A laser treatment device and process with controlled cooling. The device contains a cooling element with high heat conduction properties, which is transparent to the laser beam. A surface of the cooling element is held in contact with the tissue being treated while at least one other surface of the cooling element is cooled by the evaporation of a cryogenic fluid. The cooling is coordinated with the application of the laser beam so as to control the temperatures of all affected layers of tissues. In a preferred embodiment useful for removal of wrinkles and spider veins, the cooling element is a sapphire plate. A cryogenic spray cools the top surface of the plate and the bottom surface of the plate is in contact with the skin. In preferred embodiments the wavelength of the laser beam is chosen so that absorption in targeted tissue is low enough so that substantial absorption occurs throughout the targeted tissue. In a preferred embodiment for treating large spider veins with diameters in the range of 1.5 mm, Applicants use an Er:Glass laser with a wavelength of 1.54 microns.

Patent
   RE46208
Priority
Oct 16 1998
Filed
Jun 21 2011
Issued
Nov 22 2016
Expiry
Oct 16 2018

TERM.DISCL.
Assg.orig
Entity
unknown
0
161
EXPIRED
0. 29. A method for cryogenically treating tissue below a skin surface, comprising:
placing a hand-held unit in contact with the skin surface;
cryogenically cooling the skin surface by contacting the skin surface with a material which has high thermal conductivity;
monitoring a temperature of either the material or the skin surface; and
controlling an amount of time the hand-held unit is in contact with the skin surface and an amount of cooling applied in order to cryogenically reach a desired temperature of the tissue at a desired depth below the skin surface, which is lower than a temperature before treatment, to promote lymphatic drainage by cold therapy.
0. 49. A method for cryogenically treating tissue below a skin surface, comprising:
placing a hand-held unit in contact with the skin surface;
cryogenically cooling the skin surface by contacting the skin surface with a material which has high thermal conductivity;
monitoring a temperature of either the material or the skin surface; and
controlling an amount of time the hand-held unit is in contact with the skin surface and an amount of cooling applied in order to cryogenically reach a desired temperature of the tissue at a desired depth below the skin surface, which is lower than a temperature before treatment, to promote lymphatic drainage by cold therapy,
wherein cooling of the skin tissue is accompanied by no heating with laser light or other heating mechanism.
0. 1. A laser system for tissue treatment, comprising:
A) A hand-held portable battery powered tissue cooling unit comprising:
1) a cooling transmitting element comprised of material transparaent to light at a nominal wavelength and having high thermal conductivity and having a contact surface for contacting a surface of tissue being treated,
2) a cryogenic container mounted within or on said cooling unit,
3) a cryogen contained in said container,
4) a cryogenic cooling chamber for cooling at least one surface of said cooling element, said chamber having an entrance port communicating with said container and an exit port,
5) a battery powered cryogenic control means for permitting a flow of vaporizing cryogen from said container into said chamber to cool said at least one surface in order to remove heat from said tissue surface and to produce desired temperature distribution in target tissue being treated, and
6) a battery mounted on or within said cooling unit for providing power to said control means, and
B) a source of laser light defining a nominal wavelength arranged to transmit said laser light through said cooling transmitting element.
0. 2. A laser system as in claim 1 and further comprising a temperature-monitoring element mounted adjacent to but insulated from said contact surface for monitoring tissue surface temperature.
0. 3. A laser system as in claim 1 and further comprising a temperature-monitoring element configured to monitor temperature of said cooling element.
0. 4. A laser system as in claim 1 and further comprising a processor programmed for controlling said source of laser light and said flow of cryogen.
0. 5. A laser system as in claim 1 wherein said source of laser light is a free running mode Er:Glass pulse laser.
0. 6. A laser system as in claim 1 wherein said source of laser light is a Nd:YAG laser.
0. 7. A laser system as in claim 6 wherein said Nd:YAG laser is arranged to operate at a pulse width of about 50 ms.
0. 8. A laser system as in claim 6 wherein said Nd:YAG laser is arranged to operate at a pulse width of about 100 to 200 ms.
0. 9. A laser system as in claim 1 wherein said cooling transmitting element is sapphire plate and substantially all cooling of said plate is through a single non-circumferential surface.
0. 10. A laser system as in claim 1 wherein said cooling transmitting element is sapphire rod defining a circumferential surface and substantially all cooling is through said circumferential surface.
0. 11. A laser system as in claim 1 wherein said cooling transmitting element is a diamond plate.
0. 12. A laser system as in claim 1 wherein said cooling transmitting element is a diamond rod.
0. 13. A laser system as in claim 1 wherein said cooling transmitting element is a patterned rod.
0. 14. A laser system as in claim 1 wherein said cooling transmitting element has a concave form for self-collimating beam properties.
0. 15. A laser system as in claim 1 wherein said cooling transmitting element is a cylindrical rod mounted horizontally.
0. 16. A process for treating tissue, comprising the steps of:
A) generating from a source a laser light defining a nominal wavelength,
B) transmitting said laser light through a hand-held portable battery operated tissue cooling unit comprising a cooling transmitting element comprised of material transparent to light at said nominal wavelength and having high thermal conductivity and having a contact surface for contacting a surface of tissue being treated,
C) inserting cryogen from a cryogenic container, mounted on or within said cooling unit, into a cryogenic cooling chamber for said cooling element, said chamber having an entrance port communicating with said container and an exit port,
wherein said inserting permits a flow of vaporizing cryogen from said container into said chamber to cool said cooling element in order to remove heat from the tissue surface and to produce desired temperature distribution in target tissue and wherein the battery is mounted on or within the cooling unit.
