An auto-injector for injecting a fluid medicament into a patient from a pre-filled syringe requires a disposable cassette that is selectively engageable with the reusable injector. The syringe is latched onto the cassette, and the cassette is then engaged with the injector. Activation of the injector causes a first motor to move the syringe so its needle is extended from a concealed position inside the cassette for injection of the medicament. A second motor on the injector is then activated to expel fluid medicament from the syringe. Then, the first motor is again activated to withdraw the syringe into the cassette for disposal of the cassette/syringe after an injection.
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9. A system for injecting a fluid medicament into a patient, the system comprising:
a reusable injector; and
a removable and disposable cassette containing a hypodermic syringe including a syringe chamber for holding the fluid medicament therein and an injection needle extending from the syringe chamber;
the reusable injector including:
a first motor for moving the syringe within the disposable cassette between a first position and a second position while the disposable cassette is held on or in the injector in a fixed position;
a second motor for expelling the fluid medicament from the syringe chamber and through the injection needle; and
a computer for coordinated control of the first and second motors,
wherein the disposable cassette contains the hypodermic syringe including the syringe chamber and the injection needle when the disposable cassette is removed from the injector.
18. A method for injecting a fluid medicament from a syringe into a patient comprising:
providing a removable and disposable cassette containing a hypodermic syringe, the syringe including a syringe chamber for holding the fluid medicament therein and an injection needle extending from the syringe chamber;
mounting the cassette containing the hypodermic syringe on or in a reusable injector;
holding the cassette on or in the injector in a fixed position while moving the syringe within the cassette between a first position and a second position with a first motor of the injector to extend the injection needle out from within the cassette, into the patient;
expelling the fluid medicament from the syringe chamber, through the injection needle and into the patient, with a second motor of the injector;
removing the cassette containing the hypodermic syringe including the syringe chamber and the injection needle, from the injector; and
controlling the operation of the first and second motors with a computer.
1. A system for injecting a fluid medicament into a patient which comprises:
a removable and disposable cassette having a latch mechanism;
a hypodermic syringe engageable with the latch mechanism for latching the syringe within the disposable cassette;
a reusable injector;
a fixation member for holding the disposable cassette on or in the injector in a fixed position during the operation of the injector;
a first motor mounted on or in the injector, the first motor being engageable with the disposable cassette for selectively latching and unlatching the syringe within the disposable cassette, and engageable with the syringe for moving the unlatched syringe within the disposable cassette between a first position and a second position;
a second motor mounted on or in the injector, the second motor being engageable with the syringe for expelling the fluid medicament from the syringe; and
a computer mounted on or in the injector for coordinated control of the first and second motors,
wherein the disposable cassette contains the hypodermic syringe comprising the injection needle when the disposable cassette is removed from the injector.
2. A system as recited in
a syringe chamber for holding the fluid medicament therein;
an injection needle extending from the syringe chamber; and
a plunger slidably mounted for advancement into the syringe chamber to expel fluid medicament therefrom through the injection needle.
3. A system as recited in
4. A system as recited in
5. A system as recited in
computer control of the first motor for movement of the unlatched syringe at a predetermined speed from the first position to the second position;
computer control of the second motor for advancement of the plunger into the syringe chamber at a predetermined rate for expelling fluid medicament from the syringe; and
computer control of the first motor for withdrawal of the syringe from the second position to the first position and for activation of the latch to fixedly hold the syringe in the first position within the disposable cassette.
6. A system as recited in
7. A system as recited in
8. A system as recited in
a cassette body defining the fixation member; and
a sleeve slidingly mounted on or in the cassette body for movement between the first position and the second position,
wherein the syringe is fixedly held in the sleeve for movement therewith, and
wherein the latch mechanism includes a first part formed on the cassette body and a second part formed on the sleeve.
10. A system as recited in
11. A system as recited in
13. A system as recited in
14. A system as recited in
15. A system as recited in
16. A system as recited in
a housing; and
a sleeve slidingly disposed in the housing for movement between the first position and the second position,
wherein the syringe is fixedly held in the sleeve for movement therewith.
