A method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the epidermis layer, comprising the steps of: arranging a pulsed dye laser generator in light communication with a pulsed dye laser delivery device. The pulsed dye laser delivery device is applied against tissue having wrinkles. The pulsed dye laser generator generates a pulsed dye laser light. A pulsed dye laser light from the pulsed dye laser delivery device is directed onto the tissue, to reach hemoglobin in a collagen layer up to about 1.2 mm. beneath the surface of the tissue to effect growth changes therein.

Patent
   RE40403
Priority
Jun 11 1998
Filed
Jun 19 2002
Issued
Jun 24 2008
Expiry
Jun 11 2018
Assg.orig
Entity
Large
117
33
all paid
0. 3. A method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the epidermis layer, comprising the steps of:
arranging a pulsed dye laser generator in light communication with a pulsed dye laser delivery device;
applying the pulsed dye laser delivery device against tissue having wrinkles;
generating a laser light pulse with the pulsed dye laser generator, the laser light pulse having a wavelength in a range of about 570 nanometers to about 650 nanometers, a pulse width in a range of 150 microseconds to about 1500 microseconds, and a fluence of less than about 5 joules per cm2; and
directing the laser light pulse from the pulsed dye laser delivery device onto the tissue, to reach hemoglobin in a collagen layer beneath the surface of the tissue.
2. A method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the epidermis layer, comprising the steps of:
arranging a pulsed dye laser generator in light communication with a pulsed dye laser delivery device;
applying said pulsed dye laser delivery device against tissue having wrinkles;
generating a pulsed dye laser light by said pulsed dye laser; and
directing said pulsed dye laser light from said pulsed dye laser delivery device onto said tissue, to reach hemoglobin in a collagen layer beneath the surface of said tissue; and
tuning said pulsed dye laser to deliver a laser light at a wavelength having a range of about 585 nanometers;
generating said pulsed dye laser at a pulse width of about 450 microseconds; and
energizing said collagen down to a depth of about 1.0-mm to about 1.2 mm. below the surface of the skin by said pulsed dye laser.
1. A method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the epidermis layer, comprising the steps of:
arranging a pulsed dye laser generator in light communication with a pulsed dye laser delivery device;
applying said pulsed dye laser delivery device against tissue having wrinkles;
generating a pulsed dye laser light by said pulsed dye laser; and
directing said pulsed dye laser light from said pulsed dye laser delivery device onto said tissue, to reach hemoglobin in a collagen layer beneath the surface of said tissue;
adjusting said range of pulsed dye laser light generated to a wavelength of about 585 nanometers;
generating said pulsed dye laser at a pulse width of about 450 microseconds;
directing said pulsed dye laser light at the tissue at a target spot diameter of about 10-mm; and
maintaining a fluence of said pulsed dye laser light of less than 5 joules per square cm.
0. 4. The method of claim 3, wherein the laser light pulse energizes the collagen down to a depth of about 1.0 mm to about 1.2 mm below the surface of the skin.
0. 5. The method of claim 3, wherein the pulsed dye laser delivery device comprises a handpiece connected by an optical fiber or waveguide to the pulse dye laser generator.
0. 6. The method of claim 3, wherein the laser light pulse has a wavelength of about 585 nanometers.
0. 7. The method of claim 3, wherein the laser light pulse has a pulse duration of about 450 microseconds.
0. 8. The method of claim 3, wherein the laser light pulse has a fluence of about 3 joules per cm2.

1. Field of The Invention

The present invention relates to the field of resurfacing skin, or wrinkle removal using laser radiation for treatment of underlying layers of skin.

2. Prior Art

Plastic surgeons, dermatologists and their patients continually search for new and approved methods for treating the effects of an aging skin. Historically, the treatment of facial wrinkles was primarily accomplished with the use of chemical peels or dermabrasion. The use of chemical peels has fallen out of favor, because it is difficult to accurately control and predict the depth of tissue injury after such peels are applied. Deeper chemical peels in particle have an increased risk of hypopigmentation and scarring. Such injury to the top layer of skin, which would be peeled away, would permit new cells to supposedly rejuvenate the skin. A less expensive way of injuring the outer layer of the skin is the utilization of an abrasive wheel, to rough off the skin layer. This method is not well controlled, and is very difficult especially around the eyelids.