0. 17. A process as in claim 16, further comprising the additional step of sliding said cooling element across surface of tissue while applying laser radiation through a portion of said cooling transmitting element so as to provide pre, during and post cooling of said tissue.
0. 18. A process as in claim 17, further comprising the step of controlling said source of laser light and said flow of cryogen with a processor programmed with a control algorithm.
0. 19. A process as in claim 17, wherein said method is for the purpose of treating spider veins.
0. 20. A hand-held portable battery powered tissue cooling unit, useful for both cryogenic tissue treatment and for cooling tissue during laser treatment, comprising:
A) a cooling transmitting element comprised of material transparent to light at a nominal wavelength and having high thermal conductivity and having a contact surface for contacting a surface of tissue being treated,
B) a cryogenic container mounted on or within said cooling unit,
C) a cryogen contained in said container,
D) a cryogenic cooling chamber for cooling at least one surface of said cooling element, said chamber having an entrance port communicating with said container and an exit port,
E) a battery powered cryogenic control means for permitting a flow of vaporizing cryogen from said container into said chamber to cool said at least one surface in order to remove heat from said tissue surface and to produce desired temperature distribution in target tissue being treated, and
F) a battery mounted on or within said cooling unit providing power to said control means.
0. 21. A cooling unit as in claim 20 wherein said cooling transmitting element is comprised of sapphire.
0. 22. A cooling unit as in claim 20 wherein said cooling transmitting element is comprised of diamond.
0. 23. A cooling unit as in claim 20 wherein said control means includes a temperature detector.
0. 24. A cooling unit as in claim 23 wherein said temperature detector is a thermocouple.
0. 25. A cooling unit as in claim 24 wherein said cryogenic container is a replaceable container.
0. 26. A cooling unit as in claim 25 wherein said control means comprises a microprocessor for providing a controlled spray from said cryogenic container.
0. 27. A cooling unit as in claim 26 wherein said cooling transmitting element comprises a sapphire plate and wherein said microprocessor is programmed to provide a controlled spray from said cryogen container onto said sapphire plate.
0. 28. A cooling unit as in claim 27 wherein said cryogen is tetrafluoethan.
0. 30. The method of claim 29, wherein the temperature of the material is monitored.
0. 31. The method of claim 29, wherein the temperature of the skin surface is monitored.
0. 32. The method of claim 29, wherein the temperature is monitored with a thermocouple.
0. 33. The method of claim 32, wherein the temperature of the skin surface is controlled so as to not fall below 0 degrees Centigrade for more than one second.
0. 34. The method of claim 29, wherein the cooling results in skin rejuvenation.
0. 35. The method of claim 29, wherein the amount of cooling applied is automatically controlled in response to the monitored temperature.
0. 36. The method of claim 29, wherein the tissue below the skin surface is destroyed without any significant damage to the skin surface.
0. 37. The method of claim 29, wherein the tissue comprises epidermal tissue.
0. 38. The method of claim 29, wherein the material is cooled by evaporation of a cryogenic fluid.
0. 39. The method of claim 29, wherein the cooling results in either removal of wrinkles or removal of spider veins.
0. 40. The method of claim 29, wherein a temperature of all desired tissue layers being treated are controlled.
0. 41. The method of claim 29, wherein cooling of the skin tissue is accompanied by no heating with laser light or other heating mechanism.
0. 42. The method of claim 29, further comprising:
cleaning the skin surface with alcohol prior to placing the hand-held unit in contact with the skin.
0. 43. The method of claim 29, further comprising:
heating the skin surface.
0. 44. The method of claim 43, wherein the skin surface is heated prior to being cooled.
0. 45. The method of claim 43, wherein the skin surface is heated as it is cooled.
0. 46. The method of claim 29, wherein the material has a convex surface that contacts the skin surface.
0. 47. The method of claim 29, wherein the material has a planar surface that contacts the skin surface.
0. 48. The method of claim 29, wherein the cooling results in cryogenic treatment of skin surface lesions.
0. 50. The method of claim 49, wherein the temperature of the material is monitored.
0. 51. The method of claim 49, wherein the temperature of the skin surface is monitored.
0. 52. The method of claim 49, wherein the temperature is monitored with a thermocouple.
0. 53. The method of claim 49, wherein the temperature of the skin surface is controlled so as to not fall below 0 degrees Centigrade for more than one second.
0. 54. The method of claim 49, wherein the cooling results in skin rejuvenation.
0. 55. The method of claim 49, wherein the amount of cooling applied is automatically controlled in response to the monitored temperature.
0. 56. The method of claim 49, wherein the tissue below the skin surface is destroyed without any significant damage to the skin surface.
0. 57. The method of claim 49, wherein the tissue comprises epidermal tissue.
0. 58. The method of claim 49, wherein the material is cooled by evaporation of a cryogenic fluid.
0. 59. The method of claim 49, wherein the cooling results in either removal of wrinkles or removal of spider veins.
0. 60. The method of claim 49, wherein a temperature of all desired tissue layers being treated are controlled.
0. 61. The method of claim 49, further comprising:
cleaning the skin surface with alcohol prior to placing the hand-held unit in contact with the skin.
0. 62. The method of claim 49, further comprising:
heating the skin surface.
0. 63. The method of claim 62, wherein the skin surface is heated prior to being cooled.
0. 64. The method of claim 62, wherein the skin surface is heated as it is cooled.
0. 65. The method of claim 49, wherein the material has a convex surface that contacts the skin surface.
0. 66. The method of claim 49, wherein the material has a planar surface that contacts the skin surface.
0. 67. The method of claim 49, wherein the cooling results in cryogenic treatment of skin surface lesions.

