The invention concerns herbal compositions which improve lactation of farmed livestock comprising an effective amount of an extract and/or at least one bioactive fraction or powder from herbs such as Asparagus, Gossypium, Foeniculum, Lepidium, Chlorophytum, Ipomoea, Withania, Leptadenia and optionally dicalcium phosphate, chelated minerals and/or mineral mixture.
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1. A method for improving milk letting down in a milch animal comprising:
selecting a milch animal with a let-down problem, and
feeding an effective amount of an herbal composition to the milch animal with the let-down problem, wherein the herbal composition comprises at least four powders or extracts obtained from (i) Asparagus racemosus, (ii)Gossypium arboreum, (iii) Foeniculum vulgare or Chlorophytum borivilianum, and (iv) Lepidium sativum or Ipomoea digitata,
thereby improving milk letting down in the milch animal with the let-down problem.
16. A method for improving milk letting down in a milch animal comprising:
selecting a milch animal with a let-down problem, and
feeding an effective amount of an herbal composition to the milch animal with the let-down problem, wherein the herbal composition comprises at least four herbs in powder form selected from: (i) 40 to 70% (w/w) Asparagus racemosus, (ii) 5 to 20% (w/w) Gossypium arboretum, (iii) 10 to 25% (w/w) Foeniculum vulgare or 10 to 25% (w/w) Chlorophytum borivilianum, and (iv) 10 to 25% (w/w) Lepidium sativum or 10 to 25% (w/w) Ipomoea digitata wherein the combined percentage does not exceed 100%,
thereby improving milk letting down in the milch animal with the let-down problem.
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This application is a divisional of U.S. patent application Ser. No. 13/501,574, filed Apr. 12, 2012, which is a U.S. National Stage entry of PCT/IN2009/000572, filed Oct. 12, 2009, each of which is incorporated by reference in its entirety herein.
The invention relates to herbal compositions for solving problem of letting down of milk in milch animals by feeding either through the concentrate feed or feed supplement. More specifically, the present invention is related to an alternative herbal based remedy for solving problem of letting down of milk in milch animals. The herbal composition acts on central nervous system, giving stress free anxiolytic effect resulting in a smooth ejection. It makes the contraction of the cisternal cavity to facilitate milk ejection which helps the emptying of alveoli. The herbal composition increases the blood circulation in the udder which reduces the chances of occurrence of infections such as Mastitis, udder, oedema etc. The herbal composition reduces milk resurge time taken for the milk ejection after initiation of the tactile stimulus. The composition comprises an effective amount of an extract and/or at least one bioactive fraction or powder from herbs such as Asparagus, Gossypium, Foeniculum, Lepidium, Chlorophytum, Ipomoea, Withania, Leptadenia etc. with or without dicalcium phosphate (DCP), chelated minerals and mineral mixture; and process for the preparation of such extracts or powder and herbal compositions.
The “Letting down” is a reflex, which is stimulated by the hormone oxytocin. The actual milking can begin after the letting down reflex has been elicited. The hormone oxytocin is required to enable milch animal to fully letting down the bulk of her milk. A sucking calf or a gentle pre-milking routine is the only way for the ilch animal to release this hormone and letting down her milk more fully.
Suckling for a short period (1-2 minutes only) before milking, to stimulate milk letting down is a common practice in many farms, but the presence of calves during milking may complicate management, specially when machine milking is used. An alternatively used in some farms is only to allow suckling after milking.
Milking stimuli, such as a sucking calf, a warm wash cloth, the regime of parlour etc., causes the release of a hormone called oxytocin. Oxytocin is released from the pituitary gland, below the brain, to begin the process of milk letting down. As a result of this hormone stimulation, the muscles begin to compress the alveoli, causing a pressure in the udder known as letting down reflex, and the milk components stored in the lumen are released into the duct system. The milk is forced down into the teat cistern from which it is milked. The letting down reflex fades as the oxytocin is degraded, within 4-7 minutes. It is very difficult to milk after this time.
Ejection of milk is accomplished by contraction of the myo-epithelial cells surrounding each alveolus. The ejection process results in a rapid transfer of milk from the lobulo-alveolar spaces into larger ducts. The flow of milk due to passive withdrawal, which is greatly increased following ejection, is commonly known as letting down. In some occasions, the intra-mammary pressure is sufficiently great to overcome the resistance of the teat sphincter so that the milk may leak from the teat. Milk ejection is a neurohormonal reflex associated with the release of oxytocin. Milk ejection reflex has a neural (afferent) and a hormonal (efferent) component.