Laser skin resurfacing began with a carbon dioxide laser. The carbon dioxide laser energy is absorbed by tissue water causing vaporization of the outer skin layer. Carbon dioxide lasers have been utilized for approximately 3 decades. However it has only been the past few years that these lasers have been arranged to remove only thin tissue layers with minimal heat damage to the surrounding skin. While carbon dioxide lasers may remove about 150 microns of skin, that skin may take a month or more to heal under such a procedure.

Er:YAG lasers have been utilized to ablate even thinner layers of tissue than carbon dioxide layers. However they lack the coagulation characteristics and thus allow more bleeding than a carbon dioxide laser during use.

Non-ablative skin resurfacing, is a methodology which does not take the top layer of skin off, but which shrinks the collagen under the skin, and modifies that collagen, so that the wrinkled skin appears to be fill-in by the collagen modified beneath the skin. This methodology however, has a low efficiency, and a cryogen coolant must be sprayed on to the skin so as to minimize damaging the top or upper layer thereof and also to minimize pain generation. The “fluence” or energy density used is greater than 10 joules per square centimeter and to be more effective this fluence often reaches 30 Joules per square centimeter. This level of energy often causes pain and epidermal damage.

It is an object of the present invention to improve upon the shortcomings of the prior art.

It is yet a further object of the present invention to provide a skin resurfacing laser treatment, which is nonablative, and minimizes any pain to the patient being treated.

It is yet still a further object of the present invention, to provide a new method to stimulate the collagen beneath the skin surface, to improve the surface appearance from beneath that surface of skin of the patient.

The present invention comprises a system and methodology for noninvasive wrinkle removal for the modification of collagen beneath the epidermis. The laser system of the present invention, in a preferred embodiment, utilizes a pulsed dye laser having a deep penetrating wavelength of about 585 nanometers (nm) laser, so as to target hemoglobin of blood in the skin tissue. This particular laser energy is absorbed by the hemoglobin. The heat is generated in the skin area up to about 1 mm in depth and typically uses energy of less than 5 Joules per square cm, having a preferred target spot size of about 10 mm diameter.

The pulsed dye laser apparatus of the present invention includes a handpiece connected by an optical fiber or wave guide, critically, to a pulsed dye laser generator device.

The handpiece focuses, through a plurality of lenses, the pulsed dye laser light from the pulsed dye laser generator, onto the spot of about 10 mm in diameter, so as to stimulate new collagen growth beneath the epidermis without injuring the surrounding structures.

In the preferred embodiment of the present invention, the pulse width has a range of 150 microseconds to about 1500 microseconds with a preferred width of about 450 microseconds. The wavelength of the pulsed dye laser apparatus of the present invention lies in a range of about 570 nanometers to about 650 nanometers, with a preferred wavelength of about 585 nanometers. The present invention provides a preferred fluence of less than 5 Joules per square cm., and preferably 3 Joules per square cm at a 10-millimeter diameter skin treatment spot.

By treating the skin to this low fluence pulsed dye laser light, collagen may be stimulated to regenerate and “fill in” valleys of wrinkles for a younger more clearer skin.

Thus what has been shown is a new method of stimulating modification of the collagen layer at a depth of at least about 1 mm to about 1.2 mm beneath the skin surface, utilizing a low energy level of less than 5 Joules per square cm., in a manner not appreciated by the prior art.

The invention thus comprises a method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the epidermis layer, comprising the steps of: arranging a pulsed dye laser generator in light communication with a pulsed dye laser delivery device; applying said pulsed dye laser delivery device against tissue having wrinkles; generating a pulsed dye laser light by said pulsed dye laser; and directing said pulsed dye laser light from said pulsed dye laser delivery device onto said tissue, to reach hemoglobin in a collagen layer beneath the surface of said tissue. The method includes the steps of: tuning said pulsed dye laser to deliver a laser light at a wavelength having a range of from about 570 nanometers to about 650 nanometers, and adjusting said range of pulsed dye laser light generated to a wavelength of about 585 nanometers. The pulsed dye laser has a pulse width in a range of from about 150 microseconds to about 1500 microseconds. Preferably the pulsed dye laser has a pulse width of about 450 microseconds. The method included the pulsed dye laser light being directed at the tissue at a target spot diameter of about 10 mm. The method includes maintaining a fluence of the pulsed dye laser light of less than 5 Joules per square cm.

