An anhydrous dental bleaching gel composition is provided which has improved package stability, improved rheology and reduced sensitivity during use. An illustrative anhydrous dental bleaching gel composition embodying these features comprises propylene glycol, polyethylene glycol, glycerin in an amount not exceeding about 10 wt. %, neutralized carboxypolymethylene, hydroxypropylcellulose, and carbamide peroxide.
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1. An anhydrous tooth whitening gel composition comprising carbamide peroxide dispersed in an anhydrous gelatinous carrier, said carrier comprising:
(a) a liquid polyol wherein glycerin, if present, is limited to an amount that does not exceed about 10 wt. % based on the total weight of the composition; and (b) a thickener component containing neutralized carboxypolymethylene and cellulosic ether soluble in the liquid component,
said anhydrous tooth whitening gel composition having enhanced package stability, reduced tooth sensitivity, and improved thixotropic properties. 6. An anhydrous tooth whitening gel composition comprising:
(a) propylene glycol in an amount from about 10 wt. % to about 55 wt. %, (b) polyethylene glycol in an amount from about 10 wt. % to about 50 wt. %, and having a molecular weight from about 400 to about 1500, (c) glycerin in an amount from about 0 wt. % to about 10 wt. %, (d) carboxypolymethylene in an amount from about 0.5 wt. % to about 3.0 wt. %, (e) hydroxypropylcellulose in an amount from about 0.5 wt. % to about 10 wt. %, (f) neutralizing reagent in an amount to substantially neutralize carboxypolymethylene, and (g) carbamide peroxide in an amount from about 5.0 wt. % to about 25 wt. %,
said anhydrous tooth whitening gel composition having enhanced package stability, reduced tooth sensitivity, and improved thixotropic properties. 17. A method for preparing an anhydrous tooth whitening gel composition, which method comprises admixing:
(a) propylene glycol in an amount from about 10 wt. % to about 55 wt. %, (b) polyethylene glycol in an amount from about 10 wt. % to about 50 wt. %, (c) glycerin in an amount from about 0 wt. % to about 10 wt. %, (d) carboxypolymethylene in an amount from about 0.5 wt. % to about 3.0 wt. %, (e) hydroxypropylcellulose in an amount from about 0.5 wt. % to about 10 wt. %, (f) neutralizing reagent in an amount to substantially neutralize carboxypolymethylene, and (g) carbamide peroxide in an amount from about 5.0 wt. % to about 25 wt. %, (h) wherein weight percent is based on the total weight of the gel composition,
said anhydrous tooth whitening gel composition having enhanced package stability, reduced tooth sensitivity, and improved thixotropic properties. 13. A method for whitening teeth which comprises:
(1) extruding an anhydrous tooth whitening gel composition into the reservoir system of a tooth bleaching dental tray, said gel composition comprising: (a) propylene glycol in an amount from about 10 wt. % to about 55 wt. %, (b) polyethylene glycol in an amount from about 10 wt. % to about 50 wt. %, and having a molecular weight from about 400 to about 1500, (c) glycerin in an amount from about 0 wt. % to about 10 wt. %, (d) carboxypolymethylene in an amount from about 0.5 wt. % to about 3.0 wt. %, (e) hydroxypropylcellulose in an amount from about 0.5 wt. % to about 10 wt. %, (f) neutralizing reagent in an amount to substantially neutralize carboxypolymethylene, and (g) carbamide peroxide in an amount from about 5.0 wt. % to about 25 wt. %; (2) placing said dental tray in the oral cavity so as to bring the gel composition into contact with the teeth to be whitened; (3) maintaining said gel composition in contact with said teeth for a plurality of hours per day; and (4) repeating steps 1, 2 and 3 for multiple days to thereby whiten the teeth,
said anhydrous tooth whitening gel composition having enhanced package stability, reduced tooth sensitivity, and improved thixotropic properties. 2. The composition of
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This invention relates to dental compositions and, more particularly, to anhydrous tooth whitening gel compositions, a method for preparing the gel compositions, and a method for utilizing the gel compositions.
In that aspect of aesthetic dentistry which relates to self-administered use of in-home tooth whitening compositions, the dental patient is provided with a custom-fitted dental tray having selectively enlarged tooth treating compartments which are adapted to receive a whitening gel that is dispensed from a syringe. The dental tray, with its gel content, is unobtrusively and advantageously worn by the patient at night and while the patient sleeps. This treatment is repeated for a sufficient period of time to effect the tooth bleaching and whitening process.