Physical stimulation of the teats, either by the calf's suckling or the milkers hands, excite receptors from which nerve impulses are send to the posterior pituitary gland causing secretion of the hormone oxytocin. The hormone is transported via the blood to the mammary gland. Because both hormones and nerve impulses are involved in the milk ejection reflex, it is called a neurohormonal reflex. Oxytocin stimulates the contraction of the alveoli and small ducts thereby emptying the milk into the larger ducts and the cistern. Hereafter the milk can be evacuated from the udder.
The contraction of the alveoli may, to some extent, be enhanced by tactile stimuli of the udder (massaging, squeezing) the so-called tap reflex. When calves suckle, they butt at the udder in order to increase milk secretion. Manual massage of the udder during milking imitates this reflex.
The greatest amount of innervation in the mammary gland of the milch animal is in the teats. Mechanical stimulation of the teat activates pressure-sensitive nerve receptors in the skin of the teat. The nerve impulses travel to the brain through the spinothalamic nerve tract. When the cell bodies of the oxytocin-containing neurons are stimulated by these impulses originating in the teat, an action potential moves down the oxytocin-containing neurons from the cell body in the hypothalamus down the axon to the neuron ending in the posterior pituitary. This causes release of oxytocin and neurophysin into the blood. The efferent pathway starts at this point. The efferent pathway begins with the release of oxytocin into the blood. Oxytocin is released into the blood in response to action potential of nerve impulses originated in the teat. It then travels to the mammary gland and binds to protein receptor sites on the epithelial secretory cells. This results in contraction of the secretory cells and expulsion of milk from the mammary gland.
Various stressful stimuli that inhibit milk ejection are associated with increased activity of the sympathetic nervous system. Oxytocin action can be blocked by catecholamines (epinephrine and norepinephrine). The hormones are usually released in response to stressful situations and increase the tone of the smooth muscles of the mammary ducts and blood vessels. This results in the reduction of oxytocin reaching the myo-epithelial cells and partial occlusion of the mammary ducts. Moreover, epinepherin directly blocks oxytocin from binding to myo-epithelial cells. This is termed as peripheral inhibition of milk ejection. Thus, exogenous oxytocin will not cause milk ejection in animals exhibiting peripheral inhibition.
A common cause of failure to milk ejection is associated with stress. The stress inhibits the release of oxytocin from the posterior pituitary gland (central inhibition of milk ejection). Exogenous oxytocin is usually administered in these cases causing milk ejection. Based on the above discussion about peripheral and central inhibition of milk ejection, it can be stated that milk ejection occurs as a result of oxytocin release, which is normally couples with inhibition of the central and peripheral inhibitory controls. Milch animals are sensitive to changes in the environment. They may withhold the milk, if they are uncomfortable with the situation. If the animals are stressed, scared or in pain, the hormone adrenaline is secreted. This hormone causes constriction of the blood vessels, thereby hindering the supply of sufficient amount of oxytocin to the udder. Adrenaline also directly acts on the myo-epithelial cells in the alveoli by blocking the oxytocin receptors. The inhibition if milk letting down will result in the leaving of milk in the secretory parts of the udder. Continuous exposure of stress to the cattle will affect the milk production negatively. Post parturient death of calf, separation of calf after birth, change of place, owner, climatic conditions and stress due to long travel, change of milker or milking routine, application of wrong milking technique or milking machines in bad conditions are the main reasons for the milch animals to withhold the milk.
In the case of cattle which do not normally letting down milk in the absence of the calf, it is traditional practice to stimulate milk flow by very brief suckling followed by partial milking, after which the calf is allowed to suck the residual milk. Poor milk ejection can be due to impaired oxytocin release, mammary insensitivity to oxytocin or to pituitary dysfunction (Murugaiyah et al., 2001). Moreover, cow's temperament can contribute to the impaired milk ejection since stress was found to inhibit oxytocin release (Bruckmaier and Blum, 1998).
Milch animals are susceptible to shock or stress caused from nutritional deficiencies, trauma, infection or extreme environmental changes such as lot adaptation stress in animal. While such stress does not necessarily exhibit its most extreme form in shock in all cases, it nevertheless adversely affects the milch animal. Unfortunately, if animals are frightened, fear may trigger the release of the hormone adrenaline, which is an antagonist of oxytocin. Death of calves is a common reason for short lactations, as tropical milch animal often fail to letting down of milk unless stimulated by suckling. Due to this there is a decrease in the milk production.