The objects and advantages of the present invention will become more apparent, when viewed in conjunction with the following drawings, in which:

FIG. 1 is a schematic representation of the laser apparatus of the present invention, as it is applied to a layer of skin; and

FIG. 2 is a graph showing the absorption characteristics of certain body tissue chromophors versus laser wavelength.

Referring now to the drawings in detail, and particularly to FIG. 1, there is shown the present invention, which comprises a system 10, and methodology for nonivasive wrinkle removal for the modification of collagen beneath the epidermis. The laser system 10 of the present invention, in a preferred embodiment, utilizes a pulsed dye laser 12 having a deep tissue-penetrating wavelength of about 585 nanometers (nm) laser, so as to target hemoglobin “H” of blood in the skin tissue “T”. The preferred pulsed dye laser 12 generates a particular laser wavelength energy of 585 nanometers, which is absorbed by the hemoglobin “H”. The heat is generated in the skin tissue “T” area up to about 1 mm in depth and typically uses energy of less than 5 Joules per square cm, having a preferred target spot size “S” of about 10 mm diameter circle or larger.

The pulsed dye laser apparatus 12 of the present invention includes a handpiece 14 connected by an optical fiber or wave guide 16, critically, to a pulsed dye laser generator for generating the particular wavelength and fluence of the present invention.

The handpiece 14 focuses, through a plurality of lenses 20 22 and 22 24, the pulsed dye laser light “L” from the pulsed dye laser generator 12, onto the spot “S” of about 10 mm in diameter or larger, so as to stimulate new collagen growth beneath the epidermis “E”.

In the preferred embodiment of the present invention, the pulse width has a range of 150 microseconds to about 1500 microseconds with a preferred width of about 450 microseconds. The wavelength of the pulsed dye laser apparatus 12 of the present invention lies in a range of about 570 nanometers to about 650 nanometers, with a preferred wavelength of about 585 nanometers. The present invention provides a preferred fluence of less than 5 Joules per square cm., and preferably 3 Joules per square cm at a 10-millimeter diameter skin treatment spot “S”.

By treating the skin “T” to this low fluence pulsed dye laser light “L”, collagen beneath the epidermis, that is below about 0.06 mm. beneath the surface may be stimulated to regenerate and “fill in” valleys of wrinkles for a younger more clearer skin.

Thus what has been shown is a new method of stimulating modification of the collagen layer at a depth of up to about 1 mm to about 1.2 mm beneath the skin surface, utilizing a low energy level of less than 5 Joules per square cm., in a manner not appreciated by the prior art.

Zelickson, Brian D., Cho, George, Furumoto, Horace W.

