The present invention relates to a device for providing spongy bone with bone substitute and/or bone reinforcing material, wherein at least one perforating device (4) is provided for making at least one hole (5) in the spongy bone (1) and wherein at least one flushing or rinsing device (6) is provided for flushing or rinsing the hole (5) with a rinsing agent (7). At least one vacuum source (9) is provided for generating a vacuum in the hole (5) in the spongy bone (1) for sucking and/or facilitating insertion or feeding of the bone substitute and/or bone reinforcing material (3) into said spongy bone (1). The invention also relates to bone substitute and/or bone reinforcing material and methods in connection with the invention.
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53. A method for providing spongy bone with bone substitute and/or bone reinforcing material (3) comprising, applying bone substitute material and/or bone reinforcing material (3) from at least one supply device (8) in at least one hole (5) in spongy bone (1) by generating a pulsating vacuum in the hole (5) by at least one vacuum source (9) such that the bone substitute and/or bone reinforcing material (3) is brought to pulsate during its application in the spongy bone (1), the vacuum generated is between −0.5 bar and −0.92 bar.
56. A system for providing spongy bone with bone substitute and/or bone reinforcing material, including:
at least one supply device (8) configured to permit the supply of bone substitute and/or bone reinforcing material (3) to a hole (5) in a spongy bone (1); and
at least one vacuum source (9) configured to generate a vacuum in the hole (5) in the spongy bone (1), and suck the bone substitute and/or bone reinforcing material (3) from the at least one supply device (8) into the hole (5) in the spongy bone (1);
wherein the vacuum source (9) is configured to generate a vacuum of between about −0.5 bar and about −0.92 bar in the hole (5) of the spongy bone (1).
55. A method for providing spongy bone with bone substitute and/or bone reinforcing material (3) comprising:
rinsing at least one hole (5) in spongy bone (1) with rinsing agent by at least one flushing or rinsing device, wherein the rinsing agent (7) is sucked pulsatingly through the hole (5) in the spongy bone (1) by generating a pulsating vacuum by at least one vacuum source (9) in said hole (5), such that the rinsing agent (7) is sucked into the hole (5) in the spongy bone (1), where the vacuum generated in the hole (5) is of between −0.5 bar and −0.92 bar,
applying bone substitute and/or bone reinforcing material (3) from at least one supply device (8) in the hole (5) in the spongy bone (1) by generating a vacuum by the at least one vacuum source (9).
50. A method for providing spongy bone with bone substitute and/or bone reinforcing material, wherein:
at least one hole (5) is made in the spongy bone (1) by at least one perforating device,
the at least one hole (5) is flushed or rinsed with rinsing agent (7) by at least one flushing or rinsing device (6),
the at least one hole (5) is supplied with bone substitute and/or bone reinforcing material by at least one supply device (8), and
a vacuum is generated in the hole (5) for sucking and/or facilitating insertion or feeding of the bone substitute and/or bone reinforcing material (3) into the hole (5) by at least one vacuum source (9), such that the bone substitute and/or bone reinforcing material (3) is sucked into the hole (5) in the spongy bone (1), the vacuum generated is between −0.5 bar and −0.92 bar.
1. A system for providing spongy bone with bone substitute and/or bone reinforcing material, including:
at least one perforating device (4) configured to make at least one hole (5) in the spongy bone (1),
at least one flushing or rinsing device (6) configured to flush or rinse the hole (5) with a rinsing agent (7),
at least one supply device (8) configured to supply the bone substitute and/or bone reinforcing material (3) to the hole (5) in the spongy bone (1), and
at least one vacuum source (9) configured to generate a vacuum in the hole (5) in the spongy bone (1), suck the rinsing agent (7) into the hole (5) in the spongy bone (1), and to suck rinsing agent (7) and tissue material out of said hole (5), wherein
said vacuum source (9) is further configured to suck the bone substitute and/or bone reinforcing material (3) into the hole (5) in the spongy bone (1) from the supply device, and wherein
said vacuum source (9) is configured to generate a vacuum of between −0.5 bar and −0.92 bar in the hole (5) of the spongy bone (1).
2. The system according to
3. The system according to
4. The system according to
5. The system according to
6. The system according to
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18. The system according to
an outer tube member (11) located at the spongy bone (1); and
a perforating means (12), wherein the perforating means (12) is configured to be movable in said outer tube member (11) in coaxial and/or rotary direction and includes and/or cooperates with a perforating member (13) for making the hole (5) in the spongy bone (1).
19. The system according to
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33. The system according to
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49. The system according to
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52. The method according to
54. The method according to
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The present invention relates to a device for providing spongy bone with bone substitute and/or bone reinforcing material, wherein at least one perforating device is provided for making at least one hole in the spongy bone and wherein at least one flushing or rinsing device is provided for flushing or rinsing the hole with a rinsing agent. The invention further relates to a bone substitute and/or bone reinforcing material and a method.
