A method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the epidermis layer, comprising the steps of: arranging a pulsed dye laser generator in light communication with a pulsed dye laser delivery device. The pulsed dye laser delivery device is applied against tissue having wrinkles. The pulsed dye laser generator generates a pulsed dye laser light. A pulsed dye laser light from the pulsed dye laser delivery device is directed onto the tissue, to reach hemoglobin in a collagen layer up to about 1.2 mm. beneath the surface of the tissue to effect growth changes therein.
|
0. 3. A method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the epidermis layer, comprising the steps of:
arranging a pulsed dye laser generator in light communication with a pulsed dye laser delivery device;
applying the pulsed dye laser delivery device against tissue having wrinkles;
generating a laser light pulse with the pulsed dye laser generator, the laser light pulse having a wavelength in a range of about 570 nanometers to about 650 nanometers, a pulse width in a range of 150 microseconds to about 1500 microseconds, and a fluence of less than about 5 joules per cm2; and
directing the laser light pulse from the pulsed dye laser delivery device onto the tissue, to reach hemoglobin in a collagen layer beneath the surface of the tissue.
2. A method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the epidermis layer, comprising the steps of:
arranging a pulsed dye laser generator in light communication with a pulsed dye laser delivery device;
applying said pulsed dye laser delivery device against tissue having wrinkles;
generating a pulsed dye laser light by said pulsed dye laser; and
directing said pulsed dye laser light from said pulsed dye laser delivery device onto said tissue, to reach hemoglobin in a collagen layer beneath the surface of said tissue; and
tuning said pulsed dye laser to deliver a laser light at a wavelength having a range of about 585 nanometers;
generating said pulsed dye laser at a pulse width of about 450 microseconds; and
energizing said collagen down to a depth of about 1.0-mm to about 1.2 mm. below the surface of the skin by said pulsed dye laser.
1. A method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the epidermis layer, comprising the steps of:
arranging a pulsed dye laser generator in light communication with a pulsed dye laser delivery device;
applying said pulsed dye laser delivery device against tissue having wrinkles;
generating a pulsed dye laser light by said pulsed dye laser; and
directing said pulsed dye laser light from said pulsed dye laser delivery device onto said tissue, to reach hemoglobin in a collagen layer beneath the surface of said tissue;
adjusting said range of pulsed dye laser light generated to a wavelength of about 585 nanometers;
generating said pulsed dye laser at a pulse width of about 450 microseconds;
directing said pulsed dye laser light at the tissue at a target spot diameter of about 10-mm; and
maintaining a fluence of said pulsed dye laser light of less than 5 joules per square cm.
0. 4. The method of
0. 5. The method of
0. 6. The method of
0. 7. The method of
0. 8. The method of
|
1. Field of The Invention
The present invention relates to the field of resurfacing skin, or wrinkle removal using laser radiation for treatment of underlying layers of skin.
2. Prior Art
Plastic surgeons, dermatologists and their patients continually search for new and approved methods for treating the effects of an aging skin. Historically, the treatment of facial wrinkles was primarily accomplished with the use of chemical peels or dermabrasion. The use of chemical peels has fallen out of favor, because it is difficult to accurately control and predict the depth of tissue injury after such peels are applied. Deeper chemical peels in particle have an increased risk of hypopigmentation and scarring. Such injury to the top layer of skin, which would be peeled away, would permit new cells to supposedly rejuvenate the skin. A less expensive way of injuring the outer layer of the skin is the utilization of an abrasive wheel, to rough off the skin layer. This method is not well controlled, and is very difficult especially around the eyelids.
Laser skin resurfacing began with a carbon dioxide laser. The carbon dioxide laser energy is absorbed by tissue water causing vaporization of the outer skin layer. Carbon dioxide lasers have been utilized for approximately 3 decades. However it has only been the past few years that these lasers have been arranged to remove only thin tissue layers with minimal heat damage to the surrounding skin. While carbon dioxide lasers may remove about 150 microns of skin, that skin may take a month or more to heal under such a procedure.