The milk producers are not having alternative remedy for solving problem of letting down of milk in milch animals, oxytocin injection is still used for the same inspite of knowing its undesirable side effects. Moreover the biochemical half-life of injected oxytocin is very short and requires several injections. Oxytocin injection which may result into get animal habituate as well as hormonal imbalance which causes fertility problems like repeat breeding, threats of abortion and threats of uterine prolapse. Biosecurity is another problem, since many farmers use same needle for the different animals which spreads contagious diseases. A better way would be the use of a long action composition, which provided a similar response over an extended time period.
There are very few patents available for solving the problem of milk letting down in cattle and related one include U.S. Pat. No. 4,490,391, which discloses the composition for treatment of shock and stress in animals comprising equal volume amounts of solutions of sodium acetate and sodium propionate. U.S. Pat. No. 4,349,544 discloses the method for increasing the milk let down in mammals by the use of long-acting oxytocin analogs. But none of the prior art documents disclose the solving problem of letting down of milk in milch animals by using the naturally available medicinal herbs.
A significant problem with herbal medicine is that herbs are slow acting in treating an ailment. In contrast, allopathic drugs act comparatively quickly. For this reason, veterinarians prefer allopathic drugs as the effective means of treatment, even though the drugs have side effects. Clearly, it would be desirable to increase the speed by which herbal medicines act, but while maintaining the natural, herbal character of the medicine so as to avoid or minimize harmful side effects. An increasing number of people are gaining awareness of the advantages of herbal medicine together with a concern over the disadvantages of modern purified drugs. Consequently, there has been an increasing public interest in the use of herbal based compositions. Thus, many people consider herbs primarily useful as a maintenance or prophylactic treatment to be taken regularly in order to prevent onset of illness. A faster acting type of herbal medicine would create far broader utility.
Accordingly, there is a real and continuing need for an inexpensive shock and/or stress treatment composition to cattle for increasing the milk production. Hence the present inventor aims to develop the compositions and specifically to those compositions with naturally occurring herb extracts and/or bioactive fraction or powder to solve the problem of letting down of milk in milch animals without the undesired side effects. In particular, the herbal compositions, which can be fed to cattle for solving the problems letting down of milk in milch animal. The present invention provides compositions that require little technical expertise to use and may be used as a nutritional supplement for milch animal. The compositions are inexpensive and cost effective.
It is the primary object of the invention to provide herbal compositions for solving problem of letting down of milk in milch animals by feeding the composition either through the concentrate feed or feed supplement.
It is an object of the invention to develop an alternative herbal based remedy using herbal extracts and/or bioactive fraction or powder for solving problem of letting down of milk in milch animals.
It is another object of the present invention to increase milk production in milch animal by feeding the herbal composition.
It is yet another object of the present invention to increase the acceptance of milk obtained after feeding the present invention herbal compositions in comparison to milk obtained by applying an injection of oxytocin to milch animal.
It is the further object of the present herbal compositions to increase dietary intake of vitamins and minerals associated with hormone production by improving the overall nutritional status of the cattle.
It is a further object of the present invention to provide herbal compositions having a longer shelf life.
It is a further object of the present invention to develop herbal compositions, which are inexpensive and cost effective.