Patent Priority Assignee Title
10010721, Oct 06 2004 Guided Therapy Systems, L.L.C. Energy based fat reduction
10010724, Oct 07 2004 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
10010725, Oct 06 2004 Guided Therapy Systems, LLC Ultrasound probe for fat and cellulite reduction
10010726, Oct 07 2004 Guided Therapy Systems, LLC Ultrasound probe for treatment of skin
10039938, Sep 16 2004 GUIDED THERAPY SYSTEMS LLC System and method for variable depth ultrasound treatment
10046181, Oct 06 2004 Guided Therapy Systems, LLC Energy based hyperhidrosis treatment
10046182, Oct 06 2004 Guided Therapy Systems, LLC Methods for face and neck lifts
10183182, Aug 02 2010 Guided Therapy Systems, LLC Methods and systems for treating plantar fascia
10238894, Oct 06 2004 Guided Therapy Systems, L.L.C. Energy based fat reduction
10245450, Oct 06 2004 Guided Therapy Systems, LLC Ultrasound probe for fat and cellulite reduction
10252086, Oct 07 2004 Gen-Y Creations, LLC Ultrasound probe for treatment of skin
10265550, Oct 07 2004 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
10328289, Sep 24 2004 Guided Therapy Systems, LLC Rejuvenating skin by heating tissue for cosmetic treatment of the face and body
10420960, Mar 08 2013 Ulthera, Inc. Devices and methods for multi-focus ultrasound therapy
10525288, Oct 06 2004 Guided Therapy Systems, LLC System and method for noninvasive skin tightening
10532230, Oct 06 2004 Guided Therapy Systems, LLC Methods for face and neck lifts
10537304, Jun 06 2008 ULTHERA, INC Hand wand for ultrasonic cosmetic treatment and imaging
10561862, Mar 15 2013 Guided Therapy Systems, LLC Ultrasound treatment device and methods of use
10603519, Oct 06 2004 Guided Therapy Systems, LLC Energy based fat reduction
10603521, Apr 18 2014 Ulthera, Inc. Band transducer ultrasound therapy
10603523, Oct 06 2004 Guided Therapy Systems, LLC Ultrasound probe for tissue treatment
10610705, Oct 07 2004 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
10610706, Oct 07 2004 Guided Therapy Systems, LLC Ultrasound probe for treatment of skin
10864385, Sep 24 2004 Guided Therapy Systems, LLC Rejuvenating skin by heating tissue for cosmetic treatment of the face and body
10888716, Oct 06 2004 Guided Therapy Systems, LLC Energy based fat reduction
10888717, Oct 06 2004 Guided Therapy Systems, LLC Probe for ultrasound tissue treatment
10888718, Oct 07 2004 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
10960236, Oct 06 2004 Guided Therapy Systems, LLC System and method for noninvasive skin tightening
11123039, Jun 06 2008 Ulthera, Inc. System and method for ultrasound treatment
11167155, Oct 07 2004 Guided Therapy Systems, LLC Ultrasound probe for treatment of skin
11179580, Oct 06 2004 Guided Therapy Systems, LLC Energy based fat reduction
11207547, Oct 06 2004 Guided Therapy Systems, LLC Probe for ultrasound tissue treatment
11207548, Oct 07 2004 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
11224895, Jan 18 2016 Ulthera, Inc. Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board and method of assembly thereof
11235179, Oct 06 2004 Guided Therapy Systems, LLC Energy based skin gland treatment
11235180, Oct 06 2004 Guided Therapy Systems, LLC System and method for noninvasive skin tightening
11241218, Aug 16 2016 ULTHERA, INC Systems and methods for cosmetic ultrasound treatment of skin
11253720, Feb 29 2020 Cutera, Inc. Dermatological systems and methods with handpiece for coaxial pulse delivery and temperature sensing
11338156, Oct 06 2004 Guided Therapy Systems, LLC Noninvasive tissue tightening system
11351401, Apr 18 2014 Ulthera, Inc. Band transducer ultrasound therapy
11400319, Oct 06 2004 Guided Therapy Systems, LLC Methods for lifting skin tissue
11517772, Mar 08 2013 Ulthera, Inc. Devices and methods for multi-focus ultrasound therapy
11590370, Sep 24 2004 Guided Therapy Systems, LLC Rejuvenating skin by heating tissue for cosmetic treatment of the face and body
11697033, Oct 06 2004 Guided Therapy Systems, LLC Methods for lifting skin tissue
