An internal plate fixation device is provided for load bearing and non-load bearing fixation on a plantar side of a metatarsocuneiform joint in a lapidus procedure. The fixation device includes a U-shaped plate having a plantar section interconnecting a pair of opposed medial legs which are bent relative to the plantar section. The plantar section is formed with a set of threaded fixation holes for receiving locking screws therein. The legs are formed with a set of threaded fixation holes for receiving locking screws therein, and a set of non-threaded fixation holes for receiving temporary K-wires and an interfragmentary compression screw which provides compression and stability at the joint.
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1. A lapidus plantar fixation device configured for fixation of a metatarsocuneiform joint between a cuneiform and a metatarsal bone during a lapidus procedure, the fixation device comprising:
a fixation plate contoured relative to intersecting x, y and z axes extending perpendicular to each other;
the fixation plate having a U-shape when viewed in an xy plane defined by the x and y axes and including an upper surface, a lower surface and a plantar section having opposite proximal and distal ends extending along the x axis with the y axis extending transversely to and bisecting the plantar section, the plantar section interconnecting a pair of opposed medial legs which are bent relative to the plantar section and extend from the opposite proximal and distal ends of the plantar section with respect to the x and z axes;
wherein the plantar section is formed therethrough with a pair of threaded fixation holes located at opposite ends thereof and formed angularly therethrough a thickness of the plantar section;
wherein each of the legs is formed therethrough with threaded and non-threaded fixation holes spaced further away from the y axis than the threaded fixation holes in the plantar section;
wherein, in the xy plane, the legs are bent rearwardly of the plantar section and the fixation plate has a continuous outer edge that forms an outer extent of all the U-shape when viewed in the xy plane;
wherein each leg has a single threaded fixation hole located adjacent an outer end of each leg, and one of the legs has a length which is longer than a length of the other leg;
wherein a first arcuate guide wall projects angularly from the upper surface of the fixation plate of the plantar section, and extends partially around a top of one of the threaded fixation holes in the plantar section, and a second arcuate guide wall projects angularly from the lower surface of the fixation plate of the plantar section, and extends partially around a bottom of the one of the threaded fixation holes in the plantar section;
wherein the upper surface of the fixation plate of the plantar section is formed with a first grooved channel defining a first bending area located between the threaded fixation holes of the plantar section and extending along the y axis across an entire width of the plantar section;
wherein the other of the legs is formed therethrough with a slotted non-threaded temporary fixation hole located between the first grooved channel and the threaded fixation hole on the other of the legs;
wherein the upper surface of the fixation plate of the other of the legs is formed with a second grooved channel defining a bending area located between the threaded fixation hole on the other of the legs and the slotted temporary fixation hole, and extending across an entire width of the other of the legs;
wherein the one of the legs includes an interfragmentary screw hole which is formed angularly through a thickness of the one of the legs;
wherein a first arcuate guide wall projects angularly from the upper surface of the fixation plate on the one of the legs, and extends partially around a top of the interfragmentary screw hole;
wherein the upper surface of the fixation plate of the one of the legs is formed with a concave recess leading from the outer edge of the fixation plate into the interfragmentary screw hole;
wherein a second arcuate guide wall projects angularly from the lower surface of the fixation plate of the one of the legs, and extends partially around a bottom of the interfragmentary screw hole;
wherein the lower surface of the fixation plate of the one of the legs is formed with a concave recess;
wherein the upper surface of the fixation plate of the one of the legs is provided with third and fourth grooved channels defining bending areas on opposite sides of the interfragmentary screw hole and extending across an entire width of the one of the legs;
wherein the one of the legs is formed therethrough with a non-threaded circular temporary fixation hole between the third and fourth grooved channels;
wherein the plantar section is adapted to engage the cuneiform and the metatarsal bone and extend across the metatarsocuneiform joint;
wherein the other of the legs is adapted to engage the cuneiform and the one of the legs is configured to engage the metatarsal bone;
wherein the plantar section is configured with a twist as the plantar section transitions toward the one of the legs; and
wherein the interfragmentary screw hole defines an axis that extends proximal and slightly dorsal in a direction relative to the one of the legs, the axis being adapted to pass through the metatarsal cuneiform joint and configured to cross axes formed through the threaded screw holes in the plantar section.
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The present application relates to and claims the benefit and priority of U.S. Provisional Patent Application No. 61/788,183 filed Mar. 15, 2013, which is fully incorporated herein by reference.