where skin density is about 1.15 g/cm3 and specific heat of skin about 3.8J/Cgm.

Effect of skin surface cooling on temperature distribution in skin have been estimated by solving heat transfer equation in semi infinite skin tissue with boundary conditions corresponding to constant −5° C. temperature of the surface (or other constant temperature of the sapphire rod). Temperature distribution in ° C. in skin then can be calculated by formula:
T(z,t)=37*erf(z/2 αct),
where erf refers to the Gausian error function, and z is the depth into the tissue, t is time lapse in seconds from the start of the contact skin cooling and α=10−4(cm2/sec) is thermal diffusivity of skin dermis. Skin temperature was found by superposition of laser heating and surface cooling effects.

Various elaborate computer programs are available for more precise estimate of temperature distribution within the skin as a function of time. Applicants have made analysis using a Monte-Carlo computer code specifically modified for skin thermodynamic analysis and some of the results are shown in FIGS. 7A1-7 and 7B1-7 which were discussed above. Cooling experiments have been performed by using different configurations of the cooling element for the different applications. For these applications, one of the alternative embodiments is recommended.

The reader should understand that devices according to the present invention work by destroying living tissue. Hopefully the destroyed tissue is unwanted tissue and is quickly replaced by new tissue produced by the body's natural ability to repair damaged and destroyed skin tissue. Care should be taken to minimize unwanted tissue destruction. Applicants recommend that tests be performed prior to use of the device in the manner disclosed above. A test station could be constructed using a plastic material having thermal properties similar to human skin and equipping it with fast response thermocouples located at various depths and positions below the surface. The thermocouples should be connected to the real time monitors so that the technician and the patient can see the thermal effects produced by the device prior to actual use on the patient.

A second embodiment involves the use of a cryogenically cooled diamond cooling element as shown in FIGS. 5A and 5B. The device consists of copper holder 24, which has a cryogenic container 21. Synthetic diamond cooling element 23 is in the shape of a flattened cylinder and contains a circular groove through which cryogenic mist flows. The mist exits at the exit port 26.

