The invention generally relates to devices and methods for treating cardiac tissue, including percutaneous closure of cardiac openings such as a patent foramen ovale (PFO) and obliteration of the cardiac cul-de-sacs. The invention includes a device having at least one elongated member. The elongated member has a first material and a second material interwoven with at least a portion of the first material. The second material is capable of transferring energy to tissue in need of treatment.
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1. A device for treating cardiac tissue, comprising:
a first sheath comprising a distal end, a proximal end and a lumen extending between the distal end and proximal end of the sheath;
an elongated member slidably disposed within the lumen of the first sheath, the elongated member having two ends both affixed at a proximal end to form a closed loop having a hairpin turn at a distal end, wherein the elongated member is adapted to unfurl from the lumen of the first sheath by advancing one affixed end of the elongated member toward the distal end of the elongated member thereby advancing the hairpin turn beyond the distal end of the first sheath, the elongated member further comprising a first substantially non-conductive material, and a second energy transferring material at a portion of the elongated member, wherein when the elongated member is unfurled from the lumen of the first sheath, the portion of the elongated member with the second energy transferring material forms the hairpin turn extending beyond the distal end of the first sheath; and
an actuator operatively joined to the proximal end of the elongated member, wherein when the elongated member is unfurled and the device is actuated, the second energy transferring material is rotated about the hairpin turn.
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This application claims benefit of and priority to U.S. provisional application 60/714,374, filed Sep. 6, 2005 and U.S. provisional application 60/734,558, filed Nov. 8, 2005, the disclosures of each are incorporated by reference herein.
The invention generally relates to devices and related methods for treating cardiac tissue. More particularly, the invention features devices and methods of using devices comprising at least two different interwoven materials wherein at least one of the materials is an energy transferring material.
The human heart is divided into four compartments or chambers. The left and right atria are located in the upper portion of the heart and the left and right ventricles are located in the lower portion of the heart. The left and right atria are separated from each other by a muscular wall, the interatrial septum, while the ventricles are separated by the interventricular septum.
Either congenitally or by acquisition, abnormal openings, holes, or shunts can occur between the chambers of the heart or the great vessels, causing blood to inappropriately flow there through. Such deformities are usually congenital and originate during fetal life when the heart forms from a folded tube into a four chambered, two-unit system. The septal deformities result from the incomplete formation of the septum, or muscular wall, between the chambers of the heart and can cause significant morbidity.
One such septal deformity or defect, a patent foramen ovale (PFO), is a persistent, one-way, usually tunnel shaped, flap-like opening in the wall between the right atrium and left atrium of the heart. Since left atrial pressure is normally higher than right atrial pressure, the flap typically stays closed. Under certain conditions, however, right atrial pressure exceeds left atrial pressure, creating the possibility for right to left shunting that can allow blood clots to enter the systemic circulation. This is particularly problematic for patients who are prone to forming venous thrombi, such as those with deep vein thrombosis or clotting abnormalities. Patients with a PFO may be prone to a cerebrovascular accident known as a stroke.
Moreover, certain patients are prone to atrial arrhythmias (i.e., abnormal heart rhythms which can cause the heart to pump less effectively). In a common such abnormality, atrial fibrillation, the two upper chambers of the heart (i.e., the left atria and the right atria), quiver instead of beating in coordination with other cardiac chambers. Because the atria do not beat and empty cleanly during atrial fibrillation, blood can stagnate on the walls and form clots that can then pass through the heart and into the brain, causing a stroke or a transient ischemic attack. These clots typically form in a cul-de-sac in the heart called the left atrial appendage due to its tendency to have low or stagnant flow.
Nonsurgical (i.e., percutaneous) tissue treatment and closure of a patent foramen ovale and similar cardiac openings, such as an atrial septal defect or a ventricular septal defect, as well as obliteration of a left atrial appendage, can be achieved using a variety of mechanical devices that are introduced via an artery into a large peripheral vessel, e.g., the femoral vein. These devices typically consist of a structural framework with a scaffold material attached thereto. Currently available devices, however, are often complex to manufacture, are inconsistent in performance, require a technically complex implantation procedure, lack anatomic conformability, and lead to complications (e.g., thrombus formation, chronic inflammation, residual leaks, perforations, device fractures, and conduction system disturbances).
Improved devices, systems, and related methods for treating cardiac tissue and/or closing cardiac openings, such as, for example, a patent foramen ovale, and for obliterating cardiac cul-de-sacs, such as, for example, a left atrial appendage, are therefore needed.
The present invention provides devices and related methods for treating cardiac tissue. In one aspect, the invention features a device for treating cardiac tissue. The device comprises a first sheath comprising a distal end, a proximal end and a lumen extending between the distal end and proximal end of the sheath. At least one elongated member is slidably disposed within the lumen of the sheath, and the elongated member is comprised of a first material and a second material. The first material is substantially non-conductive, while the second material is an energy transferring material. At least a portion of the second material is interwoven with at least a portion of the first material.
In one embodiment, the second material comprises copper, gold, metal, platinum, silver, iron, lithium, cobalt, nickel, chromium or a combination thereof, while in another embodiment the second material comprises an energy transferring ceramic or glass material. In another embodiment according to this aspect of the invention, the energy to be transferred includes electromagnetic energy, such as, for example, microwave, infrared, visible light waves, ultraviolet light waves, x-ray, gamma ray, or cosmic ray. In a further embodiment, the electromagnetic energy comprises radio frequency energy.
According to one embodiment, at least a portion of the elongated member comprises a straight wire or bristles, while in another embodiment, the second material is disposed on a filament. In another embodiment, at least a portion of the elongated member comprises a sleeve, and in an additional embodiment, at least a portion of the elongated member comprises a braid, coil, knot, spiral or zigzag. Alternatively, in yet another embodiment, at least a portion of the elongated member comprises a tube or a cone. In further embodiments, the elongated member comprises a lumen, and a negative force such as a negative pressure or vacuum is applied to the lumen of the elongated member. In other embodiments of the invention, a negative force is applied to the lumen of the sheath, while in a further embodiment the sheath is joined to a vacuum source.
In one embodiment, the device comprises a second sheath comprising a lumen for slidably receiving the first sheath. In additional embodiments, a negative pressure such as a vacuum is applied to the second sheath. In another embodiment, the second sheath is joined to a vacuum source. In a further embodiment, the second sheath is axially disposed within the lumen of the first sheath. In an even further embodiment, the elongated member is slidably receivable within the second sheath, while in another embodiment, the second sheath is axially disposed within a lumen of the elongated member.
In another embodiment of the invention, the elongated member is operatively joined to an actuator. In one embodiment, movement of the actuator causes movement of the elongated member in an axial direction in relation to the sheath. In other embodiments, the sheath is operatively joined to an actuator.