17. A system as recited in
19. A method as recited in
20. A method as recited in
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The present invention pertains generally to systems and methods for injecting fluid medicaments into a patient from a syringe. More particularly, the present invention pertains to auto-injectors that conceal the injection needle of a hypodermic syringe before, and after an injection. The present invention is particularly, but not exclusively, useful as a system and method that employs a bifurcated drive mechanism wherein one motor moves the entire syringe for an injection, and another motor moves the syringe plunger for expelling a fluid medicament from the syringe.
In order to inject a fluid medicament into a patient when using a hypodermic syringe, three separate and distinct tasks must be performed. These are: 1) insertion of the needle into the patient; 2) injection of the fluid medicament from the syringe into the patient; and 3) withdrawal of the needle after the injection has been completed. For each task, the magnitude and direction of forces on the syringe, as well as the location of their application, are different from the other tasks. For instance, compare the task of inserting the needle, with the task of injecting the fluid medicament. Insertion of the needle requires that only minimal forces be applied on the syringe, and that they be applied for only a very short period of time. On the other hand, injection of the medicament requires a much greater force be applied. Further, this force must be applied on the plunger of the syringe for what will typically be a relatively longer period of time. In comparison with both of these tasks, needle withdrawal requires the application of a force in the opposite direction. These, and other similar considerations, become important when the injection process is to be automated.
Springs for generating forces on a syringe in an automated process have been used heretofore for various purposes. A characteristic of springs, however, is that the magnitude and direction of a spring force are not variable. Consequently, springs do not lend themselves for so-called “multi-tasking” operations. This is particularly so where precise control over a syringe injection operation is required, and different magnitude forces are sequentially required in the same direction (e.g. needle insertion and medicament injection).
In addition to the mechanical considerations mentioned above, the design of an auto-injector also requires “user-friendly” considerations. In particular, it is desirable that the injection needle of a syringe be operationally concealed from the view of a user. Preferably, this concealment can be maintained before, during and after an injection procedure. Further, it is desirable that operation of the syringe be limited to only those times when the syringe is properly positioned for an injection.
In light of the above, it is an object of the present invention to provide a two-motor device for performing the injection of a fluid medicament into a patient wherein each motor generates different forces on a hypodermic syringe for different purposes. Another object of the present invention is to provide a reusable injector that can be operationally engaged with a disposable, pre-filled syringe. Still another object of the present invention is to provide an auto-injector system wherein the needle of a pre-filled syringe is operationally concealed and the system is operable only when the injector is properly positioned against the skin of a patient for an injection. Another object of the present invention is to provide a system and a method for automatically injecting a fluid medicament from a pre-filled syringe that is relatively simple to manufacture, is easy to use and is comparatively cost effective.
In accordance with the present invention an autoinjector system includes a disposable cassette that operates in combination with a reusable injector. Prior to an engagement of the cassette with the injector, however, a pre-filled syringe is mounted and latched onto the cassette. When latched, the syringe is held on the cassette in a so-called “home position”. For the present invention, this pre-filled syringe may be of any type syringe well-known in the pertinent art that has a fluid chamber with an injection needle at its distal end, and a plunger that can be advanced into the fluid chamber. When the cassette, with syringe, is engaged with the injector, the system is ready for use.
Operation of the system of the present invention requires two separate motors that are individually mounted on the injector. Though they are mechanically independent of each other, the respective operations of these two motors must be coordinated. Specifically, a first motor is used to effect movements of the entire syringe assembly (i.e. syringe chamber, injection needle and plunger are all moved together). On the other hand, a second motor is employed to advance the plunger into the fluid chamber for performing an injection of a fluid medicament.
In a duty cycle of the system, the first motor moves a drive rod into engagement with the syringe. With this engagement, the drive rod also releases the latch that otherwise holds the syringe in its “home position.” After the syringe has been released, the first motor then advances the syringe in a distal direction on the cassette. This movement inserts the injection needle into a patient. Further, the first motor can be used to abruptly stop the needle when a specified needle depth has been achieved. The first motor can then be used to help stabilize the needle during an injection of the medical medicament from the syringe.
As mentioned above, the injection of medical medicament from the syringe is accomplished using the second motor. In detail, once the needle has been properly inserted into the patient, the second motor moves a pusher to urge against the plunger of the syringe to advance the plunger into the fluid chamber of the syringe. Importantly, the second motor can be programmed to advance the plunger into the fluid chamber at a predetermined rate(s) for compliance with an injection protocol.