Er:YAG lasers have been utilized to ablate even thinner layers of tissue than carbon dioxide layers. However they lack the coagulation characteristics and thus allow more bleeding than a carbon dioxide laser during use.
Non-ablative skin resurfacing, is a methodology which does not take the top layer of skin off, but which shrinks the collagen under the skin, and modifies that collagen, so that the wrinkled skin appears to be fill-in by the collagen modified beneath the skin. This methodology however, has a low efficiency, and a cryogen coolant must be sprayed on to the skin so as to minimize damaging the top or upper layer thereof and also to minimize pain generation. The “fluence” or energy density used is greater than 10 joules per square centimeter and to be more effective this fluence often reaches 30 Joules per square centimeter. This level of energy often causes pain and epidermal damage.
It is an object of the present invention to improve upon the shortcomings of the prior art.
It is yet a further object of the present invention to provide a skin resurfacing laser treatment, which is nonablative, and minimizes any pain to the patient being treated.
It is yet still a further object of the present invention, to provide a new method to stimulate the collagen beneath the skin surface, to improve the surface appearance from beneath that surface of skin of the patient.
The present invention comprises a system and methodology for noninvasive wrinkle removal for the modification of collagen beneath the epidermis. The laser system of the present invention, in a preferred embodiment, utilizes a pulsed dye laser having a deep penetrating wavelength of about 585 nanometers (nm) laser, so as to target hemoglobin of blood in the skin tissue. This particular laser energy is absorbed by the hemoglobin. The heat is generated in the skin area up to about 1 mm in depth and typically uses energy of less than 5 Joules per square cm, having a preferred target spot size of about 10 mm diameter.
The pulsed dye laser apparatus of the present invention includes a handpiece connected by an optical fiber or wave guide, critically, to a pulsed dye laser generator device.
The handpiece focuses, through a plurality of lenses, the pulsed dye laser light from the pulsed dye laser generator, onto the spot of about 10 mm in diameter, so as to stimulate new collagen growth beneath the epidermis without injuring the surrounding structures.
In the preferred embodiment of the present invention, the pulse width has a range of 150 microseconds to about 1500 microseconds with a preferred width of about 450 microseconds. The wavelength of the pulsed dye laser apparatus of the present invention lies in a range of about 570 nanometers to about 650 nanometers, with a preferred wavelength of about 585 nanometers. The present invention provides a preferred fluence of less than 5 Joules per square cm., and preferably 3 Joules per square cm at a 10-millimeter diameter skin treatment spot.
By treating the skin to this low fluence pulsed dye laser light, collagen may be stimulated to regenerate and “fill in” valleys of wrinkles for a younger more clearer skin.
Thus what has been shown is a new method of stimulating modification of the collagen layer at a depth of at least about 1 mm to about 1.2 mm beneath the skin surface, utilizing a low energy level of less than 5 Joules per square cm., in a manner not appreciated by the prior art.
The invention thus comprises a method for the treatment of wrinkles on human skin, by stimulating collagen growth beneath the epidermis layer, comprising the steps of: arranging a pulsed dye laser generator in light communication with a pulsed dye laser delivery device; applying said pulsed dye laser delivery device against tissue having wrinkles; generating a pulsed dye laser light by said pulsed dye laser; and directing said pulsed dye laser light from said pulsed dye laser delivery device onto said tissue, to reach hemoglobin in a collagen layer beneath the surface of said tissue. The method includes the steps of: tuning said pulsed dye laser to deliver a laser light at a wavelength having a range of from about 570 nanometers to about 650 nanometers, and adjusting said range of pulsed dye laser light generated to a wavelength of about 585 nanometers. The pulsed dye laser has a pulse width in a range of from about 150 microseconds to about 1500 microseconds. Preferably the pulsed dye laser has a pulse width of about 450 microseconds. The method included the pulsed dye laser light being directed at the tissue at a target spot diameter of about 10 mm. The method includes maintaining a fluence of the pulsed dye laser light of less than 5 Joules per square cm.