The flattened diamond rod is transparent to the laser beam. It is applied to the part of the cleaned skin to be treated. The nozzle valve opens the shutter and the cryogenic spray flows to the chamber around this window. When the window is cold the “ready” light will be switched-on. The energy delivery procedure can be started. This device is good for the large area irradiation such as subsurface tumor interstitial thermotherapy with a high frequency electromagnetic radiation.

A third embodiment for practicing this invention is to use a patterned rod to the surface of the skin in order to have damaged and healthy areas under the skin surface. FIGS. 3A and 3B show rod 31 with the perpendicular grooves 32 filled with copper stripes 33.

A laser light is sent through the cooled rod to the surface of the skin does not penetrate through the copper stripes. But the contacting surface of the rod has an almost uniform temperature distribution. It means that the surface of the skin is cooled uniformly. But under skin damage is not uniform having irradiated and not irradiated healthy spots. The reason to have these healthy untouched spots around the damaged tissue is to use the capacity of healthy spot tissue and cells for the fast immune response and wound healing process.

This embodiment is essentially the same as the first one described above except that the rod tip, which is connected to the fiber optics has concave form for the self-collimating beam properties. FIG. 4 shows a cooling element with the lens-type tip surface. For such an element, it does not require a collimated lens and can be replaced by the transparent disk-type window in the oil chamber.

This embodiment is essentially the same as the first one described above except that the cylindrical element is placed in the cooling chamber horizontally (see FIGS. 6A and 6B). The reader should note that the rod could be of different shapes to provide desired beam profiles on the skin surface or to focus the beam. The focal point (or focal line) could be under the skin to help concentrate the beam energy in target locations.

The device disclosed herein can be used in reverse. That is, surface tissue destruction can be provided by the very cold surface of the tip of the sapphire rod. Preferably, the skin is pre-warmed with a low energy laser pulse of about one-half the values specified above which should cause no damage but will provide warmth which will minimize tissue destruction caused below the surface. This process is good for freezing of warts and certain types of surface skin cancers.

In an additional embodiment pre and post cooling is provided by transparent circular part 20 as shown in FIG. 9 preferably comprised of sapphire. In this case the exhaust from chamber 17 flows through port 21 onto the surface of the circular sapphire part 20 to cool it. This cool surface which will be at a temperature above 0 C prevents the epidermis from being overheated from the hotter lower dermis. This permits the technician to move the laser beam rapidly across the skin surface. The illuminated portion of the skin is both pre-cooled and post-cooled.

Another preferred embodiment is shown in FIGS. 10A and B. Solenoid valve 50 is controlled by microprocessor 52 to provide a controlled spray from cryogen can 53 on sapphire plate 54 which cools skin surface 565. The temperature of plate 54 is monitored using thermocouple 58. Temperature data is displayed on display 60. The operator has manual control of the spray with switch 62 as desired or the spray can be automatically controlled with processor 52 based on temperature data from thermocouple 58. In a preferred process the operator holds a laser device in one hand and the cooling device in the other. He moves the cooling device in the direction of arrow 64 and the laser beam is directed as shown at 66. As in the paragraph above sapphire plate 54 provides both pre and post cooling as the cooling device is moved along the skin surface. FIG. 10B shows a bottom view of plate 54. In this example the laser beam applicator (not shown specifically) and the cooling device are handled separately, but they could be mounted together as one unit.

It is very important for all of these embodiments and in other embodiments that will be apparent to persons skilled in the art that the cooling rod has a very high thermoconductivity coefficient and low absorption of the irradiating light. The substance used for the cryogenic cooling can be chosen based on the particular application. The important thing is to use a proper time of cooling in order to reach a required low temperature of the tissue at the required depth. Persons skilled in the art will recognize that certain material and configuration of the rod, container, coolant and connector will be preferred for different skin type, different lesions and different applications. The reader should note that the preferred embodiment of this invention can be used without this laser to provide cryogenic treatment to surface skin lesions. The same skin cooling can be provided with about 1/10 the cryogen as direct open spray. An important application of the device for cryogenic treatment is to promote lymphatic drainage by cold therapy. Skin rejuvenation begins with flushing of the lymphatic system to remove dead proteins and other debris. Thermal receptors in the lymphatic system are effectively stimulated by the presence of cold applied to the skin surface. Current techniques for lymphatic drainage by cold therapy include spray and ice, both of which are messy and offer poor control of the skin temperature. The device shown in FIGS. 10A and B is useful for lymphatic drainage due to its compact hand held design, disposable canisters and accurate control of the skin temperature.