In another embodiment, the elongated member comprises a distal end and a proximal end. In a further embodiment, the elongated member comprises a wire. The wire comprises an open ended loop, the loop comprising a hairpin turn, for example, at the distal end of the elongated member and two free ends at the proximal end of the elongated member. According to one embodiment, at least one free end of the wire is affixed to an actuator. In another embodiment, movement of the actuator in a distal direction unfurls a portion of the elongated member from the lumen of the sheath moving the distal end of the elongated member even further in the distal direction. In a further embodiment, movement of the elongated member in the distal direction places at least a portion of the second material in contact with the cardiac tissue in need of treatment. In yet a further embodiment, movement of the actuator in a proximal direction retracts a portion of the elongated member inside the lumen of the sheath and moves the distal end of the elongated member in the proximal direction.
In another embodiment of the invention, the elongated member comprises a sleeve comprising an exterior surface and an interior surface. In one embodiment, the exterior surface of the sleeve is affixed to an actuator. In a particular embodiment, the sleeve comprises a first position in which a portion of the elongated member comprising the second material interwoven with the first material is located on the interior surface of the sleeve. In a further embodiment, movement of the actuator in a proximal direction transitions the sleeve into a second position wherein at least a portion the interwoven second material is located on the exterior surface of the sleeve.
Another embodiment of the invention features the interior surface of the sleeve affixed to an actuator. According to one embodiment, the sleeve comprises a first position in which the portion of the elongated member comprising the second material interwoven with the first material is located on the exterior surface of the sleeve. In another embodiment, movement of the actuator in a proximal direction transitions the sleeve into a second position wherein at least a portion the interwoven second material is located on the interior surface of the sleeve.
A further aspect of the invention includes a device for treating cardiac tissue. The device comprises at least one elongated member including a first material and a second material. The first material is a substantially non-conductive material, while the second material is an energy transferring material and at least a portion of the second material is interwoven with at least a portion of the first material. In one embodiment, the second material comprises copper, gold, metal, platinum, silver, iron, lithium, cobalt, nickel, chromium, or a combination thereof. In another embodiment, the second material comprises a glass or ceramic material.
Another aspect of the invention features a method for treating cardiac tissue. The method comprises the step of advancing a device to a position adjacent to cardiac tissue that is in need of treatment. The device includes a first sheath and at least one elongated member slidably disposed within a lumen of the sheath, the elongated member comprising a first material and a second material. The first material is substantially a non-conductive material. At least a portion of the second material is interwoven with at least a portion of the first material. The second material is capable of transferring energy from an energy source. The method further comprises the steps of advancing the elongated member through the lumen of the sheath wherein at least a portion of the second material comes into contact with the cardiac tissue in need of treatment, and applying the energy source to the second material to transfer energy to the cardiac tissue.
In one embodiment of this method of the invention, the elongated member comprises a wire, having an open ended loop. The loop comprises a hairpin turn at a distal end of the elongated member and two free ends at a proximal end of the elongated member. In another embodiment, at least one free end of the wire open-ended loop is operatively joined to an actuator. In a particular embodiment, movement of the actuator in the distal direction unfurls a portion of the elongated member from the lumen of the sheath, thereby moving the distal end of the elongated member in the distal direction. In an additional embodiment, the method further comprises the step of moving the actuator in the distal direction to place at least a portion of the second material in contact with the cardiac tissue in need of treatment. In a further embodiment, movement of the actuator in the proximal direction retracts a portion of the elongated member within the lumen of the sheath and moves the distal end of the elongated member in the proximal direction.
According to one embodiment, energy comprises microwave, infrared, visible light waves, ultraviolet light waves, x-ray, gamma ray, or cosmic ray. In another embodiment, the energy comprises radio frequency energy.
A further embodiment according to this aspect of the method of the invention comprises the step of attaching a vacuum source in communication with the lumen of the first sheath or the second sheath. The method of the invention can further comprise the step of applying a negative pressure to the lumen of the first sheath or the second sheath. In a further embodiment, the negative pressure is provided by a vacuum generating source, e.g., a pump.
In an additional embodiment, the device of the invention comprises a second sheath having a lumen wherein the first sheath is axially disposed within the second sheath. In one embodiment, the method comprises the step of applying a negative force, e.g., negative pressure to the lumen of the second sheath. In a further embodiment, the device comprises a second sheath having a lumen and the second sheath is axially disposed within the lumen of the first sheath. In a further embodiment, the elongated member is slidably receivable in the second sheath. Alternatively, the elongated member is fixed and the sheath is slideably moveable over the elongated member.
A further aspect of the invention features a method for treating cardiac tissue and comprises the step of advancing a device to a position adjacent to cardiac tissue in need of treatment. The device includes at least one elongated member comprising a first material and a second material. The first material is a substantially non-conductive material. The second material is an energy transferring material. At least a portion of the second material is interwoven with at least a portion of the first material, and the second material is capable of transferring energy from an energy source. This aspect also includes the steps of contacting at least a portion of the second material with the cardiac tissue in need of treatment, and transferring energy to the cardiac tissue in need of treatment.
In the drawings, like reference characters generally refer to the same parts throughout the different views. Also, the drawings are not necessarily to scale, emphasis instead generally being placed upon illustrating the principles of the invention.
The present invention features devices and related methods for treating cardiac tissue. The cardiac tissue in need of treatment includes, for example, cardiac septa and tissue of the left and right atria. The invention is also useful in closing various cardiac openings, for example, a patent foramen ovale (PFO), an atrial septal defect, or a ventricular septal defect.
The present invention features systems and related methods for closing cardiac openings, such as, for example, a PFO, described below. Throughout the description, the terms proximal and distal refer to the position of elements relative to the operator of the exemplary apparatus. Proximal is that portion of the device closer to the operator and distal is that portion of the device further away from the operator.
The vacuum source 102 is used to apply negative pressure through the vacuum cone 106 to stabilize the sheath 4 while delivering the elongated member 12 into, for example, a PFO tunnel. The vacuum applied to stabilize the sheath 4 may also have the advantage of collapsing the tunnel of the PFO. The lumen 128 of the vacuum cone 106 may be in communication with the lumen 10 of the sheath 4.
