A collapsing clip including a plurality of collapsed self expanding wire frame segments is contained within the distal end of a catheter. The clip can be delivered to the neck of an aneurysm within the neurovascular system using a catheter. The collapsing clip impinges the distal and proximal framed wire segments onto the neck of the aneurysm. The framed wire segments are inter positioned so that the diamond shaped spaces between the wires are substantially blocked. The neck of the aneurysm is blocked by the distal and proximal framed wire segments forming a barrier.
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1. A device for treating an aneurysm comprising:
a clip configured to be folded within a catheter, said clip comprises
a distal clip segment;
a proximal clip segment; wherein each of said segments comprising a lattice, said lattice comprises a plurality of intersecting strands forming a plurality of openings;
a collapsible joint, wherein a portion of said distal clip segment and a portion of said proximal clip segment are connected to said collapsible joint;
wherein said distal and proximal clip segments are configured to expand when said respective clip segment becomes unconstrained by the catheter and wherein said expanded clip segments are configured to extend across a neck of an aneurysm in an expanded configuration; and wherein the lattice of the distal clip segment is offset from the lattice of the proximal clip segment when the distal and proximal segments are in the expanded configuration.
12. A method for treating an aneurysm comprising the steps of:
delivering a clip to an aneurysm with a catheter, wherein at least a portion of said clip is longitudinally folded within said catheter, said clip comprising a distal clip segment and a proximal clip segment connected by a collapsible spring joint;
inserting said distal clip segment into said aneurysm by pushing said clip in the direction of the aneurysm, wherein said distal clip segment expands when unconstrained from said catheter;
placing said distal clip segment adjacent a portion of a neck of said aneurysm, said distal clip segment extends across the neck of said aneurysm when expanded;
forming a barrier across the neck of said aneurysm by releasing said proximal clip segment from said catheter, wherein said proximal clip segment expands when unconstrained from said catheter to extend across the neck of the aneurysm and attach said clip to a portion of said aneurysm,
wherein a lattice of the distal clip segment is offset from a lattice of the proximal clip segment when the distal and proximal segments are in an expanded configuration.
2. The device of
3. The device of
4. The device of
5. The device of
7. The device of
8. The device of
9. The device of
10. The device of
11. The device of
13. The method of
positioning said balloon catheter in a parent artery of said aneurysm, and
inflating a balloon of said balloon catheter to achieve at least partial occlusion of said parent artery.
14. The method of
applying suction sufficient to decompress the aneurysm; and
activating a lock mechanism to maintain relative vacuum in the aneurysm.
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This application is a continuation of U.S. patent application Ser. No. 12/434,137, filed on May 1, 2009, now U.S. Pat. No. 7,993,364, which is a continuation of U.S. patent application Ser. No. 11/039,908 filed on Jan. 24, 2005, now abandoned, which was a divisional of U.S. patent application Ser. No. 09/925,433, filed on Aug. 10, 2001, now U.S. Pat. No. 6,855,154, which claims priority to U.S. Provisional Patent Application No. 60/224,361, filed Aug. 11, 2000. The entire disclosures of these prior applications are incorporated herein by reference.
The present invention relates to systems and processes for treating an aneurysm, and more particular to an endovascular system and process for collapsing an aneurysm.
Aneurysm treatments have been proposed using a wide variety of processes and devices, which have enjoyed various levels of success and acceptance. Such systems and processes include aneurysm clips, intravascular coils, intravascular injections, detachable intravascular balloons, and the like.
These prior devices, however, have proven to be difficult to employ, oftentimes do not lend themselves to deployment in all sizes of aneurysms, can be imprecise in their deployment, their installation can be very time consuming, risk rupture of the aneurysm because they increase its size, can risk recanalization and/or migration of the device in the patient's vasculature, and may not treat the mass effect that the aneurysm may have caused. Furthermore, the presence of adhesions in the aneurysm makes it difficult to collapse the aneurysm. There therefore remains an unmet need in the art for systems and processes which do not suffer from one or more of these deficiencies.
According to a first aspect of the invention, a method of treating an aneurysm in a patient comprises the steps of advancing a compressed clip through the distal end of a catheter and into the aneurysm, expanding portions of the clip inside the aneurysm, and folding a distal segment of the clip on itself together with the adjacent wall of the aneurysm as it becomes dislodged from the stretching bar.
According to a second aspect of the invention, a system useful for treating an aneurysm in a blood vessel of a mammalian patient, the aneurysm having a neck, a wall, and a cavity, comprises an elongated shaft having a proximal end, a distal end, a longitudinal direction defined between the proximal end and the distal end, and including at least one lumen extending therethrough, and a self-expanding frame positioned at the distal end of the shaft, the frame including a plurality of self-expanding sections and at least one joint, each of the plurality of self-expanding sections having an unbiased, expanded condition and a biased, collapsed condition, each of the plurality of self-expanding sections being foldable about one of the at least one joint when in a biased, collapsed condition.