The objects and advantages of the present invention will become more apparent, when viewed in conjunction with the following drawings, in which:
Referring now to the drawings in detail, and particularly to
The pulsed dye laser apparatus 12 of the present invention includes a handpiece 14 connected by an optical fiber or wave guide 16, critically, to a pulsed dye laser generator for generating the particular wavelength and fluence of the present invention.
The handpiece 14 focuses, through a plurality of lenses 20 22 and 22 24, the pulsed dye laser light “L” from the pulsed dye laser generator 12, onto the spot “S” of about 10 mm in diameter or larger, so as to stimulate new collagen growth beneath the epidermis “E”.
In the preferred embodiment of the present invention, the pulse width has a range of 150 microseconds to about 1500 microseconds with a preferred width of about 450 microseconds. The wavelength of the pulsed dye laser apparatus 12 of the present invention lies in a range of about 570 nanometers to about 650 nanometers, with a preferred wavelength of about 585 nanometers. The present invention provides a preferred fluence of less than 5 Joules per square cm., and preferably 3 Joules per square cm at a 10-millimeter diameter skin treatment spot “S”.
By treating the skin “T” to this low fluence pulsed dye laser light “L”, collagen beneath the epidermis, that is below about 0.06 mm. beneath the surface may be stimulated to regenerate and “fill in” valleys of wrinkles for a younger more clearer skin.
Thus what has been shown is a new method of stimulating modification of the collagen layer at a depth of up to about 1 mm to about 1.2 mm beneath the skin surface, utilizing a low energy level of less than 5 Joules per square cm., in a manner not appreciated by the prior art.
Zelickson, Brian D., Cho, George, Furumoto, Horace W.
Patent | Priority | Assignee | Title |
10010721, | Oct 06 2004 | Guided Therapy Systems, L.L.C. | Energy based fat reduction |
10010724, | Oct 07 2004 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
10010725, | Oct 06 2004 | Guided Therapy Systems, LLC | Ultrasound probe for fat and cellulite reduction |
10010726, | Oct 07 2004 | Guided Therapy Systems, LLC | Ultrasound probe for treatment of skin |
10039938, | Sep 16 2004 | GUIDED THERAPY SYSTEMS LLC | System and method for variable depth ultrasound treatment |
10046181, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy based hyperhidrosis treatment |
10046182, | Oct 06 2004 | Guided Therapy Systems, LLC | Methods for face and neck lifts |
10183182, | Aug 02 2010 | Guided Therapy Systems, LLC | Methods and systems for treating plantar fascia |
10238894, | Oct 06 2004 | Guided Therapy Systems, L.L.C. | Energy based fat reduction |
10245450, | Oct 06 2004 | Guided Therapy Systems, LLC | Ultrasound probe for fat and cellulite reduction |
10252086, | Oct 07 2004 | Gen-Y Creations, LLC | Ultrasound probe for treatment of skin |
10265550, | Oct 07 2004 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
10328289, | Sep 24 2004 | Guided Therapy Systems, LLC | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
10420960, | Mar 08 2013 | Ulthera, Inc. | Devices and methods for multi-focus ultrasound therapy |
10525288, | Oct 06 2004 | Guided Therapy Systems, LLC | System and method for noninvasive skin tightening |
10532230, | Oct 06 2004 | Guided Therapy Systems, LLC | Methods for face and neck lifts |
10537304, | Jun 06 2008 | ULTHERA, INC | Hand wand for ultrasonic cosmetic treatment and imaging |
10561862, | Mar 15 2013 | Guided Therapy Systems, LLC | Ultrasound treatment device and methods of use |
10603519, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy based fat reduction |
10603521, | Apr 18 2014 | Ulthera, Inc. | Band transducer ultrasound therapy |