The present disclosure relates generally to foot and ankle surgery, and more particularly, pertains to a fixation device used in a Lapidus-type procedure for surgically correcting a hallux valgus deformity in the first metatarsocuneiform joint of the foot.
The present inventors have recognized that the prior art does not disclose any internal fixation plate or method of use that is particularly useful in the Lapidus procedure, provides a combined medial, plantar and interfragmentary fixation specific to the Lapidus hallux valgus procedure, and permits non-load bearing or load bearing post-operative care of a person having undergone Lapidus-type surgical repair of the hallux valgus.
The present inventors have sought to provide an internal fixation plate that allows for surgical correction, internal placement of the internal fixation plate, completion and internal fixation of the internal fixation plate and final internal fixation of the internal fixation plate following the Lapidus procedure to repair the hallux valgus.
In one example disclosed herein, an internal fixation device is provided for use in fixation of a metatarsocuneiform joint. The fixation device includes a fixation plate contoured relative to intersecting x, y and z axes extending perpendicular to each other. The fixation plate has a U-shape when viewed in an xy plane defined by the x and y axes and includes an upper surface, a lower surface and a plantar section having opposite proximal and distal ends extending along the x axis with the y axis extending transversely to and bisecting the plantar section. The plantar section interconnects a pair of opposed medial legs which are bent relative to the plantar section, and extend from the opposite proximal and distal ends of the plantar section with respect to the x and y axes. The plantar section is formed therethrough with a set of threaded fixation holes. Each of the legs is formed therethrough with a set of threaded and non-threaded fixation holes spaced further away from the y axis than the threaded fixation holes in the plantar section.
Preferably, the plantar section includes a pair of spaced apart threaded fixation screw holes which are formed angularly through a thickness of the plantar section. The threaded fixation holes in the plantar section are located at opposite ends thereof. A first arcuate guide wall is provided on the upper surface of the fixation plate of the plantar section, and extends partially around a top of one of the threaded fixation holes. A second arcuate guide wall is provided on the lower surface of the fixation plate of the plantar section, and extends partially around a bottom of one of the threaded fixation holes. The upper surface of the fixation plate of the plantar section is provided with a first grooved channel defining a bending area located between the threaded fixation holes. Each leg has a single threaded fixation hole which is located adjacent an outer end of each leg. In a top view of the fixation plate, the legs are bent rearwardly of the plantar section. One of the legs has a length which is longer than a length of the other leg. The plantar section has a thickness which is greater than a thickness of the legs to allow bending of the legs beyond an initial bent curvature thereof. One of the legs is formed with a slotted non-threaded temporary fixation hole. The upper surface of the fixation plate of the one of the legs is formed with a second grooved channel defining a bending area located between the one of the legs and the slotted temporary fixation hole. One of the legs includes a non-threaded interfragmentary screw hole which is formed angularly through a thickness of the one of the legs. A first arcuate guide wall is provided on the upper surface of the fixation plate of the one of the legs, and extends partially around a top of the interfragmentary screw hole. The upper surface of the fixation plate of the one of the legs is formed with a concave recess leading into the interfragmentary screw hole. A second arcuate guide wall is provided on the lower surface of the fixation plate of the one of the legs, and extends partially around a bottom of the interfragmentary screw hole. The lower surface of the fixation plate of the one of the legs is formed with a concave recess leading from the interfragmentary screw hole. The upper surface of the fixation plate of the one of the legs is provided with third and fourth grooved channels defining bending areas on opposite sides of the interfragmentary screw hole. The one of the legs is formed therethrough with a non-threaded circular temporary fixation hole. The threaded fixation screw holes are formed with axes that extend dorsal and slightly distal relative to the plantar section. The threaded fixation holes provided in the legs are formed with axes that extend substantially perpendicularly to the upper surface and the lower surface of the fixation plate. The interfragmentary screw hole is formed with an axis that extends proximal and slightly dorsal in a direction relative to one of the legs. The fixation plate is configured to be engaged on a cuneiform and a first metatarsal bone during and after a Lapidus procedure. The fixation plate has a continuous outer edge that forms an outer extent of all of the U-shape when viewed in the xy plane.