A cone, as used herein, means any tubular shape or any tubular shape with a flared end. In a preferred embodiment, the cone 106 includes a tube having a flared end, i.e., the diameter of the distal end 96 of the cone 106 is greater than the diameter of the proximal end 132 of the cone 106. The flare may begin at the proximal end 132 of the cone 106 and extend gradually to the distal end of the cone 106 as illustrated in
With continued reference to
Referring still to
With further reference to
According to one embodiment of the invention, the elongated member 12 includes a first material 14 and a second material 16. In one embodiment, at least a portion of the second material 16 is interwoven with at least a portion of the first material 14. In a particular embodiment, at least the second material 16 interwoven with first material 14 is an energy transferring material that can transfer energy from an energy source 34 to, for example, adjacent cardiac tissue. The second material 16 may be in the form of a thread, filament cord, rope, ribbon, plate or sheet, for example. In yet another embodiment, the elongated member 12 is transitioned from within the sheath 4 to extend beyond the distal end 6 of the sheath 4 to place the distal end of the elongated member 12 including the second material 16 in direct contact or, alternatively in indirect contact, for example, through water or saline, with cardiac tissue 18 in need of treatment.
The elongated member 12 can be any shape depending on the intended use of the device 2 and/or the user's preference. In certain embodiments, the elongated member 12 comprises a straight wire or, alternatively, one or more bristles (not shown) at the distal end 33 of the elongated member 12. In another embodiment, the elongated member 12 comprises a sleeve. In other embodiments, the elongated member 12 comprises a braid, coil, knot, spiral or zigzag shape. Alternatively, the elongated member 12 can be in the shape of a tube or a cone. In certain embodiments, the elongated member 12 includes a lumen. In other embodiments, the device of the invention comprises two or more elongated members 12. Each elongated member 12 can be manipulated independently or in unison with the other(s) in the manner described below.
In a particular embodiment, the second material 16 may be positioned on one or more bristles or braided, coiled, knotted, spiral or zig zag or bonded with the first material 14 on the elongated member 12. For example, the first material 14 may be an insulator of the second material 16. Uninsulated portions of the second material 16 are contacted with the tissue in need of treatment. Alternatively, the elongated member 12 may include only the second material 16.
With respect to the material of the elongated member 12, by “interwoven” it is meant that at least a portion of the first material 14 and a portion of the second material 16 are connected closely by being in direct contact with each other, e.g., threaded, woven through or overlapping the other or indirect contact. By “direct contact” it is meant that at least a portion of the first material 14 and a portion of the second material 16 are physically touching each other. By “indirect contact” it is meant that at least a portion of the first material 14 and a portion of the second material 16 are in physical contact with a common object or common third material. By “threaded” it is meant that one material in the form of a thread or wire is physically passed into or through the other.
In one embodiment according to the invention, the first material 14 and the second material 16 of the elongated member are different compositions. According to one embodiment, the first material 14 comprises, for example, a polymer, such as a plastic, for example, nylon or polyester. The second material 16 comprises any material capable of transferring energy, for example, electromagnetic energy, from an energy source to a target tissue, for example, cardiac tissue. In one embodiment, the second material is, for example, copper, gold, metal, platinum, silver, iron, lithium, cobalt, nickel, chromium, glass, ceramic or a combination thereof. The electromagnetic energy transferred may be, for example, one of microwave, infrared, visible light waves, ultraviolet light waves, x-ray, gamma ray, laser energy, or cosmic ray. In a particular embodiment, the electromagnetic energy is radio frequency energy.
According to one embodiment of the invention, at least a portion of the second material 16 is interwoven with at least portion of the first material 14. For example, the materials 14, 16 can cross each other one or more times, be braided together, threaded through one another, twisted together, coiled together, woven through each other, and/or knotted together. Alternatively, the materials 14, 16, when placed adjacent to each other, can be collectively formed into the shape of a braid, coil, knot, spiral, zigzag, straight wire, or bristles. The material 14, 16 may be laminated or crimped together. The second material 16 extends from the energy source 34 to at least the distal end of the elongated member 12.
Referring now to
In one embodiment, the second material 16 follows the path of the first material 14 forming a bipolar device. Alternatively, the second material 16 partially follows the path of the first material 14, forming a unipolar device.
With continued reference to the embodiment shown in
In a further embodiment, the one end 52 of the wire that is not joined to the cable 20 is fixed within the device 2. In another embodiment, as shown in
In a preferred embodiment, manipulation of the elongated member 12 carries the second material 16 into the PFO tunnel. Upon further manipulation of the elongated member 12, the distal end of the elongated member retracts proximally, and leaves the PFO tunnel, and the second material transfer energy to the septum tissue along the track, and therefore causes the target tissue to fuse together.
Referring now to the embodiment shown in
Alternatively, in another embodiment (not shown), the cable 20 is operatively joined to the interior surface 42 of the sleeve 12. Axial movement of the cable 20 in a distal direction lengthens the exterior surface 44 and shortens the interior surface 42 of the sleeve such that at least a portion of the interior surface 42 of the sleeve 12 becomes everted and at least a portion of the sleeve 12 comprising the interwoven second material 16 is relocated to the distal end of the sleeve 12 and the exterior surface 44 of the inverted sleeve 12. In one embodiment for treating cardiac tissues, the portion of the everted sleeve 12 comprising the interwoven second material 16 contacts the tissue in need of treatment and electromagnetic energy from the energy source is transferred from the second material 16 to the tissue.
Referring now to
In further embodiments of the invention of the device 2, the proximal end 8 of the sheath 4 is coupled to a vacuum source to allow functional communication with the lumen 10 of the sheath 4. This configuration allows the user to apply negative pressure, i.e., suction, to the targeted cardiac tissue 18 as the distal end of the sheath 4 is applied to the tissue 18. The negative pressure vacuum can be used to draw the cardiac tissue toward the second material 16. With the tissue in contact with the second material 16, energy transfers from the second material 16 directly to the tissue. In one embodiment, the negative pressure from the vacuum source is maintained while the energy is applied to the tissue.
The first sheath 4 and the second sheath 24 can be any shape suited to its function. For example, the sheath 4 or sheath 24 can be tubular or funnel shape. The sheath 4 or sheath 24 can have a lumen of uniform or variable diameter. For example, the sheath 4 or sheath 24 in a particular embodiment includes a flared distal end. In another embodiment, the sheath 4 or sheath 24 comprises an invertible sleeve.
Another aspect of the invention features a method for treating cardiac tissue. The method comprises the steps of advancing a device 2 according to the invention to a position adjacent to cardiac tissue 18 in need of treatment, the device 2 includes a sheath 4 and at least one elongated member 12 slidably disposed with a lumen 10 of the sheath 4. In one embodiment, the elongated member 12 includes a first material 14 and a second material 16. At least a portion of the second material 16 is interwoven with a portion of the first material 14. As described above with respect to other embodiments, the second material 16 is capable of transferring energy, for example, electromagnetic energy, from an energy source. According to this embodiment, the method comprises the step of advancing the elongated member 12 through the lumen 10 of the sheath. At least a portion of the second material 16 is placed into contact with cardiac tissue in need of treatment 18. The method further includes the step of applying energy from the energy source to the second material 16 to transfer energy to the cardiac tissue 18 in need of treatment.