Herbal based feed compositions for solving problem of letting down of milk in milch animals comprising mixture of effective amount of an extract and/or bioactive fraction or powder of at least one medicinal herb. The medicinal herbs are selected from the group of Asparagus, Gossypium, Foeniculum, Lepidium, Chlorophytum, Ipomoea, Withania and Leptadenia. The above said medicinal herbs are essentially selected from the group of Asparagus racemosus, Gossypium arboreum (herbaceum), Foeniculum vulgare, Lepidium sativum, Chlorophytum borivilianum, Ipomoea digitata, Withania somnifera and Leptadenia reticulata. The above said herbal mixture comprises at least four medicinal herbs which are Asparagus racemosus, Gossypium arboreum (herbaceum), Foeniculum vulgare or Chlorophytum borivilianum, Lepidium sativum or Ipomoea digitata. The effective amount of an extract or bioactive fraction or powder ranges 20 to 70% (w/w) Asparagus racemosus, 2.5 to 25% (w/w) Gossypium arboreum (herbaceum), 10 to 70% (w/w) Foeniculum vulgare or 10 to 70% (w/w) Chlorophytum borivilianum, 10 to 70% (w/w) Lepidium sativum or 10 to 70% (w/w) Ipomoea digitata. The above said effective amount of an extract or bioactive fraction or powder preferably 30 to 50% (w/w) Asparagus racemosus, 5 to 20% (w/w) Gossypium arboreum (herbaceum), 20 to 35% (w/w) Foeniculum vulgare or 20 to 35% (w/w) Chlorophytum borivilianum, 15 to 30% (w/w) Lepidium sativum or 15 to 30% (w/w) Ipomoea digitata. The effective amount of an extract or bioactive fraction or powder more preferably 40% (w/w) Asparagus racemosus, 10% (w/w) Gossypium arboreum (herbaceum), 25% (w/w) Foeniculum vulgare or 25% (w/w) Chlorophytum borivilianum, 25% (w/w) Lepidium sativum or 25% (w/w) Ipomoea digitata. Herbal based feed compositions for solving problem of letting down of milk in milch animals optionally comprise one or more of the ingredients selected from 5 to 50% (w/w) dicalcium phosphate, dolomite, calcite, chelated minerals and mineral mixture.
The invention relates to herbal feed compositions for solving problem of letting down of milk in milch animals. More specifically, the present invention is related to an alternative herbal based composition for improving milk letting down in cattle. The herbal composition acts on central nervous system, giving stress free anxiolytic effect resulting in a smooth ejection. It makes the contraction of the cisternal cavity to facilitate milk ejection which helps the emptying of alveoli. The herbal composition increases the blood circulation in the udder which reduces the chances of occurrence of infections such as Mastitis, udder, oedema etc. The herbal composition reduces milk resurge time taken for the milk ejection after initiation of the tactile stimulus.
The invention is a synergistic formulation of an effective amount of an extract and/or at least one bioactive fraction or powder from herbs such as Asparagus, Gossypium, Foeniculum, Lepidium, Chlorophytum, Ipomoea, Withania, Leptadenia etc. with or without dicalcium phosphate (DCP), dolomite, calcite, chelated minerals and mineral mixture. The DCP acts as a source of calcium and phosphorous.
The compositions can be used in several forms: powdered feed form, concentrate form, blender form and base mix form.
As used herein, the term “effective amount” means an amount necessary to achieve a desired result in solving problem of letting down of milk in milch animals.
The herbal feed compositions for solving problem of letting down of milk in milch animals mainly comprises the mixture of effective amount of an extract or bioactive fraction or powder of following medicinal herbs:
1. Asparagus racemosus: Family—Asparagaceae
It is a tall climbing, much-branched, spiny shrub with annual woody, white-grey or brown stems armed with strong, straight or recurved spines 0.5 -1.3 cm long; rootstock short, tuberous, bearing numerous fusiform, succulent tuberous roots 30-100 cm long and 1-2 cm thick. Flowers white, fragrant, small, crowded in simple and branched racemes 5-15 cm long. Fruits globose, red when ripe, 3-lobed, 0.4-0.6 cm in diameter.
2. Gossypium arboreum: Family: Malvaceae
It is commonly called tree cotton, is a species of cotton native to India and Pakistan and other tropical and subtropical regions of the Old World. There is evidence of its cultivation as long ago as 2000 BC by the Harappan civilization of the Indus Valley for the production of cotton textiles. This species of cotton was introduced into East Africa by about 2000 years ago, and was grown by the Meroe civilization in Nubia, the first cotton weavers in Africa. The shrub was included in Linnaeus's Species Plantarum published in 1753. The holotype was also supplied by him, which is now in the Linnean Herbarium in the Swedish Museum of Natural History.
3. Foeniculum vulgare: Family: Apiaceae
It is also known as common fennel and generally grows upto 1.5 mts high (Encyclopedia of Common Natural Ingredients, Used in Food, Drugs, and Cosmetics, p. 169 (1980)). The dried ripe fruit of this herb is commonly called fennel seed. The plant is also known in Arabic as Shamar. The plant is found in North Africa (Egypt), India and South America.
