To provide a swallowing-assistive drink for medicines that improves swallowing various medicines, is convenient and substitutable with ordinary drinking water, and does not disturb the efficacy of medicines and a swallowing method.
A swallowing-assistive drink for helping swallowing medicines that contains water and an adhesive paste, forming a viscous liquid or a gelatinoid. If the drink is viscous liquid, the viscosity is 1,000-25,000 cP at 20° C., and if the drink is gelatinous, jelly gel strength is 10-100 g/cm2 at 20° C.
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0. 15. A method for taking a medication, comprising the steps of:
providing a viscous swallowing-assistive material in prepared form, wherein the swallowing-assistive material has a viscosity of 1,000-25,000 cP at 20° C.;
combining the swallowing-assistive material with a medicine;
wherein the medicine is enwrapped within the swallowing-assistive material; and
swallowing the combination after the combining step.
6. A swallowing-assistive drink for helping an individual swallow a medication, the swallowing-assistive drink comprising:
water and an adhesive paste which forms a gelatinoid having a jelly gel strength in the range of from 10-100 g/cm2 at 20° C.; and
a medicine enwrapped in the gelatinoid;
wherein said swallowing-assistive drink is packaged in a prepared form in the absence of a medication prior to enwrapping the medicine.
13. A method for assisting an individual in taking a medicine by swallowing the medicine, the method comprising the steps of:
(a) providing a swallowing-assistive drink in a prepared form containing water and an adhesive paste which forms a gelatinoid having a jelly gel strength in the range of from 10-100 g/cm2 at 20° C., wherein the prepared form is in the absence of a medicine; and
(b) enwrapping the medicine in the gelatinoid.
11. A method for assisting an individual in taking a medicine by swallowing the medicine, the method comprising the steps of:
(a) providing a swallowing-assistive drink in a prepared form containing water and an adhesive paste which forms a viscous liquid having a viscosity in the range of from 1,000-25,000 cP at 20° C., wherein the prepared form is in the absence of a medicine; and
(b) enwrapping the medicine in the viscous liquid.
1. A swallowing-assistive drink for assisting an individual in swallowing a medication, the swallowing-assistive drink comprising:
water and an adhesive paste which form a viscous liquid having a viscosity in the range of from 1,000-25,000 cP at 20° C.; and
a medicine enwrapped in the viscous liquid;
wherein said swallowing-assistive drink has been packaged in a prepared form in the absence of a medication prior to enwrapping the medicine.
0. 17. A method for taking a medication, comprising the steps of:
providing a viscous swallowing-assistive material in prepared form, wherein the swallowing-assistive material has a gel strength of 10-100 g/cm2 at 20° C., and wherein the prepared form is in the absence of a medicine;
combining the swallowing-assistive material with a medicine;
wherein the medicine is enwrapped within the swallowing-assistive material; and
swallowing the combination after the combining step.
0. 19. A method for swallowing a solid material, comprising the steps of:
providing a viscous swallowing-assistive material in prepared form, wherein the swallowing-assistive material has a viscosity of 1,000-25,000 cP at 20° C., and wherein the prepared form is in the absence of the solid material;
combining the swallowing-assistive material with the solid material;
wherein the solid material is enwrapped within the swallowing-assistive material; and
swallowing the combination after the combining step.
0. 20. A method for swallowing a solid material, comprising the steps of:
providing a viscous swallowing-assistive material in prepared form, wherein the swallowing-assistive material has a gel strength of 10-100 g/cm2 at 20° C., and wherein the prepared form is in the absence of the solid material;
combining the swallowing-assistive material with the solid material;
wherein the solid material is enwrapped within the swallowing-assistive material; and
swallowing the combination after the combining step.
0. 23. A swallowing-assistive material suitable for combining with a medicine, comprising:
water; and
one or more of the following viscosity building agents: agar, carrageenan, gellan gum, furcellaran, gelatin, pectin, curdlan, locust bean gum, tara gum, guar gum, xanthan gum, arginic acid, arginic acid salt, azotobacter vinelandi gum, cassia gum, psyllium seed gum, tamarind gum, CMCNa, CMCCa, whey protein starch and modified starch;
wherein said swallowing-assistive material is in a prepared form uncombined with medicine and comprises a viscous liquid having a gel strength of 10-100 g/cm2 at 20° C.
0. 21. A swallowing-assistive material suitable for combining with a medicine, comprising:
water; and
one or more of the following viscosity building agents: agar, carrageenan, gellan gum, furcellaran, gelatin, pectin, curdlan, locust bean gum, tara gum, guar gum, xanthan gum, arginic acid, arginic acid salt, azotobacter vinelandi gum, cassia gum, psyllium seed gum, tamarind gum, CMCNa, CMCCa, whey protein starch and modified starch;
wherein said swallowing-assistive material is in a prepared form uncombined with a medicine, and comprises a viscous liquid having a viscosity in the range of from 1,000-25,000 cP at 20° C.