In another example, an internal fixation device used in fixation of a metatarsocuneiform joint defined between a cuneiform and a metatarsal bone includes a U-shaped plate having an upper surface and a lower surface. The U-shaped plate further has a plantar section transferring to and interconnecting a pair of opposed proximal and distal medial legs which are bent relative to the plantar section. The plantar section is formed therethrough with a proximal threaded fixation screw hole and a distal threaded fixation screw hole, and each leg is formed therethrough with a threaded fixation screw hole at a distal end of each leg. The legs are each formed with a non-threaded fixation hole. A proximal locking bone fastener is received in the proximal threaded fixation screw hole of the plantar section. A distal locking bone fastener is received in the distal threaded fixation screw hole of the plantar section. A proximal locking bone fastener is received in the threaded fixation screw hole of the proximal leg. A distal locking bone fastener is received in the threaded fixation screw hole of the distal leg. A non-locking interfragmentary compression bone fastener is received in the non-threaded fixation hole of the distal leg.
Each bone fastener is typically a cannulated screw adapted to receive a K-wire. The non-locking bone fastener includes a shaft which is partially threaded along a lower portion thereof. The locking bone fasteners have shafts which are threaded along entire lengths thereof. The proximal and distal locking bone fasteners are received in the plantar section such that outer ends of the plantar section locking bone fasteners point in a dorsal and slightly distal direction relative to the plantar section, and are configured for engagement with the cuneiform and the metatarsal bone. The proximal and distal locking bone fasteners are received in the leg such that outer ends of the leg locking bone fasteners point in a lateral direction relative to the legs, and are configured for engagement with the cuneiform and the metatarsal bone. The non-locking interfragmentary compression screw is received in the distal leg such that an outer end of the interfragmentary screw points in a proximal and slightly distal direction relative to the distal leg, and is configured for engagement with the cuneiform and the metatarsal bone across the metatarsocuneiform joint.
In another example, a surgical method of fixating a metatarsocuneiform joint between a cuneiform and a metatarsal bone in a Lapidus procedure to correct a hallux valgus deformity includes the steps of: a) providing a U-shaped plate configured to be engaged on a cuneiform and metatarsal bone, the plate having a plantar section interconnecting a pair of proximal and distal opposed legs which are bent relative to the plantar section, wherein the plantar section is formed therethrough with a proximal threaded fixation hole and a distal threaded fixation hole, and wherein each of the proximal and distal legs is formed with a threaded fixation hole and a non-threaded fixation hole and the distal leg is further formed with a non-threaded fixation hole; b) entering the tissues of a foot affected with a hallux valgus deformity using a longitudinally medial incision to gain exposure to a metatarsocuneiform joint; c) positioning the plate across a plantar side of the exposed metatarsocuneiform joint such that outer ends of the legs extend upwardly from the plantar section; d) temporarily fixing the plate across the metatarsocuneiform joint by inserting a K-wire in the non-threaded fixation holes of the legs; e) inserting a non-locking interfragmentary compression screw through the non-threaded fixation hole in the distal leg into the metatarsal bone and a cuneiform across the metatarsocuneiform joint; f) inserting proximal and distal threaded locking screws through the threaded fixation holes in the plantar section into the cuneiform and the metatarsal bone to secure the plantar section across the metatarsocuneiform joint; and g) inserting proximal and distal threaded locking screws through the threaded fixation holes in the legs into the cuneiform and the metatarsal bone to secure the legs on opposite sides of the metatarsocuneiform joint and complete fixation of the plate.
The drawings illustrate the best mode presently contemplated under 35 U.S.C. §112.
For purposes of promoting an understanding of the principles of the invention, reference will now be made to the examples illustrated in the drawings and described in the following written specification. It is understood that no limitation to the scope of the invention is thereby intended. It is further understood that the present invention includes any alterations and modifications to the illustrated example and includes further applications of the principles of the invention as would normally occur to one skilled in the art to which this invention pertains.
A hallux valgus deformity of the forefoot is characterized by lateral deviation (i.e. away from the centerline of the body) of the hallux formed by the proximal phalanx and the distal phalanx, and medial deviation (i.e. towards the center of the body, hallux varus) of the first metatarsal bone or metatarsus. This condition can lead to painful motion of the first metatarsophalangeal (MTP) joint, and adjustments in gait that may ultimately cause problems further up the leg.
Historically, many different surgical procedures have been proposed to correct hallux valgus deformities. In the majority of cases, the surgical treatment involves a osteotomy to correct structural deformities associated with the first metatarsal bone and the hallux phalanges, relieve symptoms and pain and restore proper foot function. The osteotomy results in the creation and correction of metatarsal segments used to return the metatarsus and MTP joint to their normal anatomical positions and restore acceptable hallux valgus. In any osteotomy, it is essential that a fixation device, such as screws, K-wires, pins, plates and the like, be used to maintain correction of the metatarsal segments until bone union occurs.
