |
9078662, | Jul 03 2012 | Cilag GmbH International | Endoscopic cap electrode and method for using the same |
9180312, | Nov 18 2005 | Hologic, Inc | Brachytherapy device for asymmetrical irradiation of a body cavity |
9220526, | Nov 25 2008 | Cilag GmbH International | Rotational coupling device for surgical instrument with flexible actuators |
9226772, | Jan 30 2009 | Ethicon Endo-Surgery, Inc | Surgical device |
9233231, | Mar 10 2011 | WESTERN NEW ENGLAND UNIVERSITY | Biopsy spacer device and method of operation |
9233241, | Feb 28 2011 | Cilag GmbH International | Electrical ablation devices and methods |
9248311, | Feb 11 2009 | Hologic, Inc; Biolucent, LLC; Cytyc Corporation; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC ; Third Wave Technologies, INC; Gen-Probe Incorporated | System and method for modifying a flexibility of a brachythereapy catheter |
9254169, | Feb 28 2011 | Cilag GmbH International | Electrical ablation devices and methods |
9277957, | Aug 15 2012 | Cilag GmbH International | Electrosurgical devices and methods |
9314620, | Feb 28 2011 | Ethicon Endo-Surgery, Inc | Electrical ablation devices and methods |
9314944, | Jun 23 2004 | Bioprotect Ltd. | Method of forming a seamless bladder |
9375268, | Feb 15 2007 | Cilag GmbH International | Electroporation ablation apparatus, system, and method |
9415239, | Nov 18 2005 | Hologic, Inc | Brachytherapy device for facilitating asymmetrical irradiation of a body cavity |
9427255, | May 14 2012 | Cilag GmbH International | Apparatus for introducing a steerable camera assembly into a patient |
9545290, | Jul 30 2012 | Ethicon Endo-Surgery, Inc | Needle probe guide |
9572623, | Aug 02 2012 | Ethicon Endo-Surgery, Inc | Reusable electrode and disposable sheath |
9579524, | Feb 11 2009 | Hologic, Inc; Biolucent, LLC; Cytyc Corporation; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC ; Third Wave Technologies, INC; Gen-Probe Incorporated | Flexible multi-lumen brachytherapy device |
9623260, | Nov 05 2004 | Theragenics Corporation | Expandable brachytherapy device |
9788885, | Aug 15 2012 | Cilag GmbH International | Electrosurgical system energy source |
9788888, | Jul 03 2012 | Cilag GmbH International | Endoscopic cap electrode and method for using the same |
9808650, | Nov 05 2004 | Theragenics Corporation | Expandable brachytherapy device |
9883910, | Mar 17 2011 | Cilag GmbH International | Hand held surgical device for manipulating an internal magnet assembly within a patient |
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