2. The swallowing-assistive drink of
3. The swallowing-assistive drink of
4. The swallowing-assistive drink of
5. The swallowing-assistive drink of
7. The swallowing-assistive drink of
8. The swallowing-assistive drink of
9. The swallowing-assistive drink of
10. The swallowing-assistive drink of
12. The method of
14. The method of
0. 16. The method of
0. 18. The method of
0. 22. The swallowing-assistive material of
0. 24. The swallowing-assistive material of
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1. Field of the Invention
The present invention relates to a swallowing-assistive drink for medicines, more particularly, to a swallowing-assistive drink which facilitates or helps swallowing medicines without difficulty and without giving foreign body sensation to patients, infants and aged persons who have difficulty when taking medicines in swallowing them with ordinary drinking water because of accompanying some pain (such as a bitter taste) owing to various diseases, infirmity or even in healthy people.
2. Description of the Prior Art
Medicines for internal use are generally taken orally with water or tea. However, patients, especially aged persons or the like are difficult to swallow such medicines with water or tea. They sometimes could not swallow well to be choked or left the medicine in their mouth when taking medicines in dosage forms of powders, granules, tablets or the like. Therefore, a sufficient therapeutic effect was not obtained, and further the patient had discomfort.
Although crashing tablets or mixing medicines into food such as boiled rice, miso soup or juice has thus been conducted when taking medicines, this is time-consuming and troublesome. Moreover, this procedure of crashing tablets sometimes resulted in not giving an expected therapeutic effect because the releasing-time of ingredients of medicine could not be controlled and masking of taste could not be performed and so on.
In order to cope with these problems, small tablets, jelly and decomposable tablets are designed as to dosage forms. Further for foods, additive powder for liquid foods which thicken the liquid foods (miso soup or the like) to make them to be swallowed easily is on the market.
However, there were problems that design only on dosage form as mentioned above can not lead sufficient effect and that the swallowing-improving agents for medicines have not yet been developed although there are some for liquid foods.
The present invention has been conducted considering these problems of prior arts. An object of the present invention is to provide a swallowing-assistive drink for medicines that improves swallowing various medicines, being convenient and substitutable for ordinary water, moreover, not disturbing the efficacy of medicines, and a swallowing method.
The present inventors made various studies on a drink that facilitates swallowing medicines orally taken in order to solve the problems described above, formed that the above problems could be solved by mixing a specific adhesive paste with water and accomplished the present invention.
In the words, a swallowing-assistive drink of the present invention is an assistive- drink to facilitate swallowing medicines characterized in that it contains water and an adhesive paste to make viscous liquid or gelatinoid.
In addition, a swallowing method of the present invention is characterized by taking medicines together with the swallowing-assistive drink as mentioned above.
Operation
The swallowing-assistive drink of the present invention has an appropriate jelly
In this Embodiment, the swallowing-assistive drink was charged up to 15 mm in a sample container having a bottom of 40 mm in diameter. The plunger was 2 cm in diameter, the press rate was 10 mm/sec, the clearance was 5 mm, and the measurement temperature was 20° C.
The jelly gel strength of the swallowing-assistive drink in this Embodiment was 46.6 g/cm2, since the maximum load was 146 g and the plunger area was 3.14 cm2 according to FIG. 1.
The swallowing-assistive drink of the present invention was obtained by repetition of the procedure similar to Embodiment 1 except for using the following formulation for blending. The jelly gel strength was measured similarly to Embodiment 1, and the result was shown in FIG. 2. The jelly gel strength of the swallowing-assistive drink in the present Embodiment was 51.9 g/cm2.
Blending quantity
Component
(pont by weight)
Agar
0.20
Locust bean gum
0.05
Pectin
0.04
Carrageenan
0.02
Xanthan gum
0.01
Citric acid
0.21
Trisodium citrate
0.14
Mannitol
8.81
Flavor
0.10
Purified water
90.42
Total amount
100.00
(pont by weight)
The swallowing-assistive drink of the present Embodiment was obtained as a viscous liquid by dissolving polysaccharides, guar gum and starch as adhesive pastes, in a fixed amount of water with other additives. The formulation for blending was illustrated in detail as follows.
Blending quantity
Component
(pont by weight)
Guar gum
1.00
Starch
1.00
Citric acid
0.21
Trisodium acid
0.14
Erythritol
8.81
Flavor
0.20
Purified water
88.64
Total amount
100.00
(pont by weight)
The viscosity of this swallowing-assistive drink was measured using a B-type rotational viscometer (Shibaura System Company made: trade name Vismetron VS-A) to show a value of 10,000 cP. Herein, the viscosity was calculated as follows. After setting the temperature of the swallowing-assistive drink at 20° C., it was rotated using a No. 4 rotator at 12 rpm, and the readings after 2 min was multiplied by a multiplier to give viscosity values.
Xanthan gum and starch as adhesive paste were dissolved in a fixed amount of water with other additives and the swallowing-assistive drink in this Embodiment was obtained as a viscous liquid. The formulation for blending is illustrated in detail as follows.