11717707, Oct 06 2004 Guided Therapy Systems, LLC System and method for noninvasive skin tightening
11723622, Jun 06 2008 Ulthera, Inc. Systems for ultrasound treatment
11724133, Oct 07 2004 Guided Therapy Systems, LLC Ultrasound probe for treatment of skin
11738206, Feb 29 2020 Cutera, Inc. Systems and methods for controlling therapeutic laser pulse duration
11883688, Oct 06 2004 Guided Therapy Systems, LLC Energy based fat reduction
8235909, May 12 2004 GUIDED THERAPY SYSTEMS, L L C Method and system for controlled scanning, imaging and/or therapy
8282554, Oct 06 2004 Guided Therapy Systems, LLC Methods for treatment of sweat glands
8330121, May 03 2011 Bear Down Brands, LLC Dynamic display and control of UV source for sanitization in mobile devices
8333700, Oct 06 2004 Guided Therapy Systems, L.L.C. Methods for treatment of hyperhidrosis
8366622, Oct 06 2004 Guided Therapy Systems, LLC Treatment of sub-dermal regions for cosmetic effects
8409097, Dec 28 2000 Guided Therapy Systems, LLC Visual imaging system for ultrasonic probe
8444562, Oct 06 2004 Guided Therapy Systems, LLC System and method for treating muscle, tendon, ligament and cartilage tissue
8460193, Oct 06 2004 Guided Therapy Systems LLC System and method for ultra-high frequency ultrasound treatment
8480585, Oct 14 1997 Guided Therapy Systems, LLC Imaging, therapy and temperature monitoring ultrasonic system and method
8506486, Oct 06 2004 Guided Therapy Systems, LLC Ultrasound treatment of sub-dermal tissue for cosmetic effects
8523775, Oct 06 2004 Guided Therapy Systems, LLC Energy based hyperhidrosis treatment
8535228, Oct 06 2004 Guided Therapy Systems, LLC Method and system for noninvasive face lifts and deep tissue tightening
8636665, Oct 06 2004 Guided Therapy Systems, LLC Method and system for ultrasound treatment of fat
8641622, Oct 07 2004 Guided Therapy Systems, LLC Method and system for treating photoaged tissue
8663112, Oct 06 2004 GUIDED THERAPY SYSTEMS, L L C Methods and systems for fat reduction and/or cellulite treatment
8672848, Oct 06 2004 Guided Therapy Systems, LLC Method and system for treating cellulite
8690778, Oct 06 2004 Guided Therapy Systems, LLC Energy-based tissue tightening
8690779, Oct 06 2004 Guided Therapy Systems, LLC Noninvasive aesthetic treatment for tightening tissue
8690780, Oct 06 2004 Guided Therapy Systems, LLC Noninvasive tissue tightening for cosmetic effects
8708935, Sep 16 2004 Guided Therapy Systems, LLC System and method for variable depth ultrasound treatment
8715186, Nov 24 2009 Guided Therapy Systems, LLC Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
8764687, May 07 2007 Guided Therapy Systems, LLC; GUIDED THERAPY SYSTEMS, INC Methods and systems for coupling and focusing acoustic energy using a coupler member
8857438, Nov 08 2010 ULTHERA, INC Devices and methods for acoustic shielding
8858471, Jul 10 2011 Guided Therapy Systems, LLC Methods and systems for ultrasound treatment
8868958, Apr 26 2005 Guided Therapy Systems, LLC Method and system for enhancing computer peripheral safety
8915853, Oct 06 2004 Guided Therapy Systems, LLC Methods for face and neck lifts
8915854, Oct 06 2004 Guided Therapy Systems, LLC Method for fat and cellulite reduction
8915870, Oct 07 2004 Guided Therapy Systems, LLC Method and system for treating stretch marks
8920324, Oct 06 2004 Guided Therapy Systems, LLC Energy based fat reduction
8932224, Oct 06 2004 Guided Therapy Systems, LLC Energy based hyperhidrosis treatment
9011336, Sep 16 2004 Guided Therapy Systems, LLC; GUIDED THERAPY SYSTEMS, INC Method and system for combined energy therapy profile
9011337, Jul 11 2011 Guided Therapy Systems, LLC Systems and methods for monitoring and controlling ultrasound power output and stability
9039617, Nov 24 2009 Guided Therapy Systems, LLC Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
9039619, Oct 07 2004 Guided Therapy Systems, L.L.C. Methods for treating skin laxity