It is disclosed in the prior art that carboxypolymethylene as well as methylcelluose can be used as the gelation agents in the formulation of tooth whitening gels. The prior art also discloses that carbamide peroxide (urea peroxide) as well as hydrogen peroxide can be used as the whitening agents in the formulation of tooth whitening gels.
U.S. Pat. No. 5,290,566 (Schow, et al., 1994) discloses a tooth whitening gel containing urea peroxide (carbamide peroxide), methylcelluose and water wherein the concentration of urea peroxide is from about 22 to about 32 wt. %.
U.S. Pat. No. 5,098,303 (Fischer, 1992), U.S. Pat. No. 5,234,342 (Fischer, 1993), U.S. Pat. No. 5,376,006 (Fischer, 1994) and U.S. Pat. No. 5,409,631 (Fischer, 1995), which are incorporated herein by reference, disclose tooth bleaching and whitening gel compositions formulated with carbamide peroxide, water, glycerin, carboxypolymethylene and sodium hydroxide. With respect to broad range ingredient concentration, the formulations contain from about 3.0 to about 20 wt. % carbamide peroxide, from about 10 to about 60 wt. % water, from about 20 to about 70 wt. % glycerin, from about 3.5 to about 12 wt. % carboxypolymethylene and sodium hydroxide in an amount to substantially neutralize the carboxypolymethylene. The gel is characterized as comprising a saturated or super saturated carboxypolymethylene composition wherein the actual concentration of carboxypolymethylene in the total quantity of water in the gel composition is in the range from about 15% to about 40%, with the concentrated carboxypolymethylene providing the gel composition with a tackiness or stickiness. As to gel preparation, the patentee recommends that the carboxypolymethylene be mixed with glycerin and the resulting admixture dispersed in water, followed by the addition of the remaining ingredients, namely, sodium hydroxide and carbamide peroxide.
It has been observed that carbamide peroxide tooth whitening gels containing relatively high concentrations of water, glycerin and carboxypolymethylene (a) tend to have limited package stability as a result of the interaction of carbamide peroxide with water, (b) tend to increase tooth sensitivity as a result of the hygroscopic properties of glycerin which can reduce the moisture level at the tooth treatment surface, and (c) tend to string from one tooth treating compartment in the bleaching tray to the next tooth treating compartment in the tray in the course of syringe loading the compartments with the bleaching gel.
An important object of the present invention is to provide new and improved dental whitening compositions which address the limitations of the prior art dental bleaching gels as hereinabove described.
Another object of this invention is to provide dental whitening compositions which have improved package stability with respect to the active bleaching agent, namely, the peroxide constituent.
A further object of this invention is to provide dental whitening compositions which have reduced sensitivity during use.
An additional object of this invention is to provide dental whitening compositions which have improved thixotropic properties with respect to flow-set characteristics.
These and other objects and features of the present invention are accomplished with the compositions, methods and procedures as described herein.
In accordance with one aspect of this invention, there is provided a dental whitening composition containing carbamide peroxide dispersed in a substantially anhydrous gelatinous carrier. The anhydrous carrier comprises a liquid component wherein glycerin, if present, is limited to an amount that does not exceed about 10 wt. % based on the total weight of the composition. The anhydrous carrier also comprises a thickener component containing neutralized carboxypolymethylene and cellulosic ether soluble in the liquid component.
In accordance with a second aspect of this invention, there is provided a method for whitening teeth which comprises (1) extruding a substantially anhydrous dental bleaching gel composition into the reservoir system of a dental bleaching tray, (2) placing the dental tray in the oral cavity so as to bring the gel composition into contact with the teeth to be whitened, (3) maintaining the gel composition in contact with the aforesaid teeth for a plurality of hours per day, and (4) repeating steps 1, 2 and 3 for multiple days to effect whitening of the teeth. The anhydrous dental bleaching gel composition which can be used in carrying out the method advantageously comprises (a) propylene glycol in an amount from about 10 wt. % to about 50 wt. %, (b) polyethylene glycol in an amount from about 10 wt. % to about 55 wt. %, and having a molecular weight from about 400 to about 1500, (c) glycerin in an amount from about 0 wt. % to about 10 wt. %, (d) carboxypolymethylene in an amount from about 0.5 wt. % to about 3.0 wt. %, (e) hydroxypropylcellulose in an amount from about 0.5 wt. % to about 10 wt. %, (f) neutralizing reagent in an amount to substantially neutralize carboxypolymethylene, and (g) carbamide peroxide in an amount from about 5.0 wt. % to about 25 wt. %.