10603523, | Oct 06 2004 | Guided Therapy Systems, LLC | Ultrasound probe for tissue treatment |
10610705, | Oct 07 2004 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
10610706, | Oct 07 2004 | Guided Therapy Systems, LLC | Ultrasound probe for treatment of skin |
10864385, | Sep 24 2004 | Guided Therapy Systems, LLC | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
10888716, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy based fat reduction |
10888717, | Oct 06 2004 | Guided Therapy Systems, LLC | Probe for ultrasound tissue treatment |
10888718, | Oct 07 2004 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
10960236, | Oct 06 2004 | Guided Therapy Systems, LLC | System and method for noninvasive skin tightening |
11123039, | Jun 06 2008 | Ulthera, Inc. | System and method for ultrasound treatment |
11167155, | Oct 07 2004 | Guided Therapy Systems, LLC | Ultrasound probe for treatment of skin |
11179580, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy based fat reduction |
11207547, | Oct 06 2004 | Guided Therapy Systems, LLC | Probe for ultrasound tissue treatment |
11207548, | Oct 07 2004 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
11224895, | Jan 18 2016 | Ulthera, Inc. | Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board and method of assembly thereof |
11235179, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy based skin gland treatment |
11235180, | Oct 06 2004 | Guided Therapy Systems, LLC | System and method for noninvasive skin tightening |
11241218, | Aug 16 2016 | ULTHERA, INC | Systems and methods for cosmetic ultrasound treatment of skin |
11253720, | Feb 29 2020 | Cutera, Inc. | Dermatological systems and methods with handpiece for coaxial pulse delivery and temperature sensing |
11338156, | Oct 06 2004 | Guided Therapy Systems, LLC | Noninvasive tissue tightening system |
11351401, | Apr 18 2014 | Ulthera, Inc. | Band transducer ultrasound therapy |
11400319, | Oct 06 2004 | Guided Therapy Systems, LLC | Methods for lifting skin tissue |
11517772, | Mar 08 2013 | Ulthera, Inc. | Devices and methods for multi-focus ultrasound therapy |
11590370, | Sep 24 2004 | Guided Therapy Systems, LLC | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
11697033, | Oct 06 2004 | Guided Therapy Systems, LLC | Methods for lifting skin tissue |
11717707, | Oct 06 2004 | Guided Therapy Systems, LLC | System and method for noninvasive skin tightening |
11723622, | Jun 06 2008 | Ulthera, Inc. | Systems for ultrasound treatment |
11724133, | Oct 07 2004 | Guided Therapy Systems, LLC | Ultrasound probe for treatment of skin |
11738206, | Feb 29 2020 | Cutera, Inc. | Systems and methods for controlling therapeutic laser pulse duration |
11883688, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy based fat reduction |
8235909, | May 12 2004 | GUIDED THERAPY SYSTEMS, L L C | Method and system for controlled scanning, imaging and/or therapy |
8282554, | Oct 06 2004 | Guided Therapy Systems, LLC | Methods for treatment of sweat glands |
8330121, | May 03 2011 | Bear Down Brands, LLC | Dynamic display and control of UV source for sanitization in mobile devices |
8333700, | Oct 06 2004 | Guided Therapy Systems, L.L.C. | Methods for treatment of hyperhidrosis |
8366622, | Oct 06 2004 | Guided Therapy Systems, LLC | Treatment of sub-dermal regions for cosmetic effects |
8409097, | Dec 28 2000 | Guided Therapy Systems, LLC | Visual imaging system for ultrasonic probe |
8444562, | Oct 06 2004 | Guided Therapy Systems, LLC | System and method for treating muscle, tendon, ligament and cartilage tissue |
8460193, | Oct 06 2004 | Guided Therapy Systems LLC | System and method for ultra-high frequency ultrasound treatment |
8480585, | Oct 14 1997 | Guided Therapy Systems, LLC | Imaging, therapy and temperature monitoring ultrasonic system and method |