4. Lepidium sativum: Family—Brassicaceae
It is a fast-growing, edible plant botanically related to watercress and mustard and sharing their peppery, tangy flavor and aroma. In some regions, garden cress is known as garden pepper cress, pepper grass or pepperwort. Garden cress is a green perennial plant used as a leaf vegetable consumed by humans typically as a garnish. Undisturbed garden cress can grow to a height of two feet with minimal maintenance. When mature, garden cress produces white flowers, and small seedpods. Garden cress is used as a medicine in India in the system of ayurveda to prevent postnatal complications. Cress may be given to pet birds such as budgerigars for a healthy and fresh treat.
5. Chlorophytum borivilianum: Family—Liliaceae
It is eaten as a leaf vegetable in some parts of India, and its roots are used medicinally as a sex tonic under the name safed moosli. Safed Musli was originally grown in thick forest in natural form, and is a traditional medicinal plant. Mainly its tuberous roots are used in ayurvedic medicines. Roots are used for the preparation of nutritive tonic used in general sexual weakness. Now-a-days, there is a very vast demand all over the world (Specially gulf countries and cold countries). Due to its vast demand it is very costly. Safed Musli is a herb with sub-erect leaves and tuberous root system. It can grow up to a maximum height of 1.5 ft. Tubers can grow up to a depth of 10″. Safed Musli is a tiny annual herb that grows well in tropical and sub-tropical climates with altitudes up to 1500 meters. Safed Musli has its origin in the India Subcontinent.
6. Ipomoea digitata: Family—Convolvulaceae
The genus occurs throughout the tropical and subtropical regions of the world, and comprises annual and perennial herbaceous plants, lianas, shrubs and small trees; most of the species are twining climbing plants.
7. Withania somnifera: Family—Solanaceae
It is an erect, evergreen, grayish tomentose shrub 0.3-2 m tall, with fairly long, stout, fleshy, whitish-brown roots.Leaves simple, alternate or subopposite, broadly ovate, glabrous, 5-12 cm long and 2.5-7 cm wide, apex subacute, base unequal, margins entire, finely stellate-pubescent beneath; main nerves about 6 pairs; petioles 0.3-1.7 cm long. The roots are considered alternative, germicidal, aphrodisiac and diuretic; they are used in Ayurveda to treat ulcers, fever,dyspnoea, cough, consumption, dropsy, rheumatism, toxicosis and memory loss. The powdered roots mixed with equal parts of honey and ghee is thought to be beneficial for impotence or seminal debility. The roots as well as the bruised leaves are also used externally to treat ulcers, painful swellings and scabies. The total alkaloids present in the roots produce relaxant and anti spasmodic effects. The fruits and seeds are diuretic. The leaves are considered anthelmintic and bitter, and their infusion is given to relieve fever.
8. Leptadenia reticulata: Family—Asclepiadaceae
It is known as jivanti (or svarnajivantz) in Sanskrit literature, the name (jiv=life) indicates that the plant is considered to have the ability to bestow health and vigour. It is considered to be a rasayana and included among the 10 drugs constituting the Jivaniya gana or ‘vitalising group. Found in the sub-Himalayan tracts of Punjab and Uttar Pradesh and throughout the Deccan peninsula up to an altitude of 900 m and found particularly in hedges. It is also distributed throughout Mauritius, Madagascar, Sri Lanka, the Himalayas and Burma. A twining shrub, with numerous branches, the stems of which have a cork-like, deeply cracked bark, glabrous in the younger ones. Leaves coriaceous, ovate, acute, glabrous above, finely pubescent below. Flowers greenish-yellow, in lateral or subaxillary cymes, often with small hairs. Fruit follicles may be woody. The external surface of the root is rough, white or buff coloured with longitudinal ridges and furrows, and in transverse section, the wide cork, lignified stone cell layers and medullary rays can be seen.’ In commerce, the root samples vary from 3 to 10 cm in length and 1.5 to 5 cm in diameter.