In accordance with a third aspect of this invention, there is provided a method for preparing substantially anhydrous dental whitening gel compositions. The method comprises admixing a settable ingredient mix to obtain a homogenous dispersion of the ingredients. The settable ingredient mix advantageously comprises (a) propylene glycol in an amount from about 10 wt. % to about 55 wt. %, (b) polyethylene glycol in an amount from about 10 wt. % to about 50 wt. %, and having a molecular weight from about 400 to about 1500, (c) glycerin in an amount from about 0 wt. % to about 10 wt. %, (d) carboxypolymethylene in an amount from about 0.5 wt % to about 3.0 wt. % (e) hydroxypropylcellulose in an amount from about 0.5 wt. % to about 10 wt. %, (f) neutralizing reagent in an amount to substantially neutralize carboxypolymethylene, and (g) carbamide peroxide in an amount from about 5.0 wt. % to about 25 wt. %, (h) wherein weight percent is based on the total weight of the gel composition.
The dental whitening gel compositions of this invention comprise carbamide peroxide dispersed in an anhydrous gelatinous carrier. Carbamide peroxide is generally present in the anhydrous gel compositions in an amount from about 5 wt. % to about 25 wt. % and, preferably, in an amount from about 10 wt. % to about 20 wt. %.
The anhydrous gelatinous carrier comprises a liquid component and a thickener component. Liquid polyols such as propylene glycol and polyethylene glycol are advantageously used in formulating the liquid component. Propylene glycol is generally present in the gel compositions in an amount from about 10 wt. % to about 55 wt. % and, preferably, in an amount from about 25 wt. % to about 45 wt. %. Polyethylene glycol which can be used in the practice of this invention has a molecular weight from about 400 to about 1500 and is generally present in the gel compositions in an amount from about 10 wt. % to about 50 wt. % and, preferably, in an amount from about 25 wt. % to about 45 wt. %.
Glycerin can also be used as a constituent of the liquid component. However, glycerin is hygroscopic and a high concentration of glycerine in the gel tends to pull moisture away from the surface of the teeth which can lead to increased dental sensitivity to the bleaching composition. Accordingly, if glycerin is used in the bleaching gel, it should be limited to a concentration that does not exceed about 10 wt. % of the gel composition. In a more specific aspect, glycerin can be present in the gel composition in an amount from about 3.0 wt. % to about 9.0 wt. %.
The thickener portion of the gel composition advantageously contains a blend of neutralized carboxypolymethylene and cellulosic ether that is soluble in the liquid component. Carboxypolymethylene is generally present in the gel compositions in an amount from about 0.5 wt. % to about 3.0 wt. % and, preferably, in an amount from about 1.5 wt. % to about 2.5 wt. %. Carboxypolymethylene is characterized as a slightly acidic vinyl polymer with active carboxyl groups. Typically, the acidic carboxypolymethylene is neutralized in situ during the preparation of the gel composition by adding an anhydrous alkalinizing agent such as anhydrous sodium hydroxide to the pre-gelatinous mix in order to bring the pH of the gel composition to an orally acceptable level as, for example, a pH from about 6.0 to about 7.5.
Cellulosic ether is generally present in the gel compositions in an amount from about 0.5 wt. % to about 10 wt. % and, preferably, in an amount from about 1.0 wt. % to about 3.0 wt. %. A preferred cellulosic ether is hydroxypropylcellulose.
The blend of neutralized carboxypolymethylene and cellulosic ether is particularly advantageous because the blend provides the gel compositions with improved thixotropic properties in respect of flow-set characteristics. This rheological enhancement constitutes an improvement in the dental bleaching art because it tends to minimize the stringing and roping of the gel from one tooth treating compartment to the next tooth treating compartment during the sequential syringe loading of the gel into the compartments of the dental bleaching tray.