8506486, | Oct 06 2004 | Guided Therapy Systems, LLC | Ultrasound treatment of sub-dermal tissue for cosmetic effects |
8523775, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy based hyperhidrosis treatment |
8535228, | Oct 06 2004 | Guided Therapy Systems, LLC | Method and system for noninvasive face lifts and deep tissue tightening |
8636665, | Oct 06 2004 | Guided Therapy Systems, LLC | Method and system for ultrasound treatment of fat |
8641622, | Oct 07 2004 | Guided Therapy Systems, LLC | Method and system for treating photoaged tissue |
8663112, | Oct 06 2004 | GUIDED THERAPY SYSTEMS, L L C | Methods and systems for fat reduction and/or cellulite treatment |
8672848, | Oct 06 2004 | Guided Therapy Systems, LLC | Method and system for treating cellulite |
8690778, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy-based tissue tightening |
8690779, | Oct 06 2004 | Guided Therapy Systems, LLC | Noninvasive aesthetic treatment for tightening tissue |
8690780, | Oct 06 2004 | Guided Therapy Systems, LLC | Noninvasive tissue tightening for cosmetic effects |
8708935, | Sep 16 2004 | Guided Therapy Systems, LLC | System and method for variable depth ultrasound treatment |
8715186, | Nov 24 2009 | Guided Therapy Systems, LLC | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
8764687, | May 07 2007 | Guided Therapy Systems, LLC; GUIDED THERAPY SYSTEMS, INC | Methods and systems for coupling and focusing acoustic energy using a coupler member |
8857438, | Nov 08 2010 | ULTHERA, INC | Devices and methods for acoustic shielding |
8858471, | Jul 10 2011 | Guided Therapy Systems, LLC | Methods and systems for ultrasound treatment |
8868958, | Apr 26 2005 | Guided Therapy Systems, LLC | Method and system for enhancing computer peripheral safety |
8915853, | Oct 06 2004 | Guided Therapy Systems, LLC | Methods for face and neck lifts |
8915854, | Oct 06 2004 | Guided Therapy Systems, LLC | Method for fat and cellulite reduction |
8915870, | Oct 07 2004 | Guided Therapy Systems, LLC | Method and system for treating stretch marks |
8920324, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy based fat reduction |
8932224, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy based hyperhidrosis treatment |
9011336, | Sep 16 2004 | Guided Therapy Systems, LLC; GUIDED THERAPY SYSTEMS, INC | Method and system for combined energy therapy profile |
9011337, | Jul 11 2011 | Guided Therapy Systems, LLC | Systems and methods for monitoring and controlling ultrasound power output and stability |
9039617, | Nov 24 2009 | Guided Therapy Systems, LLC | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
9039619, | Oct 07 2004 | Guided Therapy Systems, L.L.C. | Methods for treating skin laxity |
9095697, | Sep 24 2004 | Guided Therapy Systems, LLC | Methods for preheating tissue for cosmetic treatment of the face and body |
9114247, | Sep 16 2004 | Guided Therapy Systems, LLC | Method and system for ultrasound treatment with a multi-directional transducer |
9149658, | Aug 02 2010 | Guided Therapy Systems, LLC | Systems and methods for ultrasound treatment |
9216276, | May 07 2007 | Guided Therapy Systems, LLC; GUIDED THERAPY SYSTEMS, INC | Methods and systems for modulating medicants using acoustic energy |
9241683, | Oct 04 2006 | Guided Therapy Systems, LLC | Ultrasound system and method for imaging and/or measuring displacement of moving tissue and fluid |
9263663, | Apr 13 2012 | Guided Therapy Systems, LLC | Method of making thick film transducer arrays |
9272162, | Oct 14 1997 | Guided Therapy Systems, LLC | Imaging, therapy, and temperature monitoring ultrasonic method |
9283409, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy based fat reduction |
9283410, | Oct 06 2004 | Guided Therapy Systems, L.L.C. | System and method for fat and cellulite reduction |