While the above description contains many specifications, the reader should not construe these as limitations on the scope of the invention, buy merely as exemplifications of preferred embodiments thereof. Those skilled in the art will envision many other possible variations are within its scope. Accordingly the reader is requested to determine the scope of the invention by the appended claims and their legal equivalents, and not by the examples which have been given.

Baranov, Eugene, Tankovich, Nikolai I.

Patent Priority Assignee Title
Patent Priority Assignee Title
3622743,
4122853, Mar 14 1977 Spectra-Med Infrared laser photocautery device
4573465, Nov 19 1981 Nippon Infrared Industries Co., Ltd. Laser irradiation apparatus
4587396, Dec 31 1982 Laser Industries Ltd. Control apparatus particularly useful for controlling a laser
4653495, Jan 13 1984 Kabushiki Kaisha Toshiba Laser medical apparatus
4718416, Jan 13 1984 Kabushiki Kaisha Toshiba Laser treatment apparatus
4733660, Aug 07 1984 Medical Laser Research and Development Corporation Laser system for providing target specific energy deposition and damage
4775361, Apr 10 1986 GENERAL HOSPITAL CORPORATION THE, A CORP OF MA Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
4930504, Nov 13 1987 OMEGA UNIVERSAL LIMITED Device for biostimulation of tissue and method for treatment of tissue
4976709, Sep 27 1985 RJW ACQUISTIONS, L C , D B A 20 20 TECHNOLOGIES, INC Method for collagen treatment
5000752, Dec 13 1985 William J., Hoskin Treatment apparatus and method
5104392, Mar 22 1985 Massachusetts Institute of Technology Laser spectro-optic imaging for diagnosis and treatment of diseased tissue
5106387, Mar 22 1985 Massachusetts Institute of Technology Method for spectroscopic diagnosis of tissue
5128509, Sep 04 1990 RELIANT TECHNOLOGIES, INC Method and apparatus for transforming and steering laser beams
5178617, Jul 09 1991 Laserscope System for controlled distribution of laser dosage
5192278, Mar 22 1985 Massachusetts Institute of Technology Multi-fiber plug for a laser catheter
5282797, May 30 1989 Method for treating cutaneous vascular lesions
5302259, Apr 30 1991 Method and apparatus for altering the properties in light absorbing material
5312395, Mar 14 1990 Candela Corporation Method of treating pigmented lesions using pulsed irradiation
5312396, Sep 06 1990 MASSACHUSETTS INSTITUTE OF TECHNOLOGY A CORP OF MA Pulsed laser system for the surgical removal of tissue
5336217, Apr 24 1986 Institut National de la Sante et de la Recherche Medicale (INSEPM) Process for treatment by irradiating an area of a body, and treatment apparatus usable in dermatology for the treatment of cutaneous angio dysplasias
5339347, Apr 27 1993 Brookhaven Science Associates, LLC Method for microbeam radiation therapy
5344418, Dec 12 1991 Optical system for treatment of vascular lesions
5360447, Feb 03 1993 ESC MEDICAL SYSTEMS, INC Laser assisted hair transplant method
5411502, Jan 15 1992 LUMENIS, LTD System for causing ablation of irradiated material of living tissue while not causing damage below a predetermined depth
5421337, Apr 14 1989 Massachusetts Institute of Technology Spectral diagnosis of diseased tissue
5423803, Jan 19 1993 ThermoLase Corporation Skin surface peeling process using laser
5474549, Jul 09 1991 Laserscope Method and system for scanning a laser beam for controlled distribution of laser dosage
5486172, May 30 1989 Apparatus for treating cutaneous vascular lesions
5531740, Sep 06 1994 Rapistan Demag Corporation; RELIANT TECHNOLOGIES, INC Automatic color-activated scanning treatment of dermatological conditions by laser
5546214, Sep 13 1995 Reliant Technologies, Inc. Method and apparatus for treating a surface with a scanning laser beam having an improved intensity cross-section
5558666, Jan 14 1994 LUMENIS, LTD Handpiece for producing highly collimated laser beam for dermatological procedures
5582752, Dec 17 1993 LUMENIS, LTD Method and apparatus for applying laser beams to a working surface, particularly for ablating tissue