In one embodiment according to this aspect of the invention, the energy applied to the cardiac tissue includes one of microwave, infrared, visible and ultraviolet light waves, x-ray, gamma ray, or cosmic ray. In another embodiment, the energy is radio frequency energy.
According to a further embodiment of the method of the invention, an operator provides an elongated member 12 including a wire having a hairpin turn 36 at a distal end 33 of the elongated member 12 to form an open ended loop having two ends 52 of the wire at a proximal end of the elongated member 12. At least one end 52 of the wire is operatively joined to an actuator 32. Actuating the actuator 32 in the distal direction unfurls a portion of the elongated member 12 from the lumen 10 of the sheath 4 and moves the distal end 36 of the elongated member 12 in the distal direction. In an additional embodiment, the method further comprises the step of actuating the actuator 32 to move the elongated member 12 distally to place at least a portion of the second material 16 in contact with the cardiac tissue 18 in need of treatment. In a further embodiment, actuating the actuator 32 to move the elongated member 12 in the proximal direction retracts a portion of the elongated member 12 within the lumen 10 of the sheath 4 and moves the distal end 36 of the elongated member 12 in the proximal direction.
A further embodiment of the invention includes an additional step of attaching a vacuum source to the lumen 10 of the sheath 4. According to this embodiment, a vacuum or negative pressure, i.e., suction, is applied to the cardiac tissue 18 to draw the cardiac tissue 18 toward the device 2. In another embodiment, the device 2 comprises a second sheath 24 having a lumen 26, and the method comprises an additional step of attaching a vacuum source to the lumen 26 of the second sheath 24. According to this embodiment, a vacuum can be applied to cardiac tissue to draw the tissue toward the device 2. In both of these embodiments, the cardiac tissue drawn toward the device 2 is contacted with the second material 16 and energy is transferred from the second material 16 to the tissue 18. The vacuum or negative pressure can also be maintained on the tissue while the energy is being applied to the tissue.
A further aspect of the invention includes a method for treating cardiac tissue comprising the step of advancing a device 2 to a position adjacent to cardiac tissue in need of treatment, the device 2 having at least one elongated member 12 comprising a first material 14 and a second material 16. At least a portion of the second material 16 is interwoven with at least a portion of the first material 14. The second material 16 is capable of transferring energy from an energy source to a target tissue, for example, cardiac tissue. The method further comprises the steps of advancing the elongated member 12 through the body of a patient until at least a portion of the second material 16 comes into contact with the cardiac tissue in need of treatment, and applying the energy source to the second material 16 to transfer energy to the cardiac tissue in need of treatment.
In yet another aspect, the invention provides methods for percutaneously closing a PFO using a device 2 such as the device according to the invention depicted in
In a similar embodiment, the device 2 comprising the elongated member 12 is advanced within a patient as described above and is placed adjacent to the right atrial wall of the heart. The elongated member 12 comprises a vacuum which is placed in contact with the right atrial wall, and the portion of the elongated member 12 comprising the interwoven second material 16 is placed in contact with the tissue of the right atrial wall. The vacuum is then activated, attaching the elongated member 12 to the right side of the fossa ovalis. Energy is then delivered to the second material 16 from an energy source, and the energy is transferred from the second material 16 to the fossa ovalis. The energy is absorbed by the surrounding cardiac tissue to close the PFO.
In yet another embodiment of the method according to the invention, the elongated member of the device described herein may be used to delivery energy to the tissues within the tunnel of a PFO as described in co-owned application titled, “In tunnel electrode for sealing intra-cardiac defects”, co-filed on the same date as the instant application and incorporated by reference in its entirety herein.
Variations, modifications, and other implementations of what is described herein will occur to those of ordinary skill in the art without departing from the spirit and the scope of the invention. The invention is not to be defined only by the preceding illustrative description.
Patent | Priority | Assignee | Title |
10368942, | Sep 06 2005 | W. L. Gore & Associates, Inc. | Devices and methods for treating cardiac tissue |
9844453, | Aug 27 2001 | Boston Scientific Scimed, Inc. | Positioning tools and methods for implanting medical devices |
Patent | Priority | Assignee | Title |
3874388, | |||
4007743, | Oct 20 1975 | Baxter International Inc | Opening mechanism for umbrella-like intravascular shunt defect closure device |
4696300, | Apr 11 1985 | Dennison Manufacturing Company | Fastener for joining materials |
4710192, | Dec 30 1985 | Diaphragm and method for occlusion of the descending thoracic aorta | |
4832048, | Oct 29 1987 | CORDIS WEBSTER, INC | Suction ablation catheter |
4836204, | Jul 06 1987 | Method for effecting closure of a perforation in the septum of the heart | |
4902508, | Jul 11 1988 | METHODIST HOSPITAL OF INDIANA, INC | Tissue graft composition |
4917089, | Aug 29 1988 | Buttoned device for the transvenous occlusion of intracardiac defects | |
4921484, | Jul 25 1988 | Cordis Corporation | Mesh balloon catheter device |
4944741, | Dec 09 1988 | Laproscopic instrument with pivotable support arm | |
4945912, | Nov 25 1988 | INNOVATIVE CARDIAC SOLUTIONS, INC | Catheter with radiofrequency heating applicator |
4946440, | Oct 05 1988 | Evertible membrane catheter and method of use | |
4956178, | Jul 11 1988 | METHODIST HOSPITAL OF INDIANA, INC | Tissue graft composition |