According to a third aspect of the invention, a catheter useful for accessing a vascular location adjacent to an aneurysm, comprises a hollow shaft including a proximal end, a distal end, a longitudinal direction defined between the proximal end and the distal end, a port in a distal portion of the shaft, and including at least one lumen extending therethrough. and an inflatable member mounted on the shaft adjacent to the shaft distal end, the inflatable member in fluid communication with the shaft at least one lumen, the inflatable member including a proximal end, a distal end, and a wall between the proximal end and the distal end which extends to the shaft so that the shaft port is directly exposed to the exterior of the balloon, the wall delimiting a central working channel.
According to a fourth aspect of the invention, a method of treating an aneurysm in a patient comprises the steps of advancing a compressed clip through the distal end of a catheter and into the aneurysm, expanding portions of the clip inside the aneurysm, and folding a distal segment of the clip on itself together with the adjacent wall of the aneurysm as it becomes dislodged from the stretching bar.
Still other objects, features, and attendant advantages of the present invention will become apparent to those skilled in the art from a reading of the following detailed description of embodiments constructed in accordance therewith, taken in conjunction with the accompanying drawings.
The invention of the present application will now be described in more detail with reference to preferred embodiments of the apparatus and method, given only by way of example, and with reference to the accompanying drawings, in which:
Apparatus and methods in accordance with the present invention have numerous advantages over prior aneurysm clips and methods. Among these advantages, immediate closure of an aneurysm can be achieved with a relatively easy-to-use method. The apparatus and methods can be used to treat all aneurysms regardless of the size or the neck width, and can achieve precise locational deployment and decreased procedure time. The risk of rupture can be decreased, since the aneurysm volume is never increased. Additionally, occlusion of the aneurysm neck can be achieved by a balloon in case rupture does occur. Decreased risk of distal embolization, little or no risk of recanalization or migration, strengthening of the arterial wall at the site of the aneurysm, good visualization of the device during and after deployment, and immediate elimination of any mass effect the aneurysm may have caused can also be achieved.
Referring to the drawing figures, like reference numerals designate identical or corresponding elements throughout the several figures.
The system 100 also preferably includes a flexible portion in the distal end of the catheter 102 so that the catheter can more easily navigate the sometimes tortuous paths encountered during endovascular procedures. By way of example and not of limitation, a spring 120 can be incorporated into the distal portions of the catheter 102, preferably proximal of the balloon 112, to permit the catheter to more easily flex and bend. A pair of steering wires 122 are attached to the catheter distal to the flexible portion 120 and to a steering mechanism or station 124 at the proximal end of the catheter. Steering mechanisms for catheters have previously been proposed in the patent literature, and therefore a detailed description of station 124 will be omitted herein.
The catheter 102 also preferably includes at least one, and more preferably, several distal side perfusion holes 126 which are in fluid communication with one of the three lumenae, e.g., lumen 110. The catheter also includes a one way valve 128 positioned distally of the balloon 112 and also in fluid communication with one of the lumenae. Valve 128 is oriented to permit a vacuum drawn in the catheter to suction through the valve, for purposes which will be explained in greater detail below. In accordance with one preferred embodiment, both the side holes 126 and the valve 128 are in fluid communication with the same lumen; because the one way valve 128 only permits flow into the catheter through the valve, perfusion of fluid, e.g. contrast agent, through the side holes 126 will not exit out the catheter through the valve.
Turning briefly to
The stretching bar 118 includes at least one, and preferably several telescoping sections 132a-f of decreasing outer diameter. Thus, section f can slide into section e, section e into section d, and so forth, when the wire 130 is pulled proximally. The clip 116 includes at least one, and preferably several rings 134a-f which are releasably held on the outer surface of the stretching bar 118, e.g., by a friction fit, a frangible coupling, or the like. To each ring 134 a set of arms 136 are attached so that the arms can articulate and fold in toward the stretching bar, in a manner somewhat similar to an umbrella. An outer trellis or covering 138 extends between the opposite ends of the arms.
In order to deploy the clip 116, the distal end of the catheter 102 is positioned in the neck of an aneurysm, as illustrated in
According to additional embodiments, the releasable connections between the arms 136 and the stretching bar 118 can be formed as twist locks, meltable connections, for which a resistive heater is positioned at each arm and voltage source is connected thereto, or the like as will be readily appreciated by one of ordinary skill in the art.