TABLE 1
Details of the medicinal herbs used in herbal feed compositions for solving
problem of letting down of milk in milch animals are as below:
Latin
Common
Geographical
Parts
Adverse
S.No
Binomial
Names
Distribution
Used
Quantity
Effects
1
Asparagus
Shatawari
Throughout
Roots &
20-70%
None
racemosus
India
Leaves
Preferably
40%
2
Gossypium
Kapasbeej
Throughout
Seeds
2.5-25%
None
arboreum
India
Preferably
10%
3
Foeniculum
Badishep
North India
Seeds
10-70%
None
vulgare
Preferably
25%
4
Lepidium
Haliv
Throughout
Seeds
10-70%
None
sativum
India
Preferably
25%
5
Chlorophytum
Safed
Maharashtra &
Roots
10-70%
None
borivilianum
Musli
Gujarat
Preferably
25%
6
Ipomoea
Vidarikanda
Throughout
Roots
10-70%
None
digitata
India
Preferably
25%
7
Withania
Ashwagandha
Throughout
Roots &
10-70%
None
somnifera
India
Leaves
Preferably
25%
8
Leptadenia
Jeevanti
Throughout
Seeds,
10-70%
None
reticulata
(Dori)
India
Leaf,
Preferably
Root &
25%
whole
plant
Method-I
The present invention herbal feed compositions are prepared by one type of method comprising the following steps:
Method-II
The present invention herbal feed compositions are prepared by another type of method comprising the steps as below:
The following specific examples presented to illustrate the herbal feed compositions for solving problem of letting down of milk in milch animals prepared by above said method I, but do not limit the scope of the invention and additional compositions are being prepared and tested.
TABLE 2
Specific combinations prepared are as following:
A)
Medicinal
Composition (% by weight)
Herb
I
II
III
IV
V
VI
VII
VIII
IX
X
XI
XII
XIII
XIV
XV
XVI
XVII
XVIII
Asparagus
20
30
40
50
60
70
40
50
30
30
30
25
50
45
40
35
25
20
racemosus
Foeniculum
20
20
20
15
15
10
20
30
40
50
60
60
20
20
15
10
10
7.5
vulgare
Lepidium
35
20
20
25
15
15
30
10
20
10
05
12.5
20
30
40
50
60
70
sativum
Gossypium
25
25
20
10
10
05
10
10
10
10
05
2.5
10
05
05
05
05
2.5
arboreum
B)
Medicinal
Composition (% by weight)
Herb
I
II
III
IV
V
VI
VII
Asparagus racemosus
50
50
50
100
—
—
—
Foeniculum vulgare,
50
—
—
—
100
—
—
Lepidium sativum
—
50
—
—
—
100
—
Gossypium arboreum
—
—
50
—
—
—
100
TABLE 3
Specific combinations prepared are as following:
A)
Medicinal
Composition (% by weight)
Herb
I
II
III
IV
V
VI
VII
VIII
IX
X
XI
XII
XIII
XIV
XV
XVI
XVII
XVIII
Asparagus
20
30
40
50
60
70
40
50
30
30
30
25
50
45
40
35
25
20
racemosus
Chlorophytum
20
20
20
15
15
10
20
30
40
50
60
60
20
20
15
10
10
7.5
borivilianum
Ipomoea
35
20
20
25
15
15
30
10
20
10
05
12.5
20
30
40
50
60
70
digitata
Gossypium
25
25
20
10
10
05
10
10
10
10
05
2.5
10
05
05
05
05
2.5
arboreum
B)
Medicinal
Composition (% by weight)
Herb
I
II
III
IV
V
VI
VII
Asparagus racemosus
50
50
50
100
—
—
—
Chlorophytum
50
—
—
—
100
—
—
borivilianum
Ipomoea digitata
—
50
—
—
—
100
—
Gossypium arboreum
—
—
50
—
—
—
100
TABLE 4
Specific combinations prepared are as following:
Composition (% by weight)
Ingredient
I
II
III
IV
V
VI
VII
VIII
IX
X
XI
XII
XIII
XIV
XV
XVI
XVII XVIII
Asparagus
20
25
35
45
55
65
35
35
25
25
25
20
45
40
35
30
25
20
racemosus
Foeniculum
15
25
20
15
15
10
30
25
20
30
50
50
10
20
15
10
10
7.5
vulgare
Lepidium
20
25
10
15
15
15
20
10
25
10
05
12.5
10
20
20
30
40
50
sativum
Gossypium
7.5
10
7.5
7.5
7.5
2.5
7.5
7.5
7.5
7.5
05
2.5
7.5
05
05
2.5
2.5
2.5
arboreum
Dicalcium
37.5
15
27.5
17.5
7.5
7.5
7.5
22.5
22.5
27.5
15
15
27.5
15
25
27.5
22.5
20
phosphate
(DCP)
TABLE 5
Specific combinations prepared are as following:
Composition (% by weight)
Ingredient
I
II
III
IV
V
VI
VII
VIII
IX
X
XI
XII
XIII
XIV
XV
XVI
XVII
XVIII
Asparagus
20
25
35
45
55
65
35
35
25
25
25
20
45
40
35
30
25
20
racemosus
Chlorophytum
15
25
20
15
15
10
30
25
20
30
50
50
10
20
15
10
10
7.5
borivilianum
Ipomoea
20
25
10
15
15
15
20
10
25
10
05
12.5
10
20
20
30
40
50
digitata
Gossypium
7.5
10
7.5
7.5
7.5
2.5
7.5
7.5
7.5
7.5
05
2.5
7.5
05
05
2.5
2.5
2.5
arboreum
Dicalcium
37.5
15
27.5
17.5
7.5
7.5
7.5
22.5
22.5
27.5
15
15
27.5
15
25
27.5
22.5
20
phosphate
(DCP)
The study is conducted on a sample of 25 cattle (buffaloes/cows) which are having the problems of letting down of milk from many days by one or the other reason and are routinely treated with injectable oxytocin. The above selected cattle are injected with injectable oxytocin for 10 days and during which the milk yield is recorded from each cattle whenever the injection is given. Then after a gap of 5 days the same above cattle are fed by the herbal composition of present invention specifically composition no. V of Table-2A at a recommended dose of 15 g/day/cattle for a period of 10 days and during which also the milk yield recorded from each cattle. The feed composition has not only solved problems letting down of milk in cattle but also shown rise in milk by 250-500 ml/day after 3 days from the date of feeding. It also solved the problems of side effects associated with giving injectable oxytocin. Hence the composition serves for solving the problem of letting down of milk in milch animals without harming the cattle in every respect and also increases the acceptance of the milk by people without doubts in their mind by producing hygienic milk.