9320537, | Oct 06 2004 | Guided Therapy Systems, LLC | Methods for noninvasive skin tightening |
9345910, | Nov 24 2009 | Guided Therapy Systems LLC | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
9421029, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy based hyperhidrosis treatment |
9427600, | Oct 07 2004 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
9427601, | Oct 06 2004 | Guided Therapy Systems, LLC | Methods for face and neck lifts |
9440096, | Oct 07 2004 | Guided Therapy Systems, LLC | Method and system for treating stretch marks |
9452302, | Jul 10 2011 | Guided Therapy Systems, LLC | Systems and methods for accelerating healing of implanted material and/or native tissue |
9504446, | Aug 02 2010 | Guided Therapy Systems, LLC | Systems and methods for coupling an ultrasound source to tissue |
9510802, | Sep 21 2012 | Guided Therapy Systems, LLC | Reflective ultrasound technology for dermatological treatments |
9522290, | Oct 06 2004 | Guided Therapy Systems, LLC | System and method for fat and cellulite reduction |
9533175, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy based fat reduction |
9566454, | Sep 18 2006 | Guided Therapy Systems, LLC | Method and sysem for non-ablative acne treatment and prevention |
9694211, | Oct 07 2004 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
9694212, | Oct 07 2004 | Guided Therapy Systems, LLC | Method and system for ultrasound treatment of skin |
9700340, | Oct 06 2004 | Guided Therapy Systems, LLC | System and method for ultra-high frequency ultrasound treatment |
9707412, | Oct 06 2004 | Guided Therapy Systems, LLC | System and method for fat and cellulite reduction |
9713731, | Oct 06 2004 | Guided Therapy Systems, LLC | Energy based fat reduction |
9802063, | Sep 21 2012 | Guided Therapy Systems, LLC | Reflective ultrasound technology for dermatological treatments |
9827449, | Oct 07 2004 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
9827450, | Oct 06 2004 | Guided Therapy Systems, L.L.C. | System and method for fat and cellulite reduction |
9833639, | Oct 06 2004 | Guided Therapy Systems, L.L.C. | Energy based fat reduction |
9833640, | Oct 07 2004 | Guided Therapy Systems, L.L.C. | Method and system for ultrasound treatment of skin |
9895560, | Sep 24 2004 | Guided Therapy Systems, LLC | Methods for rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
9907535, | Dec 28 2000 | Guided Therapy Systems, LLC | Visual imaging system for ultrasonic probe |
9974982, | Oct 06 2004 | Guided Therapy Systems, LLC | System and method for noninvasive skin tightening |
Patent | Priority | Assignee | Title |
3766488, | |||
4176324, | Sep 20 1976 | Jersey Nuclear-Avco Isotopes, Inc. | High performance dye laser and flow channel therefor |
4292601, | Jun 29 1977 | Jersey Nuclear-Avco Isotopes, Inc. | Flashlamp excited fluid laser amplifier |
4829262, | Dec 08 1986 | Candela Corporation | Long pulse tunable light amplifier |
4862886, | May 08 1985 | SUMMIT TECHNOLOGY, INC , A MASSACHUSETTS CORP | Laser angioplasty |
4976709, | Sep 27 1985 | RJW ACQUISTIONS, L C , D B A 20 20 TECHNOLOGIES, INC | Method for collagen treatment |
4977571, | Mar 29 1988 | Candela Corporation | Dye laser solution circulation system |
5057099, | Feb 27 1987 | Xintec Corporation | Method for laser surgery |
5066293, | Oct 25 1984 | Candela Corporation | Light amplifier and method of photothemolysis |
5092865, | Feb 27 1987 | Xintec Corporation | Optical fiber fault detector |
5109387, | Dec 26 1990 | Candela Corporation | Dye laser system and method |
5180378, | Apr 24 1989 | ABIOMED, INC , A CORPORATION OF DE | Laser surgery system |
5287380, | Feb 19 1993 | Candela Corporation | Method and apparatus for generating long output pulses from flashlamp-excited lasers |