5586981, Aug 25 1994 Xin-Hua, Hu Treatment of cutaneous vascular and pigmented lesions
5595568, Feb 01 1995 General Hospital Corporation, The Permanent hair removal using optical pulses
5611795, Feb 03 1995 Laser Industries Limited Laser facial rejuvenation
5616140, Mar 21 1994 LASERCURE SCIENCES, INC Method and apparatus for therapeutic laser treatment
5618284, Sep 27 1985 SAND M D , BRUCE J Collagen treatment apparatus
5618285, Jan 15 1992 Laser Industries, Limited System for causing ablation of irradiated material of living tissue while not causing damage below a predetermined depth
5624434, Feb 03 1995 Laser Industries Limited Laser preparation of recipient holes for graft implantation in the treatment of icepick scars
5624435, Jun 05 1995 CYNOSYURE, INC Ultra-long flashlamp-excited pulse dye laser for therapy and method therefor
5628744, Dec 21 1993 Boston Scientific Scimed, Inc Treatment beam handpiece
5632741, Jan 20 1995 LUCID TECHNOLOGIES, INC Epilation system
5643252, Oct 28 1992 TRANSMEDICA INTERNATIONAL, INC Laser perforator
5655547, May 15 1996 ESC MEDICAL SYSTEMS LTD Method for laser surgery
5713364, Aug 01 1995 Luma Imaging Corporation Spectral volume microprobe analysis of materials
5733278, Nov 30 1994 Laser Industries Limited Method and apparatus for hair transplantation using a scanning continuous-working CO2 laser
5735844, Feb 01 1995 General Hospital Corporation, The Hair removal using optical pulses
5746735, Oct 26 1994 Cynosure, Inc. Ultra long pulsed dye laser device for treatment of ectatic vessels and method therefor
5759200, Sep 04 1996 RADIANCY, INC Method of selective photothermolysis
5798498, Dec 17 1993 LUMENIS, LTD Method and apparatus for applying laser beams to a working surface, particularly for ablating tissue
5807386, Feb 03 1995 Laser Industries, Ltd. Laser facial rejuvenation
5810801, Feb 05 1997 Candela Corporation Method and apparatus for treating wrinkles in skin using radiation
5814040, Apr 05 1994 The Regents of the University of California Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery
5814042, Dec 17 1993 LUMENIS, LTD Apparatus for applying laser beam to living tissue to cause uniform ablation of living tissue while not causing thermal damage below a predetermined depth to the surrounding tissue
5817089, Oct 29 1991 ThermoLase Corporation Skin treatment process using laser
5820626, Jul 30 1996 NEW STAR LASERS, INC Cooling laser handpiece with refillable coolant reservoir
5830208, Jan 31 1997 LaserLite, LLC Peltier cooled apparatus and methods for dermatological treatment
5843073, Jul 13 1985 CARDIOFOCUS, INC Infrared laser catheter system
5860967, Jul 21 1993 Lucid, Inc. Dermatological laser treatment system with electronic visualization of the area being treated
5860968, Nov 03 1995 Luxar Corporation Laser scanning method and apparatus
5865754, Aug 23 1996 Texas A&M University System Fluorescence imaging system and method
5879326, May 22 1995 Massachusetts General Hospital Method and apparatus for disruption of the epidermis
5879346, Dec 18 1995 Laser Industries Ltd Hair removal by selective photothermolysis with an alexandrite laser
5885211, Dec 08 1993 Nitto Denko Corporation Microporation of human skin for monitoring the concentration of an analyte
5897549, Nov 29 1995 RELIANT TECHNOLOGIES, INC Transformation of unwanted tissue by deep laser heating of water
5906609, Feb 05 1997 ESC MEDICAL SYSTEMS LTD Method for delivering energy within continuous outline
5908415, Sep 09 1994 CARDIOFOCUS, INC Phototherapy methods and apparatus
5925035, Oct 29 1991 ThermoLase Corporation Hair removal method
5938657, Feb 05 1997 LUMENIS, LTD Apparatus for delivering energy within continuous outline
5947956, Nov 04 1997 Laser apparatus for making holes and etchings
5957915, Jan 23 1995 LUMENIS, LTD Hand-held laser scanner
5964749, Sep 15 1995 LUMENIS LTD Method and apparatus for skin rejuvenation and wrinkle smoothing
5968033, Nov 03 1997 Fuller Research Corporation Optical delivery system and method for subsurface tissue irradiation