A synergistic effect is achieved when the above said herbs are included in a composition, preferably at least four herbs over those fed without the herbal composition. Thus, one embodiment of the invention provides a method of selecting herbs for compositions according to these principles. It is an important aspect of the combination herbal preparation of the present invention that it contains a mixture of herbs, or extracts of herbs. An unexpected synergistic effect is exhibited by the various ingredients of the herbal preparation of the present invention. The strategic combination of herbs of the present invention exhibits beneficial effects when optimally combined as discussed above. The advantage of the polyherbal composition also minimizes the risk of development of drug resistance.
Unless otherwise indicated, all numbers expressing quantities of ingredients, properties such as molecular weight, reaction conditions, and so forth used in the specification and claims are to be understood as being modified in all instances by the term “about.” Accordingly, unless indicated to the contrary, the numerical parameters set forth in the specification and attached claims are approximations that may vary depending upon the desired properties sought to be obtained by the present invention. At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques.
Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements.
The terms “a,” “an,” “the” and similar referents used in the context of describing the invention (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. Recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., “such as”) provided herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention.
Groupings of alternative elements or embodiments of the invention disclosed herein are not to be construed as limitations. Each group member can be referred to and claimed individually or in any combination with other members of the group or other elements found herein. It is anticipated that one or more members of a group can be included in, or deleted from, a group for reasons of convenience and/or patentability. When any such inclusion or deletion occurs, the specification is deemed to contain the group as modified thus fulfilling the written description of all Markush groups used in the appended claims.
Certain embodiments of this invention are described herein, including the best mode known to the inventors for carrying out the invention. Of course, variations on these described embodiments will become apparent to those of ordinary skill in the art upon reading the foregoing description. The inventor expects skilled artisans to employ such variations as appropriate, and the inventors intend for the invention to be practiced otherwise than specifically described herein. Accordingly, this invention includes all modifications and equivalents of the subject matter recited in the claims appended hereto as permitted by applicable law. Moreover, any combination of the above-described elements in all possible variations thereof is encompassed by the invention unless otherwise indicated herein or otherwise clearly contradicted by context.
Specific embodiments disclosed herein can be further limited in the claims using consisting of or and consisting essentially of language. When used in the claims, whether as filed or added per amendment, the transition term “consisting of” excludes any element, step, or ingredient not specified in the claims. The transition term “consisting essentially of” limits the scope of a claim to the specified materials or steps and those that do not materially affect the basic and novel characteristic(s). Embodiments of the invention so claimed are inherently or expressly described and enabled herein.
In closing, it is to be understood that the embodiments of the invention disclosed herein are illustrative of the principles of the present invention. Other modifications that can be employed are within the scope of the invention. Thus, by way of example, but not of limitation, alternative configurations of the present invention can be utilized in accordance with the teachings herein. Accordingly, the present invention is not limited to that precisely as shown and described.
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