Vertebroplasty is a technique according to which biocompatible material is injected into a spongy vertebra. After some time, the injected material hardens, whereby an inner support is obtained for fixing the vertebra and thereby alleviate pain and reduce the risk of vertebral collapse.
The material is injected into the vertebra through a needle and in doing so, it is necessary to subject the material to high pressure, often one or more MPa. Hereby, there is an obvious risk that tissue material, e.g. blood and fat, in the vertebra is pressed out into the blood vessels or into fracture gaps such that said material can affect adjacent nerves. There is also an obvious risk that the injected material is pressed out into fracture gaps or into adjacent tissue. This is well known and the material and fat being pressed out can reach the blood vessels and the lungs, resulting in a poorer oxygenation, blood pressure reduction and, in exceptional cases, death.
By inserting an extra needle into the vertebra, the risk of leakage (note publications in the enclosed reference list, point 1 and 2, in the end of the description). Normally, this extra needle is left open or preferably connected to a suction hose for generating a suction effect (note publication in the enclosed reference list, point 3). However, any decisive effect is not reached with the prior art.
Various hole making and rinsing devices for making holes in and rinsing of vertebrae are known from e.g. U.S. Pat. No. 6,440,138, U.S. Pat. No. 6,716,216, U.S. Pat. No. 6,719,761 and U.S. Pat. No. 6,740,090, but none of these publications describes generation of a vacuum in the vertebrae for providing safe suction of bone substitute and/or bone reinforcing material into said vertebrae.
The object of the present invention has been to eliminate the abovementioned problem and this is arrived at while the invention has been given the characterizing features of each of subsequent claims 1, 44, 51, 53, 56 and 58.
By making a hole in the spongy bone and rinse it, tissue material and other material can be flushed away from the hole and the sides thereof, such that said sides get rough or uneven surfaces with depressions into which the bone substitute and/or bone reinforcing material can be brought to penetrate by generating a vacuum in the hole and without risking that said bone substitute and/or bone reinforcing material penetrates into the blood paths.
The invention will be further described below with reference to the accompanying drawings, in which:
In the figures, different parts of a device for preparing spongy bone 1, e.g. a vertebra 2, to receive bone substitute and/or bone reinforcing material 3, and for locating said material in said vertebra is schematically illustrated. Said device comprises at least one perforating device 4 for making at least one hole 5 in the vertebra 2, at least one flushing or rinsing device 6 for flushing or rinsing said hole with rinsing agent 7 and at least one supply device 8 which permits suction and/or insertion of bone substitute and/or bone reinforcing material 3 into the vertebra.
At least one vacuum source 9 is provided to generate a vacuum in the hole 5 in the vertebra 2 for sucking and/or facilitate insertion of bone substitute and/or bone reinforcing material 3 into said vertebra.
The perforating device 4 can be designed in many different ways and so can also the rinsing device 6. At the exemplary embodiment of
The movements of the perforating means 12 can be obtained by means of a drive unit 14 of a suitable type.
At the exemplary embodiment, the perforating means 12 is designed as an inner tube member 15. A rinsing agent container 16 is connected to this inner tube member 15 through a connecting device 17 which permits feeding of rinsing agent 7 from the container 16 into the inner tube member 15 irrespective of whether said inner tube member is rotatable or not. Alternatively, the rinsing agent container 16 may be connected to the outer tube member 11 and the collecting device 27 and the vacuum source 9 to the inner tube member 15, such that the outer tube member 11 can lead rinsing agent 7 into the hole 5 and be sucked out of said hole through the inner tube member 15. The perforating device 4 is used preferably for making at least two holes 5 in the vertebra 2. These holes 5 are located such that they communicate with each other either by extending into each other (as is illustrated in
The vacuum source 9 is provided to suck rinsing agent 7 through the hole 5 and it is preferably connected to the outer tube member 11 for sucking, through said outer tube member, rinsing agent 7 and tissue material and other material out of said hole 5.
Between the outer tube member 11 and the vacuum source 9 there is preferably a collecting device 27 for collecting rinsing agent 7 and tissue material and other material brought along therewith out of the hole 5.
The rinsing device 6 is preferably provided also to flush or rinse the sides 5a of the hole 5 such that depressions 5b and similar are formed therein while tissue material and other material is flushed off said sides. This is advantageous since bone substitute and/or bone reinforcing material 3, by means of the vacuum generated in the hole 5, can be brought to penetrate into the depressions 5b.