4967765, | Jul 28 1988 | AMS Research Corporation | Urethral inserted applicator for prostate hyperthermia |
5003990, | Jul 28 1988 | Apparatus for implanting electrodes and the like in animal bodies | |
5007908, | Sep 29 1989 | GYRUS ACMI, INC | Electrosurgical instrument having needle cutting electrode and spot-coag electrode |
5021059, | May 07 1990 | Kensey Nash Corporation | Plug device with pulley for sealing punctures in tissue and methods of use |
5025799, | May 13 1987 | ABBOTT LABORATORIES VASCULAR ENTITLES LIMITED; Abbott Laboratories Vascular Enterprises Limited | Steerable memory alloy guide wires |
5108420, | Feb 01 1991 | MARKS, LLOYD A | Aperture occlusion device |
5156613, | Feb 13 1991 | Baxter International Inc; BAXTER HEALTHCARE S A | Collagen welding rod material for use in tissue welding |
5171259, | Apr 02 1990 | Device for nonoperatively occluding a defect | |
5176687, | May 10 1991 | Disposable pouch container for isolation and retrieval of tissues removed at laparoscopy | |
5217435, | Jan 07 1992 | Cardiac catheter apparatus | |
5222974, | Nov 08 1991 | KENSEY NASH CORPORATION, A CORPORATION OF DELAWARE | Hemostatic puncture closure system and method of use |
5275826, | Nov 13 1992 | METHODIST HOSPITAL OF INDIANA, INC | Fluidized intestinal submucosa and its use as an injectable tissue graft |
5282827, | Nov 08 1991 | KENSEY NASH CORPORATION, A DE CORP | Hemostatic puncture closure system and method of use |
5284488, | Dec 23 1992 | Adjustable devices for the occlusion of cardiac defects | |
5304184, | Oct 19 1992 | Indiana Research and Technology Corporation; Indiana University Research and Technology Corporation | Apparatus and method for positive closure of an internal tissue membrane opening |
5312341, | Aug 14 1992 | Wayne State University; WAYNE STATE UNIVERSITY, A CORP OF MICHIGAN | Retaining apparatus and procedure for transseptal catheterization |
5312435, | May 17 1993 | Kensey Nash Corporation | Fail predictable, reinforced anchor for hemostatic puncture closure |
5334217, | Jan 21 1992 | Regents of the University of Minnesota | Septal defect closure device |
5370644, | Nov 25 1988 | INNOVATIVE CARDIAC SOLUTIONS, INC | Radiofrequency ablation catheter |
5385156, | Aug 27 1993 | Rose Health Care Systems | Diagnostic and treatment method for cardiac rupture and apparatus for performing the same |
5423882, | Dec 26 1991 | CORDIS WEBSTER, INC | Catheter having electrode with annular recess and method of using same |
5425744, | Nov 05 1991 | CHILDREN S MEDICAL CENTER CORPORATION | Occluder for repair of cardiac and vascular defects |
5433727, | Aug 16 1994 | Centering buttoned device for the occlusion of large defects for occluding | |
5451235, | Nov 05 1991 | CHILDREN S MEDICAL CENTER CORPORATION | Occluder and method for repair of cardiac and vascular defects |
5484385, | Apr 21 1994 | ARROW INTERNATIONAL INVESTMENT CORP | Intra-aortic balloon catheter |
5486185, | Jan 30 1989 | Tyco Healthcare Group LP | Surgical apparatus |
5507744, | Apr 23 1992 | Boston Scientific Scimed, Inc | Apparatus and method for sealing vascular punctures |
5507811, | Nov 26 1993 | Nissho Corporation | Prosthetic device for atrial septal defect repair |
5540681, | Apr 10 1992 | Medtronic CardioRhythm | Method and system for radiofrequency ablation of tissue |
5573533, | Apr 10 1992 | Medtronic CardioRhythm | Method and system for radiofrequency ablation of cardiac tissue |
5578045, | Jan 21 1992 | Regents of the University of Minnesota | Septal defect closure device |
5597378, | Oct 14 1983 | Medtronic, Inc | Medical devices incorporating SIM alloy elements |
5620461, | May 29 1989 | MEDIFIX R&D BV TE PUTTEN | Sealing device |
5620479, | Nov 13 1992 | Regents of the University of California, The | Method and apparatus for thermal therapy of tumors |
5626599, | Jan 22 1992 | Medtronic Ave, Inc | Method for the percutaneous transluminal front-end loading delivery of a prosthetic occluder |
5630837, | Jul 01 1993 | Boston Scientific Scimed, Inc | Acoustic ablation |
5634936, | Feb 06 1995 | Boston Scientific Scimed, Inc | Device for closing a septal defect |
5636634, | Mar 16 1993 | EP Technologies, Inc | Systems using guide sheaths for introducing, deploying, and stabilizing cardiac mapping and ablation probes |
5649950, | Jan 22 1992 | Medtronic Ave, Inc | System for the percutaneous transluminal front-end loading delivery and retrieval of a prosthetic occluder |
5653684, | Mar 19 1994 | SciMed Life Systems, INC; Boston Scientific Scimed, Inc | Catheter with expandable wire mesh tip |
5669934, | Feb 13 1991 | Baxter International Inc; BAXTER HEALTHCARE S A | Methods for joining tissue by applying radiofrequency energy to performed collagen films and sheets |
5676662, | Mar 17 1995 | ST JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC | Ablation catheter |
5683411, | Apr 06 1994 | Cook Medical Technologies LLC | Medical article for implantation into the vascular system of a patient |
5690675, | Feb 13 1991 | Baxter International Inc; BAXTER HEALTHCARE S A | Methods for sealing of staples and other fasteners in tissue |
5702421, | Jan 11 1995 | Closure device for closing a vascular opening, such as patent ductus arteriosus | |
5709707, | Oct 30 1995 | Children's Medical Center Corporation | Self-centering umbrella-type septal closure device |
5725552, | Jul 08 1994 | AGA Medical Corporation | Percutaneous catheter directed intravascular occlusion devices |
5733294, | Feb 28 1996 | Scion Medical Limited | Self expanding cardiovascular occlusion device, method of using and method of making the same |
5733337, | Apr 07 1995 | Organogenesis, Inc | Tissue repair fabric |
5741249, | Nov 25 1996 | MAQUET CARDIOVASCULAR LLC | Anchoring tip assembly for microwave ablation catheter |
5741297, | Aug 28 1996 | W L GORE & ASSOCIATES, INC | Daisy occluder and method for septal defect repair |
5749895, | Feb 13 1991 | Baxter International Inc; BAXTER HEALTHCARE S A | Method for bonding or fusion of biological tissue and material |
5797905, | Aug 08 1994 | EP Technologies, Inc | Flexible tissue ablation elements for making long lesions |
5797907, | Nov 06 1989 | Mectra Labs, Inc. | Electrocautery cutter |
