Transdermal therapeutic system

Abstract

The invention relates to a transdermal therapeutic system for administering or applying active substances to the skin with a backing layer remote from the skin, an active substance depot, an active substance delivery control means controlling the delivery of the active substance through the system and a contact pressure sensitive adhesive means for fixing the therapeutic system to the skin, in which the active substance depot is a multichamber system, in which discreet chambers contain one or more active substances.

Description

BACKGROUND AND SUMMARY OF THE INVENTION

The invention relates to a transdermal therapeutic system for the administration of active substances to the skin with a backing layer remote from the skin, an active substance depot, an active substance delivery control device controlling the delivery of the active substance through the system and a contact pressure sensitive adhesive in this embodiment. However, the matrix is dependent on the active substance used. Chambers 14 for the active substance are formed in the matrix and are filled with a liquid active substance, such as a nicotine solution. Between the individual chambers 14, the two active substance layers stick together and thus prevent the free flow of nicotine solution in the entire chamber system 14. The active substance, here nicotine, is dissolved in the matrix and the liberation rate of the transdermal system is inter alia determined by the diffusion rate of the active substance in the active substance matrix. Below the active substance matrix, which here completely surrounds the chambers 14, is applied a contact pressure sensitive adhesive layer 19, which is suitable for fixing the system to the skin. This contact pressure sensitive adhesive layer is also permeable for the active substance and can optionally have a controlling action on the active substance delivery to the skin.

FIG. 2 shows a further preferred embodiment of an inventive plaster-like, transdermal therapeutic system in cross-section and in this case different chambers 14', 14 are formed in two different active substance matrixes 12, 12', which can e.g. contain different active substances or different active substance formulations. The two active substance matrices can be chosen in accordance with requirements of the particular active substance delivery speed. The system has an uninterrupted adhesive layer 19 for application to the skin or for fixing the system to the skin, the adhesive also having a certain control effect.

FIG. 3 shows an easy to manufacture inventive embodiment, in which the chambers 14 are formed in a contact pressure sensitive adhesive active substance matrix 12' adhesion characteristics of which are also adequate for fixing the system to the skin.

FIG. 4 shows another preferred embodiment of an inventive transdermal therapeutic system, in which the active substance chambers 14 are interconnected by channels, so that e.g. in the case of local pressure application to the system the active substance-containing liquid contained in the channel system/chambers 14 can flow for pressure compensation purposes.

FIG. 5 shows an inventive system, in which the multichamber system comprises channels 15 with active substance arranged in lattice-like manner. Here again the backing layer 10 of the system is removed, so that it is possible to see the active substance depots.

FIG. 6 shows an embodiment of the invention, in which the individual adhesive regions 19 are arranged in the active substance matrix 12, in order to fix the system to the skin, whilst the active substance delivery in this case mainly takes place vie the non-adhering or slightly adhering active substance matrix surfaces.

FIG. 7 shows an embodiment with concentric, channel-like chambers 14 and there can also be different active substances in the individual ring channels 14.

FIG. 8 shows another embodiment of a system, which is similar to that of FIG. 3 in that once again a contact pressure sensitive adhesive active substance matrix is used, in that here a channel system 15, which contains the active substance or a liquid containing the latter is provided. This arrangement is e.g. advantageous if the plaster is exposed to pulling or tension movements, whereby tearing would occur in the case af a flat channel system without a "tension reserve".

FIG. 9 shows a similar arrangement, in which the plaster has an additional contact pressure sensitive adhesive layer 10 for fixing the system to the skin and optionally additional control of the active substance delivery.

FIG. 10 shows an arrangement with strip-like active substance depots 12. The drawing is a plan view of the inventive system after removal of the backing layer 10. It is possible to see the desired breaking lines 17, which are usable for the random reduction/dose change of the system. This embodiment is also very advantageous for tensile loaded plasters.

In all the embodiments shown in the drawings, baglike foils or films can be provided between the active substance formulation and the matrix for further defining the active substance depots and better bounding the active substance liquid.

Claims

1. A transdermal therapeutic system for the controlled administration of active substance to the skin with a backing layer remote from the skin, an active substance depot, an active substance delivery control device controlling the delivery of the active substance through the system and a contact pressure sensitive adhesive fixing means for fixing the therapeutic system to the skin, characterized in that the active substance depot is a multichamber system, in which the chambers are interconnected by channels and are provided with active substance delivery control means.

2. transdermal therapeutic system according to claim 1, characterized in that the chambers are arranged in one or more identical active substance distribution matrices.

3. transdermal therapeutic system according to claim 2, characterized in that it has an uninterrupted skin-side contact pressure sensitive adhesive layer as a fixing means.

4. transdermal therapeutic system according to claim 3, characterized in that it also has one or more contact pressure sensitive adhesive layers between the backing layer and fixing means.

5. transdermal therapeutic system according to claim 4, characterized in that the active substance is in liquid form.

6. transdermal therapeutic system according to claim 5, characterized in that the multichamber system has desired breaking lines between the individual active substance chambers.

7. transdermal therapeutic system according to claim 6, characterized in that the channels between the chambers have an internal diameter such that they only permit a through-flow of the active substance fluid upon application of pressure thereto.

8. transdermal therapeutic system according to claim 7, characterized in that the multichamber system is a system of channels.

9. transdermal therapeutic system according to claim 8, characterized in that the chambers are arranged at different height levels.

10. transdermal therapeutic system according to claim 1, wherein the chambers are each provided with different active substance delivery control means.

11. transdermal therapeutic system according to claim 2, characterized in that it has an interrupted skinside contact pressure sensitive adhesive layer as a fixing means to the skin.

12. transdermal therapeutic system according to claim 4, characterized in that the active substance is in solution.

13. transdermal therapeutic system according to claim 5, characterized in that the multichamber system has desired breaking lines between the individual active substance chambers and in the backing layer.

14. transdermal therapeutic system according to claim 13, further characterized in that the multichamber system has desired breaking lines also in other layers.

15. transdermal therapeutic system according to claim 9, characterized in that the chambers are arranged at different height levels and in different distribution matrices.