5970983, May 15 1996 LUMENIS LTD Method of laser surgery
5976123, Jul 30 1996 NEW STAR LASERS, INC Heart stabilization
5980512, Feb 26 1998 B&S RESEARCH AND DEVELOPMENT Enhanced laser skin treatment mechanism
5983900, Aug 28 1997 SQUADRON CAPITAL IP HOLDINGS LLC Wrinkle removal
5984915, Oct 08 1997 TRIMEDYNE, INC Percutaneous laser treatment
5995265, Aug 12 1996 RELIANT TECHNOLOGIES, INC Method and apparatus for treating a surface with a scanning laser beam having an improved intensity cross-section
5995866, Mar 21 1995 Method and apparatus for scanning and evaluating matter
5997530, Apr 13 1998 Regents of the University of California, The Apparatus and method to control atmospheric water vapor composition and concentration during dynamic cooling of biological tissues in conjunction with laser irradiations
6015404, Dec 02 1996 PALOMAR MEDICAL TECHNOLOGIES, LLC Laser dermatology with feedback control
6022316, Mar 06 1998 Nitto Denko Corporation Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
6027496, Mar 25 1997 Abbott Laboratories Removal of stratum corneum by means of light
6036684, Oct 29 1991 ThermoLase Corporation Skin treatment process using laser
6050990, Dec 05 1996 ThermoLase Corporation Methods and devices for inhibiting hair growth and related skin treatments
6059820, Oct 16 1998 RELIANT TECHNOLOGIES, INC Tissue cooling rod for laser surgery
6063108, Jan 06 1997 INTERNATIONAL MEDICAL INSTRUMENTS INC Method and apparatus for localized low energy photon therapy (LEPT)
6074384, Mar 06 1998 PLC MEDICAL SYSTEMS, INC Endocardial laser revascularization with single laser pulses
6083217, Nov 29 1995 RELIANT TECHNOLOGIES, INC Destruction for unwanted tissue by deep laser heating of water
6096029, Aug 12 1996 BioLase Technology, Inc Laser method for subsurface cutaneous treatment
6096031, Apr 17 1995 LUMENIS, LTD High repetition rate erbium:YAG laser for tissue ablation
6104959, Jul 31 1997 MIRADRY, INC Method and apparatus for treating subcutaneous histological features
6106514, Aug 12 1996 BioLase Technology, Inc Laser method for subsurface cutaneous treatment
6113559, Dec 29 1997 DERMAFOCUS LLC Method and apparatus for therapeutic treatment of skin with ultrasound
6120497, Feb 05 1997 Candela Corporation Method and apparatus for treating wrinkles in skin using radiation
6142939, Nov 15 1993 Nitto Denko Corporation Microporation of human skin for drug delivery and monitoring applications
6149644, Feb 17 1998 Altralight, Inc. Method and apparatus for epidermal treatment with computer controlled moving focused infrared light
6149645, Apr 03 1998 Tact IP, LLC Apparatus and method employing lasers for removal of hair
6152917, Oct 29 1991 ThermoLase Corporation Hair removal device
6162211, Dec 05 1996 ThermoLase Corporation Skin enhancement using laser light
6165170, Jan 29 1998 International Business Machines Corporation Laser dermablator and dermablation
6168590, Aug 12 1997 Y-BEAM TECHNOLOGIES, INC Method for permanent hair removal
6171301, May 15 1995 The Regents of the University of California Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery
6171302, Mar 19 1997 LUMENIS, LTD Apparatus and method including a handpiece for synchronizing the pulsing of a light source
6173202, Mar 06 1998 Nitto Denko Corporation Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
6176854, Oct 08 1997 Percutaneous laser treatment
6183773, Jan 04 1999 GENERAL HOSPITAL CORPORATION, D B A MASSACHUSSETTS GENERAL HOSPITAL, THE Targeting of sebaceous follicles as a treatment of sebaceous gland disorders
6197020, Aug 12 1996 Sublase, Inc. Laser apparatus for subsurface cutaneous treatment
6219575, Oct 23 1998 APPLIED TISSUE OPTICS, INC Method and apparatus to enhance optical transparency of biological tissues
6235015, May 14 1997 Candela Corporation; SCHWARTZ ELECTRO-OPTICS, INC Method and apparatus for selective hair depilation using a scanned beam of light at 600 to 1000 nm
6241753, May 05 1995 THERMAGE, INC Method for scar collagen formation and contraction