At the embodiment illustrated in
The supply device 8 illustrated in
The vacuum source 9 can be an injector pump 21 which is run or driven by a suitable compressed medium from a compressed-medium device 22. The injector pump 21 may e.g. be driven by compressed air and connected, through a compressed-air conduit 23, to a compressed-medium device 22 in the form of a compressed-air device. This device may be built into a hospital or other locality in which the injector pump 21 shall be used. Alternatively, the injector pump 21 can be run or driven by another commercially available gas as is indicated with broken lines in
The compressed-medium device 22 can operate the injector pump 21 with a compressed-medium pressure of 4.5-8.5 bar and the injector pump 21 may be of a type which is placed on the floor and which has a foot pedal 24 for its operation. Thus, the injector pump 21 can be started by tilting the foot pedal 24 in one direction and stopped by tilting the foot pedal 24 in the opposite direction. As an example of a usable injector pump 21 in this connection one can mention an injector pump of the type used for producing bone cement as defined in U.S. Pat. No. 5,328,262 and sold under the product name Scan Vacuum Pumps™ by the company Scandimed International AB, Sjöbo, Sweden.
The injector pump 21 is preferably provided to generate a vacuum in all the holes 5 of the spongy bone 1 such that said holes are filled or can be filled with bone substitute and/or bone reinforcing material 3 and/or a vacuum such that the bone substitute and/or bone reinforcing material 3 is distributed therein, preferably without any or any substantial portions thereof being sucked into the second cannula 20.
The injector pump 21 can be provided to generate a vacuum of between −0.5 bar and −0.92 bar in the spongy bone 1, which vacuum corresponds to a 70% and 90% absolute vacuum. In many cases it is sufficient that the injector pump 21 generates a vacuum of between −0.7 bar and −0.8 bar in the spongy bone 1.
The injector pump 21 is preferably provided to suck tissue material such as blood and fat out of the holes 5 of the spongy bone 1 and into the second cannula 20 before bone substitute and/or bone reinforcing material 3 is sucked into the spongy bone 1 through the first cannula 19.
In at least one connecting conduit 25 between the second cannula 20 (the inlet end of which is the end which is inserted into a hole 5 of the spongy bone 1) and the injector pump 21, there may be provided a non-return valve device 26 and/or a collecting device 27 and/or a monomer filter 28 (if the bone substitute and/or bone reinforcing material 3 is of bone cement type) and/or a bacteria filter 29.
The collecting device 27 may be a container which is placed on the floor and closed or sealed by means of a cap. A portion of the connecting conduit 25, which is connected to the second cannula 20, is directed through the cap and a small distance down into the container. Another portion of the connecting conduit 25 is also directed through the cap and a small distance down into the container. When tissue material is sucked from the holes 5 of the spongy bone 1 to the collecting device 27, said material is collected down below in the container and is therefore prevented from being sucked further towards the injector pump 21 and into said pump. If there is a monomer filter 28 and/or a bacteria filter 29 between the collecting device 27 and the injector pump 21, the tissue material is prevented also from being sucked thereto.
The monomer filter 28 may be a carbon filter and is adapted to prevent monomer gases, generated during production of bone substitute and/or bone reinforcing material 3 in the form of bone cement, from being sucked into the injector pump 21 and discharged to the surroundings. The advantages with such a monomer filter 28 are described in the publication according to the enclosed reference list, point 4. The bacteria filter 29 is provided to prevent bacteria from entering or getting into the holes 5 of the spongy bone 1 if the connecting conduit 25 is opened or opens unintentionally and air is sucked therethrough to the holes 5 if there is a vacuum therein.
The monomer filter 28 and bacteria filter 29 may be provided in that portion of the connecting conduit 25 which connects the collecting device 27 with the injector pump 21.
The non-return valve device 26, which preferably can be provided in the connecting conduit 25 between the collecting device 27 and the second cannula 20, is adapted to prevent tissue material from being sucked out of the collecting device 27 and into the holes 5 of the spongy bone 1 if the connecting conduit 25 is opened or opens unintentionally such that a suction is generated therein towards the holes 5 of the spongy bone 1 if there is a vacuum therein.
The container 18 may include a feeding device 30 for feeding bone substitute and/or bone reinforcing material 3 out of the container 18 and into the holes 5 of the spongy bone 1 at the same time the injector pump 21 generates a vacuum therein or thereafter.
The feeding device 30 is schematically illustrated with a feed means 31 which is displaceably mounted relative to the container 18 and which can be displaced manually for discharge of bone substitute and/or bone reinforcing material 3 from the container 18 and through the first cannula 19 into the holes 5 of the spongy bone 1.
The container 18 may eventually be used as mixing container for mixing the components required for the production of such bone substitute and/or bone reinforcing material 3 that can be brought to harden after insertion thereof into the holes 5 of the spongy bone 1. This mixing can occur with a mixing means or in any other way. Such a mixing means can preferably be moved manually back and forth in the container 18 and is eventually rotated relative thereto for mixing the components.