The anhydrous dental bleaching gels of this invention are prepared by adding and mixing the ingredients of the formulation in a suitable vessel such as a stainless steel tank that is provided with a heavy duty mixer which is suitable for use with thick gels. If desired, the mixing vessel can be combined with vacuum equipment for carrying out the admixing of the ingredients under vacuum conditions. The ingredients of the formulation are mixed to obtain a homogenous dispersion which sets to a thixotropic gel.
In the preparation of the dental whitening gels, the formulating ingredients are advantageously added to the mixing vessel in the following order: liquid ingredients, thickener ingredients, alkalinizing agent, carbamide peroxide, and any desired flavoring.
The quantities of the formulating ingredients are so selective as to provide the whitening gels with a composition containing (a) propylene glycol in an amount from about 10 wt. % to about 55 wt. % and, preferably, in an amount from about 25 wt % to about 45 wt. %, (b) polyethylene glycol in an amount from about 10 wt. % to about 50 wt. % and, preferably, in am amount from about 25 wt. % to about 45 wt. % and having a molecular weight from about 400 to about 1500, (c) glycerin in an amount from about 0 wt. % to about 10 wt. % and, preferably, in an amount from about 3.0 wt. % to about 9.0 wt. %, (d) carboxypolymethylene in an amount from about 0.5 wt. % to about 3.0 wt. % and, preferably, in an amount from about 1.5 wt. % to about 2.5 wt. %, (e) hydroxypropylcellulose in an amount from about 0.5 wt. % to about 10 wt. % and, preferably, in an amount from about 1.0 wt. % to about 3.0 wt. %, (f) neutralizing reagent, preferably, anhydrous sodium hydroxide in an amount to substantially neutralize carboxypolymethylene, and (g) carbamide peroxide in an amount from about 5.0 wt. % to about 25 wt. % and, preferably, in an amount from about 10 wt. % to about 20 wt. %.
The following examples further illustrate the anhydrous dental bleaching gels of this invention and the concentration ranges for the ingredients thereof. As used in the examples, "PEG" is a trade designation for polyethylene glycol (Merck Index No. 7545, 11th ed.), "Carbopol" is a trademark for carboxypolymethylene (Merck Index No. 1836, 11th ed.) and "Klucel" is a trademark for hydroxypropylcellulose (Merck Index No. 4776, 11th ed.). The bleaching gels were prepared in accordance with the method and procedure as hereinabove described.
______________________________________ |
Weight Percent |
Ingredients Ex. 1 Ex. 2 Ex. 3 Ex. 4 |
Ex. 5 |
______________________________________ |
Propylene glycol |
47.4 49.0 45.4 43.4 48.4 |
PEG 600 20.0 21.7 -- 16.0 15.0 |
PEG 1000 10.0 11.7 -- -- 15.0 |
PEG 1450 -- -- 26.0 6.0 -- |
PEG 1500 -- -- -- -- -- |
Glycerin 8.0 8.0 8.0 8.0 7.0 |
Carbopol 980 |
2.2 2.2 2.2 2.2 2.2 |
Klucel GFF 1.8 1.8 1.8 1.8 1.8 |
Flavor 0.2 0.2 0.2 0.2 0.2 |
Sodium hydroxide |
0.4 0.4 0.4 0.4 0.4 |
Carbamide peroxide |
10.0 5.0 16.0 22.0 10.0 |
100.0 100.0 100.0 100.0 |
100.0 |
______________________________________ |
______________________________________ |
Weight Percent |
Ingredients Ex. 6 Ex. 7 Ex. 8 |
Ex. 9 |
______________________________________ |
Propylene glycol |
46.4 45.4 54.2 41.1 |
PEG 600 -- -- 28.0 -- |
PEG 1000 31.0 16.0 -- -- |
PEG 1450 -- 16.0 -- -- |
PEG 1500 -- -- -- 35.2 |
Glycerin 8.0 8.0 3.0 3.0 |
Carbopol 980 2.2 2.2 2.0 3.0 |
Klucel GFF 1.8 1.8 0.4 1.0 |
Klucel MFF -- -- 0.8 -- |
Flavor 0.2 0.2 0.2 0.2 |
Sodium hydroxide |
0.4 0.4 0.4 0.5 |
Carbamide peroxide |
10.0 10.0 11.0 16.0 |
100.0 100.0 100.0 |
100.0 |
______________________________________ |
The anhydrous dental whitening gel compositions, as hereinabove described, are packaged in appropriate syringes for dispensing into custom-fitted dental trays that are usually worn at night, but can also be worn during the day, with maximum whitening generally occurring when the treatment is continued for ten to fourteen days. The custom-fitted dental bleaching trays can be prepared by using materials and procedures that are well known in the dental art, and which are described in the prior art cited herein.