6245060, Mar 25 1997 Abbott Laboratories Removal of stratum corneum by means of light
6248103, Apr 05 1994 The Regents of the University of California Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery using long laser pulses
6251099, Nov 27 1996 General Hospital Corporation, The Compound delivery using impulse transients
6251100, Sep 24 1993 TRANSMEDICA INTERNATIONAL, INC Laser assisted topical anesthetic permeation
6264649, Apr 09 1998 Coolanalgesia Limited Laser treatment cooling head
6267771, Oct 29 1991 ThermoLase Corporation Hair removal device and method
6273884, May 15 1997 PALOMAR MEDICAL TECHNOLOGIES, LLC Method and apparatus for dermatology treatment
6273885, Aug 16 1997 NEW STAR LASERS, INC Handheld photoepilation device and method
6315772, Sep 24 1993 TRANSMEDICA INTERNATIONAL, INC Laser assisted pharmaceutical delivery and fluid removal
6325769, Dec 29 1998 DERMAFOCUS LLC Method and apparatus for therapeutic treatment of skin
6328733, Jan 23 1995 LUMENIS, LTD Hand-held laser scanner
6387089, Sep 15 1995 LUMENIS, LTD Method and apparatus for skin rejuvination and wrinkle smoothing
6406474, Sep 30 1999 Biolitec Pharma Marketing Ltd Device and method for application of radiation
6413267, Aug 09 1999 THERALASE, INC Therapeutic laser device and method including noninvasive subsurface monitoring and controlling means
6443946, Aug 29 1996 ICN Photonics Limited Apparatus for wrinkle removal
6443978, Apr 09 1999 BioVentures, LLC Photomatrix device
6445491, Jan 29 1999 AISIN SEIKI CO , LTD Method and apparatus for optical sectioning and imaging using time-gated parametric image amplification
6468229, Oct 20 1996 Abbott Laboratories Apparatus and method for the collection of interstitial fluids
6475138, Jul 12 1995 Laser Industries Ltd Apparatus and method as preparation for performing a myringotomy in a child's ear without the need for anaesthesia
6508813, Dec 02 1996 PALOMAR MEDICAL TECHNOLOGIES, LLC System for electromagnetic radiation dermatology and head for use therewith
6514278, May 28 1998 Carl Baasel Lasertechnik GmbH Method and device for the superficial heating of tissue
6517532, May 15 1997 PALOMAR MEDICAL TECHNOLOGIES, LLC Light energy delivery head
6530915, Mar 06 1998 Nitto Denko Corporation Photothermal structure for biomedical applications, and method therefor
6537270, Aug 13 1998 Asclepion-Meditec AG Medical hand piece for a laser radiation source
6572637, Mar 12 1999 Ya-Man Ltd. Handbreadth-sized laser beam projecting probe for beauty treatment
6575963, Jul 16 1997 CUSTOM VIS PLC Laser scanning apparatus and method
6579283, May 22 1998 Tact IP, LLC Apparatus and method employing a single laser for removal of hair, veins and capillaries
6605080, Mar 27 1998 PALOMAR MEDICAL TECHNOLOGIES, LLC Method and apparatus for the selective targeting of lipid-rich tissues
6607523, Mar 19 1999 MEDART A S Apparatus for tissue treatment
6632219, Oct 16 1998 RELIANT TECHNOLOGIES, INC Tissue cooling rod for laser surgery
6680999, Aug 15 1995 Mumps Audiofax, Inc. Interactive telephony system
6685699, Jun 09 1999 PASSPORT TECHNOLOGIES, INC Self-removing energy absorbing structure for thermal tissue ablation
6743211, Nov 23 1999 VALERITAS LLC Devices and methods for enhanced microneedle penetration of biological barriers
6758845, Oct 08 1999 LUMENIS, LTD Automatic firing apparatus and methods for laser skin treatment over large areas
6881212, Mar 03 2000 SQUADRON CAPITAL IP HOLDINGS LLC Skin wrinkle reduction using pulsed light
7204832, Dec 02 1996 PALOMAR MEDICAL TECHNOLOGIES, LLC Cooling system for a photo cosmetic device
EP827219,
EP827716,
JP1191801,
JP58086787,
JP9285471,
RE36634, Sep 05 1996 Optical system for treatment of vascular lesions
RE36872, Jan 15 1992 Laser Industries Ltd. System for causing ablation of irradiated material of living tissue while not causing damage below a predetermined depth
WO139834,
WO9824502,
WO9824507,
WO9824514,
WO9927997,
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