One well-known surgical operation used for correcting hallux valgus deformities is the Lapidus-type procedure. As first introduced in 1934, the Lapidus procedure involves completing an arthrodesis or fusion of the first metatarsocuneiform joint in the foot in order to attain a desired hallux valgus correction. The metatarsocuneiform joint consists of the first metatarsal long bone of the foot and the first cuneiform bone of the foot which is located just proximal or behind the first metatarsal bone. An arthrodesis or fusion consists of connecting bones together to relieve pain associated with the two bones of the metatarsocuneiform joint rubbing together and causing pain. Arthrodesis, also known as artificial ankylosis or syndesis, is the artificial induction of joint ossification between two bones via surgery. This is done to relieve intractable pain in a joint which cannot be managed by pain medication, splints or other normally indicated treatments. The typical causes of such pain are fractures which disrupt the joint and arthritis. It is mostly commonly preferred on joints in the spine, hand, ankle and foot. Since its introduction, the Lapidus procedure has gained popularity throughout the world for hallux valgus correction.
A Lapidus surgical procedure entails making a dorsal or medial skin incision which begins just proximal to the metatarsocuneiform joint of the foot extending to the base of the first metatarsal bone. Once exposure is obtained, the surgeon prepares the joint of the metatarsocuneiform for fusion or arthrodesis. Preparation entails removing any articular cartilage that may remain on the two joint surfaces, and the object is to expose healthy, bleeding cancellous bone on both sides of the joint in order to obtain an arthrodesis of the joint. Exposing healthy, bleeding cancellous bone is important to allow the two bones to be fused together creating the arthrodesis. A number of variations to the Lapidus procedure has occurred over the years, and reported in the literature which allows a surgeon to prepare the joint surface for a fusion. The object of the Lapidus procedure is to realign the two joint surfaces between the first metatarsal bone and the first cuneiform bone in order to achieve correction of the hallux valgus deformity. Various methods of temporary correction are utilized whether manually, or with the use of instruments or guides to temporarily achieve the appropriate correction position of the metatarsocuneiform joint to achieve correction of the hallux valgus deformity.
Once the Lapidus procedure has been performed and the metatarsocuneiform joint is positioned properly to achieve correction of the hallux valgus deformity, the metatarsocuneiform joint has been previously fixated with various types of screws, metal K-wires, dorsal plates, medial plates, and offset medial plates, but most notably with either screws or medial plates. The fixation techniques reported vary in steps, screw diameter size used, K-wires used, placement, plates, etc.
Historically, the Lapidus procedure has encountered various reported issues with achieving the object of fusing or obtaining an arthrodesis of the metatarsocuneiform joint. There are reported problems with non-unions occurring and requirements for the patient to be non-weight bearing for significant periods in order to achieve the union or arthrodesis of the metatarsocuneiform joint. A non-union occurs when the two bones of the metatarsocuneiform joint fail to fuse together after the Lapidus procedure.
Referring now to the drawings, the present disclosure describes an internal plate fixation device 10 and method of use for obtaining a more rigid, stable and precise fixation of the hallux valgus correction in a Lapidus procedure than previously known.
Referring to
The fixation plate 18 can be constructed of titanium, titanium alloy, stainless steel, plastic, resorbable material, any metal alloy or other suitable material, and is preferably made from titanium alloy. In the exemplary embodiment, the fixation plate 18 is configured with a varied thickness in the plantar section 24 and the medial sections or legs 26, 28 as represented, for example, in
Thickness of the fixation plate 18 is thinner across the respective proximal and distal medial sections or legs 26, 28 to enable low profile fixation of the plate 18 to the cuneiform 12 and the metatarsal bone 14, and to allow bending of the plate 18, if desired, when used in the surgical procedure. Typically, the plantar section 24 has a thickness of no more than 1.8 millimeters and the legs 26, 28 have a thickness of no more than 1.0 millimeter. Although not limited to these dimensions, the fixation plate 18, as shown in
In the exemplary embodiment, the upper surface 20 of the fixation plate 18 is formed across the width thereof with a number of grooved channels defining bending areas for providing additional flexibility in assisting the surgeon with bending of the fixation plate 18. More specifically, a first grooved channel 30 is provided in the plantar section 24, a second grooved channel 32 is provided in the leg 26 and respective third and fourth grooved channels 34, 36 are provided in the distal leg 28.