In a first alternative packaging embodiment, the dental whitening gels can be packaged in gel dispensing tubes or bottles for extrusion into general purpose dental trays for carrying out the dental whitening process. In a second alternative packaging embodiment, pre-packaged dental trays can be provided to the user containing dental whitening gels which have been adapted for this purpose.
In view of the foregoing descriptions and examples, it will become apparent to those of ordinary skill in the art that equivalent modifications thereof may be made without departing from the spirit and scope of this invention.
Pellico, Michael A., Sababa, Veronica
Patent | Priority | Assignee | Title |
10285915, | Oct 17 2012 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
10285916, | Oct 17 2012 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
10456366, | Nov 29 2017 | Chiou Consulting, Inc.; CHIOU CONSULTING, INC | Composition and methods for tissue regeneration |
10493016, | Sep 11 2002 | The Procter & Gamble Company | Tooth whitening product |
11033374, | Aug 31 2007 | Ultradent Products, Inc. | Dental treatment devices comprising silicone-like elastomeric material |
5718886, | Mar 11 1996 | LACLEDE PROFESSIONAL PRODUCTS, INC | Stabilized anhydrous tooth whitening gel |
5766574, | Nov 15 1996 | Colgate Palmolive Company; Colgate-Polmolive Company | Dual component tooth whitening dentifrice |
5785957, | Dec 12 1995 | CUSTOM CARE PRODUCTS, INC | Inclusion of tooth whitening oxidation chemistries into a tooth-paste composition |
5851512, | Mar 22 1990 | Ultradent Products, Inc.; Ultradent Products, INC | Dental compositions having a sticky matrix material for treating sensitive teeth |
5855870, | Mar 22 1990 | Ultradent Products, Inc.; Ultradent Products, INC | Method for treating sensitive teeth |
5902568, | Jan 15 1997 | CHURCH & DWIGHT CO , INC | Method for whitening teeth |
5908614, | Aug 15 1995 | Discus Dental, LLC | Peroxidase-activating oral compositions |
5928628, | Oct 23 1997 | Two-component dental bleaching system and method | |
5944528, | Jul 29 1996 | LORNAMEAD INC | Chlorine dioxide tooth whitening compositions |
5948420, | Apr 30 1997 | Ciba Specialty Chemicals Water Treatments Limited | Pharmaceutical and cosmetic compositions and their production |
5972374, | Apr 02 1998 | Chewing gum with teeth whitener | |
5985249, | Mar 22 1990 | Ultradent Products, INC | Sticky dental compositions for adhering a passive-type dental tray over a person's teeth |
6036943, | Mar 22 1990 | Ultradent Products, INC | Methods for treating a person's teeth using sticky dental compositions in combination with passive-type dental trays |
6149211, | Dec 12 1995 | CUSTOM CARE PRODUCTS, INC | Inclusion of tooth whitening oxidation chemistries into slow releasing food products |
6306370, | May 30 1997 | Ultradent Products, Inc. | Compositions and methods for whitening and desensitizing teeth |
6309625, | Nov 12 1998 | Ultradent Products, Inc. | One-part dental compositions and methods for bleaching and desensitizing teeth |
6312666, | Nov 12 1998 | 3M Innovative Properties Company | Methods of whitening teeth |
6312667, | Nov 12 1998 | 3M Innovative Properties Company | Methods of etching hard tissue in the oral environment |
6312670, | Sep 25 1995 | Discus Dental, LLC | Tooth bleaching compositions |
6322773, | Sep 25 1995 | Discus Dental, LLC | Tooth-bleaching compositions |
6365134, | Jul 07 1999 | Scientific Pharmaceuticals, Inc. | Process and composition for high efficacy teeth whitening |
6368576, | Nov 12 1998 | Ultradent Products, Inc. | Methods for bleaching, opacifying and desensitizing teeth |
6458340, | Sep 10 1998 | Ranir, LLC | Desensitizing bleaching gel |
6517350, | May 26 2000 | FRENCH TRANSIT, LLC | Method for whitening teeth |
6551579, | Jun 06 1997 | Procter & Gamble Company, The | Delivery systems for a tooth whitener |