After the injection has been completed, the second motor withdraws the pusher. The first motor is then used again. Specifically, the first motor is now used to withdraw the injection needle from the patient, and to return the syringe to its “home position” on the cassette, where it is re-latched onto the cassette. The cassette can then be removed from the injector and discarded.
In order to control the concerted operations of the first and second motors, the system includes a microcomputer that is mounted on the injector. Importantly, the microcomputer operates the motors with different forces, and at different speeds for different purposes. More specifically, the first motor must operate quickly to insert the needle (e.g. 0.1 to 1 m/s), but it does not require much force to do so. Similarly, needle withdrawal by the first motor requires a minimal force. Unlike the first motor, however, the second motor will typically be required to generate greater forces for the injection of fluid medicament. And, accordingly, it will also typically operate at slower speeds. Further, and most importantly, different injections (i.e. advancements of the syringe plunger by the second motor) may require different injection rates. Thus, the second motor requires speed control provided by the microcomputer.
Together with the components mentioned above, the system of the present invention may, optionally, employ a capacitance skin sensor of a type well known in the pertinent art. If used, such a sensor will allow the user to ascertain whether the system has been properly positioned for an injection. In detail, a metal foil is positioned at the extreme distal end of the injector to establish a capacitance signal whenever the foil is in contact with a skin surface of the patient. The function of this signal is actually two-fold. First, it can be used to prevent initial operation, if the system is not properly positioned. And, second, it can be used to interrupt operation of the system, if it becomes improperly positioned during an injection.
The novel features of this invention, as well as the invention itself, both as to its structure and its operation, will be best understood from the accompanying drawings, taken in conjunction with the accompanying description, in which similar reference characters refer to similar parts, and in which:
Referring initially to
In
Still referring to
An important aspect of the present invention involves the assembly of the cassette 12 into an integral unit. When assembled, it is to be appreciated that the cassette 12 is intended for use only so long as there is fluid medicament in the syringe chamber 28 and, it is thereafter disposable. Prior to assembly, the syringe assembly 26 will have a pre-filled syringe chamber 28 holding a defined dose. The pre-filled syringe assembly 26 is then inserted into the sleeve member 24 where it is fixedly held. Movements of the sleeve member 24 will thus result in a corresponding movement of the syringe assembly 26. The combination (i.e. syringe assembly 26 and sleeve member 24) is then joined with the housing 22. When so joined, the protrusion 36 on sleeve member 24 fits in the detents 44a and 44b between the resilient arms 42a and 42b. Accordingly, the syringe assembly 26 is held on the cassette 12 in a so-called “home position”. Importantly, with the syringe assembly 26 in the “home position”, the injection needle 30 of the syringe assembly 26 is held, and concealed within the housing 22. In this configuration, the cassette 12 can be engaged with the injector 14 substantially as shown in
For an operation of the system 10, reference is directed collectively to
In overview, a duty cycle for the system 10 can be envisioned as a series of sequential changes in the configuration of cassette 12. For system 10, these configuration changes are caused by separate operations of the first motor 50 and the second motor 54. In compliance with these operations, a complete duty cycle for the system 10 will constitute, in order, configurations shown from
With the syringe assembly 26 in its advanced position (
As an additional feature of the system 10, a sensor 62 can be provided at the distal end of the injector 14. In particular, the sensor 62 should be positioned adjacent the hole 58 of cassette 12. For purposes of the present invention, the sensor 62 is preferably of a type that will react to capacitance that can be measured between the sensor 62 and the skin of the patient. The purpose of this sensor 62 is to establish that the system 10 is in physical contact with the patient. Specifically, the microcomputer 18 will operate a duty cycle for the system 10 only when such contact is indicated. Otherwise, there can be no operation of the system 10.
While the particular System and Method for an Injection Using a Syringe Needle as herein shown and disclosed in detail is fully capable of obtaining the objects and providing the advantages herein before stated, it is to be understood that it is merely illustrative of the presently preferred embodiments of the invention and that no limitations are intended to the details of construction or design herein shown other than as described in the appended claims.
Slate, John B., Burk, Michael W., Koerner, Richard J., Magers, Corey M.
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