The fixation plate 18 includes a plurality of set of fixation holes that extend completely through the thickness of the plate 18. Such fixation holes are non-locking (i.e. non-threaded) or locking (i.e. threaded) for receiving K-wires or bone fasteners in the form of cannulated (hollow) screws which are known to slide over the K-wires. More particularly, opposite ends of the plantar section 24 are provided on opposite sides of the first grooved channel 30 with a proximal threaded plantar screw hole 38 and a distal threaded plantar screw hole 40. Both of the threaded plantar screw holes 38, 40 are formed angularly through the plantar section 24 along axes which are dorsal and slightly distal in direction relative to the plantar section 24. An arcuate guide wall 42 rises at an angle from the upper surface 20, and extends partially around the top of the screw hole 40 such as seen in
The proximal medial section or leg 26 is formed at an outer end 46 thereof with a threaded medial screw hole 48. The distal medial section or leg 28 is likewise formed at an outer end 50 thereof with a threaded medial screw hole 52. Axes of the threaded medial screw holes 48, 52 extend generally perpendicularly to the upper surface 20 and the lower surface 22. Diameters of the screw holes 48, 52 are substantially equal. The threaded screw holes 38, 40, 48, 52 define fixation holes which are used in the fixation of the fixation plate 18 to the cuneiform 12 and the metatarsal bone 14. The threaded screw holes 48, 52 are located outside of the threaded screw holes 38, 40, and beyond the opposite proximal and distal ends of the plantar section 24 such that the threaded holes 48, 52 are spaced further away than the threaded holes 38, 40 from the y axis.
In addition, the distal medial section or leg 28 is provided with a non-threaded interfragmentary screw hole 54 which is located between the third grooved channel 34 and the fourth grooved channel 36. The interfragmentary screw hole 54 is formed angularly through a generally central section of the distal leg 28 along an axis which is proximal and slightly dorsal in direction relative to the leg 28. A portion of the upper surface 20 is formed with a concave recess 56 leading from the outer peripheral edge 23 into the interfragmentary screw hole 54. An arcuate guide wall 58 projects at an angle from the upper surface 20, and extends partially around the top of the interfragmentary screw hole 54. A portion of the lower surface 22 is formed with a concave recess 60 exiting from the interfragmentary screw hole 54. An arcuate guide wall 62 extends angularly from the lower surface 22 around a portion of the interfragmentary screw hole 54 at the bottom thereof. The interfragmentary screw hole 54 defines a fixation hole used in fixing the fixation plate 18 across the metatarsocuneiform joint 16.
The fixation plate 18 further includes temporary fixation holes for temporarily fixing the plate 18 to the cuneiform 12 or the metatarsal bone 14 before a final fixation of the plate 18. One temporary fixation hole, as shown in
Referring to
A proximal medial locking screw 76 is received in the threaded medial locking screw hole 48, and a distal medial locking screw 78 is received in the threaded medial locking screw hole 52. The medial locking screws 76, 78 have respective shafts 80, 82 which are variously threaded along substantially entire lengths thereof. The medial locking screws 76, 78 when locked in the fixation plate 18 are designed to have outer ends of the shafts 80, 82 that extend in a lateral direction as depicted in
A non-locking interfragmentary compression screw 84 is received in the non-threaded interfragmentary screw hole 54, and is designed to cross the metatarsocuneiform joint 16 following the Lapidus procedure. The interfragmentary compression screw 84 is also designed to provide compression between fractured fragments at the joint 16, and to enhance stability and promote healing for an arthrodesis procedure. A non-locking screw as used herein, is defined as any screw that is not locked to the plate 18 by threads. The screw 84 has a shaft 86 which is partially threaded at 88 along a lower portion thereof. The screw 84 is guided at an angle relative to the leg 28 by the concave recess 56, the arcuate guide wall 58, the concave recess 60 and the arcuate guide wall 62 so that an outer end of the shaft 86 extends in a proximal and slightly distal direction as seen in phantom lines in
It should be understood that the plate 18 can be constructed to accommodate variously sized diameter locking or non-locking screws with other than those diameter sizes described herein that thread and lock in the plate 18, or that fixate to the plate 18, but do not lock and thread in the plate 18. It should likewise be appreciated that the plate 18 can be variously sized to accommodate a variety of cuneiform and first metatarsal bone anatomies.