9095697, Sep 24 2004 Guided Therapy Systems, LLC Methods for preheating tissue for cosmetic treatment of the face and body
9114247, Sep 16 2004 Guided Therapy Systems, LLC Method and system for ultrasound treatment with a multi-directional transducer
9149658, Aug 02 2010 Guided Therapy Systems, LLC Systems and methods for ultrasound treatment
9216276, May 07 2007 Guided Therapy Systems, LLC; GUIDED THERAPY SYSTEMS, INC Methods and systems for modulating medicants using acoustic energy
9241683, Oct 04 2006 Guided Therapy Systems, LLC Ultrasound system and method for imaging and/or measuring displacement of moving tissue and fluid
9263663, Apr 13 2012 Guided Therapy Systems, LLC Method of making thick film transducer arrays
9272162, Oct 14 1997 Guided Therapy Systems, LLC Imaging, therapy, and temperature monitoring ultrasonic method
9283409, Oct 06 2004 Guided Therapy Systems, LLC Energy based fat reduction
9283410, Oct 06 2004 Guided Therapy Systems, L.L.C. System and method for fat and cellulite reduction
9320537, Oct 06 2004 Guided Therapy Systems, LLC Methods for noninvasive skin tightening
9345910, Nov 24 2009 Guided Therapy Systems LLC Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
9421029, Oct 06 2004 Guided Therapy Systems, LLC Energy based hyperhidrosis treatment
9427600, Oct 07 2004 Guided Therapy Systems, L.L.C. Systems for treating skin laxity
9427601, Oct 06 2004 Guided Therapy Systems, LLC Methods for face and neck lifts
9440096, Oct 07 2004 Guided Therapy Systems, LLC Method and system for treating stretch marks
9452302, Jul 10 2011 Guided Therapy Systems, LLC Systems and methods for accelerating healing of implanted material and/or native tissue
9504446, Aug 02 2010 Guided Therapy Systems, LLC Systems and methods for coupling an ultrasound source to tissue
9510802, Sep 21 2012 Guided Therapy Systems, LLC Reflective ultrasound technology for dermatological treatments
9522290, Oct 06 2004 Guided Therapy Systems, LLC System and method for fat and cellulite reduction
9533175, Oct 06 2004 Guided Therapy Systems, LLC Energy based fat reduction
9566454, Sep 18 2006 Guided Therapy Systems, LLC Method and sysem for non-ablative acne treatment and prevention
9694211, Oct 07 2004 Guided Therapy Systems, L.L.C. Systems for treating skin laxity
9694212, Oct 07 2004 Guided Therapy Systems, LLC Method and system for ultrasound treatment of skin
9700340, Oct 06 2004 Guided Therapy Systems, LLC System and method for ultra-high frequency ultrasound treatment
9707412, Oct 06 2004 Guided Therapy Systems, LLC System and method for fat and cellulite reduction
9713731, Oct 06 2004 Guided Therapy Systems, LLC Energy based fat reduction
9802063, Sep 21 2012 Guided Therapy Systems, LLC Reflective ultrasound technology for dermatological treatments
9827449, Oct 07 2004 Guided Therapy Systems, L.L.C. Systems for treating skin laxity
9827450, Oct 06 2004 Guided Therapy Systems, L.L.C. System and method for fat and cellulite reduction
9833639, Oct 06 2004 Guided Therapy Systems, L.L.C. Energy based fat reduction
9833640, Oct 07 2004 Guided Therapy Systems, L.L.C. Method and system for ultrasound treatment of skin
9895560, Sep 24 2004 Guided Therapy Systems, LLC Methods for rejuvenating skin by heating tissue for cosmetic treatment of the face and body
9907535, Dec 28 2000 Guided Therapy Systems, LLC Visual imaging system for ultrasonic probe
9974982, Oct 06 2004 Guided Therapy Systems, LLC System and method for noninvasive skin tightening
Patent Priority Assignee Title
3766488,
4176324, Sep 20 1976 Jersey Nuclear-Avco Isotopes, Inc. High performance dye laser and flow channel therefor
4292601, Jun 29 1977 Jersey Nuclear-Avco Isotopes, Inc. Flashlamp excited fluid laser amplifier
4829262, Dec 08 1986 Candela Corporation Long pulse tunable light amplifier
4862886, May 08 1985 SUMMIT TECHNOLOGY, INC , A MASSACHUSETTS CORP Laser angioplasty
4976709, Sep 27 1985 RJW ACQUISTIONS, L C , D B A 20 20 TECHNOLOGIES, INC Method for collagen treatment
4977571, Mar 29 1988 Candela Corporation Dye laser solution circulation system