6576227, | Aug 15 1995 | Discus Dental, LLC | Peroxidase-activating oral compositions |
6582708, | Jun 28 2000 | Procter & Gamble Company, The | Tooth whitening substance |
6599126, | Dec 31 1998 | PROFESSIONAL DENTAL TECHNOLOGIES, INC | Method and apparatus for whitening teeth using a fluid delivery toothbrush |
6620405, | Nov 01 2001 | 3M Innovative Properties Company | Delivery of hydrogel compositions as a fine mist |
6669927, | Nov 12 1998 | 3M Innovative Properties Company | Dental compositions |
6682721, | Mar 17 2000 | LG Household & Healthcare Ltd. | Patches for teeth whitening |
6685922, | Mar 23 2000 | DENTSPLY International Inc. | Tooth whitening material and method of whitening teeth |
6685923, | Jan 25 2001 | Dentsply Research & Development Corp | Tooth whitening material and method of whitening teeth |
6689344, | Mar 17 2000 | LG Household & Healthcare Ltd.; LG HOUSEHOLD AND HEALTH CARE, LTD | Patches for teeth whitening |
6746664, | Aug 06 2001 | Ultradent Products, Inc. | Multi-part dental bleaching systems and methods for bleaching teeth using such systems |
6780401, | Mar 17 2000 | LG Household & Healthcare Ltd. | Patches for teeth whitening |
6824704, | Oct 29 1998 | Ranir, LLC | Stable tooth whitening gels containing high percentages of hydrogen peroxide |
6884426, | Jun 06 1997 | The Procter & Gamble Co. | Methods for whitening teeth |
6946142, | Jun 23 2001 | LG HOUSEHOLD AND HEALTH CARE, LTD | Multi-layer patches for teeth whitening |
6949240, | May 23 2002 | Procter & Gamble Company, The | Tooth whitening products |
6964571, | Jan 24 2003 | Ultradent Products, INC | Pre-shaped dental trays and treatment devices and methods that utilize such dental trays |
6997708, | Oct 22 2003 | Ultradent Products, Inc. | Treatment compositions and strips having a solid adhesive layer and treatment gel adjacent thereto |
7004756, | Jan 24 2003 | Ultradent Products, INC | Pre-shaped dental trays and treatment devices and methods that utilize such dental trays |
7011523, | Oct 22 2003 | Ultradent Products, Inc.; Ultradent Products, INC | Bleaching compositions and devices having a solid adhesive layer and bleaching gel adjacent thereto |
7018622, | Jun 06 1997 | The Procter & Gamble Company | Structures and compositions increasing the stability of peroxide actives |
7040897, | May 23 2003 | Ultradent Products, Inc. | Thin, flexible membrane dental trays and systems and methods utilizing such trays |
7048543, | May 27 2003 | Ultradent Products, Inc.; Ultradent Products, INC | Substantially solid bleaching composition in a tray-like configuration |
7052275, | May 27 2003 | Ultradent Products, Inc. | Kits and methods for bleaching and desensitizing teeth |
7056118, | May 27 2003 | Ultradent Products, Inc. | Compositions and devices having a tray-like configuration for delivering a medicament and methods of manufacturing and using such compositions and devices |
7059857, | May 27 2003 | Ultradent Products, Inc. | Substantially solid desensitizing compositions and devices having a tray-like configuration and methods of manufacturing and using such compositions and devices |
7059858, | Feb 19 2004 | Ultradent Products, Inc.; Ultradent Products, INC; ULTRADENT PRODUCTS, INC , | Universal tray design having anatomical features to enhance fit |
7067115, | Jul 07 1999 | Scientific Pharmaceuticals, INC | Process and composition for high efficacy teeth whitening |
7074042, | May 27 2003 | Ultradent Products, Inc.; Ultradent Products, INC | Tray-like dental bleaching devices having a barrier layer and a substantially solid bleaching composition |
7122199, | Jun 06 1997 | Procter & Gamble Company, The | Methods for whitening teeth |
7192280, | Feb 19 2004 | Ultradent Products, Inc. | Dental bleaching devices having a protective adhesive region |
7393519, | Nov 07 2002 | Taisho Pharmaceutical Co., Ltd. | Base for oral composition and the oral composition |