The fixation device 10 is particularly useful in connection with a Lapidus procedure for correcting a hallux valgus deformity at a surgically altered metatarsocuneiform joint 16. The goal of the Lapidus procedure is to correct and stabilize the first metatarsal bone 14 at the apex of the hallux valgus deformity. The fixation plate 18 is designed to be advantageously positioned on the tension (plantar) side of the metarsocuneiform joint 16,
The Lapidus procedure commences with a longitudinal medial incision centered slightly plantar to midline over the medial aspect of the first tarsal-metatarsal or metatarsocuneiform joint (MTCJ) 16. Such incision allows for placement of the fixation device 10 as well as excellent exposure of the MTCJ 16. This incision may be extended distally to the first metatarsophalangeal joint (MTP) to enable resection of the medial eminence. A second incision may be indicated to allow for release of the anterior adductor tendon.
Next, the deep fascia covering the anterior tibial tendon is identified, and a longitudinal incision is made to expose the tendon and the capsule of the MTCJ 16. The plate 18 is designed to lay on the plantar surface of the broad insertion of this tendon. The MTCJ 16 is exposed through a longitudinal capsular incision made dorsal to the anterior tibial tendon. The MTCJ 16 is opened and preparation of the joint surface proceeds with the goal to expose healthy, cancellous bone on both sides of the MTCJ 16. The first metatarsal bone 14 is then adducted and plantarflexed as needed to obtain an acceptable position. A number of known intraoperative techniques may be used to obtain proper preparation for positioning of the plate 18.
Referring to
Next, a K-wire 94 is inserted through a drill guide 96 inserted into the interfragmentary screw hole 54 as directed by the guide wall 58 such as depicted in
Referring to
As depicted in
If desired or necessary, the legs 26, 28 may be further bent to adjust to the particular contour of the joint site before final fixation. This is made possible by the bending areas defined by the grooved channels 30, 32, 34, 36 and the decreased thickness of the legs 26, 28 as compared to the plantar section 24.
It is contemplated that the internal fixation plate 18 described herein can be provided in a kit or case with plates 18 of multiple sizes for the left and right forefoot with multiple locking and non-locking bone fasteners or screws 68, 70, 76, 78, 84 and with various tools, instruments, guides and the like to give a surgeon flexibility in selecting the desired means for securing the plate 18 across the MTCJ 16.
The fixation device 10 shown and described provides an internal plantar and medial fixation plate that allows for surgical correction of a hallux valgus deformity, precise placement of the fixation plate, placement of an interfragmentary screw fixation and final fixation of the metatarsal cuneiform joint 16 to complete the Lapidus procedure. The fixation device 10 provides for both non-load and load bearing union at the metatarsocuneiform joint 16. Advantageously, the fixation plate 18 can withstand the weight-bearing capacity of the normal human being and the weight-bearing load displaced to the joint 16 when undergoing the normal walking gait cycle, thus making it an option to bear weight immediately following fixation of the plate 18 after the Lapidus procedure eliminating the concern of non-unions. The fixation device 10 provides the interfragmentary compression screw 84 across the joint 16 to enhance stability and promote healing for the arthrodesis procedure.
In addition, the fixation device 10 is precisely fixed on the plantar (tension) side of the metatarsocuneiform joint 16 to provide a biomechanically superior construct for fusion. The locking screws 68, 70, 76, 78 are positioned to achieve rigid stabilization transferring the weight bearing to the plate 18 and not the surgical site. The plate 18 is formed slightly thicker across the plantar section 24 than the legs 26, 28 to provide strength across the joint 16.
This written description uses examples to disclose the invention, including the best mode, and also to enable any person skilled in the art to make and use the invention. The patentable scope of the invention is defined by the claims, and may include other examples that occur to those skilled in the art. Such other examples are intended to be within the scope of the claims, if they have structural elements that do not differ from the literal language of the claims, or if they include equivalent structural elements with insubstantial differences from the literal language of the claims.
Various alternatives and embodiments are contemplated as being within the scope of the following claims, particularly pointing out and distinctly claiming the subject matter regarded as the invention.
Anapliotis, Emmanuel, Buchanan, Matthew, Austin, Albert E.
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Mar 03 2014 | BUCHANAN, MATTHEW | Merete Medical GmbH | ASSIGNMENT OF ASSIGNORS INTEREST SEE DOCUMENT FOR DETAILS | 034760 | /0783 | |
Mar 03 2014 | AUSTIN, ALBERT E | Merete Medical GmbH | ASSIGNMENT OF ASSIGNORS INTEREST SEE DOCUMENT FOR DETAILS | 034760 | /0783 | |
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