5797960, | Feb 22 1993 | Heartport, Inc | Method and apparatus for thoracoscopic intracardiac procedures |
5800428, | May 16 1996 | CORDIS WEBSTER, INC | Linear catheter ablation system |
5800478, | Mar 07 1996 | PURDUE PHARMACEUTICAL PRODUCTS L P | Flexible microcircuits for internal light therapy |
5807384, | Dec 20 1996 | Eclipse Surgical Technologies, Inc.; Eclipse Surgical Technologies, Inc | Transmyocardial revascularization (TMR) enhanced treatment for coronary artery disease |
5810810, | Apr 30 1993 | Boston Scientific Scimed, Inc | Apparatus and method for sealing vascular punctures |
5810884, | May 19 1997 | HEART-TECH CORPORATION | Apparatus and method for closing a vascular perforation after percutaneous puncture of a blood vessel in a living subject |
5823956, | Feb 22 1993 | Heartport, Inc. | Method and apparatus for thoracoscopic intracardiac procedures |
5846261, | Jul 08 1994 | AGA Medical Corp. | Percutaneous catheter directed occlusion devices |
5849028, | May 16 1997 | Irvine Biomedical, Inc. | Catheter and method for radiofrequency ablation of cardiac tissue |
5853422, | Mar 22 1996 | Boston Scientific Scimed, Inc | Apparatus and method for closing a septal defect |
5861003, | Oct 23 1996 | CLEVELAND CLINIC FOUNDATION, THE | Apparatus and method for occluding a defect or aperture within body surface |
5865791, | Jun 07 1995 | E.P. Technologies Inc. | Atrial appendage stasis reduction procedure and devices |
5879366, | Dec 20 1996 | W L GORE & ASSOCIATES, INC | Self-expanding defect closure device and method of making and using |
5893856, | Jun 12 1996 | Mitek Surgical Products, Inc. | Apparatus and method for binding a first layer of material to a second layer of material |
5895412, | Oct 11 1995 | Baxter International Inc; BAXTER HEALTHCARE S A | Device and method for sealing tissue |
5904703, | Nov 07 1997 | Medtronic Ave, Inc | Occluder device formed from an open cell foam material |
5919200, | Oct 09 1998 | Terumo Kabushiki Kaisha | Balloon catheter for abrading a patent foramen ovale and method of using the balloon catheter |
5927284, | Sep 20 1995 | Medtronic, Inc | Method and apparatus for temporarily immobilizing a local area of tissue |
5944738, | Feb 06 1998 | ST JUDE MEDICAL, CARDIOLOGY DIVISION, INC | Percutaneous catheter directed constricting occlusion device |
5948011, | May 15 1995 | THERMAGE, INC | Method for controlled contraction of collagen tissue via non-continuous energy delivery |
5954719, | Dec 11 1996 | IRVINE BIOMEDICAL, INC | System for operating a RF ablation generator |
5955110, | Apr 07 1995 | CLARIAN HEALTH PARTNERS, INC | Multilayered submucosal graft constructs and method for making the same |
5957919, | Jul 02 1997 | SRONCUB, INC | Bleb reducer |
5964782, | Sep 18 1997 | Boston Scientific Scimed, Inc | Closure device and method |
5971980, | May 02 1995 | Cardiac Pacemakers, Inc | System for controlling the energy delivered to a patient for ablation |
5976174, | Dec 15 1997 | Medical hole closure device and methods of use | |
5993844, | May 08 1997 | Organogenesis, Inc | Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix |
5997575, | Apr 05 1996 | CLARIAN HEALTH PARTNERS, INC | Perforated submucosal tissue graft constructs |
6004269, | Jul 01 1993 | Boston Scientific Scimed, Inc | Catheters for imaging, sensing electrical potentials, and ablating tissue |
6004316, | Oct 30 1996 | Terumo Kabushiki Kaisha | Method for the treatment of patent ductus arteriosus |
6010517, | Apr 10 1996 | Device for occluding abnormal vessel communications | |
6015378, | Sep 20 1995 | Medtronic, Inc | Method and apparatus for temporarily immobilizing a local area tissue |
6016811, | Sep 01 1998 | AFX, INC | Method of using a microwave ablation catheter with a loop configuration |
6024756, | Sep 23 1997 | Boston Scientific Scimed, Inc | Method of reversibly closing a septal defect |
6063080, | May 16 1996 | CORDIS WEBSTER, INC | Linear catheter ablation system |
6063085, | Apr 23 1992 | Boston Scientific Scimed, Inc | Apparatus and method for sealing vascular punctures |
6077291, | Jan 21 1992 | Regents of the University of Minnesota | Septal defect closure device |
6080182, | Dec 20 1996 | W L GORE & ASSOCIATES, INC | Self-expanding defect closure device and method of making and using |
6086581, | Sep 25 1992 | EP Technologies, Inc | Large surface cardiac ablation catheter that assumes a low profile during introduction into the heart |
6086610, | Oct 22 1996 | Cordis Corporation | Composite self expanding stent device having a restraining element |
6102926, | Dec 02 1996 | ABBOTT CARDIOVASCULAR SYSTEMS INC | Apparatus for percutaneously performing myocardial revascularization having means for sensing tissue parameters and methods of use |
6106520, | Sep 30 1997 | BROWN, TONY R ; LAUFER, MICHAEL D | Endocardial device for producing reversible damage to heart tissue |
6106532, | Apr 06 1998 | Nissho Corporation | Device for retrieval of defect closure devices |
6117159, | Mar 22 1996 | Boston Scientific Scimed, Inc | Apparatus and method for closing a septal defect |
6123718, | Nov 02 1998 | POLYMEREX MEDICAL CORP | Balloon catheter |
6132438, | Jun 07 1995 | EP Technologies, Inc | Devices for installing stasis reducing means in body tissue |
6135997, | Sep 26 1996 | Covidien LP | Method for treating hemorrhoids |
6143037, | Jun 12 1996 | MICHIGAN, REGENTS, THE, UNIVERSITY OF | Compositions and methods for coating medical devices |
6152144, | Nov 06 1998 | Boston Scientific Scimed, Inc | Method and device for left atrial appendage occlusion |
6152918, | Apr 05 1996 | Eclipse Surgical Technologies, Inc.; Eclipse Surgical Technologies, Inc | Laser device with auto-piercing tip for myocardial revascularization procedures |
6165183, | Jul 15 1998 | ST JUDE MEDICAL, INC | Mitral and tricuspid valve repair |
6171329, | Dec 19 1994 | W L GORE & ASSOCIATES, INC | Self-expanding defect closure device and method of making and using |
6174322, | Aug 08 1997 | Cardia, Inc. | Occlusion device for the closure of a physical anomaly such as a vascular aperture or an aperture in a septum |
6187039, | Dec 10 1996 | CLARIAN HEALTH PARTNERS, INC | Tubular submucosal graft constructs |