5370642, | Sep 25 1991 | Method of laser cosmetic surgery | |
5387211, | Mar 10 1993 | TRIMEDYNE, INC | Multi-head laser assembly |
5405368, | Oct 20 1992 | LUMENIS, LTD | Method and apparatus for therapeutic electromagnetic treatment |
5439954, | Oct 11 1991 | The Procter & Gamble Company; Procter & Gamble Company, The | Substituted phenyl-1,3-diketones as protectants against skin damage |
5492894, | Mar 21 1991 | The Procter & Gamble Company | Compositions for treating wrinkles comprising a peptide |
5505727, | Sep 25 1991 | Method of laser cosmetic surgery | |
5620478, | Feb 03 1995 | LUMENIS, LTD | Method and apparatus for therapeutic electromagnetic treatment |
5624435, | Jun 05 1995 | CYNOSYURE, INC | Ultra-long flashlamp-excited pulse dye laser for therapy and method therefor |
5626631, | Oct 20 1992 | LUMENIS, LTD | Method and apparatus for therapeutic electromagnetic treatment |
5720772, | Oct 20 1992 | LUMENIS, LTD | Method and apparatus for therapeutic electromagnetic treatment |
5749868, | Dec 09 1994 | Cynosure, Inc. | Near infra-red selective photothermolysis for ectatic vessels and method therefor |
5755751, | Oct 20 1992 | LUMENIS, LTD | Method and apparatus for therapeutic electromagnetic treatment |
5807386, | Feb 03 1995 | Laser Industries, Ltd. | Laser facial rejuvenation |
5810801, | Feb 05 1997 | Candela Corporation | Method and apparatus for treating wrinkles in skin using radiation |
5964749, | Sep 15 1995 | LUMENIS LTD | Method and apparatus for skin rejuvenation and wrinkle smoothing |
5983900, | Aug 28 1997 | SQUADRON CAPITAL IP HOLDINGS LLC | Wrinkle removal |
6077294, | Jun 11 1998 | Cynosure, Inc | Method for non-invasive wrinkle removal and skin treatment |
6197020, | Aug 12 1996 | Sublase, Inc. | Laser apparatus for subsurface cutaneous treatment |
6248103, | Apr 05 1994 | The Regents of the University of California | Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery using long laser pulses |
WO9504393, |
Executed on | Assignor | Assignee | Conveyance | Frame | Reel | Doc |
Jun 19 2002 | Cynosure, Inc. | (assignment on the face of the patent) | / | |||
May 01 2017 | Cynosure, Inc | BANK OF AMERICA, N A , AS COLLATERAL AGENT | SECURITY INTEREST SEE DOCUMENT FOR DETAILS | 042261 | /0911 | |
May 01 2017 | PALOMAR MEDICAL TECHNOLOGIES, LLC | BANK OF AMERICA, N A , AS COLLATERAL AGENT | SECURITY INTEREST SEE DOCUMENT FOR DETAILS | 042261 | /0911 | |
Nov 10 2017 | Hologic, Inc | BANK OF AMERICA, N A , AS COLLATERAL AGENT | SECURITY INTEREST SEE DOCUMENT FOR DETAILS | 044123 | /0353 | |
Nov 10 2017 | Gen-Probe Incorporated | BANK OF AMERICA, N A , AS COLLATERAL AGENT | SECURITY INTEREST SEE DOCUMENT FOR DETAILS | 044123 | /0353 | |
Nov 10 2017 | Cynosure, Inc | BANK OF AMERICA, N A , AS COLLATERAL AGENT | SECURITY INTEREST SEE DOCUMENT FOR DETAILS | 044123 | /0353 | |
Nov 10 2017 | Biolucent, LLC | BANK OF AMERICA, N A , AS COLLATERAL AGENT | SECURITY INTEREST SEE DOCUMENT FOR DETAILS | 044123 | /0353 |
Date | Maintenance Fee Events |
Jul 28 2008 | ASPN: Payor Number Assigned. |
Dec 20 2011 | M1553: Payment of Maintenance Fee, 12th Year, Large Entity. |
Date | Maintenance Schedule |
Jun 24 2011 | 4 years fee payment window open |
Dec 24 2011 | 6 months grace period start (w surcharge) |
Jun 24 2012 | patent expiry (for year 4) |
Jun 24 2014 | 2 years to revive unintentionally abandoned end. (for year 4) |
Jun 24 2015 | 8 years fee payment window open |
Dec 24 2015 | 6 months grace period start (w surcharge) |
Jun 24 2016 | patent expiry (for year 8) |
Jun 24 2018 | 2 years to revive unintentionally abandoned end. (for year 8) |
Jun 24 2019 | 12 years fee payment window open |
Dec 24 2019 | 6 months grace period start (w surcharge) |
Jun 24 2020 | patent expiry (for year 12) |
Jun 24 2022 | 2 years to revive unintentionally abandoned end. (for year 12) |