7452209, | May 02 2005 | Ultradent Products, Inc. | Exoskeleton support for placement of a dental treatment strip |
7481653, | Jan 24 2003 | OraTech LC | Preshaped thin-walled dental trays and methods of manufacturing and using such trays |
7625210, | Aug 09 2004 | Ultradent Products, Inc. | Treatment devices for providing oral treatments and kits and methods that utilize such treatment devices |
7648363, | Oct 01 2001 | Lion Corporation | Method of whitening teeth, tooth whitening composition and tooth whitening set |
7785572, | Mar 17 2000 | LG Household and Health Care Ltd. | Method and device for teeth whitening using a dry type adhesive |
7862802, | Mar 17 2000 | LG HOUSEHOLD & HEALTH CARE LTD. | Patches for teeth whitening |
7887328, | Jun 05 2003 | FRENCH TRANSIT, LLC | Method for whitening teeth |
8007277, | Aug 09 2007 | Ultradent Products, Inc. | Non-custom dental treatment trays and mouth guards having improved anatomical features |
8202091, | Aug 31 2007 | Ultradent Products, Inc. | Dental treatment trays comprising silicone elastomeric material |
8277215, | Feb 19 2004 | Ultradent Products, Inc. | Universal non-custom dental tray having anatomical features to enhance fit |
8308479, | Nov 26 2003 | FRENCH TRANSIT, LLC | Method and apparatus for tooth whitening |
8376746, | Jun 05 2003 | FRENCH TRANSIT, LLC | Method for whitening teeth |
8444413, | Aug 25 2006 | Ultradent Products, Inc. | Non-custom dental treatment trays having improved anatomical features |
8647607, | Mar 17 2000 | LG HOUSEHOLD & HEALTH CARE LTD. | Patches for teeth whitening |
8652446, | Mar 17 2000 | LG HOUSEHOLD & HEALTHCARE LTD | Apparatus and method for whitening teeth |
8721332, | Aug 25 2006 | Ultradent Products, Inc. | Non-custom dental treatment trays having improved anatomical features |
8747113, | Oct 12 2006 | FRENCH TRANSIT, LLC | Moldable tray, system, and method for whitening teeth |
8936778, | Nov 12 1998 | Ultradent Products, Inc. | Methods for bleaching and desensitizing teeth |
8944819, | Nov 10 2004 | Ranir, LLC | Device and method for delivering an oral care agent |
9295633, | Jul 26 2006 | Ultradent Products, Inc. | Dental bleaching compositions with rheological stability |
9554976, | Sep 11 2002 | The Procter & Gamble Company | Tooth whitening product |
9566140, | Apr 27 2005 | DENTOVATIONS INC | Method and device for whitening teeth using sonochemistry |
9616005, | Jul 26 2006 | Ultradent Products, Inc. | Methods for manufacturing dental bleaching devices |
9717577, | Feb 19 2004 | Ultradent Products, Inc. | Non-custom dental tray having anatomical cuspid-bicuspid cuts and/or V or U-shaped indentation in bottom wall |
9949809, | Aug 31 2007 | Ultradent Products, INC | Dental treatment devices comprising silicone-like elastomeric material |
RE42024, | Nov 12 1998 | 3M Innovative Properties Company | Dental compositions |
RE42126, | Jun 30 2000 | The Procter & Gamble Company | Delivery system for oral care compositions comprising organosiloxane resins using a removable backing strip |
Patent | Priority | Assignee | Title |
5098303, | Mar 22 1990 | Ultradent Products, Inc.; ULTRADENT PRODUCTS, INC , A CORP OF UT | Method for bleaching teeth |
5234342, | Mar 22 1990 | Ultradent Products, Inc. | Sustained release method for treating teeth surfaces |
5290566, | Dec 18 1990 | LUSTERDENT, LLC | Tooth whitening formulation and method |
5376006, | Mar 22 1990 | Ultradent Products, Inc. | Dental bleaching compositions and methods for bleaching teeth surfaces |
5401495, | Oct 10 1990 | LORNAMEAD BRANDS, INC | Teeth whitener |
5409631, | Mar 22 1990 | Ultradent Products | Dental bleaching compositions and methods for bleaching teeth surfaces |
5500207, | Nov 18 1994 | Method of whitening teeth and composition therefore |
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