A valve device 32 may be provided for, on one hand, close or interrupt the supply of bone substitute and/or bone reinforcing material 3 through the first cannula 19 to the holes 5 of the spongy bone 1 until the injector pump 21 has generated a suitable vacuum therein. When this is done, the valve device 32 may be opened for permitting suction of bone substitute and/or bone reinforcing material 3 into the holes 5 of the spongy bone 1 by means of the injector pump 21. The valve device 32 may be located on the first cannula 19 or on a connecting conduit between the container 18 and the first cannula 19. The valve device 32 may be manually operable by means of a control handle 33.
As an alternative to the embodiment of the flushing or rinsing device 6 described above, said device may be combined with the supply device 8. At this alternative, the rinsing agent container 16 of the rinsing device 6 may be connected to the first cannula 19 e.g. through the valve device 32 which in this case can be a three way valve permitting either that the supply of rinsing agent to the vertebra 2 is open and the supply of bone substitute and/or bone reinforcing material 3 to the vertebra 2 is closed or that said supply of rinsing agent is interrupted and said supply of material open.
The rinsing agent 7 may be of different types and it may e.g. be distilled water or a sodium chloride solution and/or be detergent and/or include at least one trombolytic substance, e.g. heparin, streptokinase, urokinase, TPA and/or other substances dissolving coagulum and thrombi.
The bone substitute and/or bone reinforcing material 3 may consist of primarily minerals or ceramics which can be mixed with a hardener, e.g. water. These substances may be selected from the group comprising calcium sulphate-α-hemihydrate, calcium sulphate-β-hemihydrate, calcium sulphate-dihydrate, calcium carbonate, α-tricalcium phosphate, hydroxyapatite, dicalcium phosphate-dihydrate, anhydrous dicalcium phosphate, tetracalcium phosphate, β-tricalcium phosphate, calcium deficient hydroxyapatite, monocalcium phosphate-monohydrate, mono-calcium phosphate, calcium-pyurophosphate, precipitated hydroxyapatite, carbonaceous apatite (dahlite), octa-calcium phosphate, amorphous calcium phosphate, oxyapatite, carbonate apatite and calcium aluminate.
A ceramic material may be calcium aluminate, which forms part of the product Doxa T from the company Doxa (www.doxa.se/pdf/nyhet—1.pdf).
X-ray contrast agents can be added to said ceramic bone substitute and/or bone reinforcing material 3, e.g. water soluble non-ionic X-ray contrast agents selected from the group comprising iohexol, ioversol, iopamidol, iotrolan, metrizamide, iodecimol, ioglucol, ioglucamide, ioglunide, iogulamide, iomeprol, iopentol, iopromide, iosarcol, iosimide, iotusal, ioxilan, iofrotal and iodecol.
Alternatively, the bone substitute and/or bone reinforcing material 3 can be a hardenable bone cement comprising polymer and monomer components. The polymer may be polymethylmethacrylate (PMMA) and the monomer methylmethacrylate (MMA). A polymer base material can be the product Cortoss™ from the company Orthovita in the U.S. For composition see www.orthovita.com/products/cortoss/oustechspecs.html. Another polymer base material can be the product SECOUR® Acrylic Resin PMMA from parallax medical inc. (www.parallax-medical.com/go/9192b550-5642-1157-a432-d7a2b98310fe).
The bone substitute and/or bone reinforcing material 3 may consist of a mineral and/or a ceramic in combination with polymer material.
The advantages with the invention is obvious when comparing the degree or ratio of fullness of the vertebra 2 of
It is also obvious from
The invention is not limited to what is described above and illustrated in the drawings, but may vary within the scope of subsequent claims. Thus, the vacuum source 9 may instead of an injector pump 21 be another vacuum pump which can be electrically operated or operated by gas or by hand or operated in any other way, that the hole 5 may be more than one hole and surrounding parts thereto, that the rinsing agent 7 may be another than those described and that the bone substitute and/or bone reinforcing material 3 may be of another type than those described.
There may be a device for imparting pulse like suction and/or insertion movements to the bone substitute and/or bone reinforcing material 3 into the hole(s) 5 in the spongy bone 1. Furthermore, there may be a device for imparting reciprocating suction and/or insertion movements to the bone substitute and/or bone reinforcing material 3 into the hole(s) 5 in the spongy bone 1.
There may also be a device for pulse like suction and/or feeding of the rinsing agent 7 through the hole(s) 5 in the spongy bone 1.
Said device may be defined by pulsating the vacuum source 9 and/or its vacuum generation and/or by generating pulses by means of the feeding device 30.
Jönsson, Sven, Lidgren, Lars, Lundgren, Torgny, Arvidsson, Pär
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