6200313, | Mar 31 1994 | Fuji Photo Optical Co., Ltd. | Puncture instrument for punctured high frequency treatments |
6206907, | May 07 1999 | ENCORE MEDICAL INC | Occlusion device with stranded wire support arms |
6212426, | Jul 28 1995 | Boston Scientific Scimed, Inc | Systems and methods for conducting electrophysiological testing using high-voltage energy pulses to stun tissue |
6214029, | Apr 26 2000 | ev3 Endovascular, Inc | Septal defect occluder |
6221092, | Mar 30 1998 | Nipro Corporation | Closure device for transcatheter operations and catheter assembly therefor |
6231516, | Oct 04 1997 | Pacesetter, Inc | Endoluminal implant with therapeutic and diagnostic capability |
6231561, | Sep 20 1999 | Boston Scientific Scimed, Inc | Method and apparatus for closing a body lumen |
6238415, | Dec 22 1994 | STRYKER EUROPEAN HOLDINGS III, LLC | Implant delivery assembly with expandable coupling/decoupling mechanism |
6251128, | Sep 01 1998 | AFX, INC | Microwave ablation catheter with loop configuration |
6270515, | Oct 17 1994 | Boston Scientific Scimed, Inc | Device for closing a septal defect |
6283935, | Sep 30 1998 | LAUFER M D , MICHAEL D | Ultrasonic device for providing reversible tissue damage to heart muscle |
6287317, | Jun 28 1997 | Medtronic Vascular, Inc | Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures |
6290674, | Sep 20 1999 | Boston Scientific Scimed, Inc | Method and apparatus for closing intracardiac septal defects |
6290699, | Jul 07 1999 | UAB Research Foundation | Ablation tool for forming lesions in body tissue |
6292700, | Sep 10 1999 | ASTORA WOMEN S HEALTH, LLC | Endopelvic fascia treatment for incontinence |
6306424, | Jun 30 1999 | ENDO-SURGERY, INC | Foam composite for the repair or regeneration of tissue |
6312446, | Mar 22 1996 | Boston Scientific Scimed, Inc | Apparatus and method for closing a septal defect |
6325798, | Feb 19 1998 | Mederi RF, LLC; HORIZON CREDIT II LLC | Vacuum-assisted systems and methods for treating sphincters and adjoining tissue regions |
6328727, | Sep 20 1999 | Boston Scientific Scimed, Inc | Transluminal anastomosis method and apparatus |
6336926, | Jan 15 1999 | Gyrus Medical Limited | Electrosurgical system |
6338726, | Feb 06 1997 | VIDACARE, INC | Treating urinary and other body strictures |
6338731, | Mar 17 1999 | NTERO SURGICAL, INC | Method and systems for reducing surgical complications |
6352561, | Dec 23 1996 | W L GORE & ASSOCIATES, INC | Implant deployment apparatus |
6355052, | Feb 09 1996 | PFM MEDICAL AG | Device for closure of body defect openings |
6364853, | Sep 11 2000 | Conmed Corporation | Irrigation and suction valve and method therefor |
6364876, | Oct 23 1998 | MAQUET CARDIOVASCULAR LLC | Vacuum-assisted securing apparatus for a microwave ablation instrument |
6364878, | Jul 07 1999 | Cardiac Pacemakers, Inc | Percutaneous transluminal ablation catheter manipulation tool |
6368340, | Apr 03 1995 | Clamp assembly and method of use | |
6375671, | Apr 19 1999 | Nipro Corporation | Closure device for transcatheter operations |
6379368, | May 13 1999 | ENCORE MEDICAL INC | Occlusion device with non-thrombogenic properties |
6398779, | Oct 23 1998 | TYCO HEALTHCARE GROUP AG; Covidien AG | Vessel sealing system |
6402772, | May 17 2000 | ST JUDE MEDICAL, CARDIOLOGY DIVISION, INC | Alignment member for delivering a non-symmetrical device with a predefined orientation |
6419669, | Sep 20 1999 | Boston Scientific Scimed, Inc | Method and apparatus for patching a tissue opening |
6430446, | May 05 1995 | Thermage, Inc. | Apparatus for tissue remodeling |
6432119, | Mar 17 1999 | ANGIOTRAX, INC | Apparatus and methods for performing percutaneous myocardial revascularization and stimulating angiogenesis using autologous materials |
6436088, | Sep 20 1999 | Boston Scientific Scimed, Inc | Method and apparatus for closing a subcutaneous tissue opening |
6440152, | Jul 28 2000 | ev3 Endovascular, Inc | Defect occluder release assembly and method |
6458100, | Sep 20 1999 | Boston Scientific Scimed, Inc | Atrial septal defect closure catheter |
6461327, | Aug 07 1998 | Edwards Lifesciences Corporation | Atrial isolator and method of use |
6488706, | May 08 1996 | CARAG AG | Device for plugging an opening such as in a wall of a hollow or tubular organ |
6494881, | Sep 30 1997 | Boston Scientific Scimed, Inc | Apparatus and method for electrode-surgical tissue removal having a selectively insulated electrode |
6503247, | Jun 27 1997 | ST JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC | Process and device for the treatment of atrial arrhythmia |
6506189, | May 04 1995 | Covidien AG; TYCO HEALTHCARE GROUP AG | Cool-tip electrode thermosurgery system |
6527767, | May 20 1998 | New England Medical Center | Cardiac ablation system and method for treatment of cardiac arrhythmias and transmyocardial revascularization |
6527786, | Apr 09 1998 | Origin Medsystems, Inc. | System and method of use for ligating and cutting tissue |
6540742, | Jul 24 1997 | Sydney West Area Health Service | Intraoperative endocardial and epicardial ablation probe |
6544260, | Aug 20 1996 | Oratec Interventions, Inc | Method for treating tissue in arthroscopic environment using precooling and apparatus for same |
6551303, | Oct 27 1999 | Boston Scientific Scimed, Inc | Barrier device for ostium of left atrial appendage |
6551344, | Apr 26 2000 | ev3 Endovascular, Inc | Septal defect occluder |
6558375, | Jul 14 2000 | CARDIOFOCUS, INC | Cardiac ablation instrument |
6558385, | Sep 22 2000 | Medtronic Advanced Energy LLC | Fluid-assisted medical device |
6582430, | Jul 07 1999 | Cardiac Pacemakers, Inc. | Ablation catheter manipulation tool and method therefor |
6596013, | Sep 20 2001 | Boston Scientific Scimed, Inc | Method and apparatus for treating septal defects |
6616655, | Jun 03 1999 | Boston Scientific Scimed, Inc | Method and apparatus for performing cardiac ablations |
6623508, | Dec 20 1996 | W L GORE & ASSOCIATES, INC | Self-expanding defect closure device and method of making and using |
6626901, | Mar 05 1997 | COLUMBIA, TRUSTEES OF THE UNIVERSITY IN THE CITY OF NEW YORK, THE; TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE | Electrothermal instrument for sealing and joining or cutting tissue |