Turning now to
The stiffening wire or stretching bar 210 extends longitudinally through the shaft 202. The wire or bar 210 allows the practitioner to straighten or laterally collapse the frame 206; that is, when the bar/wire/mandrel 210 is pushed distally against the distal end 204, the frame 206 can be stretched and collapsed, and proximal retraction removes this force on the frame and permits the frame to expand. Self-expanding frames are well known to those of skill in the art, such as those known for use in constructing vascular stents, and therefore the constructional details of frame 206 are omitted from this description for brevity's sake. As described in greater detail below, the self-expanding frame is constrained from expanding when advanced through the vasculature because the frame is carried in a catheter shaft which is sized to prevent the frame from expanded until the clip is moved out of the catheter. Such a practice is also known in the art of vascular stents, which are typically carried in a collapsed condition inside a carrier catheter, and thereafter pushed out of the catheter which permits them to expand.
Preferably, at least portions of the shaft 202 are configured so that upon rotation of the shaft about the longitudinal axis, the shaft is released from the frame 206. By way of example and not of limitation, distal portions of the shaft 202 can include a detent which will pass through correspondingly sized and shaped holes in the sections of the frame 206 only when the shaft is rotated to align the detent and hole. Other suitable mechanisms will be readily apparent to those of skill in the art.
The catheter 220 also preferably includes a mechanism or the like which directs a clip radially outward through the working channel 228 when the clip is pushed distally through the shaft 222. According to one exemplary embodiment, this mechanism can be a ramp shaped surface formed in the lumen of the shaft 222, so that when the clip is pushed distally through the shaft, the clip's distal motion is converted into radial motion out of the shaft and into the working channel. According to yet another exemplary embodiment, a deflectable tube 234 can be mounted on the shaft at the base of the working channel 228, and a steering thread 232 is attached to the tube 234. The steering thread extends proximally through the shaft 222 and exits the shaft or is otherwise made available to the practitioner to manipulate. Upon proximal pulling on the steering thread 232, the tube 236 can be deflected to point toward the central working channel 228, thus directing any clip, such as clip 200, which is pushed through the tube 234 into the working channel.
Several lumenae extend through the shaft 222. A suction lumen 236 extends from a distal port 248, located where the working channel 228 meets the shaft 222, to a proximal fitting or suction end 238, and includes a lock 242. The lock 242 is operable to seal the lumen 236 so that a relative vacuum can be maintained in the lumen. For example, lock 242 can be a stopcock valve. A proximal fitting 244 leads to another lumen of the shaft 222, and is the lumen which leads to the deflectable tube 234 and is the lumen in which the clip, e.g., clip 200, is longitudinally advanceable. Thus, the clip 200 can be loaded through the fitting 244 or the tube 234, into the shaft 222 with proximal portions of the clip extending proximally out of the fitting 244. In this orientation. the clip is in a collapsed condition because the internal dimensions of the lumen are selected to constrain the clip from self-expanding. Thereafter, the clip can be advanced distally, through the tube 234 and laterally into the working channel 228.
Turning now to
Another aspect of the present invention includes methods of treating an aneurysm. Several embodiments of methods in accordance with the present invention will now be described with reference to several of the drawing figures, and with reference to several of the exemplary devices described herein. The methods of the present invention are not restricted to the particular devices described herein, but may be performed using other devices which are employable into an aneurysm cavity and onto the outer surface of which the aneurysm wall can be collapsed. By way of example and not of limitation, vascular coils, such as those described in the numerous U.S. patents to Guglielmi et al (see, e.g., U.S. Pat. No. 6,083,220), can be used as a device in the methods of the present invention.
A first exemplary embodiment of a method in accordance with the present invention, given by way of example and not of limitation, includes, but is not limited to, the steps of:
A second exemplary embodiment of a method in accordance with the present invention, given by way of example and not of limitation, includes, but is not limited to, the steps of:
A third exemplary embodiment of a method in accordance with the present invention, given by way of example and not of limitation, includes, but is not limited to, the steps of the above described second embodiment, with the following modification. The clip is positioned at the neck of the aneurysm and the very proximal end of the aneurysm segment. Only the portion of the clip that is in the aneurysm is folded, leaving the rest of the aneurysm decompressed but not fully collapsed onto the outer surface of the clip (see
A fourth exemplary embodiment of a method in accordance with the present invention, given by way of example and not of limitation, includes, but is not limited to, utilizing the clip 300 (see
As will be readily appreciated by one of skill in the, the present invention also extends to the combination of a deployment catheter, such as catheter 220, with any of the embodiments of the aneurysm clips described herein to access and treat an aneurysm.
While the invention has been described in detail with reference to preferred embodiments thereof, it will be apparent to one skilled in the art that various changes can be made, and equivalents employed, without departing from the scope of the invention. Each of the aforementioned published documents is incorporated by reference herein in its entirety.
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