Blending quantity
Component
(pont by weight)
Xanthan gum
0.50
Starch
1.50
Citric acid
0.21
Trisodium acid
0.14
Erythritol
8.81
Flavor
0.20
Purified water
88.64
Total amount
100.00
(pont by weight)
The viscosity of this swallowing-assistive drink was measured similarly to Embodiment 3, showing a value of 8,500 cP.
The enwrapping-function of the swallowing-assistive drink of the present invention was investigated. Namely, the swallowing-assistive drink obtained in Embodiment 1 was charged into Petri dishes at room temperature followed by addition of water-soluble granules to this mixture, then the condition was observed. The result obtained is shown in FIG. 3.
In addition, after slightly stirring the mixture in the condition shown in
Furthermore, observation similar to that mentioned above was conducted by changing an amount of the above swallowing-assistive drink and the highly water-soluble granules. The results obtained are shown in
[Comparative Test on drinking water]
After filling drinking water, in place of the swallowing-assistive drink, in Petri dishes followed by addition of highly water-soluble granules similarly to Test Example 1, the condition was observed. The result obtained is shown in FIG. 8.
The results of Test Examples 1 and 2 obviously show that the swallowing-assistive drink of the present invention has an excellent enwrapping-function which is not shown by drinking water and that this function is maintained after slightly stirring: in
Thus, the swallowing-assistive drink of the present invention can enwrap appropriately even highly water-soluble granules and powders. Therefore, the drink can make it easy to take granules or the like, because it can as prevent the granules from sticking in the mouth and it can also agglutinate them.
Further, the enwrapping-function mentioned above similar to that of a wafer can mask such bitter tastes of medicines. Therefore, it makes it easy to take medicines and is extremely suitable because bitter tastes or the like do not remain.
In addition, the present swallowing-assistive drink does not disturb the disintegration and dissolution of medicines in the body because the viscosity of the present swallowing-assistive drink decreases when being heated up to the body temperature (37° C.) to lose its enwrapping function.
The following tests were conducted on the swallowing-assistive drink of Embodiments 1 and 2; the subject patients were composed of 12 women and 20 men, 32 in all, aged 75-85 with the average age of 78.
The evaluation was also conducted by asking for opinions of the subjects themselves and findings obtained by observations of nurses about the swallowing-assistive effect when taking medicines with the swallowing-assistive drinks of Embodiments 1 and 2. The evaluation was made in the following 5 levels.
The medicines for internal use were 8 capsules, 16 tablets, 4 granule formulations and 4 powder formulations. The resulting evaluation is that all the finding by 32 patients and all the findings by the nurses are “good.” The impressions of the patients and the nurses in this case are shown as follows.
[Impressions of patients and nurses]
The following test was conducted on the swallowing-assistive drink of Embodiment 1.
First, the purpose of this test was explained to a patient (the age of 75, man) who had difficulty in swallowing when taking medicines with water, and his consent was acquired.
Next, barium powder was filled up in a No. 2 capsule and the capsule was used as a placebo. The placebo was taken by the patient with about 20 ml of the swallowing-assistive drink of the present invention, while fluoroscopic video-radiographs of the conditions of taking this medicine were taken by scanning from the mouth to the stomach of the patient. The image information obtained was put into a personal computer and the time-course changes were analyzed as still image data of two sheets a second. The result is shown in FIG. 9.
Further, the still pictures of “Cup jelly 02,” “Cup jelly 03,” “Cup jelly 04,” “Cup jelly 09,”
“Cup jelly 10” and “Cup jelly 12” as shown in
[Comparative test using water]
The similar procedure to Test Example 4 except for using about 20 mL of water in place of the swallowing-assistive drink was repeated. The results obtained are shown in
Further, the enlarged still pictures of “Water 00,” “Water 04,” “Water 08,” “Water 10,” “Water 17” and “Water 24” as shown in
As obviously shown by comparing the results of Test Example 4 with those of Test Example 5, in Test Example 4 within the scope of the present invention, it takes about 8 sec to more for the mouth to the stomach, while it takes about 18 sec which is more than two times in Test Example 5, showing that the swallowing-assistive drink of the present invention gives an excellent swallowing-assistive effect.
As illustrated above, according to the present invention, by mixing specific adhesive pastes with water the swallowing-assistive drink for medicines that improves swallowing of various medicines, is convenient and substitutable with ordinary drinking water and does not disturb effectcacy of medicines and the method of swallowing can be provided.
Namely, patients who have difficulty in swallowing or who have a declined swallowing function, especially the aged patients can take medicines for internal use swallowing easily without having a sensation of foreign body by taking medicines orally together with the swallowing-assistive drink of the present invention.
Thus, the swallowing-assistive drink of the present invention improves the QOL (Quality of Life) of those who feel some pain when taken medicines and provides a help for their pleasant lives.
Nakajima, Masanori, Fukui, Atsuko, Ohta, Mika, Kamijima, Takashi
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