6632223, | Mar 30 2000 | The General Hospital Corporation | Pulmonary vein ablation stent and method |
6641579, | Sep 29 2000 | Spectrasonics Imaging, Inc. | Apparatus and method for ablating cardiac tissue |
6650923, | Apr 13 2000 | Boston Scientific Scimed, Inc | Method for accessing the left atrium of the heart by locating the fossa ovalis |
6652517, | Apr 25 2000 | UAB Research Foundation | Ablation catheter, system, and method of use thereof |
6656206, | May 13 1999 | Cardia, Inc. | Occlusion device with non-thrombogenic properties |
6659105, | Apr 03 1998 | SenoRx, Inc. | Tissue specimen isolating and damaging device and method |
6666861, | Oct 05 2000 | COMEDICUS INC | Atrial appendage remodeling device and method |
6666863, | Mar 01 2001 | Boston Scientific Scimed, Inc | Device and method for percutaneous myocardial revascularization |
6673068, | Apr 12 2000 | MAQUET CARDIOVASCULAR LLC | Electrode arrangement for use in a medical instrument |
6673090, | Aug 04 1999 | Boston Scientific Scimed, Inc | Percutaneous catheter and guidewire for filtering during ablation of myocardial or vascular tissue |
6676656, | Sep 09 1994 | CARDIOFOCUS, INC | Surgical ablation with radiant energy |
6701176, | Nov 04 1998 | Johns Hopkins University School of Medicine | Magnetic-resonance-guided imaging, electrophysiology, and ablation |
6702835, | Sep 07 2001 | PROMED, INC | Needle apparatus for closing septal defects and methods for using such apparatus |
6709432, | Apr 26 2002 | Medtronic, Inc | Ablation methods and medical apparatus using same |
6712804, | Sep 20 1999 | Boston Scientific Scimed, Inc | Method of closing an opening in a wall of the heart |
6712815, | Jan 16 2001 | CYTYC Surgical Products | Apparatus and method for treating venous reflux |
6712836, | May 13 1999 | ST JUDE MEDICAL ATG, INC | Apparatus and methods for closing septal defects and occluding blood flow |
6723092, | Dec 15 2000 | BROWN, TONY R | Atrial fibrillation RF treatment device and method |
6730081, | Oct 18 1991 | Endoscopic surgical instrument | |
6735532, | Sep 30 1998 | L. Vad Technology, Inc. | Cardiovascular support control system |
6743184, | Nov 10 1999 | Hologic, Inc; Biolucent, LLC; Cytyc Corporation; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC ; Third Wave Technologies, INC; Gen-Probe Incorporated | System and method for detecting perforations in a body cavity |
6743197, | Jul 10 1996 | Novasys Medical, Inc. | Treatment of discrete tissues in respiratory, urinary, circulatory, reproductive and digestive systems |
6755822, | Jun 01 2001 | CRYOCOR, INC | Device and method for the creation of a circumferential cryogenic lesion in a pulmonary vein |
6764486, | Apr 24 2002 | BIOTRONIK MESS-UND THERAPIEGERAETE GMBH & CO | Ablation device for cardiac tissue, especially for forming a circular lesion around a vessel orifice in the heart |
6770070, | Mar 17 2000 | AngioDynamics, Inc | Lung treatment apparatus and method |
6776780, | Jul 18 1997 | Medtronic, Inc. | Tissue sealing electrosurgery device and methods of sealing tissue |
6780183, | Sep 16 2002 | Biosense Webster, Inc. | Ablation catheter having shape-changing balloon |
6796981, | Sep 30 1999 | TYCO HEALTHCARE GROUP AG; Covidien AG | Vessel sealing system |
6802843, | Sep 13 2001 | Ethicon Endo-Surgery, Inc | Electrosurgical working end with resistive gradient electrodes |
6805130, | Jun 02 1998 | Arthrocare Corporation | Methods for electrosurgical tendon vascularization |
6813520, | Apr 12 1996 | CYTYC SURGICAL PRODUCTS, LLC; CYTEC SURGICAL PRODUCTS, LLC | Method for ablating and/or coagulating tissue using moisture transport |
6821273, | Jan 03 2002 | Microline Surgical, Inc | Combined dissecting, cauterizing, and stapling device |
6913579, | May 01 2001 | Ethicon Endo-Surgery, Inc | Electrosurgical working end and method for obtaining tissue samples for biopsy |
6939348, | Mar 27 2003 | Terumo Kabushiki Kaisha | Energy based devices and methods for treatment of patent foramen ovale |
7165552, | Mar 27 2003 | Terumo Kabushiki Kaisha | Methods and apparatus for treatment of patent foramen ovale |
20010014800, | |||
20010034537, | |||
20010037129, | |||
20010039435, | |||
20010041914, | |||
20010041915, | |||
20010049492, | |||
20020010481, | |||
20020026094, | |||
20020029048, | |||
20020032462, | |||
20020035374, | |||
20020052572, | |||
20020096183, | |||
20020111645, | |||
20020111647, | |||
20020129819, | |||
20020183786, | |||
20020183787, | |||
20030028213, | |||
20030045893, | |||
20030045901, | |||
20030050665, | |||
20030069575, | |||
20030073979, | |||
20030088242, | |||
20030100920, | |||
20030109778, | |||
20030139819, | |||
20030144694, | |||
20030181945, | |||
20030191495, | |||
20030191526, | |||
20030195530, | |||
20030195531, | |||
20030204203, | |||
20030208232, | |||
20040044361, | |||
20040049207, | |||
20040092973, | |||
20040143277, | |||
20040143291, | |||
20040143293, | |||
20040143294, | |||
20040193147, | |||
20040193239, | |||
20040215187, | |||
20040220596, | |||
20040220610, | |||
20040230185, | |||
20040243122, | |||
20040254572, | |||
20040267191, | |||
20040267306, | |||
20050021016, | |||
20050034735, | |||
20050070887, | |||
20050080406, | |||
20050125032, | |||
20050131401, | |||
20050131460, | |||
20060027241, | |||
20060074410, | |||
20060241581, | |||
20060241582, | |||
20060241583, | |||
20060241584, | |||
20060247612, | |||
20060271030, | |||
20060271040, | |||
20060271089, | |||
20060276779, | |||
20060276846, | |||
20070010806, | |||
EP317067, | |||
EP553259, | |||
EP750905, | |||
EP1013227, | |||
EP1046375, | |||
EP1222897, | |||
GB2407985, | |||
WO2005115231, | |||
WO18331, | |||
WO27292, | |||
WO74555, | |||
WO121247, | |||
WO130266, | |||
WO130267, | |||
WO130268, | |||
WO149185, | |||
WO217809, | |||
WO224106, | |||
WO3022159, | |||
WO3026525, | |||
WO3059152, | |||
WO3061481, | |||
WO3073944, | |||
WO3077733, | |||
WO2004086944, | |||
WO2004086951, | |||
WO2005070316, | |||
WO2005070491, | |||
WO9513111, | |||
WO9625179, | |||
WO9629946, | |||
WO9631157, | |||
WO9728744, | |||
WO9839063, | |||
WO9905977, | |||
WO9918862, | |||
WO9918864, | |||
WO9918870, | |||
WO9918871, |
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