5057099, Feb 27 1987 Xintec Corporation Method for laser surgery
5066293, Oct 25 1984 Candela Corporation Light amplifier and method of photothemolysis
5092865, Feb 27 1987 Xintec Corporation Optical fiber fault detector
5109387, Dec 26 1990 Candela Corporation Dye laser system and method
5180378, Apr 24 1989 ABIOMED, INC , A CORPORATION OF DE Laser surgery system
5287380, Feb 19 1993 Candela Corporation Method and apparatus for generating long output pulses from flashlamp-excited lasers
5370642, Sep 25 1991 Method of laser cosmetic surgery
5387211, Mar 10 1993 TRIMEDYNE, INC Multi-head laser assembly
5405368, Oct 20 1992 LUMENIS, LTD Method and apparatus for therapeutic electromagnetic treatment
5439954, Oct 11 1991 The Procter & Gamble Company; Procter & Gamble Company, The Substituted phenyl-1,3-diketones as protectants against skin damage
5492894, Mar 21 1991 The Procter & Gamble Company Compositions for treating wrinkles comprising a peptide
5505727, Sep 25 1991 Method of laser cosmetic surgery
5620478, Feb 03 1995 LUMENIS, LTD Method and apparatus for therapeutic electromagnetic treatment
5624435, Jun 05 1995 CYNOSYURE, INC Ultra-long flashlamp-excited pulse dye laser for therapy and method therefor
5626631, Oct 20 1992 LUMENIS, LTD Method and apparatus for therapeutic electromagnetic treatment
5720772, Oct 20 1992 LUMENIS, LTD Method and apparatus for therapeutic electromagnetic treatment
5749868, Dec 09 1994 Cynosure, Inc. Near infra-red selective photothermolysis for ectatic vessels and method therefor
5755751, Oct 20 1992 LUMENIS, LTD Method and apparatus for therapeutic electromagnetic treatment
5807386, Feb 03 1995 Laser Industries, Ltd. Laser facial rejuvenation
5810801, Feb 05 1997 Candela Corporation Method and apparatus for treating wrinkles in skin using radiation
5964749, Sep 15 1995 LUMENIS LTD Method and apparatus for skin rejuvenation and wrinkle smoothing
5983900, Aug 28 1997 SQUADRON CAPITAL IP HOLDINGS LLC Wrinkle removal
6077294, Jun 11 1998 Cynosure, Inc Method for non-invasive wrinkle removal and skin treatment
6197020, Aug 12 1996 Sublase, Inc. Laser apparatus for subsurface cutaneous treatment
6248103, Apr 05 1994 The Regents of the University of California Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery using long laser pulses
WO9504393,
///////
Executed onAssignorAssigneeConveyanceFrameReelDoc
Jun 19 2002Cynosure, Inc.(assignment on the face of the patent)
May 01 2017Cynosure, IncBANK OF AMERICA, N A , AS COLLATERAL AGENTSECURITY INTEREST SEE DOCUMENT FOR DETAILS 0422610911 pdf
May 01 2017PALOMAR MEDICAL TECHNOLOGIES, LLCBANK OF AMERICA, N A , AS COLLATERAL AGENTSECURITY INTEREST SEE DOCUMENT FOR DETAILS 0422610911 pdf
Nov 10 2017Hologic, IncBANK OF AMERICA, N A , AS COLLATERAL AGENTSECURITY INTEREST SEE DOCUMENT FOR DETAILS 0441230353 pdf
Nov 10 2017Gen-Probe IncorporatedBANK OF AMERICA, N A , AS COLLATERAL AGENTSECURITY INTEREST SEE DOCUMENT FOR DETAILS 0441230353 pdf
Nov 10 2017Cynosure, IncBANK OF AMERICA, N A , AS COLLATERAL AGENTSECURITY INTEREST SEE DOCUMENT FOR DETAILS 0441230353 pdf
Nov 10 2017Biolucent, LLCBANK OF AMERICA, N A , AS COLLATERAL AGENTSECURITY INTEREST SEE DOCUMENT FOR DETAILS 0441230353 pdf
Date Maintenance Fee Events
Jul 28 2008ASPN: Payor Number Assigned.
Dec 20 2011M1553: Payment of Maintenance Fee, 12th Year, Large Entity.


Date Maintenance Schedule
Jun 24 20114 years fee payment window open
Dec 24 20116 months grace period start (w surcharge)
Jun 24 2012patent expiry (for year 4)
Jun 24 20142 years to revive unintentionally abandoned end. (for year 4)
Jun 24 20158 years fee payment window open
Dec 24 20156 months grace period start (w surcharge)
Jun 24 2016patent expiry (for year 8)
Jun 24 20182 years to revive unintentionally abandoned end. (for year 8)
Jun 24 201912 years fee payment window open
Dec 24 20196 months grace period start (w surcharge)
Jun 24 2020patent expiry (for year 12)
Jun 24 20222 years to revive unintentionally abandoned end. (for year 12)